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51. 发明申请

US20120034269A1 ANALOGS OF ALPHA GALACTOSYLCERAMIDE AND USES THEREOF 有权
标题翻译：阿尔法胶乳酰胺的模拟物及其用途
公开(公告)号：US20120034269A1
公开(公告)日：2012-02-09
申请号：US13231403
申请日：2011-09-13
申请人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
发明人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
IPC分类号： A61K39/39 , A61P35/00 , A61P37/04
CPC分类号： C07H15/00
摘要： Compounds of formula wherein the variable are defined in the specification, are used in compositions which stimulate T cell responses.
摘要翻译：在本说明书中定义变体的式的化合物用于刺激T细胞应答的组合物中。

52. 发明申请

US20110129483A1 Membrane transporter NaPi2b (SCL34A1) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy 有权
标题翻译：用于抗体治疗的膜转运体NaPi2b（SCL34A1）表位，针对其的抗体和用于癌症治疗的靶标
公开(公告)号：US20110129483A1
公开(公告)日：2011-06-02
申请号：US12735576
申请日：2009-01-29
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lioyd Old , Kenneth Lioyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lioyd Old , Kenneth Lioyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13 , C12N1/21 , C12N1/19 , C12N5/07 , C12N5/04 , C07K14/435 , C07K7/08 , A61K39/00 , A61K38/00 , G01N33/53 , A61P35/00 , A61P37/00
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present disclosure relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide (s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.
摘要翻译：本公开总体上涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。还提供了产生免疫应答和治疗肿瘤和癌症的方法。提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。

53. 发明授权

US07780947B2 Tame based chelators and uses thereof 有权
标题翻译：温驯的螯合剂及其用途
公开(公告)号：US07780947B2
公开(公告)日：2010-08-24
申请号：US10582195
申请日：2004-12-03
申请人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
发明人： Enver Arslantas , Richard R. Schmidt , Peter M. Smith-Jones , Gerd Ritter
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07C229/16 , A61K51/0478 , C07C331/28
摘要： New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
摘要翻译：描述了新的双功能螯合配合物。这些基于所谓的“TAME-HexA”分子的结构。该化合物特别可用于形成与金属离子的螯合络合物，包括放射性同位素。

54. 发明申请

US20070208993A1 Template-based creation of electronic document 有权
标题翻译：基于模板的电子文件创建
公开(公告)号：US20070208993A1
公开(公告)日：2007-09-06
申请号：US11368841
申请日：2006-03-06
申请人： Gerd Ritter
发明人： Gerd Ritter
IPC分类号： G06F17/00
CPC分类号： G06F17/248
摘要： Operations included in creation of an electronic document having a plurality of predefined fields include receiving an input that a user makes under guidance of an input area in a graphical user interface (GUI). The input includes a character string and is made to create an electronic document in a computer system. A field with which the first character string is associated is determined. A template has a template input area for each of several predefined fields. The template is displayed in the GUI with an entry corresponding to the string entered in the correct input area. A GUI includes the input area and a template display area. Upon determining that the first character string is associated with a first predefined field, the first character string is entered in the template input area for the first predefined field. The string can also be used for template selection.
摘要翻译：包括在创建具有多个预定义字段的电子文档中的操作包括在图形用户界面（GUI）中接收用户在输入区域的引导下进行的输入。该输入包括一个字符串，并被制成在计算机系统中创建一个电子文档。确定与第一个字符串相关联的字段。模板具有用于几个预定义字段中的每一个的模板输入区域。该模板显示在GUI中，并具有与在正确输入区域中输入的字符串相对应的条目。 GUI包括输入区域和模板显示区域。在确定第一字符串与第一预定义字段相关联时，第一字符串被输入到用于第一预定义字段的模板输入区域中。该字符串也可用于模板选择。

55. 发明申请

US20070162484A1 Document role determination 审中-公开
标题翻译：文件角色确定
公开(公告)号：US20070162484A1
公开(公告)日：2007-07-12
申请号：US11322571
申请日：2005-12-30
申请人： Gerd Ritter , Andre Wachholz-Prill , Volkmar Stegmann
发明人： Gerd Ritter , Andre Wachholz-Prill , Volkmar Stegmann
IPC分类号： G06F7/00
CPC分类号： G06Q10/02
摘要： The present subject matter, in various embodiments, provides systems, software, and methods to automatically determine roles to include, and not include, in documents. Some embodiments further include populating the roles in documents. Determining roles to include and not include, in some embodiments, includes branching decisions, the result of which can be to include one of multiple roles, or not including a role.
摘要翻译：在各种实施例中，本主题提供系统，软件和方法，以自动确定在文档中包括但不包括在内的角色。一些实施例还包括在文档中填充角色。确定在一些实施例中包括和不包括的角色包括分支决定，其结果可以是包括多个角色之一，或不包括角色。

56. 发明申请

US20070156977A1 Automatic location data determination in an electronic document 审中-公开
标题翻译：电子文件中的自动位置数据确定
公开(公告)号：US20070156977A1
公开(公告)日：2007-07-05
申请号：US11319510
申请日：2005-12-29
申请人： Gerd Ritter , Christian Haas
发明人： Gerd Ritter , Christian Haas
IPC分类号： G06F12/00
CPC分类号： G06F17/243 , G06Q10/10
摘要： The automated data field processing of an input form includes the determination of a purpose identifier for the form. In the input form, input data is received associated with one or more data fields of the input form. Based on this input data, stored data is retrieved from a memory device and associated with further data fields of the input form. The automated data field processing includes determining location data for the input form based on the purpose identifier and at least one of the input data, the stored data or a combination of both. The location data identifies a particular location relating to the intended purpose of the business form and the location data is thereupon associated with the input form.
摘要翻译：输入表格的自动数据字段处理包括确定表单的目的标识符。在输入形式中，接收与输入形式的一个或多个数据字段相关联的输入数据。基于该输入数据，从存储器件检索存储的数据并与输入形式的其他数据字段相关联。自动数据字段处理包括基于目的标识符和输入数据，存储的数据或两者的组合中的至少一个确定输入表单的位置数据。位置数据标识与业务表单的预期目的相关的特定位置，并且位置数据随后与输入表单相关联。

57. 发明申请

US20070148087A1 Tame based chelators and uses thereof 有权
标题翻译：温驯的螯合剂及其用途
公开(公告)号：US20070148087A1
公开(公告)日：2007-06-28
申请号：US10582195
申请日：2004-12-03
申请人： Enver Arslantas , Richard Schmidt , Peter Smith-Jones , Gerd Ritter
发明人： Enver Arslantas , Richard Schmidt , Peter Smith-Jones , Gerd Ritter
IPC分类号： A61K51/00 , C07F5/00
CPC分类号： C07C229/16 , A61K51/0478 , C07C331/28
摘要： New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
摘要翻译：描述了新的双功能螯合配合物。这些基于所谓的“TAME-HexA”分子的结构。该化合物特别可用于形成与金属离子的螯合络合物，包括放射性同位素。

58. 发明申请

US20060149724A1 Methods relating to data repository querying 审中-公开
标题翻译：与数据仓库查询有关的方法
公开(公告)号：US20060149724A1
公开(公告)日：2006-07-06
申请号：US11027196
申请日：2005-01-03
申请人： Gerd Ritter , Winfried Schleier
发明人： Gerd Ritter , Winfried Schleier
IPC分类号： G06F17/30
CPC分类号： G06F16/217
摘要： A method to be performed before performing a data repository query includes receiving an input from a user, the input specifying a query to be performed in a data repository. Before performing the query, it is determined whether the query meets a predefined criterion associated with slow data repository queries. If the query meets the predefined criterion, a message is presented to the user regarding the query potentially being slow to perform, and it is provided that the user can modify the query before the query is performed. A method to be performed in association with a data repository query includes receiving an input that specifies a query to be performed in a data repository. The query is performed in the data repository. If performance of the query exceeds a predefined limit, the query is recorded. Recorded queries may be used in improving system performance or in educating users.
摘要翻译：在执行数据存储库查询之前执行的方法包括从用户接收输入，该输入指定要在数据存储库中执行的查询。在执行查询之前，确定查询是否符合与慢数据存储库查询相关联的预定标准。如果查询满足预定义的标准，则向用户呈现关于可能执行缓慢的查询的消息，并且提供用户可以在查询执行之前修改查询。与数据存储库查询相关联地执行的方法包括接收指定要在数据存储库中执行的查询的输入。该查询在数据存储库中执行。如果查询的性能超过预定义的限制，则会记录查询。记录的查询可用于提高系统性能或教育用户。

60. 发明授权

US5554287A Cellulose matrix filter material 失效
标题翻译：纤维素基质过滤材料
公开(公告)号：US5554287A
公开(公告)日：1996-09-10
申请号：US218323
申请日：1994-03-25
申请人： Dieter Beck , Peter P. Breitbach, deceased , Thomas Breitbach, heir , Rudiger Leibnitz , Gerd Ritter
发明人： Dieter Beck , Peter P. Breitbach, deceased , Thomas Breitbach, heir , Rudiger Leibnitz , Gerd Ritter
IPC分类号： B01D39/18 , D21H13/06 , D21H17/25 , D21H21/52 , D21H27/08 , B27N3/04
CPC分类号： D21H13/06 , B01D39/18 , D21H17/25 , D21H21/52 , D21H27/08 , Y10S264/48
摘要： A filter material forming a filter layer consisting substantially exclusively of celluloses and cellulose derivatives. In addition to cellulose acetate fibers, the filter layer contains, in the form of additives, microcrystalline cellulose and microfine cellulose, or else microcrystalline cellulose only. The amount of microcrystalline cellulose can be as high as 70% of the weight of the filter layer and that of microfine cellulose up to 50% of the weight of the filter layer. Cellulose acetate fibers can be excluded if in their place, microcrystalline cellulose having particle sizes less than 10 .mu.m. are used. The manufacturing method provides for cellulose acetate fibers to be first mixed in a wet state with microfine cellulose and microcrystalline cellulose, after which differently prepared celluloses are admixed. The mash formed by mixing is formed into a fleece by means of a known felting method, and the fleece is subsequently dried. With layers of the filter material, filtration efficiencies up to and including a sterilizing range are achieved, which renders them comparable to known kieselguhr layers.
摘要翻译：形成基本上仅由纤维素和纤维素衍生物组成的过滤层的过滤材料。除醋酸纤维素纤维外，过滤层以微晶纤维素和微细纤维素为添加剂的形式，也可以仅含微晶纤维素。微晶纤维素的量可以高达过滤层重量的70％，超细纤维素的量高达过滤层重量的50％。如果纤维素醋酸酯纤维在其位置，粒径小于10微米的微晶纤维素可以被排除。被使用。该制造方法提供先将纤维素乙酸纤维以湿态状态与微细纤维素和微晶纤维素混合，之后混合不同制备的纤维素。通过混合形成的糊状物通过已知的毡化方法形成羊毛，随后干燥羊毛。通过过滤材料层，达到直至并包括灭菌范围的过滤效率，这使得它们与已知的硅藻土层相当。

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