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51. 发明授权

US08983624B2 Delivery devices, systems and methods for stimulating nerve tissue on multiple spinal levels 有权
标题翻译：用于刺激多个脊髓水平的神经组织的输送装置，系统和方法
公开(公告)号：US08983624B2
公开(公告)日：2015-03-17
申请号：US11952053
申请日：2007-12-06
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/05 , A61N1/0558 , A61N1/3605 , A61N1/3606 , A61N1/36071
摘要： Devices, systems and methods are provided for simultaneously stimulating the spinal anatomy at various locations, such as spinal levels, along the spinal cord. By stimulating multiple levels of the spinal column with the use of a single device, a single access path is created to an implantable pulse generator (IPG) rather than individual access paths for each lead at each spinal level to an IPG. By reducing the number of pathways, the procedure complexity, time and recovery are reduced. In addition, some embodiments provide additional specificity within each targeted level, such as selective stimulation of specific tissue, such as the dorsal root ganglion.
摘要翻译：提供了装置，系统和方法，用于同时沿着脊髓刺激各种位置（例如脊柱水平）的脊柱解剖结构。通过使用单个装置刺激脊柱的多个级别，将单个访问路径创建到可植入脉冲发生器（IPG），而不是将每个脊髓级别的每个引导线的单独访问路径用于IPG。通过减少路径的数量，减少了程序的复杂性，时间和恢复。此外，一些实施方案在每个靶向水平内提供额外的特异性，例如特定组织的选择性刺激，例如背根神经节。

52. 发明授权

US08574310B2 Stomach peristalsis device and method 有权
标题翻译：胃蠕动装置及方法
公开(公告)号：US08574310B2
公开(公告)日：2013-11-05
申请号：US13088197
申请日：2011-04-15
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61F2/04 , A61F2/00
CPC分类号： A61F2/04 , A61F5/003 , A61F5/0033 , A61F5/0053 , A61F5/0079 , A61F2002/045 , A61F2002/482 , A61F2250/0003
摘要： The invention relates to an implantable stomach prosthesis for surgically replacing or augmenting all or part of the antrum and/or pylorus of a stomach. The prosthesis controls the passage of food from the stomach to the small intestine. The prosthesis may be configured to churn ingested material and release it from the stomach through a prosthetic pyloric valve. At least one expandable member is arranged to be expanded to control the passage of food and/or to mimic the churning action of a patient's stomach. The prosthesis includes an outer support structure, a flexible inner member forming a conduit for the movement of material, and at least one expandable member located between the outer support structure and inner member. An implantable pump system is provided for inflating and deflating the expandable member(s).
摘要翻译：本发明涉及一种用于手术替换或增加胃的全部或部分胃窦和/或幽门的可植入胃假体。假体控制食物从胃到小肠的通过。假体可以构造成搅动摄取的材料并通过假肢幽门阀将其从胃释放。至少一个可膨胀构件被布置成扩张以控制食物的通过和/或模拟患者胃的搅动作用。假体包括外部支撑结构，形成用于材料运动的导管的柔性内部构件以及位于外部支撑结构和内部构件之间的至少一个可扩张构件。提供可植入泵系统用于使可膨胀构件膨胀和放气。

53. 发明授权

US08517961B2 System for marking a location for treatment within the gastrointestinal tract 有权
标题翻译：用于标记胃肠道内治疗位置的系统
公开(公告)号：US08517961B2
公开(公告)日：2013-08-27
申请号：US12917446
申请日：2010-11-01
申请人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake , Harm TenHoff , Timothy J. Hughes
发明人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake , Harm TenHoff , Timothy J. Hughes
IPC分类号： A61B5/00
CPC分类号： A61M31/002 , A61B1/00016 , A61B1/00082 , A61B1/041 , A61B5/002 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/0538 , A61B5/06 , A61B5/061 , A61B5/065 , A61B5/073 , A61B5/11 , A61B5/14503 , A61B5/14539 , A61B5/1459 , A61B5/42 , A61B5/4233 , A61B5/4255 , A61B5/4839 , A61B5/6801 , A61B5/6873 , A61B18/14 , A61B2018/00482 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00821 , A61B2562/162 , A61M5/172 , A61M5/1723 , A61N1/36007 , A61N1/37205
摘要： A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract.
摘要翻译：使用通过肠道的胶囊提供用于映射，诊断和治疗肠道的装置和方法。此外，提供了胶囊跟踪系统，用于沿着肠道长度跟踪胶囊的位置，因为采用各种治疗和/或感测方式。在一个变型中，使用声信号来确定胶囊的位置。感测信息的图可以从胶囊的通过导出。随后可以将胶囊通过以沿着其长度在确定的位置治疗肠道。一个变体使用电刺激胶囊来治疗和/或诊断肠道中的病症。

54. 发明申请

US20130165991A1 NEUROSTIMULATION METHODS AND SYSTEMS 有权
标题翻译：神经病学方法与系统
公开(公告)号：US20130165991A1
公开(公告)日：2013-06-27
申请号：US13706100
申请日：2012-12-05
申请人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人： Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

55. 发明申请

US20120277839A1 SELECTIVE STIMULATION TO MODULATE THE SYMPATHETIC NERVOUS SYSTEM 审中-公开
标题翻译：选择性刺激来调节症状性神经系统
公开(公告)号：US20120277839A1
公开(公告)日：2012-11-01
申请号：US13458697
申请日：2012-04-27
申请人： Jeffery M. Kramer , Daniel H. Kim , Mir A. Imran
发明人： Jeffery M. Kramer , Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要： Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
摘要翻译：提供了系统，方法和装置，用于通过直接神经调节与条件相关联的目标解剖结构，同时最小化或排除其他解剖结构的不期望的神经调节来定向治疗各种医学状况。通常，目标解剖结构包括一个或多个背根神经节，背根，背根进入区或其部分。这些目标刺激区域部分地由于它们对交感神经系统的影响而被利用。

56. 发明授权

US08249701B2 Methods, devices and systems for programming neurostimulation 有权
标题翻译：用于编程神经刺激的方法，装置和系统
公开(公告)号：US08249701B2
公开(公告)日：2012-08-21
申请号：US12579179
申请日：2009-10-14
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. Each neurostimulation parameter set defines electrode parameters and neurostimulation signal parameters. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. All of the tested neurostimulation parameter sets comprise a same value for a specific neurostimulation signal parameter (e.g., pulse width) that if reduced reduces power consumption. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for the specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译：提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。每个神经刺激参数集定义电极参数和神经刺激信号参数。在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。所有测试的神经刺激参数组对于特定神经刺激信号参数（例如，脉冲宽度）包含相同的值，如果降低，则减少功率消耗。如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，其中针对每个重新测试的特定神经刺激信号参数的值减少相同的量神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。

57. 发明授权

US08239027B2 Responsive gastric stimulator 有权
标题翻译：响应性胃刺激物
公开(公告)号：US08239027B2
公开(公告)日：2012-08-07
申请号：US12722979
申请日：2010-03-12
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61N1/18
CPC分类号： A61F5/0026 , A61B2017/00004 , A61B2017/00017 , A61B2017/00026 , A61B2017/00084 , A61B2017/00477 , A61F2005/0016 , A61M25/02 , A61M2025/0233 , A61M2025/028 , A61N1/36007 , A61N1/36085 , A61N1/372
摘要： A responsive gastrointestinal stimulation device is provided where one or more sensors sense data corresponding to a subject or the gastrointestinal tract of a subject and responds to sensing the data by stimulating, adjusting stimulation, or stopping stimulation of the gastrointestinal tract. A stimulation device is also provided to stimulate the gastrointestinal tract to produce a sensation of satiety or to control hunger or food consumption.
摘要翻译：提供了一种响应性胃肠刺激装置，其中一个或多个传感器感测对象对象的受试者或胃肠道的数据，并通过刺激，调节刺激或停止对胃肠道的刺激来感测数据。还提供刺激装置以刺激胃肠道产生饱腹感或控制饥饿或食物消耗。

58. 发明授权

US08032223B2 Randomized stimulation of a gastrointestinal organ 有权
标题翻译：随机刺激胃肠器官
公开(公告)号：US08032223B2
公开(公告)日：2011-10-04
申请号：US12572067
申请日：2009-10-01
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61N1/00
CPC分类号： A61N1/36007
摘要： A device, system and method for stimulating a digestive organ is provided where the stimulation is randomized.
摘要翻译：提供用于刺激消化器官的装置，系统和方法，其中刺激是随机化的。

59. 发明授权

US08019422B2 Gastric device and endoscopic delivery system 有权
标题翻译：胃装置和内镜递送系统
公开(公告)号：US08019422B2
公开(公告)日：2011-09-13
申请号：US11281049
申请日：2005-11-16
申请人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake
发明人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake
IPC分类号： A61N1/18
CPC分类号： A61B5/6882 , A61B5/4238 , A61B17/3421 , A61B17/3478 , A61B2017/00004 , A61B2017/00017 , A61B2017/00026 , A61B2017/00084 , A61B2017/00477 , A61B2017/306 , A61B2017/3488 , A61F5/0003 , A61M25/02 , A61M2025/0233 , A61M2025/028 , A61N1/0509 , A61N1/0517 , A61N1/36007 , A61N1/372 , G01N27/126 , G06F19/00
摘要： A system is provided for endoscopically attaching a functional device to a stomach wall wherein the functional device is configured to perform a therapeutic or diagnostic function at the stomach.
摘要翻译：提供了一种用于将功能装置内窥镜地附接到胃壁的系统，其中功能装置构造成在胃处执行治疗或诊断功能。

60. 发明申请

US20110166582A1 Endoscopic Device Delivery System 审中-公开
标题翻译：内窥镜装置输送系统
公开(公告)号：US20110166582A1
公开(公告)日：2011-07-07
申请号：US13049329
申请日：2011-03-16
申请人： Baber Syed , Kurt Sparks , Ken Wong , Michael Wei , Mir A. Imran
发明人： Baber Syed , Kurt Sparks , Ken Wong , Michael Wei , Mir A. Imran
IPC分类号： A61B19/00 , A61N1/05
CPC分类号： A61N1/36007 , A61B2017/00278 , A61N1/05 , A61N1/0558 , A61N1/37205 , A61N1/3756
摘要： A system and method are disclosed for an implantable gastric stimulation system within the stomach. The stimulation system includes an electronics anchor, electrode lead anchor, implantable pulse generator and external programmer. The electronics anchor is configured to attach to the stomach wall at a first location and the electrode lead anchor configured to attach to the stomach wall at a second location. The electrode lead anchor includes one or more electrodes configured to contact the stomach wall and a flexible lead portion coupled to the one or more electrodes at one end with an the electrical connector portion at the other end. The implantable pulse generator has electronic circuitry and is attached to the electronics anchor; the electronic circuitry is connected to the electrical connector of the electrode lead anchor and can communicate with the one or more electrodes. The external programmer is used to communicate with the electronic circuitry of the pulse generator via a telemetry device to provide stimulation instructions to the pulse generator.
摘要翻译：公开了一种用于胃内的可植入胃刺激系统的系统和方法。刺激系统包括电子锚，电极引线锚，可植入脉冲发生器和外部编程器。电子锚固件被配置成在第一位置处附接到胃壁，并且电极引线锚定构造成在第二位置处附接到胃壁。电极引线锚定器包括被配置为接触胃壁的一个或多个电极和在一端处与一个或多个电极在另一端处与电连接器部分耦合的柔性引线部分。该植入式脉冲发生器具有电子电路并连接到电子锚定器; 电子电路连接到电极引线锚的电连接器，并且可以与一个或多个电极连通。外部编程器用于通过遥测装置与脉冲发生器的电子电路进行通信，以向脉冲发生器提供刺激指令。

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