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41. 发明授权

US07713732B1 High strength modular support for biofiltration and composting 有权
标题翻译：高强度模块化支持生物过滤和堆肥
公开(公告)号：US07713732B1
公开(公告)日：2010-05-11
申请号：US10942350
申请日：2004-09-15
申请人： Jeffrey A. Hallsten
发明人： Jeffrey A. Hallsten
IPC分类号： C12M1/14 , C12M3/04
CPC分类号： C05F17/0258 , B01D53/0407 , B01D53/85 , B01D2257/304 , B01D2257/306 , B01D2257/406 , B01D2257/70 , B01D2257/90 , B01D2258/05 , Y02A50/2359 , Y02P20/145 , Y02W30/43
摘要： A modular support system for organic filter material, compost material or other material is formed of a multiplicity of polygonal bed platform modules with planar top surfaces, the modules arranged side by side contiguously to form a bed platform which is elevated above a base surface. Perforations are included in at least some of the bed platform modules to allow passage of air, gas or liquid through the elevated support bed platform. The bottom sides of the modules have sockets to receive legs, and special legs are provided at corners where a plurality of adjacent modules meet, to engage with sockets in the undersurface in all of the adjacent nodules. At corners the modules are preferably bolted down to the corner pedestals or legs. The modular support system can support very heavy loads, such as earth-moving equipment used to move and spread filter bed or compost material.
摘要翻译：用于有机过滤材料，堆肥材料或其他材料的模块化支撑系统由具有平坦顶表面的多个多边形床平台模块形成，所述模块并排布置以形成在基面上方升高的床平台。穿孔被包括在至少一些床平台模块中以允许空气，气体或液体通过升高的支撑床平台。模块的底侧具有用于接收腿的插座，并且在多个相邻模块相交的拐角处提供特殊的腿，以与所有相邻结节中的下表面中的插座接合。在拐角处，模块优选地被螺栓固定到拐角底座或腿部。模块化支撑系统可以支持非常重的载荷，例如用于移动和铺展过滤床或堆肥材料的移土设备。

42. 发明授权

US07592173B1 Operationally enhanced bioreactor 有权
标题翻译：操作性强的生物反应器
公开(公告)号：US07592173B1
公开(公告)日：2009-09-22
申请号：US10826789
申请日：2004-04-16
申请人： David M. Stamper , Marianne Walch , Darrell H. Hill
发明人： David M. Stamper , Marianne Walch , Darrell H. Hill
IPC分类号： C12M1/14 , C12M3/04
CPC分类号： C12M25/16 , C12M25/06 , C12M41/36
摘要： Biofilm on glass beads deposited within a bottom portion of a vertically elongated bioreactor housing for possible experimental evaluation through a testing port in the housing which is also provided with inlet ports for aeration and infeed of nutrients with liquid. The biofilm collected within the housing chamber undergoes growth on glass slides within a cross-sectionally rectangular portion of the bioreactor housing from which the slides may be upwardly withdrawn under selective control without biofilm damage. The bioreactor housing arrangement also provides a high length to width ratio designed to enhance aeration.
摘要翻译：沉积在垂直伸长的生物反应器壳体的底部内的玻璃珠上的生物膜，用于通过壳体中的测试端口进行可能的实验评估，该测试端口还设置有用于通气和进入营养物质与液体的入口。收集在壳体室内的生物膜在生物反应器壳体的横截面矩形部分内的玻璃载玻片上生长，在该选择性控制下，滑块可以从其中向上引出，而没有生物膜损伤。生物反应器壳体布置还提供设计成增强曝气的高长宽比。

43. 发明申请

US20070202597A1 Process For Recycling Solid Supports For Cultivation Of Anchorage-Dependent Cells 失效
标题翻译：回收固体支持植物依赖性细胞培养的方法
公开(公告)号：US20070202597A1
公开(公告)日：2007-08-30
申请号：US10580777
申请日：2004-11-26
申请人： Alain Bernard , Frederic Papp
发明人： Alain Bernard , Frederic Papp
IPC分类号： C12M3/04 , C12N5/00
CPC分类号： C12N5/0068 , C12N5/0075 , C12N2533/30
摘要： This invention relates to methods for use in industrial production of proteins. Specifically, the present invention provides a method of recycling solid supports for cultivation of anchorage-dependent cells such as, e.g., microcarriers and Fibra-Cel® disks. Solid supports recycled by a method of the present invention allow obtaining a protein productivity level comparable to the productivity level obtained with non-recycled solid support. The method comprises the steps of rinsing with water, rinsing with a sodium hydroxide solution and second rinsing step with water.
摘要翻译：本发明涉及用于工业生产蛋白质的方法。具体地说，本发明提供一种循环固体支持物的方法，用于培养锚定依赖细胞，例如微载体和Fibra-Cel盘。通过本发明的方法回收的固体支持物可以获得与用非再循环固体支持物获得的生产力水平相当的蛋白质生产率水平。该方法包括用水冲洗，用氢氧化钠溶液冲洗和用水冲洗第二步骤的步骤。

44. 发明授权

US06946290B2 Method for the determination of the confluence of a cell layer on porous biomaterials 失效
标题翻译：用于确定细胞层在多孔生物材料上的汇合的方法
公开(公告)号：US06946290B2
公开(公告)日：2005-09-20
申请号：US10307773
申请日：2002-12-02
申请人： Manrico Paulitschke , Axel Koepenik
发明人： Manrico Paulitschke , Axel Koepenik
IPC分类号： C12M3/04 , C12N5/00
CPC分类号： A61F2/062 , C12M29/10 , C12M41/00 , C12M41/36
摘要： The invention relates to a novel method, permitting the semiquantitative determination of the confluence of a cell layer on the total surface of a porous biomaterial, without irreversible damage to part or indeed all of the hybrid construct. A method is described for the first time, which is able to detect the formation of the confluence or the confluence itself, without destroying the hybrid construct, and thus permits the finished hybrid product to be withdrawn from the essential growth conditions only after the determination of the completed confluence, and to immediately direct it to its further use.
摘要翻译：本发明涉及一种新颖的方法，允许在多孔生物材料的总表面上的细胞层的汇合的半定量测定，而对该部分或实际上所有的杂交构建体没有不可逆的损害。首次描述了一种能够检测汇合或汇合本身的形成而不破坏杂交构建体的方法，从而允许完成的杂交产物仅在确定后才从基本生长条件中取出完成的汇合，并立即引导其进一步使用。

45. 发明授权

US06911201B1 Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor 有权
标题翻译：使用固定相插塞生物反应器生产未分化造血干细胞的方法
公开(公告)号：US06911201B1
公开(公告)日：2005-06-28
申请号：US09890401
申请日：2000-02-04
申请人： Shoshana Merchav , Shai Meretzki
发明人： Shoshana Merchav , Shai Meretzki
IPC分类号： C12M3/00 , A61F2/00 , A61K35/12 , A61K35/14 , A61P7/00 , A61P43/00 , C12M3/04 , C12N5/00 , C12N5/02 , C12N5/06 , C12N5/078 , C12N5/08 , C12N11/08 , C12R1/91
CPC分类号： C12N5/0647 , A61F2/00 , A61K2035/124 , C12M25/14 , C12N5/06 , C12N11/08 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2502/1394 , C12N2533/30
摘要： A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationary phase plug-flow bioreactor in which a three-dimensional stromal cell culture has been pre-established on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells, or culturing the undifferentiated hemopoietic stem cells or progenitor cells in conditioned medium obtained from such a reactor.
摘要翻译：通过获得未分化的造血干细胞或祖细胞来扩增/维持未分化的造血干细胞或祖细胞的方法; 并且将未分化的造血干细胞或祖细胞接种到固定相插塞生物反应器中，其中三维基质细胞培养物已经以片状形式在基质上预先建立，所述基底包括无纺布形成纤维的生理上可接受的三维网络，从而扩增/维持未分化的造血干细胞或祖细胞，或在从这种反应器获得的条件培养基中培养未分化的造血干细胞或祖细胞。

46. 发明申请

US20050130254A1 Drug testing system with bio-artificial liver 审中-公开
标题翻译：生物人造肝药物检测系统
公开(公告)号：US20050130254A1
公开(公告)日：2005-06-16
申请号：US10738905
申请日：2003-12-16
申请人： Sung-Soo Park
发明人： Sung-Soo Park
IPC分类号： A01N1/00 , C12M1/34 , C12M3/00 , C12M3/04 , C12N5/00 , C12Q1/00 , C12Q1/02 , G01N33/50
CPC分类号： G01N33/5014 , G01N33/5082
摘要： A drug testing system using a liver-slice culture apparatus. The apparatus has a chamber with plasma and gas valves, animal liver slices being positioned securely in the chamber so as to maximize the surface area of liver slices exposed to the culture medium. Plasma is supplied to the chamber so that it rises to contact the liver slices, and is alternately removed from contacting the liver slices. Gas is supplied to the top of the chamber. The system also includes a reservoir for containing media entering and exiting the chamber. Methods are provided for assessing the toxicity of a drug or drug candidate.
摘要翻译：一种使用肝切片培养装置的药物检测系统。该装置具有具有等离子体和气体阀的腔室，动物肝切片被牢固地定位在腔室中，以使暴露于培养基的肝切片的表面积最大化。将血浆供应到腔室，使其升高以接触肝切片，并且交替地从与肝切片接触的位置移除。气体被供应到室的顶部。该系统还包括用于容纳进入和离开室的介质的储存器。提供了评估药物或候选药物的毒性的方法。

47. 发明授权

US06905105B2 Apparatus for preparing a biocompatible matrix 有权
标题翻译：用于制备生物相容性基质的装置
公开(公告)号：US06905105B2
公开(公告)日：2005-06-14
申请号：US10091849
申请日：2002-03-06
申请人： Steven T. Boyce
发明人： Steven T. Boyce
IPC分类号： C12M3/00 , A61L27/38 , A61L27/60 , C12M3/04 , B28B7/36
CPC分类号： A61L27/60 , A61L27/3804 , A61L27/3813 , A61L27/3886
摘要： An apparatus and method of using the apparatus to prepare a biocompatible biodegradable matrix capable of supporting cells to form an implantable or engraftable surgical device. A matrix-forming fluid is contained within a chamber defined by top and bottom surfaces of a thermally conductive material and spacers defining the thickness of the matrix. The chamber is then cooled to freeze the solution at a controlled rate, resulting in a matrix with a desired and uniform thickness having symmetric and uniform reticulations. The apparatus and method reproducibly forms such a matrix, which may be populated with cells for transplantation and engraftment into a wound.
摘要翻译：一种使用该装置制备能够支持细胞以形成可植入或可植入手术装置的生物相容性生物可降解基质的装置和方法。基体形成流体包含在由导热材料的顶表面和底表面限定的室中，并且限定基体的厚度。然后将腔室冷却以受控的速率冷冻溶液，得到具有所需和均匀厚度的基质，具有对称和均匀的网状结构。该装置和方法可重复地形成这样的基质，其可以填充有用于移植和移入伤口的细胞。

48. 发明申请

US20050101008A1 Apparatus for growing cells under variable hydrostatic pressures 有权
标题翻译：用于在可变静水压力下生长细胞的装置
公开(公告)号：US20050101008A1
公开(公告)日：2005-05-12
申请号：US11018094
申请日：2004-12-20
申请人： Gene Diresta , John Healey , Robert Schwar
发明人： Gene Diresta , John Healey , Robert Schwar
IPC分类号： C12M1/42 , C12M3/04 , C12M1/00
CPC分类号： C12M25/14 , C12M23/42 , C12M35/04 , C12M41/00
摘要： This invention provides an apparatus for growing cells under static or dynamic physiological pressure which contains a cell culture cassette having a cassette frame; two side walls secured to each side of the cassette frame to form a cell growing chamber, and at least one side wall comprises a cell growth surface. The apparatus also contains a means for adjusting fluid pressure or flow, for providing culture media or cell culture, or for sampling cell culture or culture media within the cell growing chamber. The apparatus further contains an adapter which contains two side assemblies where each side assembly includes a frame with a rigid support that fits over the cell culture cassette. The side assemblies joined by a hinge at one end and positioned over the two side walls of the cell culture cassette. The apparatus further contains a means to secure the two side assemblies over the two side walls of the cell culture cassette.
摘要翻译：本发明提供一种用于在静态或动态生理压力下生长细胞的装置，其包含具有盒式框架的细胞培养盒; 两个侧壁固定在盒框架的每一侧以形成细胞生长室，并且至少一个侧壁包括细胞生长表面。该装置还包含用于调节流体压力或流动的装置，用于提供培养基或细胞培养物，或用于在细胞生长室内取样细胞培养物或培养基。该装置还包括适配器，该适配器包含两个侧组件，其中每个侧组件包括具有装配在细胞培养盒上的刚性支撑件的框架。侧组件通过铰链在一端连接并且定位在细胞培养盒的两个侧壁上。该装置还包括将两个侧组件固定在细胞培养盒的两个侧壁上的装置。

49. 发明申请

US20050055734A1 Prenatal screening 审中-公开
标题翻译：产前筛查
公开(公告)号：US20050055734A1
公开(公告)日：2005-03-10
申请号：US10969646
申请日：2004-10-20
申请人： Lawrence Wangh
发明人： Lawrence Wangh
IPC分类号： C12M3/04 , C12N5/02 , C12N5/076 , C12N15/873 , C12Q1/68 , C12Q1/6841 , C12Q1/70 , A01K67/027
CPC分类号： C12N15/873 , A01K2217/05 , C12N5/061 , C12N2500/80 , C12N2501/01 , C12N2501/70 , C12N2517/10 , C12Q1/6841 , C12Q1/70
摘要： The present invention concerns products and methods Particularly useful for activating and analyzing non-dividing cell nuclei. The featured products include activating egg extracts, cytostatic factor (CSF) extracts, kits containing these extracts, and a microchamber microscope slide useful in analyzing nucleus activation.
摘要翻译：本发明涉及产品和方法特别适用于活化和分析非分裂细胞核。特色产品包括活化卵提取物，细胞生长因子（CSF）提取物，含有这些提取物的试剂盒和用于分析细胞核激活的微量显微镜载玻片。

50. 发明申请

US20050042745A1 Device and method for culturing cells 有权
标题翻译：培养细胞的装置和方法
公开(公告)号：US20050042745A1
公开(公告)日：2005-02-24
申请号：US10891477
申请日：2004-07-15
申请人： Hirohiko Tsuzuki , Satoru Toda , Yasunori Ichikawa , Tetsuo Kurahashi , Fumiko Shiraishi
发明人： Hirohiko Tsuzuki , Satoru Toda , Yasunori Ichikawa , Tetsuo Kurahashi , Fumiko Shiraishi
IPC分类号： C12M3/04 , C12M1/12 , C12N5/00
CPC分类号： C12M25/02 , C12M29/14 , C12M41/00 , C12M41/12 , C12M41/40 , C12N2533/72
摘要： An object of the present invention is to construct a culture device optimized for culturing animal cells. The present invention provides a device for culturing cells which comprises at least one water-containing polymer gel film for adhering animal cells onto at least one surface of the film, and has a structure capable of supplying different liquids to both sides of the film.
摘要翻译：本发明的目的是构建用于培养动物细胞的培养装置。本发明提供了一种用于培养细胞的装置，该装置包括至少一个用于将动物细胞粘附在膜的至少一个表面上的含水聚合物凝胶膜，并且具有能够向膜两侧供应不同液体的结构。

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