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51. 发明授权

US09291613B2 Sensor having a thin-film inhibition layer 有权
标题翻译：传感器具有薄膜抑制层
公开(公告)号：US09291613B2
公开(公告)日：2016-03-22
申请号：US14306156
申请日：2014-06-16
申请人： NANOMIX, INC.
发明人： Craig Bryant , Ying-Lan Chang , Jean-Christophe P. Gabriel , Bradley N. Johnson , Oleksandr Kuzmych , William Mickelson , John Loren Passmore , Sergei Skarupo , Christian Valcke
IPC分类号： G01N33/497 , B82Y30/00 , G01N27/12 , G01N27/414 , G01N33/00
CPC分类号： G01N33/497 , B82Y30/00 , G01N27/127 , G01N27/4146 , G01N33/0037 , G01N33/004 , Y02A50/245
摘要： Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.
摘要翻译：提供适用于测量分析物，如生物分子，有机和无机物质的传感器和检测系统，包括环境和医学上相关的挥发物和气体，如NO，NO2，CO2，NH3，H2，CO等。纳米结构传感器系统的某些实施例被配置用于测量呼吸中的医学上重要的气体。应用包括测量呼吸中的内源性一氧化氮（NO），如用于监测或诊断哮喘和其他肺部疾病。

52. 发明授权

US08993346B2 Magnetic carbon nanotube based biodetection 有权
标题翻译：基于磁性碳纳米管的生物检测
公开(公告)号：US08993346B2
公开(公告)日：2015-03-31
申请号：US13389247
申请日：2010-08-06
申请人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
发明人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
IPC分类号： G01N33/563 , G01N33/553 , G01N33/543 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B31/02 , G01N27/22
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B32/174 , G01N27/226
摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.
摘要翻译：本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。外部CNT表面保持完整，用于生物分子附着或其他功能化。这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

53. 发明授权

US08778269B2 Nanoelectronic electrochemical test device 有权
标题翻译：纳米电子电化学试验装置
公开(公告)号：US08778269B2
公开(公告)日：2014-07-15
申请号：US13092869
申请日：2011-04-22
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： D01F9/12
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供了用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

54. 发明授权

US08456074B2 Flexible nanostructure electronic devices 有权
标题翻译：柔性纳米结构电子器件
公开(公告)号：US08456074B2
公开(公告)日：2013-06-04
申请号：US13096891
申请日：2011-04-28
申请人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Gruner
发明人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Gruner
IPC分类号： H01J1/02
CPC分类号： H01B1/24 , B82Y10/00 , B82Y15/00 , H01L51/0048 , H01L51/0097 , H01L51/0595
摘要： A flexible electronic device is made up of nanostructures. Specifically, the device includes a flexible substrate, a film of nanostructures in contact with the flexible substrate, a first conducting element in contact with the film of nanostructures, and a second conducting element in contact with the film of nanostructures. The nanostructures may comprise nanotubes, such as carbon nanotubes disposed along the flexible substrate, such as an organic or polymer substrate. The first and second conductive elements may serve as electrical terminals, or as a source and drain. In addition, the electronic device may include a gate electrode that is in proximity to the nanotubes and not in electrical contact with the nanotubes. In this configuration, the device can operate as a transistor or a FET. The device may also be operated in a resistive mode as a chemical sensor (e.g., for sensing NH3).
摘要翻译：灵活的电子设备由纳米结构组成。具体地，该装置包括柔性基板，与柔性基板接触的纳米结构薄膜，与纳米结构薄膜接触的第一导电元件和与纳米结构薄膜接触的第二导电元件。纳米结构可以包括纳米管，例如沿着柔性基底设置的碳纳米管，例如有机或聚合物基底。第一和第二导电元件可以用作电端子，或用作源极和漏极。此外，电子器件可以包括位于纳米管附近并且不与纳米管电接触的栅电极。在这种配置中，器件可以作为晶体管或FET工作。该装置还可以作为化学传感器（例如，用于感测NH 3）以电阻模式操作。

55. 发明申请

US20120178187A1 MAGNETIC CARBON NANOTUBE BASED BIODETECTION 有权
标题翻译：基于磁性碳纳米管的生物保护
公开(公告)号：US20120178187A1
公开(公告)日：2012-07-12
申请号：US13389247
申请日：2010-08-06
申请人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
发明人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
IPC分类号： G01N33/551 , B82Y5/00
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B32/174 , G01N27/226
摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.
摘要翻译：本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。外部CNT表面保持完整，用于生物分子附着或其他功能化。这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

56. 发明授权

US08154093B2 Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices 有权
标题翻译：用于化学和生物分析物的纳米电子传感器，包括电容和生物膜装置
公开(公告)号：US08154093B2
公开(公告)日：2012-04-10
申请号：US11400038
申请日：2006-04-06
申请人： Keith Bradley , Ying-Lan Chang , Jean-Christophe P. Gabriel , John Loren Passmore , Sergei Skarupo , Eugene Tu , Christian Valcke
发明人： Keith Bradley , Ying-Lan Chang , Jean-Christophe P. Gabriel , John Loren Passmore , Sergei Skarupo , Eugene Tu , Christian Valcke
IPC分类号： H01L51/30
CPC分类号： G01N27/4146 , B82Y10/00 , B82Y15/00 , G01N27/4145 , H01L29/0665 , H01L29/0673 , Y10S977/742
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors.
摘要翻译：描述了纳米电子传感器的实施例，包括用于检测分析物无机气体，有机蒸气，生物分子，病毒等的传感器。描述了具有替代架构的电容传感器的许多实施例。具体实例包括纳米电子传感器中的集成细胞膜和膜状结构。

57. 发明申请

US20120025165A1 FLEXIBLE NANOSTRUCTURE ELECTRONIC DEVICES 有权
标题翻译：柔性纳米结构电子器件
公开(公告)号：US20120025165A1
公开(公告)日：2012-02-02
申请号：US13096891
申请日：2011-04-28
申请人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Grüner
发明人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Grüner
IPC分类号： H01L29/66 , B82Y99/00
CPC分类号： H01B1/24 , B82Y10/00 , B82Y15/00 , H01L51/0048 , H01L51/0097 , H01L51/0595
摘要： A flexible electronic device is made up of nanostructures. Specifically, the device includes a flexible substrate, a film of nanostructures in contact with the flexible substrate, a first conducting element in contact with the film of nanostructures, and a second conducting element in contact with the film of nanostructures. The nanostructures may comprise nanotubes, such as carbon nanotubes disposed along the flexible substrate, such as an organic or polymer substrate. The first and second conductive elements may serve as electrical terminals, or as a source and drain. In addition, the electronic device may include a gate electrode that is in proximity to the nanotubes and not in electrical contact with the nanotubes. In this configuration, the device can operate as a transistor or a FET. The device may also be operated in a resistive mode as a chemical sensor (e.g., for sensing NH3).
摘要翻译：灵活的电子设备由纳米结构组成。具体地，该装置包括柔性基板，与柔性基板接触的纳米结构薄膜，与纳米结构薄膜接触的第一导电元件和与纳米结构薄膜接触的第二导电元件。纳米结构可以包括纳米管，例如沿着柔性基底设置的碳纳米管，例如有机或聚合物基底。第一和第二导电元件可以用作电端子，或用作源极和漏极。此外，电子器件可以包括位于纳米管附近并且不与纳米管电接触的栅电极。在这种配置中，器件可以作为晶体管或FET工作。该装置还可以作为化学传感器（例如，用于感测NH 3）以电阻模式操作。

58. 发明申请

US20110003698A1 MODIFICATION OF SELECTIVITY FOR SENSING FOR NANOSTRUCTURE SENSING DEVICE ARRAYS 有权
标题翻译：用于感应神经传感装置阵列的选择性修改
公开(公告)号：US20110003698A1
公开(公告)日：2011-01-06
申请号：US11938180
申请日：2007-11-09
申请人： Jean-Christophe P. Gabriel , Philip G. Collins , Keith Bradley , George Gruner
发明人： Jean-Christophe P. Gabriel , Philip G. Collins , Keith Bradley , George Gruner
IPC分类号： C40B30/00 , C40B60/12 , C25B1/00
CPC分类号： G01N27/4146 , G01N2035/00158 , Y10S977/70 , Y10S977/701 , Y10S977/84 , Y10S977/882 , Y10S977/883 , Y10S977/902 , Y10S977/92 , Y10S977/953 , Y10S977/957 , Y10T29/49 , Y10T29/49002 , Y10T436/11
摘要： An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided. The methods involve comparing signals from nanostructure sensing devices that have not been exposed to the chemical species of interest with signals from nanostructure sensing devices that have been exposed to the chemical species of interest.
摘要翻译：公开了一种用于选择性地检测和识别包括纳米结构感测装置阵列的多种化学物质的电子系统。在阵列内，在纳米结构感测装置中有至少两种用于感测的不同选择性。还公开了用于制造电子系统的方法。这些方法包括修改装置内的纳米结构以具有感测化学物质的不同选择性。修饰可能涉及化学，电化学和自限制点缺陷反应。这些反应的反应物可以使用浴法或化学喷射法提供。还提供了使用纳米结构感测装置的阵列来检测和识别多种化学物种的方法。该方法涉及将未暴露于感兴趣的化学物质的纳米结构感测装置的信号与已经暴露于感兴趣的化学物质的纳米结构感测装置的信号进行比较。

59. 发明申请

US20090165533A1 SENSOR DEVICE WITH HEATED NANOSTRUCTURE 审中-公开
标题翻译：具有加热纳米结构的传感器装置
公开(公告)号：US20090165533A1
公开(公告)日：2009-07-02
申请号：US12245638
申请日：2008-10-03
申请人： Tzong-Ru Han , Alexander Star , Philip G. Collins , Jean-Christophe P. Gabriel , George Gruner , Keith Bradley
发明人： Tzong-Ru Han , Alexander Star , Philip G. Collins , Jean-Christophe P. Gabriel , George Gruner , Keith Bradley
IPC分类号： G01N7/00
CPC分类号： G01N25/20
摘要： A nanostructure sensing device includes a substrate, a nanotube disposed over the substrate, and at least two conductive elements electrically connected to the nanotube. A electric current on the order of about 10 μA, or greater, is passed through the conductive elements and the nanotube. As a result, the nanotube heats up relative to the substrate. In the alternative, some other method may be used to heat the nanotube. When operated as a sensor with a heated nanotube, the sensor's response and/or recovery time may be markedly improved.
摘要翻译：纳米结构感测装置包括衬底，设置在衬底上的纳米管以及电连接到纳米管的至少两个导电元件。大约10μA或更大的电流通过导电元件和纳米管。结果，纳米管相对于基底加热。在替代方案中，可以使用一些其它方法来加热纳米管。当作为具有加热的纳米管的传感器操作时，可以显着改善传感器的响应和/或恢复时间。

60. 发明授权

US07449757B2 Nanostructures with electrodeposited nanoparticles 有权
标题翻译：具有电沉积纳米粒子的纳米结构
公开(公告)号：US07449757B2
公开(公告)日：2008-11-11
申请号：US10945803
申请日：2004-09-20
申请人： Keith Bradley , Alona J. Davis , Jean-Christophe P. Gabriel , Tzong-Ru Han , Vikram Joshi , Alexander Star
发明人： Keith Bradley , Alona J. Davis , Jean-Christophe P. Gabriel , Tzong-Ru Han , Vikram Joshi , Alexander Star
IPC分类号： G01N27/403
CPC分类号： B82Y30/00 , G01N27/4146 , G01N33/005 , Y10S977/72
摘要： A nanoelectronic device includes a nanostructure, such as a nanotube or network of nanotubes, disposed on a substrate. Nanoparticles are disposed on or adjacent to the nanostructure so as to operatively effect the electrical properties of the nanostructure. The nanoparticles may be composed of metals, metal oxides, or salts, and nanoparticles composed of different materials may be present. The amount of nanoparticles may be controlled to preserve semiconductive properties of the nanostructure, and the substrate immediately adjacent to the nanostructure may remain substantially free of nanoparticles. A method for fabricating the device includes electrodeposition of the nanoparticles using one or more solutions of dissolved ions while providing an electric current to the nanostructures but not to the surrounding substrate.
摘要翻译：纳米电子器件包括设置在衬底上的纳米结构，例如纳米管或纳米管网络。将纳米颗粒设置在纳米结构上或与纳米结构相邻，以便有效地影响纳米结构的电性能。纳米颗粒可以由金属，金属氧化物或盐组成，并且可以存在由不同材料组成的纳米颗粒。可以控制纳米颗粒的量以保持纳米结构的半导体性质，并且紧邻纳米结构的衬底可以基本上不含纳米颗粒。制造该器件的方法包括使用一种或多种溶解离子的溶液电沉积纳米颗粒，同时向纳米结构提供电流，而不向周围的衬底提供电流。

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