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51. 发明申请

US20060052609A1 Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines 有权
标题翻译：制备取代的2-（2,6-二氧代哌啶-3-基）-1-氧代异吲哚啉的方法
公开(公告)号：US20060052609A1
公开(公告)日：2006-03-09
申请号：US11219589
申请日：2005-09-01
申请人： George Muller , Roger Chen , Manohar Saindane , Chuansheng Ge
发明人： George Muller , Roger Chen , Manohar Saindane , Chuansheng Ge
IPC分类号： C07D403/04
CPC分类号： C07D401/04
摘要： The present invention concerns new processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines which are useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNFα. The invention provides processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines including, but not limited to, the therapeutically active 3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione.
摘要翻译：本发明涉及制备取代的2-（2,6-二氧代哌啶-3-基）-1-氧代异吲哚啉的新方法，其可用于预防或治疗与异常高水平或TNFalpha活性相关的疾病或病症。本发明提供商业生产取代的2-（2,6-二氧代哌啶-3-基）-1-氧代异吲哚啉的方法，包括但不限于治疗活性的3-（4-氨基-1-氧代异吲哚啉-2-基）哌啶-2,6-二酮。

52. 发明申请

US20050096351A1 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione 有权
标题翻译： 3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基） - 哌啶-2,6-二酮的多晶型
公开(公告)号：US20050096351A1
公开(公告)日：2005-05-05
申请号：US10934863
申请日：2004-09-03
申请人： Markian Jaworsky , Roger Chen , George Muller , Manohar Saindane , Louise Cameron
发明人： Markian Jaworsky , Roger Chen , George Muller , Manohar Saindane , Louise Cameron
IPC分类号： A61K20060101 , A61K31/445 , A61K31/454 , C07D401/04 , C07D43/04
CPC分类号： C07D401/04 , B65D51/2864 , C07B2200/13
摘要： Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed.
摘要翻译：公开了3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基） - 哌啶-2,6-二酮的多晶形式。还公开了包含多晶型物的组合物，制备多晶型物的方法及其使用方法。

53. 发明申请

US20050014727A1 Diphenylethylene compounds and uses thereof 失效
标题翻译：二苯基乙烯化合物及其用途
公开(公告)号：US20050014727A1
公开(公告)日：2005-01-20
申请号：US10794931
申请日：2004-03-05
申请人： George Muller , Faribourz Payvandi , Ling Zhang , Michael Robarge , Roger Chen , Hon-Wah Man
发明人： George Muller , Faribourz Payvandi , Ling Zhang , Michael Robarge , Roger Chen , Hon-Wah Man
IPC分类号： A61K20060101 , A61K31/165 , A61K31/18 , A61K31/24 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/44 , A61K31/66 , C07C43/215 , C07C45/68 , C07C49/255 , C07C205/37 , C07C233/33 , C07C255/35 , C07C255/37 , C07C255/43 , C07C255/44 , C07C275/38 , C07C311/60 , C07D317/60 , C07D319/18 , C07D319/20 , C07F9/12 , C07F9/28
CPC分类号： C07C311/60 , C07C43/215 , C07C45/68 , C07C49/255 , C07C59/68 , C07C69/734 , C07C205/37 , C07C233/33 , C07C255/35 , C07C255/37 , C07C255/43 , C07C255/44 , C07C275/38 , C07C2601/08 , C07D317/60 , C07D319/18 , C07D319/20 , C07F9/12 , C07C49/84
摘要： The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.
摘要翻译：本发明涉及二苯基乙烯化合物和包含二苯基乙烯化合物的组合物。本发明还涉及通过向有需要的受试者施用一种或多种二苯基乙烯化合物来预防或治疗各种疾病和病症的方法。特别地，本发明涉及通过向有需要的受试者施用一种或多种二苯基乙烯化合物来预防或治疗癌症或炎症性疾病的方法。本发明还涉及包含一种或多种二苯基乙烯化合物的制品和试剂盒。

54. 发明申请

US20180073071A1 NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION OF TAG MOLECULES 审中-公开
公开(公告)号：US20180073071A1
公开(公告)日：2018-03-15
申请号：US15712763
申请日：2017-09-22
申请人： Jingyue JU , Randall DAVIS , Roger CHEN
发明人： Jingyue JU , Randall DAVIS , Roger CHEN
IPC分类号： C12Q1/68
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

55. 发明授权

US09887470B2 Torque lock anchor and methods and devices using the anchor 有权
公开(公告)号：US09887470B2
公开(公告)日：2018-02-06
申请号：US12430304
申请日：2009-04-27
申请人： Quynh Nguyen-Stella , Kenny Kinyen Chinn , John Michael Barker , Surekha B. Husmann , Roger Chen
发明人： Quynh Nguyen-Stella , Kenny Kinyen Chinn , John Michael Barker , Surekha B. Husmann , Roger Chen
IPC分类号： A61N1/05 , A61N1/04 , H01R4/36
CPC分类号： H01R4/36 , A61N1/0558 , A61N2001/0582 , H01R2201/12
摘要： A lead anchor includes a body defining a lead lumen having a first opening and a second opening through which a lead can pass. The body further defines a transverse lumen that intersects the lead lumen. An exterior member is disposed around at least a portion of the body. The exterior member is formed of a biocompatible material. A fastener anchors the lead to the body through the transverse lumen by deforming a portion of the lead. The transverse lumen is configured and arranged to receive the fastener. At least one suture element is defined by the exterior member and is configured and arranged for receiving a suture to suture the lead anchor to patient tissue.

56. 发明授权

US09581563B2 System for communicating information from an array of sensors 有权
标题翻译：用于从传感器阵列传递信息的系统
公开(公告)号：US09581563B2
公开(公告)日：2017-02-28
申请号：US13272109
申请日：2011-10-12
申请人： Roger Chen
发明人： Roger Chen
IPC分类号： G08C15/06 , G01N27/327 , G01N33/487
CPC分类号： G01N27/3278 , C12Q1/6874 , G01N27/44791 , G01N33/48721
摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.
摘要翻译：公开了一种用于从传感器阵列传送信息的系统。该系统包括传感器阵列，其包括多个传感器，其中每个传感器感测与传感器通信的材料的物理性质。该系统还包括与每个传感器相关联的信号处理电路，其将传感器的输出随时间积分，并将积分输出与阈值进行比较。该系统还包括耦合到信号处理电路的通信网络，其输出指示对应于给定传感器的集成输出已经达到阈值的信息。

57. 发明授权

US09093818B2 Nanopillar optical resonator 有权
标题翻译：纳米纤维光学谐振器
公开(公告)号：US09093818B2
公开(公告)日：2015-07-28
申请号：US13184019
申请日：2011-07-15
申请人： Connie Chang-Hasnain , Forrest Sedgwick , Roger Chen , Thai-Truong Du Tran , Kar Wei Ng , Wai Son Ko
发明人： Connie Chang-Hasnain , Forrest Sedgwick , Roger Chen , Thai-Truong Du Tran , Kar Wei Ng , Wai Son Ko
IPC分类号： H01S5/00 , H01S5/10 , H01S5/30 , H01L33/24 , H01L33/30 , H01L33/32 , H01L33/26 , H01L33/00
CPC分类号： H01S5/1042 , H01L33/0066 , H01L33/24 , H01L33/26 , H01L33/30 , H01L33/32 , H01S5/0014 , H01S5/026 , H01S5/041 , H01S5/1075 , H01S5/3013 , H01S5/32333
摘要： Monolithically integrated optical resonators are disclosed. An optical resonator may be a nanopillar optical resonator that is formed directly on a substrate and promotes a helically-propagating cavity mode. The helically-propagating cavity mode may result in significant reflection or, total internal reflection at an interface of the nanopillar optical resonator and the substrate even if refractive indices of the nanopillar optical resonator and the substrate are the same or similar. As a result, strong optical feedback, and thus strong resonance, may be provided in the nanopillar optical resonator.
摘要翻译：公开了单片集成光谐振器。光学谐振器可以是直接形成在衬底上并促进螺旋传播腔模的纳米柱光学谐振器。即使纳米柱光学谐振器和衬底的折射率相同或相似，螺旋传播的腔模式也可能导致在纳米柱光学谐振器和衬底的界面处的显着反射或全内反射。因此，可以在纳米柱光学谐振器中提供强的光学反馈，从而提供强烈的共振。

58. 发明申请

US20140353712A1 NANOPILLAR OPTICAL RESONATOR 有权
标题翻译： NANOPILLAR光学谐振器
公开(公告)号：US20140353712A1
公开(公告)日：2014-12-04
申请号：US13184019
申请日：2011-07-15
申请人： Connie Chang-Hasnain , Forrest Sedgwick , Roger Chen , Thai-Truong Du Tran , Kar Wei Ng , Wai Son Ko
发明人： Connie Chang-Hasnain , Forrest Sedgwick , Roger Chen , Thai-Truong Du Tran , Kar Wei Ng , Wai Son Ko
IPC分类号： H01S5/10 , H01L33/24 , H01L33/00 , H01L33/32 , H01L33/26 , H01S5/30 , H01L33/30
CPC分类号： H01S5/1042 , H01L33/0066 , H01L33/24 , H01L33/26 , H01L33/30 , H01L33/32 , H01S5/0014 , H01S5/026 , H01S5/041 , H01S5/1075 , H01S5/3013 , H01S5/32333
摘要： Embodiments of a monolithically integrated optical resonator are disclosed. In one embodiment, the optical resonator is a nanopillar optical resonator that is formed directly on a substrate and promotes a helically-propagating cavity mode. The helically-propagating cavity mode results in significant reflection or, in some embodiments, total internal reflection at an interface of the nanopillar optical resonator and the substrate even if refractive indices of the nanopillar optical resonator and the substrate are the same or similar. As a result, strong optical feedback, and thus strong resonance, is provided in the nanopillar optical resonator.
摘要翻译：公开了单片集成光谐振器的实施例。在一个实施例中，光学谐振器是直接形成在衬底上并促进螺旋传播腔模式的纳米柱光学谐振器。螺旋传播的腔模式导致了显着的反射，或者在一些实施例中，即使纳米柱光学谐振器和衬底的折射率相同或相似，在纳米柱光学谐振器和衬底的界面处的全内反射。结果，在纳米柱光学谐振器中提供了强的光学反馈，从而提供了强烈的共振。

59. 发明授权

US08788063B2 Electrode array having a rail system and methods of manufacturing the same 有权
标题翻译：具有轨道系统的电极阵列及其制造方法
公开(公告)号：US08788063B2
公开(公告)日：2014-07-22
申请号：US12946659
申请日：2010-11-15
申请人： Roger Chen
发明人： Roger Chen
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , Y10T29/49117 , Y10T29/49208
摘要： A device for brain stimulation includes a lead having a longitudinal surface and a distal end. The lead includes a longitudinal rail disposed within the distal end of the lead. The longitudinal rail includes at least two prongs, each prong being configured and arranged to receive at least one segmented electrode. The lead further includes a plurality of segmented electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. Each of the plurality of segmented electrodes is coupled to one of the at least two prongs of the rail.
摘要翻译：用于脑刺激的装置包括具有纵向表面和远端的引线。引线包括设置在引线的远端内的纵向轨道。纵向导轨包括至少两个插脚，每个插脚被构造和布置成容纳至少一个分段电极。引线还包括沿引线的远端附近的导线的纵向表面设置的多个分段电极。多个分段电极中的每一个耦合到轨道的至少两个插脚中的一个。

60. 发明申请

US20140034497A1 CHIP SET-UP AND HIGH-ACCURACY NUCLEIC ACID SEQUENCING 有权
标题翻译：芯片设置和高精度核酸序列
公开(公告)号：US20140034497A1
公开(公告)日：2014-02-06
申请号：US13918626
申请日：2013-06-14
申请人： Randall Davis , Roger Chen , Arkadiusz Bibillo , Kevin Deierling
发明人： Randall Davis , Roger Chen , Arkadiusz Bibillo , Kevin Deierling
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , C12Q1/6869 , G01N33/48721 , C12Q2565/631
摘要： The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm2. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.
摘要翻译：本公开提供了用于测序核酸分子的装置，系统和方法。使用包含独立可寻址的纳米孔传感器阵列的芯片，密度为每1mm 2至少约500个位点，核酸分子可以以高精度（例如，单次通过中大于97％）进行测序。单个纳米孔传感器可以包括邻近或接近检测电极的膜中的纳米孔。

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