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51. 发明申请

US20120053177A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：US20120053177A1
公开(公告)日：2012-03-01
申请号：US13243748
申请日：2011-09-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

52. 发明授权

US08067434B2 Compounds and methods for development of Ret modulators 有权
标题翻译： Ret调制剂的开发化合物和方法
公开(公告)号：US08067434B2
公开(公告)日：2011-11-29
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

53. 发明申请

US20110174360A1 RACK ASSEMBLY FOR MOUNTING SOLAR MODULES 有权
标题翻译：用于安装太阳能模块的机架组件
公开(公告)号：US20110174360A1
公开(公告)日：2011-07-21
申请号：US12949551
申请日：2010-11-18
申请人： Joshua Reed Plaisted , Brian West
发明人： Joshua Reed Plaisted , Brian West
IPC分类号： H01L31/058 , F16B1/02
CPC分类号： H02S40/44 , F24S25/10 , F24S25/20 , F24S25/35 , F24S25/636 , F24S2020/17 , F24S2030/16 , H02S20/23 , Y02B10/12 , Y02B10/20 , Y02B10/70 , Y02E10/47 , Y02E10/60
摘要： A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures to be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.
摘要翻译：提供了用于将太阳能模块安装在下面的主体上的机架组件。齿条组件可以包括多个轨道结构，其可布置在下面的主体上方以形成用于齿条组件的整个周边。一个或多个保持结构可以设置有多个轨道结构，其中每个保持结构被配置为在下面的身体上方的给定高度处支撑一个或多个太阳能模块。多个轨道结构中的至少一些适于使单独的轨道结构能够密封在下面的主体上，以限制太阳能模块下方的空气流动。另外，（i）一个或多个轨道结构中的至少一个，或（ii）一个或多个保持结构是可调节的，以便使齿条组件适应于适应不同形式或尺寸的太阳能模块。

54. 发明申请

US20110173900A1 MOUNTING ASSEMBLY FOR ARRAYS AND OTHER SURFACE-MOUNTED EQUIPMENT 有权
标题翻译：安装组件和其他表面安装设备
公开(公告)号：US20110173900A1
公开(公告)日：2011-07-21
申请号：US12947601
申请日：2010-11-16
申请人： Joshua Reed Plaisted , Brian West
发明人： Joshua Reed Plaisted , Brian West
IPC分类号： E04D13/18 , E04B1/38 , E04D13/00
CPC分类号： F16L3/127 , F24S25/12 , F24S25/61 , F24S25/617 , F24S25/70 , F24S30/425 , F24S2030/16 , H02S20/24 , H02S20/30 , Y02B10/12 , Y02B10/20 , Y02E10/47
摘要： A mounting system is provided for supporting equipment such as solar module arrays on a rooftop or other underlying surface. The mounting system includes a pipe, and a grasp section. These couple to a base that is extended into or otherwise integrated with the underlying surface. The pipe may be coupled so as to extend a height from the underlying surface. The grasp section is coupled to a top section of the pipe and is structured to secure to a section of the solar module array when the solar module array is installed on the underlying surface.
摘要翻译：提供了一种用于在诸如屋顶或其它下面的表面上的诸如太阳能模块阵列之类的设备的支撑系统。安装系统包括管道和抓握部分。这些耦合到延伸到底层表面或以其他方式与底层表面集成的基底。管可以联接以便从下表面延伸高度。抓握部分连接到管道的顶部，并且当太阳能模块阵列安装在下面的表面上时，被构造成固定到太阳能模块阵列的一部分。

55. 发明授权

US07759475B2 Enzyme expression methods and compositions 有权
标题翻译：酶表达方法和组成
公开(公告)号：US07759475B2
公开(公告)日：2010-07-20
申请号：US12409443
申请日：2009-03-23
申请人： Brian West
发明人： Brian West
IPC分类号： C07J21/02 , C12N9/00 , C12P21/04 , C07H21/04 , C12N1/12
CPC分类号： C12N9/16 , C12N9/1205
摘要： Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme and/or for identification of soluble and/or active catalytic domains by systematic variation of fragment lengths around catalytic domain boundaries.
摘要翻译：描述了表达活性酶的方法，其涉及共同表达具有逆转第一酶修饰的酶活性的第二酶的第一酶和/或用于通过片段的系统变化鉴定可溶性和/或活性催化结构域的第一酶长度在催化畴边界周围。

56. 发明授权

US07721492B2 Strut runner member and assembly using same for mounting arrays on rooftops and other structures 有权
标题翻译：支柱浇道构件和组件使用相同的安装阵列在屋顶和其他结构上
公开(公告)号：US07721492B2
公开(公告)日：2010-05-25
申请号：US11851299
申请日：2007-09-06
申请人： Joshua Reed Plaisted , Brian West
发明人： Joshua Reed Plaisted , Brian West
IPC分类号： E04D13/18 , E04C2/38 , H01L35/00 , H01L35/02 , H01L31/042
CPC分类号： H02S20/23 , F24S25/33 , F24S25/40 , F24S25/61 , F24S25/632 , F24S40/44 , F24S2025/021 , Y02B10/12 , Y02B10/20 , Y02E10/47
摘要： A strut runner includes a member extending lengthwise in a first direction, where the member includes an underlying panel and one or more walls that extend from the panel. The member may be configured to at least partially support the panel array while being integrated or directly connected to the underlying structure. Additionally, the strut runner may include one or more peripheral extensions that extend a distance outward from the body.
摘要翻译：支柱流道包括沿第一方向纵向延伸的构件，其中构件包括下面的面板和从面板延伸的一个或多个壁。该构件可以被配置为至少部分地支撑面板阵列，同时被集成或直接连接到下面的结构。此外，支柱转轮可以包括从主体向外延伸一定距离的一个或多个外围延伸部。

57. 发明申请

US20070010917A1 Adaptive digital power control system 失效
公开(公告)号：US20070010917A1
公开(公告)日：2007-01-11
申请号：US11178671
申请日：2005-07-11
申请人： Simeon Masson , Chris Hearn , Edward Prado , Brian West
发明人： Simeon Masson , Chris Hearn , Edward Prado , Brian West
IPC分类号： G05D11/00
CPC分类号： G06F1/26 , H02M3/157
摘要： An adaptive digital power control system is disclosed, which implements a digitally controlled, near real-time algorithm to accommodate multiple loop current mode controls for low voltage, high performance computing system power needs. For example, an adaptive digital power control system that is implemented with an FPGA to generate low voltages for high performance computing systems is disclosed, which includes a current and voltage loop compensation algorithm that enables the adaptive digital power control system to dynamically compensate for high current transients and EMI-related noise. The current and voltage loop compensation algorithm uses a combination of linear predictive coding and Kalman filtering techniques to provide dynamic current and voltage compensation, and implement a feed-forward technique using knowledge of the power system's output parameters to adequately adapt to the system's compensation needs. More specifically, an adaptive digital power control system is disclosed, which includes a power stage for generating a plurality of low voltages, a multiplexer and A/D converter stage for receiving and converting the plurality of low voltages and a plurality of associated currents to a plurality of digital voltage and current signals, a current and voltage compensation algorithm stage for receiving the plurality of digital voltage and current signals and generating a plurality of digital voltage and current compensation control signals using linear predictive coding, Kalman filtering and feed-forward estimation techniques, and a digitally controlled pulse width modulator stage for receiving the plurality of digital voltage and current compensation control signals and controlling the duty cycles of a plurality of transistor switching devices in the power stage. Thus, the adaptive digital power control system can dynamically compensate for high current transients and EMI-related noise generated in low voltage power systems for high performance computing systems.

58. 发明申请

US20060160135A1 SF-1 and LRH-1 modulator development 审中-公开
标题翻译： SF-1和LRH-1调节剂的开发
公开(公告)号：US20060160135A1
公开(公告)日：2006-07-20
申请号：US11297793
申请日：2005-12-07
申请人： Weiru Wang , Chao Zhang , Adhirai Marimuthu , Heike Krupka , Maryam Tabrizizad , Rafe Shellooe , Upasana Mehra , Brian West
发明人： Weiru Wang , Chao Zhang , Adhirai Marimuthu , Heike Krupka , Maryam Tabrizizad , Rafe Shellooe , Upasana Mehra , Brian West
IPC分类号： G01N33/53 , G06F19/00 , C07K14/575
CPC分类号： C07K14/705 , C07K14/70567 , G01N33/743 , G01N2500/00
摘要： Structures of SF1 and LRH are described, along with methods for identifying or developing modulators of those receptors and uses for such modulators.
摘要翻译：描述了SF1和LRH的结构，以及用于鉴定或开发这些受体的调节剂和用于这种调节剂的方法。

59. 发明申请

US20060149521A1 Modulating nuclear receptor coactivator binding 审中-公开
标题翻译：调节核受体共激活因子结合
公开(公告)号：US20060149521A1
公开(公告)日：2006-07-06
申请号：US11274682
申请日：2005-11-14
申请人： John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
发明人： John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
IPC分类号： C07K14/72 , G06G7/48
CPC分类号： G01N33/6875 , G01N2500/20 , H01L21/3065 , H01L21/314 , H01L29/6659
摘要： The present invention comprises cocrystal of a nuclear receptor comprising a molecule bound to the coactivator binding site of said nuclear receptor. The present invention further comprises a machine-readable data storage medium encoded with machine readable data corresponding to the structure coordinates of amino acids of a nuclear receptor coactivator binding site which, when using a machine programmed with instructions for using said data, is capable of displaying a graphical three-dimensional representation of a molecular complex of a compound bound to a nuclear receptor coactivator binding site.
摘要翻译：本发明包括核受体的共晶体，其包含与所述核受体的共激活因子结合位点结合的分子。本发明还包括一种机器可读数据存储介质，其被编码有对应于核受体共激活剂结合位点的氨基酸的结构坐标的机读数据，当使用编程有用于使用所述数据的指令的机器时，能够显示与核受体共激活子结合位点结合的化合物的分子复合物的图形三维表示。

60. 发明申请

US20060118163A1 Rack assembly for mounting solar modules 有权
标题翻译：用于安装太阳能模块的机架组件
公开(公告)号：US20060118163A1
公开(公告)日：2006-06-08
申请号：US11332000
申请日：2006-01-13
申请人： Joshua Plaisted , Brian West
发明人： Joshua Plaisted , Brian West
IPC分类号： H01L25/00
CPC分类号： H02S40/44 , F24S25/10 , F24S25/20 , F24S25/35 , F24S25/636 , F24S2020/17 , F24S2030/16 , H02S20/23 , Y02B10/12 , Y02B10/20 , Y02B10/70 , Y02E10/47 , Y02E10/60
摘要： A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures o be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.
摘要翻译：提供了用于将太阳能模块安装在下面的主体上的机架组件。齿条组件可以包括多个轨道结构，其可布置在下面的主体上方以形成用于齿条组件的整个周边。一个或多个保持结构可以设置有多个轨道结构，其中每个保持结构被配置为在下面的身体上方的给定高度处支撑一个或多个太阳能模块。多个轨道结构中的至少一些适于使得单独的轨道结构能够被密封在下面的主体上，以便限制太阳能模块下面的空气流动。另外，（i）一个或多个轨道结构中的至少一个，或（ii）一个或多个保持结构是可调节的，以便使齿条组件适应于适应不同形式或尺寸的太阳能模块。

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