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41. 发明授权

US4606336A Method and apparatus for non-surgically sterilizing female reproductive organs 失效
标题翻译：非手术消毒女性生殖器官的方法和装置
公开(公告)号：US4606336A
公开(公告)日：1986-08-19
申请号：US674244
申请日：1984-11-23
申请人： James W. Zeluff
发明人： James W. Zeluff
IPC分类号： A61F6/22 , A61F5/46 , A61M31/00
CPC分类号： A61F6/225
摘要： An ostial occlusion device forms an hermetic seal around the tubal ostium of the uterotubal junction and includes a hub fabricated from a non-porous material having a circumferential edge and upper and lower surfaces. A locator pin is oriented perpendicular to and extends outward from the lower surface of the hub and is insertable into the fallopian tube at the uterotubal junction to center the hub about the tubal ostium. A ring of porous material surrounds the circumferential edge of the hub and includes an exposed lower surface which contacts the tissue surrounding the tubal ostium and receives fibroblast ingrowth to create an hermetic seal around the tubal ostium. This hermetic seal isolates the fallopian tube from the uterine cavity and renders the female reproductive system infertile.
摘要翻译：口腔闭塞装置围绕子宫交界处的输卵管口形成气密密封，并且包括由具有圆周边缘和上表面和下表面的无孔材料制成的毂。定位销定位成垂直于毂的下表面并向外延伸，并且可在子宫交界处插入输卵管，以使毂围绕输卵管口位置居中。多孔材料环围绕轮毂的圆周边缘并且包括暴露的下表面，该下表面接触输卵管口周围的组织并且接收成纤维细胞向内生长以在输卵管口周围产生气密封。这种气密密封将输卵管与子宫腔隔离，使女性生殖系统不育。

42. 发明授权

US4595000A Tubular pessary as a contraceptive means 失效
标题翻译：管状子宫托作为避孕手段
公开(公告)号：US4595000A
公开(公告)日：1986-06-17
申请号：US612758
申请日：1984-05-21
申请人： Jacques Hamou
发明人： Jacques Hamou
IPC分类号： A61F6/06 , A61F6/22 , A63B69/36 , A61F5/46
CPC分类号： A61F6/225
摘要： Tubular pessary as a contraceptive means, which can be carried or worn on either side by hysteroscopy.The invention relates to a tubular pessary having a contraceptive action through the obturation of the proximal uterine tube in non-surgical manner by hysteroscopy and which can easily be worn on either side.The tubular pessary has a cylindrical, sensitive central part permitting the obturation of the uterine tube. It has a distal elastic loop, which prevents sliding back into the uterus of the device. It has a proximal elastic loop, which prevents migration of the device into the abdominal cavity and which can easily be removed through a hysteroscope.The object of the invention is to overcome the inadequacies of the known contraceptive means.
摘要翻译：作为避孕方式的管状子宫托，可以通过宫腔镜检查在两侧携带或佩戴。本发明涉及一种管状子宫帽，其通过宫腔镜检查以非手术方式通过近端子宫管的封闭而具有避孕作用，并且可以容易地在任一侧佩戴。管状子宫托具有圆柱形，敏感的中心部分，允许子宫管的封闭。它具有远端的弹性环，防止滑回到装置的子宫内。它具有近端弹性环，其防止装置进入腹腔，并且可以通过宫腔镜容易地移除。本发明的目的是克服已知的避孕方法的不足之处。

43. 发明授权

US4416660A Method of transvaginal sterilization 失效
标题翻译：经阴道灭菌方法
公开(公告)号：US4416660A
公开(公告)日：1983-11-22
申请号：US902159
申请日：1978-05-02
申请人： Charles A. Dafoe
发明人： Charles A. Dafoe
IPC分类号： A61F6/22 , A61M1/00
CPC分类号： A61F6/225
摘要： A method for sterilization of females has been devised in which one or more hypodermic needles can be inserted into the uterus to a predetermined position or location at the uterine cornu and the internal tubal ostra followed by injecting a sclerosing agent which produces a chronic lesion at that point. The entire needle assembly is characterized by slidable mounting of the needle or needles within a guide or sleeve projecting forwardly from a disposable cartridge, and a hand-held actuator is provided to selectively control successive advancement of each needle through the needle guide into the tissue and advancement of the ampule or cartridge to force the sclerosing agent or other medicament through the needle. Thereafter, the needle assembly may either be withdrawn or relocated to another position for injection of medicament through the same or other needle advancing through the same needle guide into the opposite cornul portion.
摘要翻译：已经设计了一种用于对雌性进行灭菌的方法，其中可以将一个或多个皮下注射针插入到子宫中到子宫颈和内部输卵管ostra处的预定位置或位置，然后注射一种产生慢性损伤的硬化剂点。整个针组件的特征在于将针或针可滑动地安装在从一次性药筒向前突出的引导件或套筒内，并且提供手持致动器以选择性地控制每个针通过针引导件进入组织的连续前进，推进安瓿或药筒以迫使硬化剂或其它药物穿过针头。此后，针组件可以被抽出或重新定位到另一个位置，用于通过穿过相同的针引导件前进到相对的凹槽部分中的相同或其它针头来注射药物。

44. 发明授权

US4182328A Dispensing instrument and method 失效
标题翻译：配药仪器及方法
公开(公告)号：US4182328A
公开(公告)日：1980-01-08
申请号：US854081
申请日：1977-11-23
申请人： Lee R. Bolduc , Eugene A. Dickhudt
发明人： Lee R. Bolduc , Eugene A. Dickhudt
IPC分类号： A61F2/958 , A61F6/22 , A61M31/00 , A61M1/00
CPC分类号： A61M25/10 , A61F6/225 , A61M25/1018 , A61M31/00 , Y10S604/904
摘要： A fluid dispensing instrument and method for placing a drug material into the canals of the Fallopian tubes of a female. The instrument has a housing carrying a piston and cylinder assembly. An elongated flexible tubular probe attached to the housing carries an expandable sleeve. The piston and cylinder assembly is operable to fully collapse the sleeve prior to insertion through the cervical opening into the uterine cavity. After the sleeve is inserted into the uterine cavity, an ampulla storing the drug material is loaded into the instrument. The piston and cylinder assembly is then actuated to initially partially expand the sleeve. Operation of the piston and cylinder assembly moves a plunger into the ampulla to dispense the drug material into the uterine cavity above the partly expanded balloon. The sleeve is then fully expanded to move the drug material from the uterine cavity into the canals of the Fallopian tubes.
摘要翻译：一种用于将药物放置到女性输卵管的运河中的流体分配仪器和方法。该仪器具有承载活塞和气缸组件的壳体。连接到壳体的细长柔性管状探针携带可膨胀套管。活塞和气缸组件可操作以在插入通过子宫颈开口进入子宫腔之前使套管完全折叠。将套管插入子宫腔后，将储存药物的壶腹装载到仪器中。然后致动活塞和气缸组件以最初部分地扩张套筒。活塞和气缸组件的操作将柱塞移动到壶腹中以将药物材料分配到部分膨胀的气囊上方的子宫腔中。然后将套管完全膨胀以将药物材料从子宫腔移动到输卵管的运河中。

45. 发明授权

US3938499A Implant and implanting method and tool 失效
标题翻译：种植体和植入方法和工具
公开(公告)号：US3938499A
公开(公告)日：1976-02-17
申请号：US439836
申请日：1974-02-05
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61F6/22 , A61F6/24 , A61B17/11 , A61B19/00
CPC分类号： A61F6/22 , A61F6/24
摘要： A method for introducing a valve into a vas deferens, according to which a continuous portion of the vas is deflected to form a pair of flaps while the vas is advanced onto opposed portions of the implanted valve, and these flaps engage each other and project laterally from the lumen of the vas. The flaps are fastened together so that they will grow together and maintain the free ends of the lumen adjacent an intermediate portion of the implanted valve.
摘要翻译：一种用于将阀引入输精管的方法，根据该方法，当血管进入植入的瓣膜的相对部分时，血管的连续部分被偏转以形成一对瓣，并且这些瓣彼此接合并且侧向突出从血管的内腔。襟翼被紧固在一起，使得它们将一起生长并且保持腔的自由端邻近植入的瓣膜的中间部分。

46. 发明授权

US3822702A Dispensing method and apparatus 失效
标题翻译：分配方法和装置
公开(公告)号：US3822702A
公开(公告)日：1974-07-09
申请号：US37297173
申请日：1973-06-25
申请人： POPULATION RES INC
发明人： BOLDUC L , DICKHUDT E
IPC分类号： A61B17/42 , A61F6/22 , A61K9/00 , A61M31/00 , A61M1/00
CPC分类号： A61K9/0039 , A61B17/42 , A61F6/225 , A61M31/00
摘要： A fluid dispensing instrument and method for introducing a fluid, as drug materials, into the canals of the Fallopian tubes of a primate female. The dispensing instrument has a tubular probe carrying an expandable balloon assembly. A stop collar on the probe positions the balloon assembly in the uterine cavity. The balloon assembly has a sleeve member which is initially expanded to close the lower portion of the uterine cavity. The drug material is introduced through the probe into the upper portion of the uterine cavity above the expanded balloon assembly. The balloon assembly is then further expanded to force the drug material from the upper portion of the uterine cavity into the canals of the Fallopian tubes. The expanding balloon assembly divides the material and forces the drug material into both of the canals.
摘要翻译：一种流体分配仪器和方法，用于将作为药物材料的流体引入灵长类动物女性的输卵管的运河中。分配仪器具有携带可膨胀气囊组件的管状探针。探针上的止动环将气囊组件放置在子宫腔中。气囊组件具有套筒构件，该套筒构件最初膨胀以封闭子宫腔的下部。药物材料通过探针引入扩张的气囊组件上方的子宫腔的上部。然后气囊组件进一步膨胀以迫使药物材料从子宫腔的上部进入输卵管的运河。膨胀的气囊组件将材料分开并将药物材料迫使成两个运河。

47. 发明授权

US3648683A Reversible intra-vas device 失效
标题翻译：可逆的内部设备
公开(公告)号：US3648683A
公开(公告)日：1972-03-14
申请号：US3648683D
申请日：1970-06-29
申请人： NATHAN BRODIE
发明人： BRODIE NATHAN
IPC分类号： A61F6/22 , A61B19/00
CPC分类号： A61F6/22
摘要： A device is disclosed for blocking body passages, having special application in the vas deferens for preventing the flow of sperm from the testis to the seminal vesicle. The device is maintained in place by one or more sutures, ligatures, or clips. If desired, the device may subsequently be removed.
摘要翻译：公开了一种用于阻止身体通道的装置，其具有在输精管中的特殊应用以防止精子从睾丸流到精囊。该装置通过一根或多根缝合线，连线或夹子保持在适当位置。如果需要，随后可以移除该装置。

48. 发明申请

US20230116862A1 SYSTEMS AND METHODS FOR DELIVERING BIOMATERIALS 有权
公开(公告)号：US20230116862A1
公开(公告)日：2023-04-13
申请号：US17974264
申请日：2022-10-26
申请人： Contraline, Inc.
发明人： Gregory GROVER , Kevin S. EISENFRATS
IPC分类号： A61F6/00 , A61F6/22 , A61M5/145 , A61M5/168 , A61M39/10 , A61M5/14
摘要： Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.

49. 发明申请

US20220249365A1 BIOERODIBLE IMPLANT FOR LONG-TERM DRUG DELIVERY AND ASSOCIATED METHODS OF MANUFACTURE AND USE 有权
公开(公告)号：US20220249365A1
公开(公告)日：2022-08-11
申请号：US17531658
申请日：2021-11-19
申请人： Gesea Biosciences Inc.
发明人： John H. Baillie , Ruth Baillie , George Blouin , Newsha Farahani , Christopher Marx
IPC分类号： A61K9/00 , A61K31/567 , A61K47/36 , A61K9/50 , A61F6/08 , A61F6/22 , A61K31/167 , A61K31/192 , A61K31/325 , A61K31/57 , A61K31/593 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/28
摘要： A drug delivery system is provided in the form of a controlled release, bioerodible pellet for subdermal implantation. The pellet is bioerodible, and provides for the sustained release of a pharmacologically active agent over an extended time period. As such, the drug delivery system finds significant utility in chronic drug administration. Bioerosion products are water soluble, bioresorbed, or both, obviating the need for surgical removal of the implant. Methods for manufacturing and using the drug delivery system are also provided.

50. 发明授权

US11364141B2 Uterotubar implant device 有权
公开(公告)号：US11364141B2
公开(公告)日：2022-06-21
申请号：US15775755
申请日：2016-11-14
申请人： Andrea Brohm-Schmitz-Rode , Heinz Gerhards
发明人： Andrea Brohm-Schmitz-Rode
IPC分类号： A61F6/22 , A61B17/12 , A61F6/24
摘要： According to the invention, an uterotubal implant device is provided. Said uterotubal implant device comprises at least two compressible self-expanding bodies which are composed of a grid structure and are coupled to one another in a longitudinal direction such that one body is arranged distally in the longitudinal direction and the other body is arranged proximally in the longitudinal direction, at least one of the bodies having a spindle- or funnel-shaped design.

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