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51. 发明申请

US20170052204A1 Metabolic and Genetic Biomarkers for Memory Loss 审中-公开
标题翻译：记忆丧失的代谢和遗传生物标志物
公开(公告)号：US20170052204A1
公开(公告)日：2017-02-23
申请号：US15307988
申请日：2015-04-30
申请人： GEORGETOWN UNIVERSITY , UNIVERSITY OF ROCHESTER
发明人： Howard J. Federoff , Mark E. Mapstone , Amrita K. Cheema , Massimo S. Fiandaca
IPC分类号： G01N33/92 , C12Q1/68
CPC分类号： G01N33/92 , C12Q1/6883 , C12Q2600/158 , G01N2570/00 , G01N2800/2814 , G01N2800/52
摘要： The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subject's biomarker profile (lipidomic profile plus gene expression profile) with the value of a normal biomarker profile. A change in the value of the subject's biomarker profile, including a change in the subject's biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
摘要翻译：本发明涉及确定受试者是否具有增加患记忆障碍风险的方法。所述方法包括分析来自受试者的至少一种血浆样品以确定受试者的脂质体谱的值，并且还分析来自白细胞的基因表达谱，并将受试者的生物标志物谱（脂质体谱和加基因表达谱）的值与正常生物标志物谱的值。主题生物标志物概况的价值变化（包括主题生物标志物概况的变化）超过正常值，表明该受试者与正常个体相比具有增加的记忆障碍风险。

52. 发明申请

US20170000746A1 METHODS FOR TREATING HEAT STRESS AND RELATED COMPOSITIONS 审中-公开
标题翻译：用于处理热应力的方法及相关组合物
公开(公告)号：US20170000746A1
公开(公告)日：2017-01-05
申请号：US15265350
申请日：2016-09-14
申请人： GEORGETOWN UNIVERSITY
发明人： Harry George Preuss
IPC分类号： A61K31/122 , A61K38/17 , A61K33/24
CPC分类号： A61K31/122 , A61K33/24 , A61K38/1709
摘要： Methods of treating, reducing, and/or preventing heat stress are provided. For example, provided is a method of treating or preventing heat stress in a subject comprising selecting a subject in need of heat stress treatment or prevention and administering an effective amount of one or more of astaxanthin and milk casein hydrolysate, or a derivative thereof to the subject. Also provided are methods of reducing the effects of a fever in a subject comprising administering an effective amount of one or more of astaxanthin, chromium and milk casein hydrolysate, or a derivative thereof, to the subject. Also provided are pharmaceutical compositions, comprising astaxanthin and one or more of chromium or milk casein hydrolysate.
摘要翻译：提供了治疗，减少和/或预防热应激的方法。例如，提供了治疗或预防受试者的热应激的方法，包括选择需要热应激治疗或预防的对象，并将有效量的一种或多种虾青素和乳酪蛋白水解产物或其衍生物施用于学科。还提供了降低受试者发烧效果的方法，包括向受试者施用有效量的一种或多种虾青素，铬和乳酪蛋白水解物或其衍生物。还提供了包含虾青素和铬或乳酪蛋白水解产物中的一种或多种的药物组合物。

53. 发明申请

US20160368927A1 SYNTHESIS OF MAHANINE AND RELATED COMPOUNDS 审中-公开
标题翻译：马来西亚和相关化合物的合成
公开(公告)号：US20160368927A1
公开(公告)日：2016-12-22
申请号：US15189512
申请日：2016-06-22
申请人： Georgetown University
发明人： Milton L. Brown , Shujie Hou
IPC分类号： C07D491/048
CPC分类号： C07D491/048
摘要： Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition metal catalyzed cross-coupling and intramolecular carbazole forming reaction.
摘要翻译：本文公开了合成马汉酸和相关化合物的方法。该合成具有分子内芳基炔异构化，过渡金属催化的交叉偶联和分子内咔唑形成反应。

54. 发明授权

US09474753B2 Treating neural disease with tyrosine kinase inhibitors 有权
标题翻译：用酪氨酸激酶抑制剂治疗神经病
公开(公告)号：US09474753B2
公开(公告)日：2016-10-25
申请号：US14398379
申请日：2013-05-02
申请人： Georgetown University
发明人： Charbel Moussa
IPC分类号： A61K31/506 , A61K31/496 , A61K45/06
CPC分类号： A61K31/506 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.
摘要翻译：本文提供了治疗或预防受试者中的神经变性疾病，畸形疾病或朊病毒疾病的方法，其包括施用酪氨酸激酶抑制剂。

55. 发明申请

US20160263086A1 METHODS AND COMPOSITIONS FOR TREATING CANCER 有权
标题翻译：用于治疗癌症的方法和组合物
公开(公告)号：US20160263086A1
公开(公告)日：2016-09-15
申请号：US15030713
申请日：2014-10-20
申请人： GEORGETOWN UNIVERSITY
发明人： Jeffrey A. Toretsky , Aykut Uren
IPC分类号： A61K31/404 , A61K47/40 , A61K45/06
CPC分类号： A61K31/404 , A61K45/06 , A61K47/40 , C07D209/38
摘要： Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
摘要翻译：本文提供的方法和组合物涉及癌症的治疗。在一些实施方案中，所述组合物可用于治疗癌症，包括多形性成胶质细胞瘤和肺癌。

56. 发明授权

US09433895B2 Reversible room-temperature ionic liquids 有权
公开(公告)号：US09433895B2
公开(公告)日：2016-09-06
申请号：US14072439
申请日：2013-11-05
申请人： Georgetown University
发明人： Tao Yu , Richard G. Weiss , Taisuke Yamada , Mathew George
IPC分类号： B01D53/62 , B01D53/78 , B01D53/14 , B01D53/96 , C01B31/16 , C09K3/00 , C07C213/08 , C07C257/14 , C07C271/02 , C07C319/20 , C07C323/43 , C07D487/04
CPC分类号： B01D53/62 , B01D53/1493 , C07C213/08 , C07C257/14 , C07C271/02 , C07C319/20 , C07C323/43 , C07D487/04 , C07C323/25 , C07C215/08 , C07C215/30
摘要： One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.

57. 发明申请

US20160238622A1 BIOMARKERS FOR MEMORY LOSS 审中-公开
标题翻译：内存损失的生物标记
公开(公告)号：US20160238622A1
公开(公告)日：2016-08-18
申请号：US15134976
申请日：2016-04-21
申请人： Georgetown University , University of Rochester
发明人： Howard J. FEDEROFF , Mark E. MAPSTONE , Amrita K. CHEEMA , Massimo S. FIANDACA
IPC分类号： G01N33/92
摘要： The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
摘要翻译：本发明涉及确定受试者是否具有增加患记忆障碍风险的方法。所述方法包括分析来自受试者的至少一种血浆样品以确定受试者的脂质体谱的值，以及将受试者的脂质体谱的值与正常脂质体谱的值进行比较。与正常值相比，受试者的脂质组学特征值的降低表明与正常个体相比，受试者具有增加的记忆障碍风险。

58. 发明申请

US20160220523A1 TREATING NEURODEGENERATIVE DISEASE WITH FENOFIBRATE AND ANALOGS THEREOF 审中-公开
标题翻译：用芬太尼及其类似物治疗神经病变疾病
公开(公告)号：US20160220523A1
公开(公告)日：2016-08-04
申请号：US15022654
申请日：2014-09-18
申请人： GEORGETOWN UNIVERSITY , VANDA PHARMACEUTICALS INC.
发明人： Mihael Polymeropoulos , Howard J. Federoff , Xiaomin Su
IPC分类号： A61K31/216 , G01N33/50 , A61K45/06
CPC分类号： A61K31/216 , A61K31/13 , A61K31/198 , A61K31/27 , A61K31/36 , A61K31/428 , A61K31/4745 , A61K45/06 , G01N33/5023 , G01N2333/4706 , A61K2300/00
摘要： Provided herein are methods of treating or preventing a neurodegenerative by administering fenofibrate or an analog thereof.
摘要翻译：本文提供了通过施用非诺贝特或其类似物来治疗或预防神经变性的方法。

59. 发明申请

US20160038477A1 ANTIFUNGAL DRUGS 有权
标题翻译：抗真菌药
公开(公告)号：US20160038477A1
公开(公告)日：2016-02-11
申请号：US14776398
申请日：2014-03-14
申请人： GEORGETOWN UNIVERSITY
发明人： Richard A. Calderone , Nuo Sun
IPC分类号： A61K31/4745 , A61K45/06
CPC分类号： A61K31/4745 , A61K45/06
摘要： The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.
摘要翻译：本发明涉及用于治疗和/或预防有需要的受试者中真菌感染的式（I）化合物。本发明的方法还涉及包含式（I）化合物的药物组合物的施用，用于治疗和/或预防有需要的受试者的真菌感染。患有真菌感染和免疫受损受试者的受试者可能特别受益于本发明的方法和组合物。

60. 发明申请

US20160025828A1 FMRI BIOMARKER OF NEURODEGENERATIVE DISEASE 审中-公开
标题翻译：功能强大的生物标志物神经病变疾病
公开(公告)号：US20160025828A1
公开(公告)日：2016-01-28
申请号：US14774750
申请日：2014-03-14
申请人： GEORGETOWN UNIVERSITY
发明人： Xiong Jiang , Maximilian Riesenhuber
IPC分类号： G01R33/48 , A61B5/00 , A61B5/055
CPC分类号： G01R33/4806 , A61B5/0042 , A61B5/055 , A61B5/4088 , A61B5/4839 , A61B2576/026
摘要： Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
摘要翻译：本文提供了与鉴定神经变性疾病的早期，无症状（前驱）阶段或鉴定具有症状性神经变性疾病的受试者相关的方法，包括例如轻度认知障碍（MCI），阿尔茨海默病（AD）或HIV- 相关的神经认知障碍（HAND），使用受试者的功能性MRI数据。还提供了用于治疗用本文教导的方法鉴定的受试者并且基于fMRI的结果修改或选择治疗的方法。方法还可用于分期神经变性疾病和用于鉴定可用于治疗它们的药剂。

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