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51. 发明授权

US5647979A One-step preparation of separation media for reversed-phase chromatography 失效
标题翻译：用于反相色谱的一步制备分离介质
公开(公告)号：US5647979A
公开(公告)日：1997-07-15
申请号：US666061
申请日：1996-06-14
申请人： Jia-Li Liao , Stellan Hjerten
发明人： Jia-Li Liao , Stellan Hjerten
IPC分类号： B01J20/285 , C08F2/44 , C08F18/08 , C08F20/06 , C08F20/12 , C08F20/32 , C08F20/34 , C08F20/56 , C08F20/58 , C08F26/02 , C08F28/02 , G01N30/56 , G01N30/88 , B01D15/08
CPC分类号： G01N30/482 , B01J2220/54 , G01N30/56
摘要： A separation medium for reversed-phase chromatography is prepared by polymerizing an aqueous vinyl monomer mixture to which a hydrophobic alkyl methacrylate with 3 or more carbon atoms in the alkyl group and a detergent have been added. The further inclusion of a vinyl monomer with a charged group in the reaction mixture produces a separation medium useful for reversed-phase electrochromatography. Performance of the polymerization in a capillary produces a continuous bed inside the capillary. An alternative for non-capillary separations, such as those conducted in larger diameter tubing, is the preparation of the medium in a vessel outside the tubing, followed by granulation of the polymer and placement of the granules in the tubing.
摘要翻译：通过聚合乙烯基单体混合物制备反相色谱分离介质，其中烷基中具有3个或更多个碳原子的疏水性甲基丙烯酸烷基酯和已经加入了洗涤剂。在反应混合物中进一步包含具有带电基团的乙烯基单体产生用于反相电色谱的分离介质。在毛细管中聚合的性能在毛细管内产生连续的床。用于非毛细管分离的替代方案，例如在较大直径的管中进行的那些，是在管外的容器中制备介质，然后将聚合物造粒并将颗粒放置在管道中。

52. 外观设计

USD885635S1 Exploded star lights 有权
公开(公告)号：USD885635S1
公开(公告)日：2020-05-26
申请号：US29667550
申请日：2018-10-23
申请人： Shenzhen Dai Jia Li Optoelectronics Technology Co., Ltd.
设计人： Yingdong Cao
摘要： FIG. 1 is a perspective view of the exploded starburst lights showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top plan view thereof;
FIG. 7 is a bottom plan view thereof; and,
FIG. 8 is an enlarged fragmentary view taken from the circle shown in FIG. 2.
The broken lines are for the purposes of illustrating portions of the exploded star lights that form no part of the claimed design.

53. 发明授权

US09328345B2 Compositions of asymmetric interfering RNA and uses thereof 有权
标题翻译：不对称干扰RNA的组成及其用途
公开(公告)号：US09328345B2
公开(公告)日：2016-05-03
申请号：US12199797
申请日：2008-08-27
申请人： Chiang Jia Li , Xiangao Sun , Harry Rogoff , Youzhi Li
发明人： Chiang Jia Li , Xiangao Sun , Harry Rogoff , Youzhi Li
IPC分类号： A61K48/00 , C12N15/63 , C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51
摘要： The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5′-overhang, 3′-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
摘要翻译：本发明提供能够实现序列特异性基因沉默的不对称双链RNA分子。 RNA分子包含第一链和第二链。第一条链比第二条链长。 RNA分子包含由第一链和第二链形成的双链区，两端独立地选自5'-突出端，3'突出端和平端。本发明的RNA分子可以用作研究工具和/或治疗剂。

54. 发明授权

US08889144B2 PCSK9 vaccine 有权
标题翻译： PCSK9疫苗
公开(公告)号：US08889144B2
公开(公告)日：2014-11-18
申请号：US12872645
申请日：2010-08-31
申请人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人： Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
IPC分类号： A61K39/385 , A61K39/05 , A61K39/12 , A61K39/00 , A61K45/00 , C12N9/64
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供免疫原，其包含与免疫原性载体连接的抗原性PCSK9肽，用于预防，治疗或缓解PCSK9介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

55. 发明授权

US08457403B2 Method of detecting and correcting digital images of books in the book spine area 有权
标题翻译：检索和纠正书脊图书籍数字图像的方法
公开(公告)号：US08457403B2
公开(公告)日：2013-06-04
申请号：US13111199
申请日：2011-05-19
申请人： Jia Li , Mikhail Brusnitsyn , Sujay Sukumaran
发明人： Jia Li , Mikhail Brusnitsyn , Sujay Sukumaran
IPC分类号： G06K9/34
CPC分类号： H04N1/3873 , G06K2009/363 , H04N1/387
摘要： An image of a scanned book is segmented using a feature image to map pixels corresponding to a page area and to create page objects and detect borders of the page. A book spine region is detected by locating a plain background area between two of the page objects, analyzing the page borders to detect their shape, and analyzing their shape to detect the book spine end points. Using the page borders, the feature image is examined to detect top-to-bottom and bottom-to-top declines in pixel values to determine the corners of a shadow distortion in the original scanned image. Squeeze and curvature distortion are also detected. A Bezier curve is used to model each of the three distortions detected on the page. The detected distortion is corrected by first defining a trapezoidal correction area. The intensity, squeeze, and curvature corrections are then applied along lines within the trapezoidal correction area.
摘要翻译：使用特征图像对扫描书的图像进行分割，以对应于页面区域的像素映射并创建页面对象并检测页面的边界。通过在两个页面对象之间定位一个简单的背景区域，分析页面边框以检测其形状并分析其形状以检测书脊柱端点来检测书脊区域。使用页面边框，检查特征图像以检测像素值中的从上到下和从底部到顶部的下降，以确定原始扫描图像中阴影失真的角。也检测到挤压和曲率失真。贝塞尔曲线用于对页面上检测到的三个失真进行建模。通过首先定义梯形校正区域来校正检测到的失真。然后沿着梯形校正区域内的线施加强度，挤压和曲率校正。

56. 发明申请

US20130018483A1 RAPID MANUFACTURING OF POROUS METAL PROSTHESES 有权
公开(公告)号：US20130018483A1
公开(公告)日：2013-01-17
申请号：US13486310
申请日：2012-06-01
申请人： Jia Li , Adam M. Griner
发明人： Jia Li , Adam M. Griner
IPC分类号： A61F2/28 , B05D3/06
CPC分类号： A61F2/28 , A61L27/04 , A61L27/56 , B05D1/12 , B05D3/0254 , B05D5/00 , B22F3/105 , B22F3/11 , B33Y80/00
摘要： An orthopaedic prosthesis and a method for rapidly manufacturing the same are provided. The orthopaedic prosthesis includes a solid bearing layer, a porous bone-ingrowth layer, and an interdigitating layer therebetween. A laser sintering technique is performed to manufacture the orthopaedic prosthesis.

57. 发明申请

US20130011070A1 STUDYING AESTHETICS IN PHOTOGRAPHIC IMAGES USING A COMPUTATIONAL APPROACH 有权
标题翻译：使用计算方法研究摄影图像中的美学
公开(公告)号：US20130011070A1
公开(公告)日：2013-01-10
申请号：US13542326
申请日：2012-07-05
申请人： Ritendra Datta , Jia Li , James Z. Wang
发明人： Ritendra Datta , Jia Li , James Z. Wang
IPC分类号： G06K9/62 , G06K9/46
CPC分类号： G06K9/6228 , G06K9/00624 , G06K9/4652 , G06K9/4671
摘要： The aesthetic quality of a picture is automatically inferred using visual content as a machine learning problem using, for example, a peer-rated, on-line photo sharing Website as data source. Certain visual features of images are extracted based on the intuition that they can discriminate between aesthetically pleasing and displeasing images. A one-dimensional support vector machine is used to identify features that have noticeable correlation with the community-based aesthetics ratings. Automated classifiers are constructed using the support vector machines and classification trees, with a simple feature selection heuristic being applied to eliminate irrelevant features. Linear regression on polynomial terms of the features is also applied to infer numerical aesthetics ratings.
摘要翻译：使用例如同行评级的在线照片共享网站作为数据源，使用视觉内容作为机器学习问题自动推断图片的美学品质。基于它们可以在美学上令人不愉快的图像之间区分的直觉来提取图像的某些视觉特征。一维支持向量机用于识别与基于社区的美学评级具有显着相关性的特征。使用支持向量机和分类树构建自动分类器，并采用简单的特征选择启发式来消除不相关的特征。特征的多项式项的线性回归也用于推断数字美学评级。

58. 发明授权

US08331698B2 Ethnicity classification using multiple features 有权
标题翻译：种族分类采用多种特征
公开(公告)号：US08331698B2
公开(公告)日：2012-12-11
申请号：US12755576
申请日：2010-04-07
申请人： Jia Li
发明人： Jia Li
IPC分类号： G06K9/00 , G06K9/56 , G06K9/62
CPC分类号： G06K9/00281 , G06K9/00288 , G06K9/6292
摘要： Frontal face images are classified into four categories such as Asian, Caucasian, African and others. A new representation of face appearance, named BITF (Block Intensity and Texture Feature), is employed as the discrimination feature. An ensemble of three component classifiers, each trained with a different number of BITF features as inputs, is designed to achieve a reliable classification. Further reliability is obtained by taking into consideration other secondary features to boost the classification performance.
摘要翻译：正面图像分为四类，如亚洲，高加索，非洲等。作为辨别特征，采用名为BITF（块强度和纹理特征）的面部外观的新表示。三组分分类器的组合，每个训练有不同数量的BITF特征作为输入，被设计为实现可靠的分类。通过考虑其他次要特征来提高分类性能，可以获得进一步的可靠性。

59. 发明申请

US20120302815A1 MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE 有权
标题翻译：多功能多环链抑制剂及其使用方法
公开(公告)号：US20120302815A1
公开(公告)日：2012-11-29
申请号：US13401642
申请日：2012-02-21
申请人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
发明人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
IPC分类号： C07F1/12 , A61L2/08 , A61M37/00 , C12N5/09
CPC分类号： A61K38/00 , A61K41/0038 , A61K47/6923 , B82Y5/00 , C07D233/64 , C07K5/06034 , C07K5/06043 , C07K5/06052
摘要： A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.
摘要翻译：提供了用于开发用于研究细胞功能和治疗癌症中的Ubl修饰的试剂的组合物。该组合物包含金纳米颗粒（AuNP） - 偶联物，其包含至少两个组分：金纳米颗粒（AuNP）和修饰的泛素或泛素样相互作用基序（UIM或ULIM）模拟物。在一个实施方案中，修饰的ULM模拟物是修饰的SUMO相互作用基序（SIM）模拟物。根据本文所述的实施方案，化合物抑制泛素或泛素样蛋白（Ubl）介导的蛋白质 - 蛋白质相互作用并使细胞对电离辐射敏感。修饰的UIM和ULIM模拟物可以与AuNP缀合，使得每个AuNP与多个修饰的UIM或ULIM模拟物缀合。修饰的ULIM模拟物可以通过硫醇基团与AuNP缀合。

60. 发明申请

US20120268612A1 ON-SITE COMPOSITION AND AESTHETICS FEEDBACK THROUGH EXEMPLARS FOR PHOTOGRAPHERS 有权
标题翻译：现场组合和美学反馈通过摄影师的例证
公开(公告)号：US20120268612A1
公开(公告)日：2012-10-25
申请号：US13493564
申请日：2012-06-11
申请人： James Z. Wang , Jia Li , Lei Yao , Poonam Suryanarayan , Mu Qiao
发明人： James Z. Wang , Jia Li , Lei Yao , Poonam Suryanarayan , Mu Qiao
IPC分类号： H04N5/225
CPC分类号： G06K9/6267 , G06K9/00624 , G06K9/46 , G06K9/4652 , G06K9/4671 , G06K9/6228 , H04N5/23222
摘要： A comprehensive system to enhance the aesthetic quality of the photographs captured by mobile consumers provides on-site composition and aesthetics feedback through retrieved examples. Composition feedback is qualitative in nature and responds by retrieving highly aesthetic exemplar images from the corpus which are similar in content and composition to the snapshot. Color combination feedback provides confidence on the snapshot to contain good color combinations. Overall aesthetics feedback predicts the aesthetic ratings for both color and monochromatic images. An algorithm is used to provide ratings for color images, while new features and a new model are developed to treat monochromatic images. This system was designed keeping the next generation photography needs in mind and is the first of its kind. The feedback rendered is guiding and intuitive in nature. It is computed in situ while requiring minimal input from the user.
摘要翻译：提高移动消费者拍摄的照片的美学质量的全面系统通过检索的例子提供现场构图和美学反馈。组合反馈本质上是定性的，并通过从语料库中检索与内容和构图相似的快照的高度审美的示例图像来进行响应。颜色组合反馈提供了对快照的信心，以包含良好的颜色组合。整体美学反馈预测了彩色和单色图像的审美等级。一种算法用于提供彩色图像的等级，同时开发新特征和新模型来处理单色图像。该系统的设计保持了下一代摄影的需要，是同类产品中的第一个。呈现的反馈本质上是指导和直观的。它是原地计算的，同时需要用户的最小输入。

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