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51. 发明申请

US20050096264A1 Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones 审中-公开
标题翻译：用糖蛋白激素β家族激素治疗肥胖症和相关病症的方法
公开(公告)号：US20050096264A1
公开(公告)日：2005-05-05
申请号：US10990058
申请日：2004-11-16
申请人： Lynn MacDonald , Mark Sleeman , Andrew Murphy
发明人： Lynn MacDonald , Mark Sleeman , Andrew Murphy
IPC分类号： A61K38/00 , C07K14/59 , A61K38/22
CPC分类号： C07K14/59 , A61K38/00
摘要： A method of treating or ameliorating an orphan glycoprotein hormone (OGH)-related condition or a condition which responds to OGH administration, comprising administering an OGH-related compound to a subject in need thereof.
摘要翻译：一种治疗或改善孤儿糖蛋白激素（OGH）相关病症或对OGH给药作出反应的病症的方法，包括向有需要的受试者施用OGH相关化合物。

52. 发明申请

US20210368751A1 HUMANIZED RODENTS THAT EXPRESS HEAVY CHAIN CONTAINING VL DOMAINS 有权
公开(公告)号：US20210368751A1
公开(公告)日：2021-12-02
申请号：US17224524
申请日：2021-04-07
申请人： Lynn Macdonald , Cagan Gurer , Karolina A. Meagher , Sean Stevens , Andrew J. Murphy
发明人： Lynn Macdonald , Cagan Gurer , Karolina A. Meagher , Sean Stevens , Andrew J. Murphy
IPC分类号： A01K67/027 , C07K16/46 , C12N9/64
摘要： Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.

53. 发明申请

US20210137560A1 FLEXIBLE DRIVE TUBE FOR LAPAROSCOPIC DEVICE 有权
公开(公告)号：US20210137560A1
公开(公告)日：2021-05-13
申请号：US17088291
申请日：2020-11-03
申请人： Jeffrey MacDonald , Jeffrey Radziunas , Lynn MacDonald , Zev Kartiganer
发明人： Jeffrey MacDonald , Jeffrey Radziunas , Lynn MacDonald , Zev Kartiganer
IPC分类号： A61B17/42 , A61B17/32 , A61B17/00
摘要： A colpotomy device for performing a hysterectomy is provided. The device includes a flexible drive tube having a proximal end and a distal end and bendable therebetween. The device also has a rotatable cutting implement at the distal end of the flexible drive tube at a specified offset from a bendable longitudinal axis of the flexible drive tube. Furthermore, the device includes couplings located within the flexible drive tube and rotatable about the bendable longitudinal axis of the flexible drive tube. The couplings can be in a series that includes inter-coupling joints and transmits a rotational force between the proximal and distal ends of the flexible drive tube through a variable angle between the couplings. The variable angle can correspond to bending of the drive tube in order to drive rotation of the cutting implement at the specified offset about the axis of the flexible drive tube.

54. 发明授权

US09035128B2 Hybrid light chain mice 有权
公开(公告)号：US09035128B2
公开(公告)日：2015-05-19
申请号：US13166200
申请日：2011-06-22
申请人： Lynn MacDonald , Sean Stevens , Cagan Gurer , Andrew J. Murphy , Karolina A. Hosiawa
发明人： Lynn MacDonald , Sean Stevens , Cagan Gurer , Andrew J. Murphy , Karolina A. Hosiawa
IPC分类号： A01K67/027 , C12N5/07 , C12N5/0781 , C07K16/00 , C07K16/46 , C12N15/85 , C07K16/18
CPC分类号： C12N5/0606 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2217/052 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/02 , A01K2267/0381 , C07K16/00 , C07K16/18 , C07K16/461 , C07K16/462 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/50 , C07K2317/515 , C07K2317/56 , C07K2317/64 , C12N15/10 , C12N15/8509
摘要： Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.

55. 发明授权

US08883496B2 Humanized FcgR mice 有权
标题翻译：人源化FcgR小鼠
公开(公告)号：US08883496B2
公开(公告)日：2014-11-11
申请号：US13113677
申请日：2011-05-23
申请人： Lynn MacDonald , Naxin Tu , Cagan Gurer , Li-Hsien Wang , Sean Stevens , Andrew J. Murphy
发明人： Lynn MacDonald , Naxin Tu , Cagan Gurer , Li-Hsien Wang , Sean Stevens , Andrew J. Murphy
IPC分类号： C12N5/00 , A01K67/027
CPC分类号： C07K14/70535 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0387 , G01N33/56977 , G01N2333/70535
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
摘要翻译：提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性低亲和性FcγR基因座的缺失，并且其中所述小鼠能够表达功能性FcRγ-链。描述了转基因小鼠，包括从内源性FcγR基因座表达低亲和性人FcγR基因的小鼠，其中小鼠包含功能性FcRγ-链。提供了在宿主免疫系统的辅助细胞上表达多达五个低亲和力的人FcγR基因的转基因小鼠。

56. 发明授权

US08658853B2 Low affinity FcγR deficient mice 有权
标题翻译：低亲和力FcgammaR缺陷小鼠
公开(公告)号：US08658853B2
公开(公告)日：2014-02-25
申请号：US13466225
申请日：2012-05-08
申请人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
发明人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
IPC分类号： A01K67/027 , C12N5/00 , C12N5/02
CPC分类号： A61K49/0008 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/03 , A01K2267/0387 , C07K14/70535 , G01N33/5014
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
摘要翻译：提供了遗传修饰的非人动物，以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性低亲和力FcγAMR基因座的缺失，并且其中所述小鼠能够表达功能性Fcγγ链。描述了转基因小鼠，包括从内源性FcgammaR基因座表达低亲和力的人FcγRR基因的小鼠，其中所述小鼠包含功能性Fcγγ链。提供了在宿主免疫系统的辅助细胞上表达多达五个低亲和力的人FcgammaR基因的转基因小鼠。

57. 发明申请

US20140017782A1 Methods for Modifying Eukaryotic Cells 审中-公开
标题翻译：改造真核细胞的方法
公开(公告)号：US20140017782A1
公开(公告)日：2014-01-16
申请号：US14036865
申请日：2013-09-25
申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
发明人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
IPC分类号： C12N15/85
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译：一种用于工程化和利用大型DNA载体通过同源重组靶向并以任何所需方式修饰真核细胞中的内源基因和染色体基因座的方法。用于真核细胞的这些大的DNA靶向载体，称为LTVEC，衍生自克隆基因组DNA的片段，大于通常用于在真核细胞中进行同源靶向的其它方法通常使用的那些。还提供了检测真核细胞的快速和方便的方法，其中LTVEC已经正确靶向和修饰了所需的内源基因或染色体基因座（位点），以及使用这些细胞产生具有遗传修饰的生物体。

58. 发明授权

US08613927B2 High affinity human antibodies to human nerve growth factor 有权
标题翻译：人类神经生长因子高亲和力抗体
公开(公告)号：US08613927B2
公开(公告)日：2013-12-24
申请号：US13406734
申请日：2012-02-28
申请人： Lynn MacDonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt
发明人： Lynn MacDonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt
IPC分类号： A61K39/395 , A61P25/02 , A61P25/04 , A61P29/00 , A61P19/02 , A61P19/06
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译：抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛，以及肝细胞癌，乳腺癌和肝硬化等疾病。

59. 发明申请

US20110307966A1 Mice Expressing Human Voltage-Gated Sodium Channels 有权
标题翻译：表达人电压门控钠通道的小鼠
公开(公告)号：US20110307966A1
公开(公告)日：2011-12-15
申请号：US13155491
申请日：2011-06-08
申请人： Lynn Macdonald , Andrew J. Murphy , Michael L. LaCroix-Fralish , Nicole M. Alessandri Haber
发明人： Lynn Macdonald , Andrew J. Murphy , Michael L. LaCroix-Fralish , Nicole M. Alessandri Haber
IPC分类号： A01K67/027 , C12N15/63 , C12N5/10
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0356
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous NaV channel gene, in particular a humanization of the one or more extracellular pore loops of a NaV1.7 channel protein. Genetically modified non-human animals are also provided, wherein the genetic modification comprises replacement of an endogenous NaV channel gene, in particular a replacement of the endogenous NaV1.7 gene with a human NaV1.7 gene, and wherein the genetically modified non-human animals are capable of generating action potentials and communicating through the excitable cells of the genetically modified non-human animals via the expressed human or humanized NaV1.7 protein the surface of the excitable cells. Genetically modified mice are described, including mice that express the human or humanized NaV1.7 gene from the endogenous NaV1.7 locus, and wherein the mice comprise functional β-subunits.
摘要翻译：提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性NaV通道基因的细胞外环的人源化，特别是一种或多种细胞外孔环的人源化 NaV1.7通道蛋白。还提供了遗传修饰的非人动物，其中遗传修饰包括内源性NaV通道基因的替换，特别是用人NaV1.7基因替代内源性NaV1.7基因，并且其中所述遗传修饰的非人动物动物能够通过表达的人或人源化NaV1.7蛋白质产生动力电位并通过基因修饰的非人动物的可兴奋细胞进行通信，所述可激活细胞的表面。描述了转基因小鼠，包括从内源性NaV1.7基因座表达人或人源化NaV1.7基因的小鼠，其中小鼠包含功能性和亚基。

60. 发明申请

US20110256587A1 HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR 有权
标题翻译：人类神经生长因子的高亲和力人体抗体
公开(公告)号：US20110256587A1
公开(公告)日：2011-10-20
申请号：US13166905
申请日：2011-06-23
申请人： Lynn Macdonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt
发明人： Lynn Macdonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt
IPC分类号： C12P21/02 , C07H21/04 , C12N5/10 , C12N15/63 , C12N1/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译：抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛，以及肝细胞癌，乳腺癌和肝硬化等疾病。

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