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51. 发明申请

US20090169572A1 METHODS FOR DAMAGING CELLS USING EFFECTOR FUNCTIONS OF ANTI-CDH3 ANTIBODIES 审中-公开
标题翻译：使用抗CDH3抗体的影响功能破坏细胞的方法
公开(公告)号：US20090169572A1
公开(公告)日：2009-07-02
申请号：US12280956
申请日：2007-02-28
申请人： Shuichi Nakatsuru , Megumi Yoshikawa , Shinichi Hiroshima
发明人： Shuichi Nakatsuru , Megumi Yoshikawa , Shinichi Hiroshima
IPC分类号： A61K39/00 , C07K16/18 , C12N5/06
CPC分类号： C07K16/30 , C07K2317/732
摘要： The present invention relates to the use of cytotoxicity based on the effector function of anti-CDH3 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient for damaging CDH3-expressing cells using antibody effector function. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
摘要翻译：本发明涉及基于抗CDH3抗体的效应子功能的细胞毒性的用途。具体地，本发明提供了包含抗CDH3抗体作为活性成分的方法和药物组合物，用于使用抗体效应子功能损伤表达CDH3的细胞。由于CDH3在胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌细胞中强烈表达，本发明可用于胰腺，肺癌，结肠癌，前列腺癌，乳腺癌，胃癌或肝癌的治疗。

52. 发明申请

US20090162361A1 Method for diagnosing pancreatic cancer 审中-公开
标题翻译：诊断胰腺癌的方法
公开(公告)号：US20090162361A1
公开(公告)日：2009-06-25
申请号：US12291912
申请日：2008-11-13
申请人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa
发明人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa
IPC分类号： A61K39/395 , C12Q1/68 , C40B30/00 , C07H21/04 , G01N33/53 , C40B40/06 , A61K31/7088 , A61K39/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
摘要翻译：本文描述了胰腺癌（PNC）检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定鉴别PNC细胞和正常细胞的PNC相关基因的表达水平。本发明进一步提供筛选用于治疗胰腺癌的治疗剂的方法，胰腺癌治疗方法和疫苗接种胰腺癌的方法。

53. 发明授权

US07531300B2 Method of diagnosing breast cancer 有权
标题翻译：诊断乳腺癌的方法
公开(公告)号：US07531300B2
公开(公告)日：2009-05-12
申请号：US10573297
申请日：2004-09-24
申请人： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru
IPC分类号： C12Q1/00
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。在一个实施方案中，诊断方法涉及确定区分BRC细胞和正常细胞的BRC相关基因的表达水平。在另一个实施方案中，诊断方法涉及确定鉴别BRC细胞之间，DCIS和IDC细胞之间的BRC相关基因的表达水平。本发明还提供了使用具有淋巴结转移的乳腺癌细胞中具有独特改变的表达模式的BRC相关基因预测和预防乳腺癌转移的方法。最后，本发明提供了筛选用于治疗乳腺癌的治疗剂的方法，以及用于治疗乳腺癌的方法以及接种受试者对乳腺癌的方法。

54. 发明授权

US07521205B2 Genes and polypeptides relating to prostate cancers 失效
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：US07521205B2
公开(公告)日：2009-04-21
申请号：US10529381
申请日：2003-09-22
申请人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： C12P21/06
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
摘要翻译：本申请提供了新型人基因MICAL2-PV，其表达在前列腺癌中显着升高。此外，它提供由该基因编码的多肽以及由PCOTH编码的多肽，其表达也被发现在前列腺癌中升高。由该基因编码的基因和多肽可以用于例如前列腺癌的诊断，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。

55. 发明授权

US07514084B2 KDR peptides and vaccines comprising the same 失效
标题翻译： KDR肽和包含其的疫苗
公开(公告)号：US07514084B2
公开(公告)日：2009-04-07
申请号：US10527496
申请日：2003-09-12
申请人： Hideaki Tahara , Satoshi Wada , Takuya Tsunoda
发明人： Hideaki Tahara , Satoshi Wada , Takuya Tsunoda
IPC分类号： A61K39/00 , A61K38/08
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C07K7/06 , C07K14/71
摘要： The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO: 2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO: 29, 30, 33, 34, 40, or 46; and peptides with cytotoxic T cell inducibility, in which one, two, or several amino acids are substituted or added to the above-mentioned amino acid sequences, as well as pharmaceuticals for treating or preventing tumors, where the pharmaceuticals comprise these peptides. The peptides of this invention can be used as vaccines.
摘要翻译：本发明提供了选自包含SEQ ID NO：2,3,5,8,11或12的氨基酸序列的肽的非肽; 选自包含SEQ ID NO：29,30,33,34,40或46的氨基酸序列的肽的非肽或十肽; 和具有细胞毒性T细胞诱导能力的肽，其中一个，两个或几个氨基酸被取代或加入到上述氨基酸序列中，以及用于治疗或预防肿瘤的药物，其中药物包含这些肽。本发明的肽可用作疫苗。

56. 发明申请

US20080220455A1 p53-DEPENDENT APOPTOSIS-INDUCING PROTEIN AND METHOD OF SCREENING FOR APOPTOSIS REGULATOR 审中-公开
标题翻译： p53依赖性病毒诱导蛋白和筛选调节因子的方法
公开(公告)号：US20080220455A1
公开(公告)日：2008-09-11
申请号：US12103867
申请日：2008-04-16
申请人： Yusuke Nakamura , Hirofumi Arakawa
发明人： Yusuke Nakamura , Hirofumi Arakawa
IPC分类号： G01N33/574 , C12N15/11 , C07K14/00 , C12N15/00 , C12N5/06 , C12P21/04 , C07K16/18 , C07H21/00 , G01N33/566
CPC分类号： G01N33/5008 , C07K14/4747 , C07K16/18 , C12Q1/485 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
摘要翻译： p53依赖性损伤诱导核蛋白1（p53DINP1蛋白）是p53诱导的核蛋白，其通过调节p53功能通过Ser 46磷酸化诱导p53依赖性凋亡。编码p53DINP1的DNA可用作破坏肿瘤等肿瘤的抗癌剂，也可用作与p53介导的凋亡异常有关的疾病的治疗或预防剂。还可以将上述蛋白质和DNA应用于筛选用于调节p53介导的凋亡的候选化合物的方法中。

57. 发明申请

US20070202109A1 Method Of Diagnosing Breast Cancer 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：US20070202109A1
公开(公告)日：2007-08-30
申请号：US10573522
申请日：2004-08-10
申请人： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Toyomasa Katagiri , Shuichi Nakatsuru
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , A61K39/395
CPC分类号： G01N33/57415 , A61K39/00 , C12Q1/6809 , C12Q1/6827 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2537/143 , C12Q2545/114 , C12Q2565/549
摘要： Compositions and objective methods for detecting, diagnosing, and treating breast cancer (BRC) are described herein. In particular, the present invention describes three BRC-associated genes, referred to herein as A5657, B9769, and C7965, up-regulated in BRC cells as compared to normal cells. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells; in an alternate embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS cells and IDC cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and methods for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测，诊断和治疗乳腺癌（BRC）的组合物和客观方法。特别地，本发明描述了与正常细胞相比，在BRC细胞中上调的三种BRC相关基因（本文称为A5657，B9769和C7965）。在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平; 在替代实施方案中，诊断方法包括确定区分BRC细胞，DCIS细胞和IDC细胞之间的BRC相关基因的表达水平。本发明还提供了筛选用于治疗乳腺癌的治疗剂的方法，以及用于治疗乳腺癌的方法以及接种受试者抵抗乳腺癌的方法。

58. 发明申请

US20060204960A1 Method for diagnosing diffuse-type gastric cancers 审中-公开
标题翻译：诊断弥漫性胃癌的方法
公开(公告)号：US20060204960A1
公开(公告)日：2006-09-14
申请号：US10533026
申请日：2003-09-19
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： G01N33/57446 , A61K48/00 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
摘要： Objective methods for detecting and diagnosing diffuse-type gastric cancer (DGC) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of DGC-associated gene that discriminate between DGC and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of DGC, methods of treating DGC and method of vaccinating a subject against DGC.
摘要翻译：本文描述了弥漫性胃癌（DGC）的检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定区分DGC和正常细胞的DGC相关基因的表达水平。本发明还提供筛选用于治疗DGC的治疗剂的方法，DGC治疗方法和用DGC接种受试者的方法。

59. 发明申请

US20050272063A1 Method for treating synovial sarcoma 有权
标题翻译：滑膜肉瘤治疗方法
公开(公告)号：US20050272063A1
公开(公告)日：2005-12-08
申请号：US11067231
申请日：2005-02-28
申请人： Yusuke Nakamura , Toyomasa Katagiri , Chikako Fukukawa
发明人： Yusuke Nakamura , Toyomasa Katagiri , Chikako Fukukawa
IPC分类号： C12Q1/68
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/34 , C07K2317/732 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject is provided.
摘要翻译：公开了使用差异表达基因检测滑膜肉瘤的方法。还公开了鉴定用于治疗滑膜肉瘤的药剂的方法。此外，提供了治疗或预防与受试者中的卷曲同源物10（FZD10）相关的疾病的方法。

60. 发明申请

US20050259483A1 Genes and polypeptides relating to prostate cancers 审中-公开
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：US20050259483A1
公开(公告)日：2005-11-24
申请号：US11088634
申请日：2005-03-23
申请人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Toyomasa Katagiri , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： C07K14/47 , G11C5/00
CPC分类号： C07K14/4748
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of PRC-associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
摘要翻译：本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。

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