专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20120202840A1 Use of Flubendazole and Vinca Alkaloids for Treatment of Hematological Diseases 审中-公开
标题翻译：使用氟苯达唑和长春花碱生物碱治疗血液病
公开(公告)号：US20120202840A1
公开(公告)日：2012-08-09
申请号：US13500162
申请日：2010-10-08
申请人： Aaron David Schimmer , Jiayi Hu , Paul Anthony Spangnuolo
发明人： Aaron David Schimmer , Jiayi Hu , Paul Anthony Spangnuolo
IPC分类号： A61K31/475 , A61K31/4184 , A61P35/00 , C07D235/32 , C07D519/00
CPC分类号： A61K31/4184 , A61K31/475 , A61K45/06 , A61K2300/00
摘要： Provided are methods for treating a hematological malignancy comprising administering an effective amount of flubendazole alone or in combination with a vinca alkaloid. Also provided are compositions and kits comprising an effective amount of flubendazole and/or a vinca alkaloid for use in the methods of the disclosure.
摘要翻译：提供了用于治疗血液恶性肿瘤的方法，其包括单独或与长春花生物碱组合施用有效量的氟苯达唑。还提供了组合物和试剂盒，其包含用于本公开的方法的有效量的氟苯达唑和/或长春花生物碱。

42. 发明申请

US20110176998A1 IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS 审中-公开
标题翻译：病毒相关肿瘤的成像和治疗
公开(公告)号：US20110176998A1
公开(公告)日：2011-07-21
申请号：US12903842
申请日：2010-10-13
申请人： Martin G. Pomper , Richard Ambinder , Jun O. Liu , Curtis R. Chong , Jianmeng Chen
发明人： Martin G. Pomper , Richard Ambinder , Jun O. Liu , Curtis R. Chong , Jianmeng Chen
IPC分类号： A61K51/00 , C07F5/02 , C07C229/66 , C07D261/18 , C07D235/32 , C07H19/09 , C07D209/46 , C07F5/00 , C07F9/00 , C12Q1/70 , C12N5/09 , A61P29/00 , A61P31/12 , A61P35/00 , A61P31/04
CPC分类号： A61K51/0491 , A61K31/00 , A61K31/192 , A61K31/403 , A61K31/4168 , A61K31/42 , A61K31/7068 , A61K33/22 , A61K45/06 , A61K2300/00 , Y02A50/402 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479
摘要： The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
摘要翻译：本发明的特征在于用于检测，选择与病毒感染相关的瘤形成的治疗方法，监测和治疗的组合物和方法。

43. 发明授权

US06927036B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof 有权
标题翻译：从1-酰基 - 烷基衍生物合成前药的方法及其组合物
公开(公告)号：US06927036B2
公开(公告)日：2005-08-09
申请号：US10167797
申请日：2002-06-11
申请人： Mark A. Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy X. Zhou
发明人： Mark A. Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy X. Zhou
IPC分类号： C07C271/12 , C07C271/22 , C07F9/40 , C07C271/10 , C07D215/227 , C07D233/50 , C07D235/32 , C07H15/236
CPC分类号： C07C269/06 , C07C271/12 , C07C271/22 , C07C2601/14 , C07F9/4087
摘要： Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.
摘要翻译：公开了一种主要或仲胺药物的1-酰基 - 烷基衍生物由一级或二级胺药物的1-酰基 - 烷基衍生物合成的方法，其通常以高产率立体特异性地进行，不需要使用活化的中间体和/或有毒化合物，并且易于放大。例如，加巴喷丁和普瑞巴林的1-酰基 - 烷基衍生物被氧化，分别得到加巴喷丁和普瑞巴林的1-（酰氧基） - 烷基衍生物。

44. 发明申请

US20050171175A1 Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors 审中-公开
公开(公告)号：US20050171175A1
公开(公告)日：2005-08-04
申请号：US10508561
申请日：2003-03-12
申请人： Dominique, Louis, Nestor, Ghislain Surleraux , Piet, Tom, Bert, Paul Wigerinck , Marieke, Christiane, Johanna Voets , Sandrine, Marie, Helene Vendeville , Herman, Augustinus De Kock , Bernhard, Joanna, Bernard Vergouwen
发明人： Dominique, Louis, Nestor, Ghislain Surleraux , Piet, Tom, Bert, Paul Wigerinck , Marieke, Christiane, Johanna Voets , Sandrine, Marie, Helene Vendeville , Herman, Augustinus De Kock , Bernhard, Joanna, Bernard Vergouwen
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , A61P31/14 , A61P31/18 , A61P43/00 , C07D235/30 , C07D235/32 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , C07D493/04 , C07D403/06
CPC分类号： C07D401/12 , A61K31/415 , C07D235/30 , C07D235/32 , C07D405/12 , C07D413/12 , C07D417/12 , C07D493/04
摘要： The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9—; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is —C(═O)—, —O—C(═O)—, —NR8—C(═O)—, —O—C1-6alkanediyl-C(═O)—, —NR8—C1-6alkanediyl-C(═O)—, —S(═O)2—, —O—S(═O)2—, —NR8—S(═O)2; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC(═O), carboxyl, aminoC(═O), mono- or di(C1-4alkyl)aminoC(═O), C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; A is C1-6alkanediyl, —C(═O)—, —C(═S)—, —S(═O)2—, C1-6alkanediyl-C(═O)—, C1-6alkanediyl-C(═S)— or C1-6alkanediyl-S(═O)2—; R5 is H, OH, C1-6alkyl, Het1C1-6alkyl, Het2C1-6alkyl, optionally substituted aminoC1-6alkyl; R6 is C1-6alkylO, Het1, Het1O, Het2, Het2O, aryl, arylO, C1-6alkyloxy-carbonylamino or amino; and in case -A- is other than C1-6alkanediyl then R6 may also be C1-6alkyl, Het1C1-4alkyl, Het1OC1-4alkyl, Het2C1-4alkyl, Het2OC1-4alkyl, arylC1-4alkyl, arylOC1-4alkyl or aminoC1-4alkyl; whereby each of the amino groups in the definition of R6 may optionally be substituted; R5 and -A-R6 taken together with the nitrogen atom to which they are attached may also form Het1 or Het2′R12 is H, —NH2, —NR5AR6, —C1-6alkyl or alkyl-W—R14, wherein said alkyl is optionally substituted with halogen, hydroxy, aryl, heteroaryl, Het1, Het2, or amino wherein said amino is optionally mono- or di-substituted with C1-4alkyl and R13 is H, C1-6-alkyl, optionally substituted by aryl, Het1, Het2, hydroxy, halogen, amino whereby the amino group may be optionally be mono- or di-substituted with C1-4alkyl.

45. 发明授权

US06900235B1 Benzimidazole compounds, and pharmaceutical compositions and unit dosages thereof 失效
标题翻译：苯并咪唑化合物及其药物组合物及其单位剂量
公开(公告)号：US06900235B1
公开(公告)日：2005-05-31
申请号：US09676032
申请日：2000-09-29
申请人： Joseph K. Agyin , James C. Quada, Jr. , James Berger Camden
发明人： Joseph K. Agyin , James C. Quada, Jr. , James Berger Camden
IPC分类号： C07D235/32 , A61K31/415 , A61K31/4184 , A61P31/12 , A61P35/00
CPC分类号： A61K31/4184
摘要： Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
摘要翻译：公开了苯并咪唑衍生物及其盐和前药，以及通过施用这些化合物治疗温血动物中的癌症或病毒感染的方法。这样的化合物可以与化疗剂和/或增效剂组合使用。

46. 发明授权

US6077862A Virus and cancer treatments 失效
标题翻译：病毒和癌症治疗
公开(公告)号：US6077862A
公开(公告)日：2000-06-20
申请号：US259969
申请日：1999-03-01
申请人： James Berger Camden
发明人： James Berger Camden
IPC分类号： C07D235/32 , A61K31/415 , A61K31/4184 , A61P31/12 , A61P35/00
CPC分类号： A61K31/4184
摘要： A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide is disclosed. The particular fungicide used is a benzimidazole derivative having the formula: ##STR1## wherein R is selected from the group consisting of H, carboxyl (--CO.sub.2 H), hydroxyl, amino or esters (--CO.sub.2 R') wherein R' is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl wherein the alkyl groups have from 1-8 carbons or CH.sub.3 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n --or CH.sub.3 CH.sub.2 CH.sub.2 (OCH.sub.2 CH.sub.2 CH.sub.2).sub.n --or (CH.sub.3).sub.2 CH--(OCH(CH.sub.3)CH.sub.2).sub.n -- wherein n is from 1-3, the pharmaceutically acceptable salts thereof, or mixtures thereof.
摘要翻译：公开了抑制哺乳动物肿瘤和癌症生长并可用于治疗包含杀真菌剂的病毒感染的药物组合物。所用的特定杀真菌剂是具有下式的苯并咪唑衍生物：其中R选自H，羧基（-CO 2 H），羟基，氨基或酯（-CO 2 R'），其中R'选自烷氧基，卤代烷基，烯基和环烷基，其中烷基具有1-8个碳原子或CH3CH2（OCH2CH2）n-或CH3CH2CH2（OCH2CH2CH2）n-或（CH3）2CH-（OCH（CH3）CH2）n-，其中n为 1-3，其药学上可接受的盐，或其混合物。

47. 发明授权

US5141950A Benzimidazole compounds and their use 失效
标题翻译：苯并咪唑化合物及其用途
公开(公告)号：US5141950A
公开(公告)日：1992-08-25
申请号：US583264
申请日：1990-09-14
申请人： Masami Nakane , Rodney W. Stevens
发明人： Masami Nakane , Rodney W. Stevens
IPC分类号： C07D235/06 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61P29/00 , A61P37/08 , A61P43/00 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/26 , C07D235/28 , C07D235/30 , C07D235/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14
CPC分类号： C07D401/04 , C07D235/08 , C07D235/18 , C07D235/28 , C07D235/30 , C07D401/12
摘要： Certain benzimidazole compounds and their pharmaceutically acceptable salts, are dual inhibitors of lipoxygenase and cycylooxygenase enzymes, and so are useful as antiallergy and antiinflammatory agents.

48. 发明授权

US4792610A Process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole 失效
标题翻译： 5-苯基亚磺酰基-1H-2-（甲氧基羰基氨基） - 苯并咪唑的制备方法
公开(公告)号：US4792610A
公开(公告)日：1988-12-20
申请号：US80087
申请日：1987-07-31
申请人： Stephen Lachhein , Hilmar Mildenberger , Hans-Joachim Ressel
发明人： Stephen Lachhein , Hilmar Mildenberger , Hans-Joachim Ressel
IPC分类号： C07D235/32 , C07D235/30
CPC分类号： C07D235/32
摘要： A highly selective, inexpensive and quantitative process is described for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole (oxfendazole) through reaction of 5-phenylmercapto-1H-2-(methoxycarbonylamino)-benzimidazole with hydrogen peroxide in the presence of one or more aliphatic C.sub.1 -C.sub.6 -alcohols with addition of a strong, nonoxidizing mineral acid.
摘要翻译：描述了通过5-苯基巯基-1H-（2-甲氧基羰基氨基） - 苯并咪唑与过氧化氢反应制备5-苯基亚磺酰基-1H-2-（甲氧基羰基氨基） - 苯并咪唑（恶灵唑）的高度选择性，廉价和定量的方法存在一种或多种脂肪族C 1 -C 6醇，同时加入强的非氧化无机酸。

49. 发明授权

US4780473A Bicyclic fungicides 失效
标题翻译：双环杀菌剂
公开(公告)号：US4780473A
公开(公告)日：1988-10-25
申请号：US132129
申请日：1987-12-14
申请人： Alister C. Baillie , Antony D. Buss , John H. Parsons , Philip E. Russell
发明人： Alister C. Baillie , Antony D. Buss , John H. Parsons , Philip E. Russell
IPC分类号： A01N57/24 , A01N43/90 , C07D235/24 , C07D235/32 , C07F9/6506 , A01N43/52 , A01N57/32 , C07D235/30
CPC分类号： C07D235/24 , C07F9/65068
摘要： Compounds are disclosed having fungicidal activity and are of general formula I ##STR1## where at least three of A, C, D and E are --CX.dbd. and the other is --CX.dbd. or --N.dbd., where X is hydrogen, C.sub.1-8 -alkyl (optionally substituted by halogen), halo, nitro or phenoxy, in which the phenyl is optionally substituted by one or more groups selected from halo and trifluoromethyl;R.sup.1 is --SO.sub.2 R.sup.3 or ##STR2## and R.sup.2 is ##STR3## where R.sup.6 is hydrogen, C.sub.1-8 -alkyl (optionally substituted by one or more groups selected from halogen and hydroxy), C.sub.1-8 -alkanoyl, benzoyl, cyclohexylcarbonyl or aminocarbonyl (in which the amino is substituted by benzoyl or chlorobenzenesulphonyl);R.sup.3, R.sup.4, and R.sup.5 may be the same or different and have the meanings given to R.sup.6 or can be di-C.sub.1-8 -alkylamino; and Z is oxygen or sulphur; and when R.sup.1 is ##STR4## R.sup.2 can also be --CN.
摘要翻译：公开了具有杀真菌活性并具有通式I（I）的化合物，其中A，C，D和E中的至少三个是-CX =，另一个是-CX =或-N =，其中X是氢，C 1-8 - 烷基（任选被卤素取代），卤素，硝基或苯氧基，其中苯基任选被一个或多个选自卤素和三氟甲基的基团取代; R 1是-SO 2 R 3或者R 2是＆lt; IMAGE＆gt;其中R 6是氢，C 1-8 - 烷基（任选被一个或多个选自卤素和羟基的基团取代），C 1-8 - 烷酰基，苯甲酰基，环己基羰基或氨基羰基（其中氨基被苯甲酰基或氯代苯磺酰基取代）; R 3，R 4和R 5可以相同或不同，并具有对R 6给出的含义，或可以是二-C 1-8 - 烷基氨基; Z是氧或硫; 当R1为 R2时，也可以是-CN。

50. 发明授权

US4656290A Process for preparing thio, dithio or carbonyl compounds 失效
标题翻译：制备硫代，二硫代或羰基化合物的方法
公开(公告)号：US4656290A
公开(公告)日：1987-04-07
申请号：US691972
申请日：1985-01-16
申请人： Istvan Kaldor , Andras Szasz , Ilona Vegh nee Ba , Jozsef Heizer , Eva Behedek nee Haraszin
发明人： Istvan Kaldor , Andras Szasz , Ilona Vegh nee Ba , Jozsef Heizer , Eva Behedek nee Haraszin
IPC分类号： C07C49/00 , B01J27/00 , C07B31/00 , C07B35/02 , C07B35/06 , C07B45/06 , C07B61/00 , C07C45/00 , C07C45/65 , C07C67/00 , C07C313/00 , C07C319/14 , C07C319/24 , C07C321/00 , C07C321/14 , C07C321/28 , C07C321/30 , C07C323/00 , C07C323/12 , C07C323/16 , C07C323/17 , C07C323/21 , C07C323/25 , C07D235/32
CPC分类号： C07D235/32 , C07B45/06 , C07C201/12 , C07C319/14 , C07C319/24 , C07C321/14 , C07C321/28 , C07C45/65
摘要： A process is disclosed for the preparation of compounds of the Formula IR--X--R.sup.1 (I)wherein X is thio, dithio or carbonyl and R and R.sup.1 are defined hereinbelow which comprises reducing a compound of the Formula IIR--A (II)wherein A is chlorosulfonyl or a group of the Formula ##STR1## with a sulfur compound comprising sulfur which is of the (+)4 oxidation degree and is converted into the (+)6 oxidation degree during the process or with a sulfur compound which is decomposed in acidic medium to a compound of the latter oxidation degree in the presence of a catalytic amount but not more than 0.5 mole--related to 1 mole of the starting material of the Formula II--of elemental iodine or a compound capable of delivering hydrogen iodide in acidic medium or a compound which can be reduced to hydrogen iodide in acidic medium with the sulfur compound used.
摘要翻译：公开了制备式I的化合物RX-R1（Ⅰ）的方法，其中X是硫代，二硫代或羰基，R和R 1定义如下，其中包括将式Ⅱ的化合物RA（II）氯代磺酰基或一组式（IMAGE）与含硫（+）4氧化度的硫化合物反应，并在该过程中转化为（+）6氧化度，或与酸分解的硫化合物反应在相对于1摩尔元素碘的式II的原料或能够在酸性介质中输送碘化氢的化合物的催化量但不超过0.5摩尔存在下，将其培养至后一种氧化度的化合物或可以在酸性介质中用所用硫化合物还原成碘化氢的化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式