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41. 发明授权

US4612313A Pharmaceutical phenylacetonitrile derivatives 失效
标题翻译：药用苯乙腈衍生物
公开(公告)号：US4612313A
公开(公告)日：1986-09-16
申请号：US774354
申请日：1985-09-10
申请人： Herbert Leinert , Wolfgang Kampe , Klaus Strein , Bernd Muller-Beckmann , Wolfgang Bartsch
发明人： Herbert Leinert , Wolfgang Kampe , Klaus Strein , Bernd Muller-Beckmann , Wolfgang Bartsch
IPC分类号： A61K31/21 , A61K31/275 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , C07C67/00 , C07C253/00 , C07C255/24 , C07C255/32 , C07C255/42 , C07C255/43 , C07C255/53 , C07C255/58 , C07C255/59 , C07D207/08 , C07D211/22 , C07D241/04 , C07D295/16 , C07D295/18 , A61K31/495 , C07C121/80
CPC分类号： C07C255/00 , C07D211/22
摘要： The present invention provides phenylacetonitrile derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are hydrogen or haolgen atoms or alkyl, alkoxy, nitro, amino or acylamino radicals and two adjacent substituents can together also form a methylenedioxy or ethylenedioxy radical, A is a radical of the general formula: ##STR2## in which R.sub.6 is a straight-chained, cyclic or branched, saturated or unsaturated alkyl radical containing 2 to 12 carbon atoms, R.sub.7 is a hydrogen atom or a straight-chained or branched, saturated alkyl radical containing up to 6 carbon atoms, m and n, which can be the same or different, are 2 or 3, p is 1 or 2 and X is a straight-chained, cyclic or branched alkyl radical containing 2 to 10 carbon atoms which is optionally substituted by an amino group or is a grouping of the general formula: ##STR3## wherein Y and Z, which can be the same or different, are straight-chained or branched alkyl radicals containing up to 8 carbon atoms or cycloalkyl, alkylcycloalkyl or cycloalkylalkyl radicals, in which these radicals are optionally interrupted by an oxygen or sulphur atom, and one of the groups Z in general formula II can also be a hydrogen atom or both Z groups are joined to form a ring containing 4 to 6 carbon atoms which is optionally interrupted by a further nitrogen atom which can be substituted by alkyl or alkanoyl, the --O--NO.sub.2 groups being substituents of Y as well as of Z; as well as the salts thereof with physiologically acceptable acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
摘要翻译：本发明提供以下通式的苯乙腈衍生物：其中R 1，R 2，R 3，R 4和R 5可以相同或不同，为氢或卤素原子或烷基，烷氧基，硝基，氨基或酰基氨基和两个相邻的取代基可以一起形成亚甲二氧基或亚乙二氧基，A是下列通式的基团：其中R 6是含有2至12个直链的直链，环状或支链的饱和或不饱和烷基碳原子，R7是氢原子或含有至多6个碳原子的直链或支链饱和烷基，m和n可相同或不同，为2或3，p为1或2，X为是含有2至10个碳原子的直链，环状或支链烷基，其任选被氨基取代，或者是通式如下的基团：其中Y和Z可以相同或不同，是直链或支链烷基基团引入多达8个碳原子或环烷基，烷基环烷基或环烷基烷基，其中这些基团任选地被氧或硫原子中断，通式II中的基团Z之一也可以是氢原子或两个Z基团连接形成含有4至6个碳原子的环，其任选被可被烷基或烷酰基取代的另外的氮原子中断，-O-NO 2基团是Y和Z的取代基; 以及其与生理上可接受的酸的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

42. 发明授权

US4592773A Substituted propargyloxyacetonitrile derivatives, process for production thereof, and herbicide and agricultural-horticultural fungicide comprising said derivatives as active ingredients 失效
标题翻译：取代的炔丙氧基乙腈衍生物，其制备方法，除草剂和农业园艺杀真菌剂，其包含所述衍生物作为活性成分
公开(公告)号：US4592773A
公开(公告)日：1986-06-03
申请号：US762382
申请日：1985-08-05
申请人： Yoshinori Tanaka , Kazuya Sakai , Toshiyuki Kouno , Mithuo Itakura , Koichi Takeuchi , Yuji Enomoto , Hitoshi Shimotori , Shunichi Inami , Yoshikata Hojo , Masahiro Sakakibara
发明人： Yoshinori Tanaka , Kazuya Sakai , Toshiyuki Kouno , Mithuo Itakura , Koichi Takeuchi , Yuji Enomoto , Hitoshi Shimotori , Shunichi Inami , Yoshikata Hojo , Masahiro Sakakibara
IPC分类号： A01N37/34 , A01N20060101 , A01N31/14 , A01N33/18 , A01N37/06 , A01N37/20 , A01N37/46 , A01N37/48 , A01N43/28 , A01N43/30 , C07C20060101 , C07C5/00 , C07C43/166 , C07C67/00 , C07C253/00 , C07C255/24 , C07C255/29 , C07C255/60 , C07D317/68 , C07C121/80
CPC分类号： C07C255/00 , A01N37/46 , A01N37/48 , A01N43/28 , C07D317/68
摘要： Substituted propargyloxyacetonitrile derivative represented by the general formula (I) ##STR1## wherein R represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group, a lower alkoxy group, a methylenedioxy group, a nitro group or a cyano group, n represents an integer of 1 to 5 and when n is an integer of 2 or more, R's may be identical or different, R.sup.1 represents a hydrogen atom or a lower alkyl group, and R.sup.2 represents a hydrogen atom, a lower alkyl group, a lower haloalkyl group or a halogen atom, provided that R.sup.1 and R.sup.2 are not simultaneously hydrogen atoms.The compounds have herbicidal and fungicidal activities.
摘要翻译：由通式（I）表示的取代的炔丙氧基乙腈衍生物其中R表示氢原子，卤素原子，低级烷基，低级卤代烷基，低级烷氧基，亚甲二氧基，硝基或氰基，n表示1〜5的整数，当n为2以上的整数时，R可以相同或不同，R 1表示氢原子或低级烷基，R 2表示氢原子，低级烷基，低级卤代烷基或卤素原子，条件是R1和R2不同时为氢原子。该化合物具有除草和杀真菌活性。

43. 发明授权

US4543215A .alpha.-iminodiacetonitriles and their preparation 失效
标题翻译： α-亚氨基二乙腈及其制备方法
公开(公告)号：US4543215A
公开(公告)日：1985-09-24
申请号：US547851
申请日：1983-11-02
申请人： Fritz Brunnmueller , Michael Kroener
发明人： Fritz Brunnmueller , Michael Kroener
IPC分类号： C07C255/24 , C07C255/26 , C07C121/42 , C07C121/78
CPC分类号： C07C255/00
摘要： Novel .alpha.-iminodiacetonitriles are prepared by a process in which an aldehyde-cyanohydrin or a haloacetonitrile is reacted with an aminonitrile, the reaction being carried out in the presence of a lower alkanol in the case of the preparation of symmetric .alpha.-iminodiacetonitriles, and in the presence of an auxiliary base in the case of the preparation employing a haloacetonitrile. The .alpha.-iminodiacetonitriles obtainable by the process of the invention are useful starting materials for the preparation of dyes, fungicides, bactericides, herbicides, textile assistants, anticorrosion agents, complex-forming agents, stabilizers in electroplating baths and inhibitors for antifreezes.
摘要翻译：通过将醛 - 羟腈或卤代乙腈与氨基腈反应的方法制备新的α-亚氨基二乙腈，该反应在制备对称的α-亚氨基二乙腈的情况下在低级烷醇的存在下进行，并且在在使用卤代乙腈的制备的情况下存在辅助碱。通过本发明方法可获得的α-亚麻子二腈是用于制备染料，杀真菌剂，杀菌剂，除草剂，纺织助剂，防腐剂，络合物形成剂，电镀浴中的稳定剂和防冻剂抑制剂的起始材料。

44. 发明授权

US4478759A Preparation of aminoitriles 失效
标题翻译：氨基腈的制备
公开(公告)号：US4478759A
公开(公告)日：1984-10-23
申请号：US283649
申请日：1981-07-15
申请人： Harry Distler , Karl-Ludwig Hock
发明人： Harry Distler , Karl-Ludwig Hock
IPC分类号： C07C255/24 , C07C255/25 , C07C120/00
CPC分类号： C07C255/00
摘要： Aminonitriles are prepared by reacting a nitrogen compound with formaldehyde and hydrogen cyanide in the presence of an additional acid at a pH below 2 and at from 10.degree. to 70.degree. C., the concentration of the hydrogen cyanide during the reaction being not more than 3 per cent by weight, based on the reaction mixture.The aminoacetonitriles obtained by the novel process are valuable starting materials for the preparation of dyes, fungicides, bactericides, textile assistants, rubber additives, and auxiliaries used in water softening, cosmetics, the photographic industry, the paper industry and the electroplating industry.
摘要翻译：氨基腈是通过使氮化合物与甲醛和氰化氢在另外的酸存在下，在低于2和10至70℃的pH下反应制备的，反应中氰化氢的浓度不大于3 基于反应混合物的重量百分比。通过新方法获得的氨基乙腈是用于制备染料，杀真菌剂，杀菌剂，纺织助剂，橡胶添加剂和用于水软化，化妆品，摄影工业，造纸工业和电镀工业的助剂的有价值的起始材料。

45. 发明授权

US4435332A M-Phenoxybenzamide derivatives 失效
标题翻译：间苯氧基苯甲酰胺衍生物
公开(公告)号：US4435332A
公开(公告)日：1984-03-06
申请号：US213637
申请日：1980-12-05
申请人： Hiroshi Noguchi , Shunichi Hashimoto , Shigeyoshi Kitamura , Takashi Matsuo , Akihiko Mine , Katsuzo Kamoshita
发明人： Hiroshi Noguchi , Shunichi Hashimoto , Shigeyoshi Kitamura , Takashi Matsuo , Akihiko Mine , Katsuzo Kamoshita
IPC分类号： A01N37/40 , A01N37/46 , A01N43/34 , C07C231/00 , C07C233/12 , C07C255/24 , C07D203/18 , C07D207/06 , C07D211/16 , C07D265/30 , C07D295/10 , C07D295/16 , C07D295/192 , C07C103/76
CPC分类号： C07D265/30 , C07C255/00 , C07D203/18 , C07D207/06 , C07D211/16 , C07D295/192
摘要： A herbicidal composition which comprises as an active ingredient a m-phenoxybenzamide compound of the formula: ##STR1## wherein X, which may be the same or different, is a halogen atom or a lower alkyl or lower alkoxy group, n is zero or an integer of 1 to 5 and R is a group of the formula: ##STR2## (in which R.sub.1 is a hydrogen atom or a lower alkyl or lower alkenyl group and R.sub.2 is a lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower cycloalkyl, lower haloalkyl, lower alkoxy-substituted lower alkyl, lower cyanoalkyl, lower alkylamino-substituted lower alkyl or benzyl group) or an ethylenimino, pyrrolidino, dimethylpyrrolidino, piperidino, methylpiperidino, hexamethylenimino, morpholino or dimethylmorpholino group.
摘要翻译：一种除草组合物，其包含下式的间苯氧基苯甲酰胺化合物作为活性成分：其中X可以相同或不同，为卤素原子或低级烷基或低级烷氧基，n为零或 1〜5的整数，R为下式的基团：其中R 1为氢原子或低级烷基或低级烯基，R 2为低级烷基，低级烯基，低级炔基，低级烷氧基，低级低级烷基氨基取代的低级烷基或苄基）或亚乙基亚氨基，吡咯烷子基，二甲基吡咯烷子基，哌啶子基，甲基哌啶子基，六亚甲基亚氨基，吗啉代或二甲基吗啉代基。

46. 发明授权

US4427597A Amidodicyanoalkanolamines and process for selective cyanoalkylation of amidodialkanolamines 失效
标题翻译：酰胺二烷基链烷醇胺和酰胺二链烷醇胺的选择性氰烷基化方法
公开(公告)号：US4427597A
公开(公告)日：1984-01-24
申请号：US346788
申请日：1982-02-08
申请人： Edward W. Kluger
发明人： Edward W. Kluger
IPC分类号： C07C255/24 , C07C121/417
CPC分类号： C07C255/00
摘要： Nitrogen-containing compounds are provided of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently selected from H or a lower alkyl group having from 1 to about 6 carbon atoms. Also provided is a process involving selective cyanoalkylation of amidoalkyldialkanolamines whereby nitrogen-containing compounds may be prepared.
摘要翻译：含氮化合物由下式提供：其中R 1，R 2和R 3各自独立地选自H或具有1至约6个碳原子的低级烷基。还提供了包括选择性氰基烷基化酰氨基烷基二烷醇胺的方法，由此可以制备含氮化合物。

47. 发明授权

US4402953A Fungicidal N-(morpholinoacetyl)-anilines, compositions and use 失效
标题翻译：杀真菌N-（吗啉代乙酰） - 苯胺，组合物和用途
公开(公告)号：US4402953A
公开(公告)日：1983-09-06
申请号：US205356
申请日：1980-11-10
申请人： Adolf Hubele , Walter Kunz , Wolfgang Eckhardt
发明人： Adolf Hubele , Walter Kunz , Wolfgang Eckhardt
IPC分类号： A01N37/22 , A01N37/44 , A01N37/46 , A01P3/00 , C07C67/00 , C07C237/04 , C07C237/12 , C07C253/00 , C07C255/24 , C07C325/00 , C07C327/22 , C07C327/30 , C07D203/08 , C07D207/32 , C07D207/327 , C07D211/34 , C07D211/38 , C07D231/12 , C07D237/04 , C07D237/08 , C07D249/08 , C07D263/04 , C07D265/30 , C07D295/10 , C07D295/15 , C07D521/00 , A01N43/84 , C07D295/14
CPC分类号： C07D203/08 , A01N37/46 , C07D207/327 , C07D211/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/15
摘要： Amino aceto anilides of the formula I shown hereinafter are effective microbicides. They may be used to control fungi on plants or parts of plants or to prevent them from fungi attack.
摘要翻译：下文所示的式I的氨基乙酰苯胺是有效的杀微生物剂。它们可用于控制植物或植物部分上的真菌或防止真菌发生攻击。

48. 发明授权

US4256767A Phenoxy alkylamides 失效
标题翻译：苯氧基烷基酰胺
公开(公告)号：US4256767A
公开(公告)日：1981-03-17
申请号：US50106
申请日：1979-06-19
申请人： Andre Esanu
发明人： Andre Esanu
IPC分类号： A61K31/16 , A61K31/165 , A61K31/18 , A61P37/04 , C07C67/00 , C07C255/24 , C07C311/29 , C07C313/00 , C07C323/41 , C07C103/19 , C07C143/72
CPC分类号： C07C255/24
摘要： A new phenoxy alkylamide is disclosed. The compound has been found to have beneficial activity in the field of immuno-stimulation.
摘要翻译：公开了一种新的苯氧基烷基酰胺。发现该化合物在免疫刺激领域具有有益的活性。

49. 发明授权

US4240977A 2-Cyanoethyl isocyanide dichloride 失效
标题翻译： 2-氰基乙基异氰化物二氯化物
公开(公告)号：US4240977A
公开(公告)日：1980-12-23
申请号：US67650
申请日：1979-08-17
申请人： Gunther Beck , Gerhard Dankert , Fritz Doring
发明人： Gunther Beck , Gerhard Dankert , Fritz Doring
IPC分类号： C07C67/00 , C07C241/00 , C07C253/00 , C07C255/24 , C07C255/61 , C07D239/30 , C07C121/43
CPC分类号： C07D239/30
摘要： Process for the preparation of tetrachloropyrimidine, characterized in that 2-cyanoethyl isocyanide dichloride is reacted with chlorine in the gas phase in the temperature range from 200.degree.-650.degree. C.
摘要翻译：制备四氯嘧啶的方法，其特征在于2-氰基乙基异腈化合物二氯化物在气相中与氯反应，温度范围为200-650℃。

50. 发明授权

US4007213A Process for preparing 1-(N-.beta.-cyanethylaminol-3-acylaminobenzenes 失效
标题翻译：制备1-（N- {62-氰乙基氨基-3-酰氨基苯
公开(公告)号：US4007213A
公开(公告)日：1977-02-08
申请号：US680706
申请日：1976-04-27
申请人： Rudolf Schickfluss
发明人： Rudolf Schickfluss
IPC分类号： C07C253/00 , B01J27/00 , B01J27/20 , B01J31/00 , B01J31/04 , C07B61/00 , C07C20060101 , C07C67/00 , C07C231/00 , C07C255/24 , C07C121/78
CPC分类号： C07C253/30
摘要： Process for the manufacture of 1-(N-.beta.-cyanethylamino)-3-acylaminobenzenes of the formula (1) ##STR1## in which R.sub.1 represents hydrogen, methyl or alkoxy of 1 to 4 carbon atoms, R.sub.2 represents hydrogen, alkyl from 1 to 3 carbon atoms or phenyl, R.sub.3 represents hydrogen or alkyl from 1 to 3 carbon atoms, and n represents the integer 0 or 1, which comprises reacting 1 mole of an amino of the formula (2) ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are defined as above, with 1 to 1.75 moles of acrylonitrile between 70.degree. and 150.degree. C in water with the addition of 1 to 30% by weight of an organic carboxylic acid or carbonic acid, and oxethylating the compound at the said formula (1) obtained, if n stands for the integer 0, without or after isolation, with 1 to 10 moles of ethylene oxide between 50.degree. and 100.degree. C.
摘要翻译：制备式（1）的1-（N-β-氰基乙基氨基）-3-酰氨基苯的方法其中R1代表氢，甲基或1-4个碳原子的烷氧基，R2代表氢， 1至3个碳原子的烷基或苯基，R 3表示氢或1至3个碳原子的烷基，n表示整数0或1，其包括使1摩尔式（2）的氨基），其中R 1，R 2和R 3如上定义，在水中加入1至30重量％的有机羧酸或碳酸，其中1至1.75摩尔丙烯腈在70至150℃之间，并加入氧乙基化所述式（1）中的化合物，如果n代表整数0，则在分离后没有或分离后，其中1至10摩尔环氧乙烷在50至100℃之间。

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