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41. 发明申请

US20050118207A9 Photoactivatable diazirine-active agent compounds, compositions comprising them and uses thereof 有权
标题翻译：可光活化的二氮丙啶活性剂化合物，包含它们的组合物及其用途
公开(公告)号：US20050118207A9
公开(公告)日：2005-06-02
申请号：US10436050
申请日：2003-05-13
申请人： Gabin Vic , Aude Livoreil
发明人： Gabin Vic , Aude Livoreil
IPC分类号： A61K8/49 , A61K8/55 , A61K8/58 , A61K8/90 , A61Q5/00 , A61Q5/10 , C07D229/00 , C07D229/02 , A61K7/00
CPC分类号： C07D229/00 , A61K8/49 , A61K8/494 , A61K8/55 , A61K8/585 , A61K8/90 , A61Q5/00 , A61Q5/10
摘要： Disclosed herein are a cosmetic composition comprising at least one diazirine active-agent compound comprising a diazirine covalently bonded to a cosmetic active agent, said at least one diazirine-active agent compound and the uses of the composition or of the compound, as well as cosmetic treatment processes using the composition or the compound.
摘要翻译：本文公开了一种化妆品组合物，其包含至少一种二氮嗪活性剂化合物，其包含与化妆品活性剂共价结合的二氮丙啶，所述至少一种二氮丙啶活性剂化合物以及所述组合物或化合物的用途，以及化妆品使用组合物或化合物的处理方法。

42. 发明申请

US20040106789A1 Preparation of polyisocyanates containing uretdione groups 有权
标题翻译：含有脲二酮基团的多异氰酸酯的制备
公开(公告)号：US20040106789A1
公开(公告)日：2004-06-03
申请号：US10719175
申请日：2003-11-21
发明人： Frank Richter , Reinhard Halpaap , Hans-Josef Laas , Andreas Hecking
IPC分类号： C07D229/00
CPC分类号： C08G18/027 , C07D229/00 , C08G18/168
摘要： The invention relates to the use of cycloalkylphosphines as catalysts for isocyanate dimerization and to a process for preparing polyisocyanates containing uretdione groups.
摘要翻译：本发明涉及环烷基膦用作异氰酸酯二聚化的催化剂以及制备含有脲二酮基团的多异氰酸酯的方法。

43. 发明申请

US20020022612A1 New amidino derivatives and their use as thrombin inhibitors 失效
标题翻译：新的脒基衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US20020022612A1
公开(公告)日：2002-02-21
申请号：US09844428
申请日：2001-04-30
申请人： AstraZeneca AB
发明人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nystrom
IPC分类号： A61K031/397 , C07D229/00
CPC分类号： C07D405/06 , C07D205/04
摘要： There is provided compounds of formula I, 1 wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R1，Rx，Y，Ry，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在治疗条件需要抑制凝血酶（如血栓形成）或作为抗凝剂。

44. 发明授权

US6156863A Urea- and uretdione-functional polyisocyanates 失效
标题翻译：尿素和脲二酮官能的多异氰酸酯
公开(公告)号：US6156863A
公开(公告)日：2000-12-05
申请号：US292374
申请日：1999-04-15
申请人： Andreas Wenning
发明人： Andreas Wenning
IPC分类号： C07D229/00 , C08G18/32 , C08G18/79 , C08G18/80 , C09D5/00 , C09D5/03 , C09D5/46 , C09D175/04
CPC分类号： C08G18/798 , C08G18/8038 , C08G2150/20
摘要： A urea- and uretdione-functional polyaddition compound having free, partially or totally blocked isocyanate groups and having the following structure: ##STR1## wherein the substituents are defined as follows: ##STR2## n: 1-20; R.sub.1 is R or a linear, branched or cyclic alkylene or phenylene radicals having 2-16 carbon atoms;R.sub.2, R.sub.3 are each H, R.sub.4 or a ##STR3## R.sub.4, R.sub.5 are each identical or different hydrocarbon radicals having 1-14 carbon atoms;prepared by reacting isophorone diisocyanate-uretdione with diamine mixtures comprising 1-60 mol % diprimary diamines, 1-98 mol % primary/secondary diamines and 1-98 mol % disecondary diamines.
摘要翻译：具有游离，部分或完全封闭的异氰酸酯基团并具有以下结构的脲和脲二酮官能加聚化合物：其中取代基定义如下：n：1-20; R1是R或具有2-16个碳原子的直链，支链或环状亚烷基或亚苯基; R 2，R 3各自为H，R 4或R 4，R 5为相同或不同的具有1-14个碳原子的烃基; 通过异佛尔酮二异氰酸酯 - 脲二酮与包含1-60mol％二元二胺，1-98mol％伯/仲二胺和1-98mol％二中二胺的二胺混合物反应制备。

45. 发明授权

US5914383A Isocyanate trimers containing iminooxadiazine dione groups, their preparation and use 失效
标题翻译：含有亚氨基恶二嗪二酮的异氰酸酯三聚体，其制备和用途
公开(公告)号：US5914383A
公开(公告)日：1999-06-22
申请号：US822072
申请日：1997-04-30
申请人： Frank Richter , Josef Pedain , Harald Mertes , Carl-Gerd Dieris
发明人： Frank Richter , Josef Pedain , Harald Mertes , Carl-Gerd Dieris
IPC分类号： C07D251/34 , C07D229/00 , C07D251/32 , C07D273/04 , C08G18/02 , C08G18/78 , C08G18/79 , C08G18/12
CPC分类号： C07D251/32 , C07D273/04 , C08G18/022 , C08G18/7875 , C08G18/791
摘要： The present invention relates to a polyisocyanate mixture containing isocyanate trimers provided thati) 30 to 100 mole percent of the trimers are iminooxadiazine diones B and ##STR1## ii) 0 to 70 mole percent of the trimers are isocyanurates A iii) less than 10 mole percent of the polyisocyanate mixture is of the uretone imine structural type, andiv) the ratio of the sum of the mole percents of trimers A and B to the mole percent of uretdiones is greater than 4:1whereinR.sup.1, R.sup.2 and R.sup.3 are the same or different and represent the groups obtained by removing an isocyanate group from an aliphatic, cycloaliphatic, aromatic and/or araliphatic isocyanate having an NCO content of less than 70% and/or their oligomers.The present invention also relates to a process for the preparation of these isocyanate trimers, mixtures of these isocyanate trimers with other polyisocyanates and compositions containing these isocyanate trimers, in which the isocyanate groups may optionally be blocked with blocking agents, and compounds containing two or more isocyanate-reactive groups.
摘要翻译：本发明涉及含有异氰酸酯三聚体的多异氰酸酯混合物，条件是i）30-100摩尔％的三聚体是亚氨基恶二嗪二酮B和ii）0-70摩尔％的三聚体是异氰脲酸酯A iii）小于10摩尔％多异氰酸酯混合物具有尿素亚胺结构型，并且iv）三聚体A和B的摩尔百分数之和与脲化合物的摩尔百分比之比大于4:1，其中R1，R2和R3相同或不同并且表示通过从NCO含量小于70％的脂族，脂环族，芳族和/或芳脂族异氰酸酯和/或其低聚物除去异氰酸酯基而获得的基团。本发明还涉及制备这些异氰酸酯三聚体的方法，这些异氰酸酯三聚物与其它多异氰酸酯的混合物和含有这些异氰酸酯三聚体的组合物，其中异氰酸酯基团可以任选地被封闭剂封闭，以及含有两个或多个异氰酸酯反应性基团。

46. 发明授权

US5677330A Medical uses of allosteric hemoglobin modifier compounds in patient care 失效
标题翻译：变应性血红蛋白修饰剂化合物在病人护理中的医学用途
公开(公告)号：US5677330A
公开(公告)日：1997-10-14
申请号：US478371
申请日：1995-06-07
申请人： Donald J. Abraham , Michael Gerber
发明人： Donald J. Abraham , Michael Gerber
IPC分类号： A61K31/192 , A61K31/195 , A61K31/215 , A61K31/325 , A61K31/40 , A61K45/06 , C07C233/29 , C07C233/73 , C07C235/38 , C07C235/46 , C07C271/58 , C07D209/48 , C07D229/00
CPC分类号： A61K31/195 , A61K31/192 , A61K31/215 , A61K31/325 , A61K31/40 , A61K45/06 , C07C233/29 , C07C233/73 , C07C235/38 , C07C235/46 , C07C271/58 , C07D209/48 , C07C2102/08 , C07C2103/74 , Y10S514/833
摘要： A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgical blood loss, acute nonvolemic hemodilutions, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, tissue transplants, and sepsis. The compounds are capable of acting on hemoglobin in whole blood.
摘要翻译：发现一系列化合物可用于将血红蛋白右移至低氧亲和力状态。该效果特别适用于低氧，低温，缺血，中风，ARDS，COPD，手术失血，急性非血液性血液稀释，创伤，糖尿病性溃疡，慢性腿部溃疡，压疮，组织移植和败血症等各种治疗。该化合物能够作用于全血中的血红蛋白。

47. 发明授权

US5328804A Image producing element containing a photopolymerizable monomer 失效
标题翻译：包含可光聚合单体的图像产生元件
公开(公告)号：US5328804A
公开(公告)日：1994-07-12
申请号：US932963
申请日：1992-08-20
申请人： Wolfgang Podszun , Michael Muller , Herman Uytterhoeven
发明人： Wolfgang Podszun , Michael Muller , Herman Uytterhoeven
IPC分类号： G03F7/004 , B41M5/30 , B41M5/337 , B41M5/48 , C07C275/62 , C07D229/00 , C08F20/36 , C09D4/02 , G03F7/027 , G03F7/095 , G03F7/105 , G03F7/26 , G03F7/031 , G03C1/805
CPC分类号： B41M5/48 , C07C275/62 , C07D229/00 , C08F20/36 , G03F7/027 , G03F7/0955 , G03F7/105 , B41M5/3372 , B41M5/3375
摘要： Transfer images with high resolution are obtained with an image producing element containing a layer of a photopolymerisable composition with a monomer of Formula I by imagewise exposure and transfer of the unhardened parts of the photopolymerisable composition to an acceptor material. ##STR1## In Formula I A denotes a double-bonded or triple-bonded condensed urea group;X denotes O or NR in which R=C.sub.1 -C.sub.12 -alkyl;R.sup.1 denotes a double-bonded hydrocarbon group having 2 to 25 carbon atoms;R.sup.2 denotes a double-bonded to six-bonded linear or branched hydrocarbon group with 2 to 18 carbon atoms optionally interrupted by up to 3 O atoms;R.sup.3 denotes H or methyl;n denotes an integer from 1 to 5 andm stands for 2 or 3.
摘要翻译：通过图像曝光并将可光聚合组合物的未硬化部分转移到受主材料，通过具有含有式I单体的可光聚合组合物的图像产生元件获得高分辨率的图像。（I）式Ⅰ中，A表示双键或三键缩合脲基; X表示O或NR，其中R = C1-C12-烷基; R1表示碳原子数2〜25的双键烃基; R2表示任选地被至多3个O原子间隔的具有2至18个碳原子的双键连接的六键连接的直链或支链烃基; R3表示H或甲基; n表示1〜5的整数，m表示2或3。

48. 发明授权

US5043092A Process for the production of polyisocyanate mixtures containing uretdione and isocyanurate groups 失效
标题翻译：制备含有脲二酮和异氰脲酸酯基团的多异氰酸酯混合物的方法
公开(公告)号：US5043092A
公开(公告)日：1991-08-27
申请号：US323538
申请日：1989-03-13
申请人： Josef Pedain , Klaus Konig , Winfried Dell
发明人： Josef Pedain , Klaus Konig , Winfried Dell
IPC分类号： C07B61/00 , C07D229/00 , C07D251/34 , C08G18/78 , C08G18/79 , C09D175/00 , C09D175/04
CPC分类号： C08G18/792 , C07D229/00 , C07D251/34 , C08G18/798 , C08G2150/20
摘要： The present invention is directed to a process for the production of polyisocyanate mixtures containing isocyanurate groups and uretdione groups in a molar ratio of about 1:9 to 9:1 by oligomerizing a portion of the isocyanate groups of hexamethylene diisocyanate using trialkyl phosphines and/or peralkylated phosphorus acid triamides as the catalysts which accelerate the dimerization and trimerization of isocyanate groups, terminating the reaction at the desired degree of oligomerization by the addition of a catalyst poison and removing unreacted hexamethylene diisocyanate to a residual content of at most 0.5% by weight, characterized in that, before addition of the catalyst, the hexamethylene diisocyanate starting material is freed from carbon dioxide to a residual content of less than 20 ppm (weight).The present invention is also directed to the polyisocyanates containing uretdione groups and isocyanurate groups obtainable by this process and their use, optionally blocked by blocking agents for isocyanate groups, as the isocyanate component for the production of polyisocyanate polyaddition products.
摘要翻译：本发明涉及通过使用三烷基膦和/或它们的一部分使六亚甲基二异氰酸酯的一部分异氰酸酯基团低聚而制备含有摩尔比为约1:9至9:1的异氰脲酸酯基和脲二酮基团的多异氰酸酯混合物的方法和/或全烷基化的磷酸三酰胺作为加速异氰酸酯基团的二聚和三聚的催化剂，通过加入催化剂毒物终止反应在所需的低聚度程度，并除去未反应的六亚甲基二异氰酸酯至残余含量至多0.5重量％其特征在于，在加入催化剂之前，将六亚甲基二异氰酸酯原料从二氧化碳中除去至少于20ppm（重量）的残留量。本发明还涉及含有脲二酮基团和异氰脲酸酯基团的多异氰酸酯基团，其可通过该方法获得，并且其用途，任选地被异氰酸酯基团的封闭剂封闭，作为用于制备多异氰酸酯加聚产物的异氰酸酯组分。

49. 发明授权

US5030726A Polymerizable cyclic urea derivatives 失效
标题翻译：可聚合的环脲衍生物
公开(公告)号：US5030726A
公开(公告)日：1991-07-09
申请号：US456650
申请日：1989-12-29
申请人： Tsuboniwa Noriyuki , Urano Satoshi , Umemoto Hirotoshi , Sakamoto Hiroyuki , Tobinaga Kenshiro , Tsuchiya Yasuyuki
发明人： Tsuboniwa Noriyuki , Urano Satoshi , Umemoto Hirotoshi , Sakamoto Hiroyuki , Tobinaga Kenshiro , Tsuchiya Yasuyuki
IPC分类号： C07D247/02 , C07D229/00 , C07D233/32 , C07D233/38 , C07D239/10 , C07D243/04 , C08F12/00 , C08F12/14 , C08F16/14 , C08F16/28 , C08F20/34 , C08F20/36 , C08F20/38 , C08F20/52 , C08F20/60 , C08F26/00 , C08F26/02 , C08F28/00 , C08F28/02 , C08F246/00
CPC分类号： C07D239/10 , C07D229/00 , C07D233/38 , C07D243/04 , C08F20/36 , C08F20/60
摘要： The present invention relates to polymerizable cyclic urea derivatives which can be thermally split to give rise to an isocyanate group; and to a polymer having cyclic urea pendant groups, which can be cured by heating without any additional curing agent such as an isocyanate blocked with a volatile lower molecular weight material, so that volatile material is not released in a thermal curing process.

50. 发明授权

US4937012A Low temperature stable polymethylene polyphenylene polyisocyanates 失效
标题翻译：低温稳定的聚亚甲基聚亚苯基多异氰酸酯
公开(公告)号：US4937012A
公开(公告)日：1990-06-26
申请号：US85883
申请日：1987-08-14
申请人： Peter T. Kan , John W. Lightsey
发明人： Peter T. Kan , John W. Lightsey
IPC分类号： C07D229/00 , C08G18/79
CPC分类号： C08G18/797 , C07D229/00
摘要： Low temperature stable polymethylene polyphenylene polyisocyanates are composed of crude polymethylene polyphenylene polyisocyanate containing from about 50 to about 80 percent by weight 2-ring diphenylmethane diisocyanate wherein from about 65 to about 93 weight percent of the 2-ring diisocyanate is 4,4'- and from about 7 to about 35 weight percent is 2,4'- and furthermore the composition contains from about 1 to about 5 weight percent carbodiimide-uretonimine structure. The polyisocyanates are useful in preparing polyurethane foams.
摘要翻译：低温稳定的聚亚甲基聚亚苯基多异氰酸酯由含有约50至约80重量％的2-环二苯基甲烷二异氰酸酯的粗多亚甲基多亚苯基多异氰酸酯组成，其中约65-约93重量％的2-环二异氰酸酯是4,4'-和约7至约35重量％为2,4'-，此外该组合物含有约1至约5重量％的碳二亚胺 - 脲酮亚胺结构。多异氰酸酯可用于制备聚氨酯泡沫。

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