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    • 53. 发明授权
    • Cephem compounds
    • 头孢烯化合物
    • US4452851A
    • 1984-06-05
    • US343243
    • 1982-01-27
    • Takao TakayaHisashi TakasugiHideaki Yamanaka
    • Takao TakayaHisashi TakasugiHideaki Yamanaka
    • A61K31/545C07C251/60C07D277/20C07D277/30C07D285/10C07D501/36C07D501/59
    • C07D277/587C07D277/30C07D285/10
    • This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino substituted thiazolyl selected from the group consisting of 2-aminothiazol-4-yl, 2-aminothiazol-5-yl, 4-aminothiazol-2-yl, 2-amino-5-halothiazol-4-yl, 2-amino-4-halothiazol-5-yl, and 4-amino-5-halothiazol-2-yl,protected amino substituted thiazolyl selected from said group,lower alkylamino substituted thiazolyl,amino substituted thiadiazolyl,protected amino substituted thiadiazolyl,amino substituted pyridyl,protected amino substituted pyridyl,furyl,thiazolyl,thiadiazolyl,phenyl, ornaphthyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is lower alkylthio, andR.sup.4 is carboxy or protected carboxy, and pharmaceutically acceptable salts thereof.
    • 本发明涉及具有下式的高抗微生物活性的新型头孢烯化合物:其中R1是选自2-氨基噻唑-4-基,2-氨基噻唑-5-基,4-氨基噻唑-4-基, 2-氨基-5-卤代噻唑-4-基,2-氨基-4-卤代噻唑-5-基和4-氨基-5-卤代噻唑-2-基,保护的氨基取代的噻唑基,其选自所述基团, 低级烷基氨基取代的噻唑基,氨基取代的噻二唑基,被保护的氨基取代的噻二唑基,氨基取代的吡啶基,被保护的氨基取代的吡啶基,呋喃基,噻唑基,噻二唑基,苯基或萘基,R2是羧基(低级)烷基或保护的羧基 是低级烷硫基,R 4是羧基或被保护的羧基,及其药学上可接受的盐。