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51. 发明授权

US08626255B2 Noninvasive multi-parameter patient monitor 有权
标题翻译：无创多参数患者监护仪
公开(公告)号：US08626255B2
公开(公告)日：2014-01-07
申请号：US13477979
申请日：2012-05-22
申请人： Ammar Al-Ali , Joe E. Kiani , Mohamed K. Diab , Greg A. Olsen , Roger C. Wu , Rick Fishel
发明人： Ammar Al-Ali , Joe E. Kiani , Mohamed K. Diab , Greg A. Olsen , Roger C. Wu , Rick Fishel
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B1/00 , A61B5/0022 , A61B5/0205 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/0295 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/6815 , A61B5/6826 , A61B5/6829 , A61B5/6832 , A61B5/6838 , A61B5/7221 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/7405 , A61B5/742 , A61B5/746 , A61B5/7475 , A61B2562/08 , A61B2562/085 , A61B2562/222 , G06F19/00 , G06F19/3418 , Y10S439/909
摘要： Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor advantageously includes a plurality of display modes enabling more parameter data to be displayed than the available physical display real estate.
摘要翻译：本公开的实施例包括手持多参数患者监视器，其能够从能够检测由身体组织衰减的光的光敏检测器的输出确定多个生理参数。例如，在一个实施例中，监视器能够有利地和准确地显示脉搏率，体积描记器数据，灌注质量，信号置信度和身体组织中血液成分的值中的一个或多个，包括例如动脉一氧化碳饱和度 “HbCO”），高铁血红蛋白饱和度（“HbMet”），总血红蛋白（“Hbt”），动脉血氧饱和度（“SpO2”），分数动脉血氧饱和度（“SpaO2”）等。在一个实施例中，监视器有利地包括多个显示模式，使得能够显示比可用的物理显示空间更多的参数数据。

52. 发明授权

US08447374B2 Systems and methods for determining blood oxygen saturation values using complex number encoding 有权
公开(公告)号：US08447374B2
公开(公告)日：2013-05-21
申请号：US12248868
申请日：2008-10-09
申请人： Mohamed K. Diab
发明人： Mohamed K. Diab
IPC分类号： A61B5/1455 , G06F19/00
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/7207 , A61B5/7239 , A61B5/7253 , A61B5/7278 , A61B5/742 , A61B5/743
摘要： The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase filtering.

53. 发明申请

US20120165624A1 SIGNAL PROCESSING APPARATUS 失效
公开(公告)号：US20120165624A1
公开(公告)日：2012-06-28
申请号：US13397564
申请日：2012-02-15
申请人： Mohamed K. Diab , Esmaiel Kiani-Azarbayjany , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
发明人： Mohamed K. Diab , Esmaiel Kiani-Azarbayjany , Ibrahim M. Elfadel , Rex J. McCarthy , Walter M. Weber , Robert A. Smith
IPC分类号： A61B5/0205 , A61B5/08 , A61B5/024 , A61B5/1455
CPC分类号： A61B5/0205 , A61B5/021 , A61B5/02154 , A61B5/024 , A61B5/029 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/4821 , A61B5/7214 , A61B5/7246 , A61B5/7253 , A61B5/7257 , A61B5/726 , A61B6/00 , A61B8/00 , A61B8/5276 , G06K9/0051 , H04B1/123
摘要： The present invention involves a method and an apparatus for analyzing measured signals, including the determination of a measurement of oxygen saturation and respiration rate in the measured signals during a calculation of a physiological parameter of a monitored patient. Use of this invention is described in particular detail with respect to oximetry-based measurements but extends to other types of measurements.

54. 发明授权

US08190227B2 Signal processing apparatus and method 有权
公开(公告)号：US08190227B2
公开(公告)日：2012-05-29
申请号：US12368222
申请日：2009-02-09
申请人： Mohamed K. Diab , Rex McCarthy
发明人： Mohamed K. Diab , Rex McCarthy
IPC分类号： A61B5/1455 , A61B5/024
CPC分类号： A61B5/7257 , A61B5/0205 , A61B5/02416 , A61B5/02433 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/6826 , A61B5/7203 , A61B5/7214 , A61B5/7225 , A61B5/726 , A61B5/7278 , A61B5/742 , G06K9/0051
摘要： A method and an apparatus to analyze two measured signals that are modeled as containing desired and undesired portions such as noise, FM and AM modulation. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, a transformation is used to evaluate a ratio of the two measured signals in order to find appropriate coefficients. The measured signals are then fed into a signal scrubber which uses the coefficients to remove the unwanted portions. The signal scrubbing is performed in either the time domain or in the frequency domain. The method and apparatus are particularly advantageous to blood oximetry and pulserate measurements. In another embodiment, an estimate of the pulserate is obtained by applying a set of rules to a spectral transform of the scrubbed signal. In another embodiment, an estimate of the pulserate is obtained by transforming the scrubbed signal from a first spectral domain into a second spectral domain. The pulserate is found by identifying the largest spectral peak in the second spectral domain.

55. 发明授权

US08185180B2 Method and apparatus for demodulating signals in a pulse oximetry system 有权
标题翻译：用于在脉搏血氧测定系统中解调信号的方法和装置
公开(公告)号：US08185180B2
公开(公告)日：2012-05-22
申请号：US11842106
申请日：2007-08-20
申请人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
发明人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
IPC分类号： A61B5/1455
CPC分类号： A61B5/7228 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/7203 , A61B5/7217 , A61B5/7232 , A61B2560/0242 , A61B2562/0238 , H04J3/10 , H04J14/08
摘要： A method and an apparatus measure blood oxygenation in a subject. A light source is activated to cause a first emission at a first wavelength and a second emission at a second wavelength. A detector detects a composite signal indicative of an attenuation of the first and second wavelengths by tissue of a patient. The composite signal is demodulated into a first intensity signal and a second intensity signal. Blood oxygenation in the subject is determined from the first and second intensity signals. In one embodiment, demodulation is based at least in part on a period when at least one of the wavelengths is not activated. In one embodiment, a modulation of the first and second wavelengths is determined in order to avoid frequencies of ambient noise. In one embodiment, the composite signal's sampling rate is reduced before and/or after demodulation.
摘要翻译：一种测量受试者血液氧合的方法和装置。光源被激活以引起第一波长的第一发射和第二波长的第二发射。检测器通过患者的组织检测指示第一和第二波长的衰减的复合信号。复合信号被解调为第一强度信号和第二强度信号。从第一和第二强度信号确定受试者的血氧。在一个实施例中，解调至少部分地基于至少一个波长未被激活的周期。在一个实施例中，确定第一和第二波长的调制以避免环境噪声的频率。在一个实施例中，复合信号的采样率在解调之前和/或之后被减小。

56. 发明申请

US20110288383A1 PLETHYSMOGRAPH PULSE RECOGNITION PROCESSOR 有权
标题翻译： PLETHYSMOGRAPH脉冲识别处理器
公开(公告)号：US20110288383A1
公开(公告)日：2011-11-24
申请号：US13196220
申请日：2011-08-02
申请人： Mohamed K. Diab
发明人： Mohamed K. Diab
IPC分类号： A61B5/021 , A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/7264
摘要： A time domain rule-based processor provides recognition of pulses in a pulse oximeter-derived waveform.
摘要翻译：基于时域规则的处理器提供了脉冲血氧计衍生波形中脉冲的识别。

57. 发明授权

US08028701B2 Respiratory monitoring 有权
标题翻译：呼吸监测
公开(公告)号：US08028701B2
公开(公告)日：2011-10-04
申请号：US11756501
申请日：2007-05-31
申请人： Ammar Al-Ali , Mohamed K. Diab
发明人： Ammar Al-Ali , Mohamed K. Diab
IPC分类号： A61M11/00
CPC分类号： A61B5/0836 , A61B5/0004 , A61B5/0816 , A61B5/097 , A61B5/6819 , A61B5/682 , A61B5/6822 , A61M16/0666 , A61M16/0672 , A61M16/085 , A61M16/10 , A61M16/1065 , A61M2202/0208 , A61M2205/18 , A61M2205/3561 , A61M2205/581 , A61M2205/583 , A61M2230/42 , A61M2230/432 , A61M2230/435
摘要： A patient interface in accordance with one embodiment of the present invention is configured to be at least partially carried by a patient and to receive gas exhaled by the patient. The patient interface includes first and second cannula tubes each having a first end and a second end, the first ends are configured to be inserted into the nostrils of a patient, the first and second cannula tubes are configured to direct exhaled gas from the patient from the first ends to said second ends. The patient interface also includes first and second sensors positioned near the second ends, and the first and second sensors are configured to provide first and second signals based upon the gas, wherein the first and second signals are indicative of a physiological parameter of the patient. The patient interface also includes a communications link configured to provide the signal to a physiological monitor.
摘要翻译：根据本发明的一个实施例的患者接口被配置为至少部分地由患者携带并且接收由患者呼出的气体。所述患者界面包括第一和第二插管管，每个具有第一端和第二端，所述第一端构造成插入患者的鼻孔中，所述第一和第二插管管被构造成将来自患者的呼出气体从第一端到所述第二端。患者接口还包括位于第二端附近的第一和第二传感器，并且第一和第二传感器被配置为基于气体提供第一和第二信号，其中第一和第二信号指示患者的生理参数。患者接口还包括被配置为向生理监视器提供信号的通信链路。

58. 发明授权

US07991446B2 Systems and methods for acquiring calibration data usable in a pulse oximeter 有权
标题翻译：用于获取可用于脉搏血氧计的校准数据的系统和方法
公开(公告)号：US07991446B2
公开(公告)日：2011-08-02
申请号：US11431151
申请日：2006-05-08
申请人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian M. Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
发明人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian M. Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
IPC分类号： A61B5/1455
CPC分类号： A61B5/7278 , A61B5/0002 , A61B5/0205 , A61B5/0402 , A61B5/14551 , A61B5/1495 , A61B5/742 , A61B5/743 , A61B2560/0271 , A61B2560/0456 , A61B2562/085 , G06F19/00
摘要： The present disclosure includes a pulse oximeter attachment having an accessible memory. In one embodiment, the pulse oximeter attachment stores calibration data, such as, for example, calibration data associated with a type of a sensor, a calibration curve, or the like. The calibration data is used to calculate physiological parameters of pulsing blood.
摘要翻译：本公开包括具有可访问存储器的脉搏血氧计附件。在一个实施例中，脉搏血氧计附件存储校准数据，例如与传感器类型相关联的校准数据，校准曲线等。校准数据用于计算脉冲血液的生理参数。

59. 发明授权

US07801581B2 Optical spectroscopy pathlength measurement system 有权
标题翻译：光谱光程测量系统
公开(公告)号：US07801581B2
公开(公告)日：2010-09-21
申请号：US11636863
申请日：2006-12-11
申请人： Mohamed K. Diab
发明人： Mohamed K. Diab
IPC分类号： A61B5/1455
CPC分类号： A61B5/6826 , A61B5/14558 , A61B5/6838 , G01N21/21 , G01N21/49
摘要： A physiological monitor utilizes rotation measurements to estimate mean photon pathlengths through tissue. These pathlength estimates, along with corresponding optical spectroscopy measurements allow the noninvasive monitoring of blood constituent concentrations. The technique is particularly applicable to noninvasive blood glucose measurements. The physiological monitor has a polarized light source for illuminating tissue and a magnetic field generator which creates a magnetic field within the tissue during illumination. The magnetic field imparts a rotation in the plane of polarization of the incident light beam as it propagates through the tissue and emerges as a transmitted light beam. A polarimeter is used to measure the rotation of the transmitted light. A signal processor then computes an estimate of the mean pathlength from the polarimeter output. The polarized light source has a multiple wavelength optical emitter and, in conjunction with the polarimeter detector, also functions as a spectrometer. The signal processor combines spectroscopic measurements at various wavelengths with corresponding mean pathlength estimates to compute blood constituent concentrations.
摘要翻译：生理监视器利用旋转测量来估计通过组织的平均光子路径长度。这些光程长度估计以及相应的光学光谱测量可以对血液成分浓度进行非侵入性监测。该技术特别适用于无创血糖测量。生理监视器具有用于照射组织的偏振光源和在照明期间在组织内产生磁场的磁场发生器。当入射光束传播通过组织时，磁场在入射光束的偏振平面中产生旋转，并作为透射光束出射。使用偏光计来测量透射光的旋转。然后，信号处理器从偏振计输出计算平均路径长度的估计。偏振光源具有多波长光发射器，并且与偏振仪检测器一起也用作光谱仪。信号处理器将各种波长的光谱测量结合相应的平均光程长度估计来计算血液成分浓度。

60. 发明授权

US07791155B2 Detector shield 有权
标题翻译：探测器盾
公开(公告)号：US07791155B2
公开(公告)日：2010-09-07
申请号：US11963518
申请日：2007-12-21
申请人： Mohamed K. Diab
发明人： Mohamed K. Diab
IPC分类号： H01L31/0232
CPC分类号： A61B5/6826 , A61B5/14552 , A61B5/6838 , A61B2562/182
摘要： An improved photodiode detector shielding apparatus and method are provided which shield a photodiode detector from electromagnetic interference and ambient light, without affecting the wavelengths of light that reach the photodiode. The improved photodiode detector shield has two layers. A bottom layer is substantially made from an electrically conducting material and is fixed over a photodiode in order to shield it from EMI and ambient light. A top layer is substantially made from a lustrous, shiny, reflective material that reflects an equal amount of light across a band of wavelengths. Both layers have areas with optically transmissive openings, which are aligned to allow for the unobstructed passage of light of a band of wavelengths to the photodiode. Light within a band of wavelengths is evenly reflected off the top of the first surface and also reaches the photodiode. In this regard, the detector shield blocks EMI and ambient light without affecting the wavelengths of light desired to reach the photodiode.
摘要翻译：提供了一种改进的光电二极管检测器屏蔽装置和方法，其屏蔽光电二极管检测器免受电磁干扰和环境光的影响，而不影响到达光电二极管的光的波长。改进的光电二极管检测器屏蔽层有两层。底层基本上由导电材料制成并固定在光电二极管上，以便防止EMI和环境光。顶层基本上由有光泽的，有光泽的反射材料制成，其反映了波长波段上等量的光。这两个层都具有光学透射开口的区域，这些区域被对准以允许波长带的光线不受阻碍地通向光电二极管。波长范围内的光均匀地从第一表面的顶部反射，并且也到达光电二极管。在这方面，检测器屏蔽物阻挡EMI和环境光，而不影响到达光电二极管所需的光的波长。

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