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41. 发明申请

US20170028011A1 DIETARY COMPOSITIONS FOR REDUCING BLOOD GLUCOSE LEVELS AND FOR WEIGHT MANAGEMENT 审中-公开
标题翻译：用于减少血液葡萄糖水平和体重管理的膳食组合物
公开(公告)号：US20170028011A1
公开(公告)日：2017-02-02
申请号：US15303021
申请日：2015-04-12
申请人： MARMAR INVESTMENT SP. Z O.O.
发明人： Marek ORLOWSKI , Marcin KROTKIEWSKI , Katarzyna BILLING-MARCZAK
IPC分类号： A61K36/74 , A61K36/48 , A61K31/7004 , A61K31/736 , A61K31/733 , A23L33/21 , A61K9/08 , A23L2/52 , A23L7/109 , A23L23/00 , A23L33/105 , A61K36/605 , A61K9/00
CPC分类号： A61K36/74 , A23L2/52 , A23L7/109 , A23L23/00 , A23L33/105 , A23L33/21 , A23L33/30 , A23V2002/00 , A61K9/0053 , A61K9/08 , A61K31/7004 , A61K31/733 , A61K31/736 , A61K36/48 , A61K36/605 , A61K47/46 , A61K2300/00
摘要： The present invention provides dietary compositions comprising mulberry extract, coffee extract, bean extract, optionally, dietary fibers, and a nutraceutically acceptable carrier. The present invention further provides methods for preventing the increase in postprandial hyperglycemia and hypoglycemia, hyperinsulinemia and diseases and disorders associated therewith, including, endothelial dysfunction, inflammatory conditions, oxidative stress, hyperlipidemia, and consecutive pathologies like insulin resistance, diabetes, visceral obesity, hypertension and cardiovascular diseases.
摘要翻译：本发明提供了包含桑叶提取物，咖啡提取物，豆提取物，任选的膳食纤维和营养可接受的载体的饮食组合物。本发明还提供了防止餐后高血糖和低血糖，高胰岛素血症及其相关疾病和病症增加的方法，包括内皮功能障碍，炎性病症，氧化应激，高脂血症和连续病理如胰岛素抵抗，糖尿病，内脏肥胖，高血压和心血管疾病。

42. 发明申请

US20170020932A1 METHODS AND COMPOSITIONS RELATING TO MICROBIAL TREATMENT AND DIAGNOSIS OF DISORDERS 审中-公开
标题翻译：关于微生物治疗和疾病诊断的方法和组合
公开(公告)号：US20170020932A1
公开(公告)日：2017-01-26
申请号：US15286218
申请日：2016-10-05
申请人： Whole Biome Inc.
发明人： Colleen CUTCLIFFE , John S. EID , James H. BULLARD , Marcus F. SCHICKLBERGER
IPC分类号： A61K35/745 , A61K35/741 , A23L33/135 , A61K9/00 , A61K31/733 , A61K35/742 , C12Q1/68
摘要： The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
摘要翻译：本公开提供了解决与微生物组相关的健康状况和疾病的治疗的需要的方法，系统，组合物和试剂盒。本公开提供了使用微生物组合物治疗代谢病症。

43. 发明申请

US20160367590A1 PHOSPHOLIPID COMPOSITIONS AND USE THEREOF TO ENHANCE SPERMATOZOA MOTILITY AND VIABILITY 有权
标题翻译：磷脂组合物及其用途，以增强SPERMATOZA的动态和可变性
公开(公告)号：US20160367590A1
公开(公告)日：2016-12-22
申请号：US15256245
申请日：2016-09-02
申请人： ALLERGY RESEARCH GROUP, LLC
发明人： Garth Nicolson , Gonzalo Ferreira de Mattos , Robert A. Settineri
IPC分类号： A61K31/733 , C12N5/076 , A61K31/683 , A61K31/70 , A61K31/685 , A61K31/661
CPC分类号： A61K31/733 , A61K31/07 , A61K31/201 , A61K31/205 , A61K31/355 , A61K31/375 , A61K31/661 , A61K31/683 , A61K31/685 , A61K31/70 , A61K33/04 , A61K33/30 , C12N5/061 , C12N2500/05 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2501/90 , C12N2501/999 , A61K2300/00
摘要： Sperm mobility and impregnation of an oocyte is enhanced by placing sperm in an aqueous solution of phospholipids prior to in vitro fertilization or artificial insemination. The aqueous phospholipid solution can also be used during storage or cryopreservation of the sperm. Also, the motility of sperm produced or ejaculated and the environment into which it is placed is enhanced my ingestion of the phospholipid composition by the male or female, or a vaginal placement of compositions containing the phospholipids.
摘要翻译：通过在体外受精或人工授精之前将精子置于磷脂水溶液中来增强卵母细胞的精子迁移率和浸润。磷脂水溶液也可以在精子储存或冷冻保存期间使用。此外，精子产生或射精的动力及其放置的环境增强了我通过男性或女性摄入磷脂组合物，或增加了含有磷脂的组合物的阴道放置。

44. 发明授权

US09518975B2 Alpha-keto-isovalerate as a biomarker of prebiotic efficacy for weight gain prevention 有权
标题翻译： α-酮 - 异戊酸酯作为增益预防的益生元效能的生物标志物
公开(公告)号：US09518975B2
公开(公告)日：2016-12-13
申请号：US14774655
申请日：2014-03-13
申请人： Nestec S.A.
发明人： Francois-Pierre Martin , Sebastiano Collino , Ivan Montoliu Roura
IPC分类号： G01N33/493 , G01N33/50 , A61K31/733 , A61K31/715 , G01N33/68 , G01N24/08
CPC分类号： G01N33/493 , A61K31/715 , A61K31/733 , C12Q2565/633 , G01N24/08 , G01N33/50 , G01N33/6893 , G01N2570/00 , G01N2800/044 , G01N2800/50 , G01N2800/52 , G01N2800/70
摘要： The present invention relates generally to the field of nutrition and health, particular, the present invention relates to alpha-keto-isovalerate as a biomarker urine of the efficacy of prebiotics for the prevention of diet induced weight gain.
摘要翻译：本发明一般涉及营养和健康领域，特别地，本发明涉及α-酮 - 异戊酸酯作为益生元用于预防饮食诱导体重增加的功效的生物标志物尿。

45. 发明授权

US09512239B2 Compositions and methods for making alpha-(1,2)-branched alpha-(1,6) oligodextrans 有权
标题翻译：制备α-（1,2） - 支链的α-（1,6）寡聚体的组合物和方法
公开(公告)号：US09512239B2
公开(公告)日：2016-12-06
申请号：US14329549
申请日：2014-07-11
申请人： Tate & Lyle Ingredients France SAS
发明人： Thierry Naeye , Alexandra Einerhand , Michel Lopez , Susan M. Potter , Magali Remaud-Siméon , Pierre Frédéric Emmanuel Monsan
IPC分类号： C08B37/02 , A61K31/721 , A23L1/308 , A61K31/702 , A61K31/733 , A61K35/741 , A61K45/06 , C08L5/02 , C12P19/08 , C12P19/18 , C07B37/00 , A23L1/30 , A61K35/00
CPC分类号： C08B37/0021 , A23L33/10 , A23L33/21 , A23V2002/00 , A61K31/702 , A61K31/721 , A61K31/733 , A61K35/741 , A61K45/06 , A61K2035/115 , C07B37/00 , C08L5/02 , C08L2203/02 , C08L2205/02 , C08L2205/025 , C12P19/08 , C12P19/18 , A61K2300/00 , A23V2200/3202
摘要： Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial indigestibility in the subject. Methods for improving the health of a subject comprise administering the composition to a subject in an amount effective to improve gut health, or to prevent or treat a gastrointestinal disorder, a cholesterol-related disorder, diabetes, or obesity. Methods for making oligodextrans having controlled size and controlled degree of branching comprise providing alpha-(1,6) oligodextrans having an average molecular weight between 0.5 and 100 kDa and introducing at least 10% alpha-(1,2)-osidic side chains onto the alpha-(1,6) oligodextrans.
摘要翻译：用于改善受试者健康的组合物包括α-（1,2） - 支链的α-（1,6）寡聚葡聚糖，优选具有约10kDa至70kDa的平均分子量，约10％至50％的α- （1,2） - 苷侧链，并且在受试者中具有至少部分难消化性。用于改善受试者健康的方法包括以有效改善肠道健康的量或预防或治疗胃肠道疾病，胆固醇相关病症，糖尿病或肥胖症的方式向受试者施用该组合物。制备具有受控大小和受控支化程度的寡聚葡聚糖的方法包括提供平均分子量为0.5至100kDa的α-（1,6）寡聚葡聚糖，并将至少10％的α-（1,2） - 苷侧链引入 α-（1,6）寡聚葡聚糖。

46. 发明申请

US20160029666A1 ANIMAL FEED COMPOSITIONS AND FEED ADDITIVES 有权
标题翻译：动物饲料组合物和饲料添加剂
公开(公告)号：US20160029666A1
公开(公告)日：2016-02-04
申请号：US14812598
申请日：2015-07-29
申请人： BIOWISH Technologies, Inc.
发明人： Richard S. Carpenter , JoElla Barnes , Michael Stanford Showell
IPC分类号： A23K1/00 , A61K9/16 , A61K35/742 , A61K31/733 , A23K1/14 , A61K35/747
CPC分类号： A23K40/25 , A23K10/18 , A23K10/30 , A23K40/20 , A23K40/30 , A23Y2220/67 , A23Y2280/15 , A23Y2280/55 , A61K9/1664 , A61K31/733 , A61K35/742 , A61K35/747
摘要： The present invention relates to pre-, pro-, and postbiotic compositions and methods of use for improving the health and nutrition of commercial livestock and companion pets.
摘要翻译：本发明涉及用于改善商业牲畜和伴侣宠物的健康和营养的前，后和益生元组合物和使用方法。

47. 发明申请

US20140100189A1 CARBOHYDRATES MIXTURE 审中-公开
标题翻译：碳酸氢钾混合物
公开(公告)号：US20140100189A1
公开(公告)日：2014-04-10
申请号：US14047811
申请日：2013-10-07
申请人： N.V. Nutricia
发明人： Gunther SAWATZKI , Bernd Stahl
IPC分类号： A23L1/29 , A61K31/733 , A61K31/702 , A61K31/7016 , A23L1/30 , A61K31/715
CPC分类号： A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23L33/40 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/733 , A61K31/7004 , A61K2300/00
摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals is provided. The carbohydrate mixture comprises two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed. Carbohydrate component A may comprise at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or a mixture of two or more of these saccharides. Carbohydrate component B may comprise a polysaccharide (from heptasaccharide onwards) or a mixture of two or more polysaccharides. Carbohydrate component A=5 to 95 wt-% and carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and at least 80 wt-% of the carbohydrates/saccharides of both carbohydrate components have a prebiotic effect. The carbohydrate mixtures have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.
摘要翻译：提供饮食食品和药物的碳水化合物混合物。碳水化合物混合物包含两种不同的，基本上可溶的碳水化合物组分A和B，其在胃肠道中未消化并进入大肠而不被再吸收。碳水化合物成分A可以包含至少一种单糖或至少一种寡糖（二糖与六糖）或两种或更多种这些糖的混合物。碳水化合物组分B可以包含多糖（来自七糖以上）或两种或更多种多糖的混合物。碳水化合物组分A = 5至95重量％，碳水化合物组分B =碳水化合物组分A + B（= 100重量％）和至少80重量％的碳水化合物/ 两种碳水化合物组分的糖都具有益生元效应。碳水化合物混合物不仅具有营养作用，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

48. 发明申请

US20120196811A1 VETERINARY PHARMACEUTICAL COMPOSITION AND METHOD (ALTERNATIVES) FOR THE PROPHYLAXIS AND TREATMENT OF DISEASES OF THE GASTROINTESTINAL TRACT AND INTOXICATIONS OF DIVERSE ETIOLOGY IN ANIMALS 审中-公开
公开(公告)号：US20120196811A1
公开(公告)日：2012-08-02
申请号：US13497303
申请日：2010-09-21
申请人： Aleksander Vladimirovich Dikovskiy , Sergei Viktorovich Tretyakov , Oleg Aleksandrovich Turchev
发明人： Aleksander Vladimirovich Dikovskiy , Sergei Viktorovich Tretyakov , Oleg Aleksandrovich Turchev
IPC分类号： A61K31/7016 , A61K31/702 , A61P1/16 , A61P1/14 , A61P1/00 , A61K31/733 , A61K31/70
CPC分类号： A61K31/702 , A23K10/32 , A23K20/163 , A23K50/10 , A23K50/30 , A23K50/75 , A61K31/7016 , A61K45/06 , A61K2300/00
摘要： A veterinary pharmaceutical composition for treating diseases of the gastrointestinal tract and intoxications of diverse etiology in animals comprises, as the active component, hydrolyzed lignin and a prebiotic from the following group: lactulose, fructooligo-saccharides, galacto-saccharides and inulin, and is in a form suitable for use in the composition of a mixture with combined feed, with a lignin content of from 30 to 95% by mass, in the form of powder of granules. The method for the prophylaxis and treatment of intoxication of diverse etiology, including mycotoxicoses, in animals, including birds, envisages that the animal will receive the above-mentioned veterinary pharmaceutical composition mixed with feed in a dosage of from 2 to 4.5 kg of the preparation per ton of combined feed, proportional to the content of mycotoxins in the combined feed. The method for the prophylaxis and treatment of diseases of the gastrointestinal tract, including dyspepsia, gastroenteritis, enteritis, colitis, hepatitis, and hepato-dystrophy, including in a toxic form, in animals, including cattle and pigs, envisages that the animal will receive the veterinary pharmaceutical composition according to claim 1 30±10 minutes prior to feeding, perorally individually or in a group method with water for watering or with the feed, 1 to 2 times per day in a dosage of from 0.2 to 0.3 g/kg of the mass of the animal. This ensures an increase in the effectiveness of the treatment and elimination of the above-mentioned defects in the use of hydrolyzed lignin, activated carbon and other generally known sorbents. At the same time, the joint use of lignin with a prebiotic as a means for the prophylaxis and treatment of animals makes it possible to produce a result in the form of a set of positive effects: minimization of side effects from the use of a sorbent; restoration of homeostasis in the gastrointestinal tract; and normalization of the metabolism indices, this finally resulting in a qualitative increase in the zootechnical and economic indices of animal husbandry.

49. 发明申请

US20120028914A1 PHARMACEUTICAL COMPOSITION COMPRISING A PROTON PUMP INHIBITOR AND A PREBIOTIC FOR THE TREATMENT OF ULCEROUS LESIONS OF THE STOMACH AND DUODENUM 审中-公开
标题翻译：包含原料泵抑制剂的药物组合物和用于治疗STOMACH和DUODENUM的ULCEROUS LESIONS的预防性
公开(公告)号：US20120028914A1
公开(公告)日：2012-02-02
申请号：US13257361
申请日：2010-04-23
申请人： Aleksander Vladimirovich Dikovskiy , Oleg Valentinovich Dorozhko
发明人： Aleksander Vladimirovich Dikovskiy , Oleg Valentinovich Dorozhko
IPC分类号： A61K31/715 , A61P1/00 , A61P31/04 , A61K31/732 , A61K31/7032 , A61K31/7016 , A61K31/702 , A61K31/733 , A61K31/4439 , A61K31/047
CPC分类号： A61K31/7032 , A61K31/047 , A61K31/4439 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/732 , A61K31/733 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition including proton pump inhibitors and prebiotics is proposed for the treatment of gastric and duodenal ulcer, this allowing effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics. The comprehensive treatment of ulcer disease associated with a helicobaterial infection using a pharmaceutical composition of a PPI and a prebiotic makes it possible, in conditions of an elevated pH of the stomach contents, actively to stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially to increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment.
摘要翻译：提出包括质子泵抑制剂和益生元的药物组合物用于治疗胃十二指肠溃疡，这样可以在不使用广谱抗生素的情况下进行胃和十二指肠粘膜的有效溃疡治疗和根除幽门螺杆菌。使用PPI和益生元的药物组合物与螺旋体感染相关的溃疡疾病的综合治疗使得在胃内容物的pH升高的条件下，可以主动地刺激胃肠上部的乳酸杆菌的生长包括十二指肠，并且基本上增加作为幽门螺杆菌拮抗剂的乳酸杆菌的滴度，这极大地提高了溃疡治疗的有效性。

50. 发明授权

US07919479B2 Antiadhesive carbohydrates 有权
标题翻译：防粘碳水化合物
公开(公告)号：US07919479B2
公开(公告)日：2011-04-05
申请号：US11511500
申请日：2006-08-29
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/702 , A61K31/733 , A61K31/732
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C4和C5原子之间的双键。

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