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51. 发明授权

US07897625B2 Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases 有权
标题翻译：氨基甲酰基苯并三唑衍生物作为脂肪酶和磷脂酶的抑制剂
公开(公告)号：US07897625B2
公开(公告)日：2011-03-01
申请号：US12099924
申请日：2008-04-09
申请人： Stefan Petry , Gerhard Zoller , Norbert Tennagels , Günter Müller
发明人： Stefan Petry , Gerhard Zoller , Norbert Tennagels , Günter Müller
IPC分类号： A61K31/4192 , C07D249/18
CPC分类号： C07D249/18 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.
摘要翻译：本发明涉及通式（I）的氨基甲酰基苯并三唑衍生物，其定义如本说明书中引用的其药学上可应用的盐及其作为药物的用途。

52. 发明申请

US20110039883A1 AZOLOPYRIDIN-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS 审中-公开
标题翻译：作为脂质体和磷脂酰抑制剂的AZOLOPYRIDIN-2-ONE衍生物
公开(公告)号：US20110039883A1
公开(公告)日：2011-02-17
申请号：US12914045
申请日：2010-10-28
申请人： Gerhard Zoller , Stefan Petry , Gunter Müller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Müller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/437 , A61P5/50 , A61P3/10 , A61P3/06 , A61P9/10 , C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides compounds which have an inhibitory effect on hormone-sensitive lipase or endothelial lipase. The compounds of the invention are azolopyridin-2-one derivatives of the general formula I wherein the substituents are as defined herein. The compounds of formula I wherein R2 is hydrogen are distinguished by favorable effects on disorders of lipid metabolism. They beneficially influence the HDL to LDL ratio and increase in particular the HDL level and are suitable for the prevention and treatment of dyslipidemias and metabolic syndrome and their diverse sequelae such as atherosclerosis, coronary heart disease, heart failure, obesity and diabetes. The compounds of formula I wherein R1 and R2 together form a ring system are distinguished by favorable effects on metabolic disorders. They beneficially influence lipid and sugar metabolism; in particular they lower the triglyceride level and are suitable for the prevention and treatment of type II diabetes and arteriosclerosis and the diverse sequelae thereof.
摘要翻译：本发明提供对激素敏感性脂肪酶或内皮脂肪酶具有抑制作用的化合物。本发明的化合物是通式I的偶氮吡啶-2-酮衍生物，其中取代基如本文所定义。其中R2是氢的式I化合物的特征在于对脂质代谢紊乱的有利影响。它们有利地影响HDL与LDL的比例，特别是HDL水平的升高，适用于预防和治疗血脂异常和代谢综合征及其各种后遗症如动脉粥样硬化，冠心病，心力衰竭，肥胖和糖尿病。其中R1和R2一起形成环系的式I化合物的特征在于对代谢紊乱的有利影响。它们有利地影响脂质和糖代谢; 特别是它们降低甘油三酯水平，并且适合于预防和治疗II型糖尿病和动脉硬化及其各种后遗症。

53. 发明授权

US07781613B2 Substituted N-aminomethylene sulfonamides, production and use thereof as medicaments 有权
标题翻译：取代的N-氨基亚甲基磺酰胺，其制备和用途作为药物
公开(公告)号：US07781613B2
公开(公告)日：2010-08-24
申请号：US11767660
申请日：2007-06-25
申请人： Karl Schoenafinger , Stefan Petry , Guenter Mueller , Karl-Heinz Baringhaus
发明人： Karl Schoenafinger , Stefan Petry , Guenter Mueller , Karl-Heinz Baringhaus
IPC分类号： C07C311/16 , A61K31/18 , A61K31/445 , A61K31/495 , C07D211/26 , C07D265/30 , C07D241/30
CPC分类号： C07C311/51 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D295/096 , C07D295/32
摘要： Disclosed are compounds of the general formula (I), with the definitions of the substituents R1 to R5, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).
摘要翻译：公开了通式（I）的化合物，其中取代基R 1至R 5，A和X的定义在文中详述，以及其生理学上可接受的盐，用于制备这些化合物的方法及其作为抑制剂的用途激素敏感性脂肪酶（HSL）。

54. 发明授权

US07741491B2 Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1B (PTB1B) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes 有权
标题翻译：二苯胺取代的水杨基噻唑衍生物和相关化合物作为磷酸降解活性成分用于治疗糖尿病的磷酸酪氨酸磷酸酶1B（PTB1B）抑制剂
公开(公告)号：US07741491B2
公开(公告)日：2010-06-22
申请号：US11609463
申请日：2006-12-12
申请人： Stefan Petry , Karl-Heinz Baringhaus , Norbert Tennangels , Guenter Mueller , Reinhard Kirsch
发明人： Stefan Petry , Karl-Heinz Baringhaus , Norbert Tennangels , Guenter Mueller , Reinhard Kirsch
IPC分类号： A61K31/426 , C07D277/42
CPC分类号： C07D277/42 , C07D277/46
摘要： The invention therefore relates to compounds of the formula I in which the variables are as defined in the specification, to pharmaceutical compositions containing them and to their use for therapeutically lowering blood glucose levels.
摘要翻译：因此，本发明涉及式I化合物，其中变量如说明书中所定义，含有它们的药物组合物及其用于治疗降低血糖水平的用途。

55. 发明授权

US07737144B2 Pyrimido[5,4-e][1,2,4]triazine-5-7-diones, processes for preparing them and their use 有权
标题翻译：嘧啶并[5,4-e] [1,2,4]三嗪-5,7-二酮，其制备方法及其应用
公开(公告)号：US07737144B2
公开(公告)日：2010-06-15
申请号：US11770106
申请日：2007-06-28
申请人： Stefan Petry , Karl-Heinz Baringhaus , Norbert Tennagels , Guenter Mueller
发明人： Stefan Petry , Karl-Heinz Baringhaus , Norbert Tennagels , Guenter Mueller
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00 , A61P31/10
CPC分类号： C07D487/04
摘要： The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives.The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.
摘要翻译：本发明涉及嘧啶并[5,4-e] [1,2,4]三嗪-5,7-二酮，其药用盐和生理功能衍生物。因此，本发明涉及式I化合物，其中基团具有给定的含义，以及它们的生理上耐受的盐及其制备方法。该化合物例如适合用作抗糖尿病药。

56. 发明授权

US07528155B2 Indazole derivatives as inhibitors of hormone sensitive lipase 有权
标题翻译：吲唑衍生物作为激素敏感性脂肪酶的抑制剂
公开(公告)号：US07528155B2
公开(公告)日：2009-05-05
申请号：US11042565
申请日：2005-01-25
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Karl-Heinz Baringhaus
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Karl-Heinz Baringhaus
IPC分类号： A61K31/454
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.
摘要翻译：本发明涉及具有本说明书所示含义的通式I或II的吲唑衍生物，其药学上可用的盐及其作为药物的用途。

57. 发明申请

US20080287448A1 Diacyl indazole derivatives as lipase and phospholipase inhibitors 有权
标题翻译：二酰基吲唑衍生物作为脂肪酶和磷脂酶抑制剂
公开(公告)号：US20080287448A1
公开(公告)日：2008-11-20
申请号：US12099337
申请日：2008-04-08
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , A61K31/437 , A61P3/00 , A61K31/4985 , A61K31/5025
CPC分类号： C07D231/56 , C07D401/14 , C07D471/04 , C07D495/04
摘要： The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds as pharmaceutical products.
摘要翻译：本发明涉及通式（I）或（II）的二酰基吲唑衍生物及其药学上可接受的盐：其中X，R 1和R 2如本文所定义。本发明还涉及这些化合物作为药物产品的用途。

58. 发明申请

US20080027134A1 HYDROXYBIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES, METHOD FOR PRODUCING THE SAME AND THEIR USE 有权
标题翻译：羟基二苯甲酸和衍生物，其生产方法及其用途
公开(公告)号：US20080027134A1
公开(公告)日：2008-01-31
申请号：US11759997
申请日：2007-06-08
申请人： Stefan PETRY , Karl-Heinz BARINGHAUS , Norbert TENNAGELS , Gunter MULLER
发明人： Stefan PETRY , Karl-Heinz BARINGHAUS , Norbert TENNAGELS , Gunter MULLER
IPC分类号： A61K31/195 , A61K31/357 , A61P3/00 , A61P9/10 , C07C229/38 , C07D317/46
CPC分类号： C07C233/51 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C2601/02 , C07C2601/14 , C07D307/68 , C07D317/68
摘要： Disclosed are novel compound of formula I, As defined herein and their use as pharmaceutically active compounds for reducing blood glucose, and/or treating one or more of type II diabetes, disturbances of lipid and carbohydrate metabolism, arteriosclerotic manifestations, and insulin resistance.
摘要翻译：公开了本文定义的式I的新化合物及其作为用于降低血糖的药物活性化合物和/或治疗II型糖尿病，脂质和碳水化合物代谢紊乱，动脉硬化表现和胰岛素抵抗的一种或多种的用途。

59. 发明申请

US20060160142A1 Phosophoinositoglycan binding proteins 有权
标题翻译：磷酸正辛糖结合蛋白
公开(公告)号：US20060160142A1
公开(公告)日：2006-07-20
申请号：US11377531
申请日：2006-03-16
申请人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
发明人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/1709
摘要： The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.
摘要翻译：本发明涉及脂肪细胞质膜的蛋白质。该蛋白质对磷酸肌醇蛋白具有特异性结合亲和力。它通过绕过胰岛素信号级联来调节葡萄糖摄取。

60. 发明授权

US06900233B2 Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof 有权
标题翻译：取代的3-苯基-5-烷氧基-3H-（1,3,4） - 恶二唑-2-酮药物组合物及其肥胖症的治疗方法
公开(公告)号：US06900233B2
公开(公告)日：2005-05-31
申请号：US10375247
申请日：2003-02-27
申请人： Karl Schoenafinger , Stefan Petry , Günter Müller , Armin Bauer , Hubert Otto Heuer
发明人： Karl Schoenafinger , Stefan Petry , Günter Müller , Armin Bauer , Hubert Otto Heuer
IPC分类号： C07D271/10 , C07D271/113 , A61K31/4245 , A61P3/00
CPC分类号： C07D271/113
摘要： A substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-one, compound of formula 1, wherein R1, R2, R3, R4 and R5 are as defined herein, pharmaceutical composition comprising the compound and use of the compound for inhibiting pancreatic lipase, or the prophylaxis or treatment of obesity are described.
摘要翻译：取代的3-苯基-5-烷氧基-3H-（1,3,4） - 恶二唑-2-酮，式1的化合物，其中R 1，R 2， >，R 3，R 4和R 5如本文所定义，包含该化合物的药物组合物和用于抑制胰脂肪酶的化合物，或预防或治疗肥胖症。

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