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51. 发明申请

US20090148836A1 Method for Rapid Detection and Identification of Bioagents 有权
公开(公告)号：US20090148836A1
公开(公告)日：2009-06-11
申请号：US11929707
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.

52. 发明申请

US20090125245A1 Methods For Rapid Forensic Analysis Of Mitochondrial DNA 失效
标题翻译：线粒体DNA快速法医分析方法
公开(公告)号：US20090125245A1
公开(公告)日：2009-05-14
申请号：US12049949
申请日：2008-03-17
申请人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
发明人： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
IPC分类号： C12Q1/68 , G01N33/48 , C07H21/04
CPC分类号： G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G06F19/28 , C12Q2565/627 , C12Q2521/301
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
摘要翻译：本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法已知线粒体DNA序列的理论限制性消化存储在数据库中。

53. 发明申请

US20080160512A1 Method for rapid detection and identification of bioagents 有权
标题翻译：快速检测和鉴定生物标签的方法
公开(公告)号：US20080160512A1
公开(公告)日：2008-07-03
申请号：US11233630
申请日：2005-09-21
申请人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
发明人： David J. Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译：通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域识别生物制剂。结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。

54. 发明授权

US07255992B2 Methods for rapid detection and identification of bioagents for environmental and product testing 有权
标题翻译：用于快速检测和鉴定环境和产品测试的生物标签的方法
公开(公告)号：US07255992B2
公开(公告)日：2007-08-14
申请号：US10660996
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings, containers, towers and the like, as well as testing of foodstuff and cosmetics.
摘要翻译：本发明提供用于快速检测环境和产品测试的生物标签的方法。该方法可用于测试空气，水，土壤，建筑物，容器，塔架等的表面，以及食品和化妆品的测试。

55. 发明授权

US07226739B2 Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations 有权
标题翻译：在流行病学和法医学调查中快速检测和鉴定生物标本的方法
公开(公告)号：US07226739B2
公开(公告)日：2007-06-05
申请号：US10660997
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译：本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。该方法也可用于通过基因分型生物学的流行病学调查。

56. 发明授权

US06969763B1 Molecular interaction sites of interleukin-2 RNA and methods of modulating the same 失效
标题翻译：白细胞介素-2 RNA的分子相互作用位点及其调控方法
公开(公告)号：US06969763B1
公开(公告)日：2005-11-29
申请号：US09310844
申请日：1999-05-12
申请人： David J. Ecker , Richard Griffey , Stanley T. Crooke , Ranga Sampath , Eric Swayze , Venkatraman Mohan , Steven Hofstadler , John McNeil
发明人： David J. Ecker , Richard Griffey , Stanley T. Crooke , Ranga Sampath , Eric Swayze , Venkatraman Mohan , Steven Hofstadler , John McNeil
IPC分类号： C07H21/04 , C07K14/54 , C07K14/55 , C40B30/02 , C40B50/02 , G06F19/00
CPC分类号： C40B50/02 , C07H21/04 , C07K14/5406 , C07K14/55 , C40B30/02 , G06F19/14 , G06F19/16 , G06F19/28
摘要： Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.
摘要翻译：提供了用于鉴定调节，抑制或刺激生物分子的化合物的方法。核酸，特别是RNA是用于这种调节的优选底物。本发明的方法特别强大，因为它们提供了引起化合物（通常是“小”）有机化合物的技术的新组合，其是RNA和其它生物分子活性的高效调节剂。根据本发明的优选方面，可以基本上同时测试非常大量的化合物以确定它们是否可能与分子相互作用位点相互作用并且调节生物分子的活性。根据本发明的实施方案，可以鉴定药物，兽药，农药，工业化学品，研究化学品和许多其它有益化合物。

57. 发明授权

US06770738B1 Higher order structure and binding of peptide nucleic acids 失效
标题翻译：高级结构和肽核酸的结合
公开(公告)号：US06770738B1
公开(公告)日：2004-08-03
申请号：US09442054
申请日：1999-11-16
申请人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
发明人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
IPC分类号： A61K3800
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

58. 发明授权

US06451524B1 Identification of disease predictive nucleic acids 有权
标题翻译：疾病预测核酸的鉴定
公开(公告)号：US06451524B1
公开(公告)日：2002-09-17
申请号：US09200355
申请日：1998-11-25
申请人： David J. Ecker
发明人： David J. Ecker
IPC分类号： C12Q168
CPC分类号： C12Q1/6809
摘要： The present invention is directed to methods of identifying target nucleic acid sequences which are predictive of preselected disease states or biological conditions in cells containing the nucleic acid sequence. Members of a set of mRNA molecules from a common gene, but containing different sequences and structures, are compared. The gene is predictive of the disease state or biological condition in cells containing the gene. At least one molecular interaction site from among those present in the members of the set are identified. The molecular interaction site is present in cells likely to have the disease state or biological condition. At least one nucleic acid sequence from the molecular interaction site is ascertained.
摘要翻译：本发明涉及鉴定靶核酸序列的方法，所述靶核酸序列预测含有核酸序列的细胞中预选疾病状态或生物学条件。比较来自共同基因，但含有不同序列和结构的一组mRNA分子的成员。该基因是预测含有该基因的细胞中的疾病状态或生物学条件。确定存在于该组成员中的至少一个分子相互作用位点。分子相互作用位点存在于可能具有疾病状态或生物学条件的细胞中。确定来自分子相互作用位点的至少一个核酸序列。

59. 发明授权

US06448373B1 Phosphate linked oligomers formed of monomeric diols and processes for preparing same 失效
标题翻译：由单体二醇形成的磷酸酯连接的低聚物及其制备方法
公开(公告)号：US06448373B1
公开(公告)日：2002-09-10
申请号：US08179970
申请日：1994-01-11
申请人： Phillip D. Cook , Oscar L. Acevedo , Peter W. Davis , David J. Ecker , Normand Herbert
发明人： Phillip D. Cook , Oscar L. Acevedo , Peter W. Davis , David J. Ecker , Normand Herbert
IPC分类号： A61K3800
CPC分类号： C07H21/00 , B01J2219/00592 , B01J2219/00695 , C07B2200/11 , C07F9/143 , C07F9/2408 , C07F9/2429 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/65031 , C07F9/65038 , C07F9/6506 , C07F9/6512 , C07F9/6521 , C07F9/6533 , C07F9/65335 , C07F9/6547 , C07F9/6561 , C07F9/65616
摘要： Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.
摘要翻译：使用具有各种官能团的新型乙二醇化合物来制备低聚结构。乙二醇单体可以通过包括磷酸二酯和硫代磷酸酯键的标准磷酸键连接。有用的官能团包括核碱基以及参与氢键的极性基团，疏水基团，离子基团，芳族基团和/或基团。

60. 发明授权

US06262241B1 Compound for detecting and modulating RNA activity and gene expression 失效
标题翻译：用于检测和调节RNA活性和基因表达的化合物
公开(公告)号：US06262241B1
公开(公告)日：2001-07-17
申请号：US08383666
申请日：1995-02-03
申请人： Phillip Dan Cook , David J. Ecker , Charles John Guinosso , Oscar Leobardo Acevedo , Andrew Kawasaki , Kandasamy Ramasamy
发明人： Phillip Dan Cook , David J. Ecker , Charles John Guinosso , Oscar Leobardo Acevedo , Andrew Kawasaki , Kandasamy Ramasamy
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , A61K47/51 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through backbone sugar bond cleavage or through base modification are preferrably employed. Groups which improve the pharmacodynamic and pharmacokinetic properties of the oligonucleotides are also useful in accordance with certain embodiments of this invention. Delivery of the reactive or non-reactive functionalities into the minor groove formed by the hybridization of the composition with the target RNA is also preferrably accomplished. Therapeutics, diagnostics and research methods and also disclosed. Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.
摘要翻译：公开了调节RNA和DNA活性的组合物和方法。根据优选实施方案，制备包含靶向和反应部分的反义组合物。优选使用通过骨架糖键切割或通过碱改性而作用或通过磷酸酯键断裂的反应性部分。根据本发明的某些实施方案，提高寡核苷酸的药效学和药代动力学性质的组也是有用的。通过组合物与靶RNA的杂交形成的反应性或非反应性官能团的递送也是优选的。治疗，诊断和研究方法也被披露。合成核苷和核苷片段也可用于制备用于这些目的的寡核苷酸和寡核苷酸类似物。

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