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41. 发明授权

US09188540B2 Integrated circuit and manufacturing method 有权
标题翻译：集成电路及制造方法
公开(公告)号：US09188540B2
公开(公告)日：2015-11-17
申请号：US14147214
申请日：2014-01-03
申请人： NXP B.V.
发明人： Aurelie Humbert , Roel Daamen , Youri Victorovitch Ponomarev
IPC分类号： H01L31/02 , G01N21/76 , G01N29/02 , G01N29/036 , G01N33/00
CPC分类号： H01L31/18 , G01N21/766 , G01N21/77 , G01N21/783 , G01N29/022 , G01N29/036 , G01N33/004 , G01N2291/021 , G01N2291/0256 , G01N2291/02809 , G01N2291/0427 , H01L31/02 , Y02A50/243 , Y02A50/244
摘要： Disclosed is an integrated circuit comprising a substrate (10); and an optical CO2 sensor comprising: first and second light sensors (12, 12′) on said substrate, said second light sensor being spatially separated from the first light sensor; and a layer portion (14) including an organic compound comprising at least one amine or amidine functional group over the first light sensor; wherein said integrated circuit further comprises a signal processor (16) coupled to the first and second light sensor for determining a difference in the respective outputs of the first and second light sensor. An electronic device comprising such a sensor and a method of manufacturing such an IC are also disclosed.
摘要翻译：公开了一种包括基板（10）的集成电路; 和光学CO 2传感器，包括：在所述基板上的第一和第二光传感器（12,12'），所述第二光传感器在空间上与第一光传感器分离; 以及包含在所述第一光传感器上的包含至少一个胺或脒官能团的有机化合物的层部分（14）其中所述集成电路还包括耦合到所述第一和第二光传感器的信号处理器（16），用于确定所述第一和第二光传感器的相应输出的差。还公开了一种包括这种传感器的电子设备和制造这种IC的方法。

42. 发明申请

US20150323466A1 CAVITY OPTO-MECHANICAL SENSOR SYSTEM 有权
标题翻译： CAVITY机电传感器系统
公开(公告)号：US20150323466A1
公开(公告)日：2015-11-12
申请号：US14466090
申请日：2014-08-22
申请人： Marcel W. Pruessner , Todd H. Stievater , William S. Rabinovich
发明人： Marcel W. Pruessner , Todd H. Stievater , William S. Rabinovich
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , G01B9/02004 , G01B9/02051 , G01B2290/25 , G01G3/165 , G01N21/17 , G01N29/036 , G01N2021/757 , G01N2291/0256
摘要： A mass sensor system including multiple Fabry-Perot microcavities connected in parallel by multiple waveguides. Each of the mass sensors includes a microbridge having a fundamental resonance frequency, and a movable reflective mirror etched into the microbridge; a fixed reflective mirror etched in a substrate, the fixed reflective mirror being fixed to the substrate in a region spaced apart from the movable reflective mirror; and an optical waveguide etched in the substrate that connects the movable mirror and the fixed mirror forming the Fabry-Perot microcavity interferometer. The system includes a tunable continuous-wave laser operative to optically interrogate the Fabry-Perot microcavity of each of the plurality of mass sensors, and a receiver operative to receive sensor signals from each of the plurality of mass sensors, the sensor signals comprising reflective signals and transmitted signals. A continuous-wave laser may generate optical forces that modify the motion, dynamics, or mechanical Q-factor of the microbridge.
摘要翻译：一种质量传感器系统，包括由多个波导并联连接的多个法布里 - 珀罗微腔。每个质量传感器包括具有基本共振频率的微桥和蚀刻到微桥中的可移动反射镜; 在基板中蚀刻的固定反射镜，所述固定反射镜在与所述可移动反射镜间隔开的区域中固定到所述基板; 以及在连接可移动镜和形成法布里 - 珀罗微腔干涉仪的固定镜的基板中蚀刻的光波导。该系统包括可调谐的连续波激光器，用于光学询问多个质量传感器中的每一个的法布里 - 珀罗微腔，以及接收器，用于接收来自多个质量传感器中的每一个的传感器信号，传感器信号包括反射信号并发送信号。连续波激光器可以产生改变微桥的运动，动力学或机械Q因子的光学力。

43. 发明申请

US20150293060A1 SENSOR ARRAY CHIP WITH PIEZOELECTRIC TRANSDUCER INCLUDING INKJET FORMING METHOD 有权
标题翻译：带压电传感器的传感器阵列芯片，包括喷墨成型方法
公开(公告)号：US20150293060A1
公开(公告)日：2015-10-15
申请号：US14252222
申请日：2014-04-14
申请人： Texas Instruments Incorported
发明人： STUART M. JACOBSEN
IPC分类号： G01N29/036 , G01N33/487 , G01N29/24
CPC分类号： G01N29/036 , G01N29/022 , G01N29/2437 , G01N33/48707 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/106
摘要： A method of forming a functionalized sensor array includes providing a substrate having at least one sensor array chip including a plurality of sensor structures. The sensor structures include a piezoelectric layer interposed between upper and lower electrodes and positioned across an area of the sensor array chip in a spatial arrangement. An inkjet cartridge chip is also provided having a plurality of microfluidic channels including a fill side having a plurality of fill side orifices and a dispense side having a plurality of dispense nozzles, wherein two or more of the plurality of microchannels are loaded with different sensing materials, and wherein locations of the plurality of dispense nozzles are matched to the spatial arrangement. The plurality of dispense nozzles are aligned to the plurality of sensor structures, and the plurality of dispense nozzles are actuated to deposit the different sensing materials on the plurality of sensor structures.
摘要翻译：形成官能化传感器阵列的方法包括提供具有至少一个包括多个传感器结构的传感器阵列芯片的衬底。传感器结构包括插入在上电极和下电极之间的压电层，并以空间方式定位在传感器阵列芯片的一个区域上。还提供了具有多个微流体通道的喷墨墨盒芯片，其包括具有多个填充侧孔口的填充侧和具有多个分配喷嘴的分配侧，其中多个微通道中的两个或更多个装载有不同的感测材料并且其中多个分配喷嘴的位置与空间布置相匹配。多个分配喷嘴与多个传感器结构对准，并且多个分配喷嘴被致动以将不同的传感材料沉积在多个传感器结构上。

44. 发明授权

US09078956B2 Modification of biomedical polymers for prevention of fouling and clotting 有权
标题翻译：改进生物医学聚合物，防止结垢和凝结
公开(公告)号：US09078956B2
公开(公告)日：2015-07-14
申请号：US13935526
申请日：2013-07-04
申请人： Econous Systems Inc.
发明人： Michael Thompson , Sonia Sheikh , Jack Chih-Chieh Sheng , Christophe Blaszykowski , Kiril Fedorov
IPC分类号： A61L33/00 , G01N29/02 , G01N29/036
CPC分类号： A61L33/0082 , C07B2200/11 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： A surface-modified polymer is described, comprising a polymeric material and a self-assembling monolayer covalently bound thereto. The monolayer comprises monoethylene glycolated-OH (MEG-OH); 2-(3-trichlorosilyl-propyloxy)-ethyl-trifluoroacetate (7-OEG or MEG-TFA); 2,2,2-trifluoroethyl-13-trichlorosilyl-tridecanoate (TTTA); OEGylated TTTA (OEG-TTTA); S-(2-(2-(2-(3-trichlorosilyl-propyloxy)-ethoxy)-ethoxy)-ethyl)-benzenethiosulfonate (OEG-TUBTS); or a combination thereof. Methods are described for forming a surface-modified polymer by surface activation, such as with plasma. By utilizing the surface-modified polymer to make medical equipment or devices for contacting biological fluids, a reduction in surface fouling and thrombus formation can result. Advantageously, polymeric equipment or components so modified may have a reduction in unwanted chemical interactions leading to fouling or clotting. Short trichlorosilane surface modifiers allow films to be deposited onto poly(ethylene terephthalate), polycarbonate, polypropylene, polyvinyl chloride, polyurethane, and other polymers activated using plasma.
摘要翻译：描述了表面改性的聚合物，其包含聚合物材料和与其共价结合的自组装单层。单层包括单乙基甘氨酸-OH（MEG-OH）; 2-（3-三氯甲硅烷基 - 丙氧基） - 乙基 - 三氟乙酸盐（7-OEG或MEG-TFA）; 2,2,2-三氟乙基-13-三氯甲硅烷基十三酸酯（TTTA）; OEG化TTTA（OEG-TTTA）; （2-（2-（2-（3-三氯甲硅烷基 - 丙氧基） - 乙氧基） - 乙氧基） - 乙基） - 苯硫代磺酸酯（OEG-TUBTS）; 或其组合。描述了通过表面活化形成表面改性聚合物的方法，例如用等离子体。通过利用表面改性聚合物制造用于接触生物流体的医疗设备或装置，可能导致表面结垢减少和血栓形成。有利的是，如此改性的聚合物设备或组分可能导致不想要的化学相互作用的减少，导致结垢或凝结。短三氯硅烷表面改性剂使薄膜沉积在聚（对苯二甲酸乙二醇酯），聚碳酸酯，聚丙烯，聚氯乙烯，聚氨酯和其他使用等离子体活化的聚合物上。

45. 发明授权

US09023283B2 Resonant type mass sensor 有权
标题翻译：谐振式质量传感器
公开(公告)号：US09023283B2
公开(公告)日：2015-05-05
申请号：US14081573
申请日：2013-11-15
申请人： Incorporated National University Iwate University
发明人： Masaki Yamaguchi
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N19/00
CPC分类号： G01N19/00 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , Y10T436/11
摘要： A separate excitation and high sensitive resonant type mass sensor is provided. The resonant type mass sensor 1 includes: an oscillator 3; an vibrator 2 placed on the oscillator 3; and a detecting unit 5 for detecting the resonant frequency of the vibrator 2, and is characterized in that the vibrator 2 and the oscillator 3 are not coupled mechanically and that the vibrator 2 is not mechanically coupled to any members. The vibration of the vibrator 2 is represented by a standing wave. The vibrator 2 includes a molecular recognition means for recognizing the molecules of a substance to be measured. The molecular recognition means may collect specific molecules by antigen-antibody reaction. The vibrator 2 may include at least a magnetizable part. To the magnetizable part, magnetic beads 26, to which an antibody or antigen is immobilized, may be adsorbed magnetically. The detecting unit 5 is made up of a light-emitting device and a photo-sensitive device, and may include a means to detect any one of frequency, displacement, velocity, and acceleration.
摘要翻译：提供单独的激发和高灵敏度共振型质量传感器。谐振型质量传感器1包括：振荡器3; 放置在振荡器3上的振动器2; 以及用于检测振动器2的谐振频率的检测单元5，其特征在于振动器2和振荡器3没有机械耦合，并且振动器2没有机械耦合到任何构件。振动器2的振动由驻波表示。振动器2包括用于识别待测物质的分子的分子识别装置。分子识别方法可以通过抗原 - 抗体反应收集特定的分子。振动器2可以至少包括可磁化部分。对于可磁化部分，可以磁性吸附抗体或抗原固定于其上的磁珠26。检测单元5由发光装置和感光装置构成，并且可以包括检测频率，位移，速度和加速度中的任何一种的装置。

46. 发明授权

US08997557B2 Device and method for carrying out measurements of an analysis fluid 有权
标题翻译：用于进行分析流体测量的装置和方法
公开(公告)号：US08997557B2
公开(公告)日：2015-04-07
申请号：US13000006
申请日：2009-06-19
申请人： Frank Gehring
发明人： Frank Gehring
IPC分类号： G01N29/00 , G01N29/036 , G01N29/02 , G01N29/22
CPC分类号： G01N29/036 , G01N29/022 , G01N29/222 , G01N2291/014 , G01N2291/0255 , G01N2291/0256
摘要： The invention relates to an apparatus (10) for carrying out measurements of a analyte fluid having a housing (12, 18), a measurement chamber (40) arranged in the housing (18), a resonator (16, 34) and conduits (42, 44) for inputting and outputting media for the measurements into/out of the measurement chamber (40), wherein the resonators (16, 34) delimit the measurement chamber (40) in areas. The invention distinguishes thereby that two resonators (16, 34) are provided which delimit the measurements chamber (40) each.
摘要翻译：本发明涉及一种用于对具有壳体（12,18）的分析物流进行测量的设备（10），布置在壳体（18）中的测量室（40），谐振器（16,34）和导管 42,44），用于输入和输出测量进出测量室（40）的介质，其中所述谐振器（16,34）在区域中限定测量室（40）。本发明区别于此，提供了分别限定测量室（40）的两个谐振器（16,34）。

47. 发明申请

US20150065394A1 SENSOR, DETECTION METHOD, DETECTION SYSTEM, AND DETECTION DEVICE 有权
标题翻译：传感器，检测方法，检测系统和检测装置
公开(公告)号：US20150065394A1
公开(公告)日：2015-03-05
申请号：US14389745
申请日：2013-03-29
申请人： KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION , KYOCERA Corporation
发明人： Shinsuke Sando , Hideharu Kurioka
IPC分类号： G01N33/543 , G01N29/22 , G01N29/02
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/222 , G01N33/54306 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423
摘要： In an aspect, a sensor includes a combining portion that combines with a second substance having a molecular weight larger than a molecular weight of a first substance. Further, in an aspect, the sensor includes a substrate including a surface on which the combining portion is disposed. The combining portion detects whether or not the first substance is included in an analyte that has come into contact with both an aptamer and the second substance. The aptamer includes a first combining part for the first substance and a second combining part for the second substance and is combined with either of the first substance and the second substance.
摘要翻译：一方面，传感器包括与分子量大于第一物质的分子量的第二物质组合的组合部分。此外，在一方面，传感器包括包括其上配置有组合部分的表面的基板。组合部分检测第一物质是否包含在与适体和第二物质接触的分析物中。适体包括用于第一物质的第一组合部分和用于第二物质的第二组合部分，并与第一物质和第二物质中的任一物质组合。

48. 发明授权

US08960004B2 Synchronous one-pole surface acoustic wave resonator 有权
标题翻译：同步单极表面声波谐振器
公开(公告)号：US08960004B2
公开(公告)日：2015-02-24
申请号：US13075088
申请日：2011-03-29
申请人： Mona E. Zaghloul , Hsu-Cheng Ou
发明人： Mona E. Zaghloul , Hsu-Cheng Ou
IPC分类号： G01N29/12 , G01N29/02 , G01N29/036 , H03H9/64
CPC分类号： G01N29/022 , G01N29/036 , G01N2291/0256 , G01N2291/0423 , H03H9/6476
摘要： A surface acoustic wave resonator including an input interdigital transducer (IDT), an output IDT, and a pair of gratings with each being spaced from each other by a predetermined distance and attached to a substrate. In at least one embodiment, the distance is equal to one-half of the wavelength of the acoustic wave produced by the input IDT. In a further embodiment, the surface acoustic wave further includes a polymer layer and a biomedical coating covering at least a part of the polymer layer. The surface acoustic wave resonator has uses in the mass sensor and communications fields.
摘要翻译：一种表面声波谐振器，其包括输入叉指式换能器（IDT），输出IDT和一对光栅，每个光栅彼此间隔开预定距离并附着于基板。在至少一个实施例中，距离等于由输入IDT产生的声波的波长的一半。在另一个实施方案中，表面声波还包括聚合物层和覆盖聚合物层的至少一部分的生物医学涂层。表面声波谐振器在质量传感器和通信领域具有应用。

49. 发明申请

US20140260566A1 DEVICE AND METHODS OF USING A PIEZOELECTRIC MICROBALANCE SENSOR 有权
公开(公告)号：US20140260566A1
公开(公告)日：2014-09-18
申请号：US13803027
申请日：2013-03-14
申请人： ECOLAB USA INC.
发明人： Arthur J Kahaian , Dmitri L Kouznetsov , John E Hoots , Rodney H Banks , David Ambrose
IPC分类号： G01N33/18
CPC分类号： G01N5/02 , G01N17/008 , G01N29/022 , G01N29/2443 , G01N2291/0256 , G01N2291/0258 , G01N2291/0426
摘要： Methods for monitoring scale deposition in a water-containing industrial process are disclosed. In certain embodiments, the water-containing industrial process is an aqueous cooling system. In certain embodiments, the methods incorporate fluorometric monitoring and control techniques along with a piezoelectric microbalance sensor. A particular embodiment of a piezoelectric microbalance sensor is additionally disclosed, along with at least one method for using the particular embodiment that is independent of whether fluorometric monitoring and control techniques are utilized.

50. 发明申请

US20140224002A1 BIOSENSOR 有权
标题翻译：生物传感器
公开(公告)号：US20140224002A1
公开(公告)日：2014-08-14
申请号：US14123752
申请日：2012-07-30
申请人： Atsuomi Fukuura , Toru Fukano , Yuji Kishida , Hiroyasu Tanaka , Hideharu Kurioka
发明人： Atsuomi Fukuura , Toru Fukano , Yuji Kishida , Hiroyasu Tanaka , Hideharu Kurioka
IPC分类号： G01N29/02
CPC分类号： G01N29/02 , G01N29/022 , G01N29/222 , G01N33/48707 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423
摘要： To provide a biosensor including a suctioning mechanism while using a detection element such as a surface acoustic wave device, included are: a first cover member 1 including an element-accommodating recess 5 on an upper face thereof; a detection element 3 including an element substrate 10, and at least one detection unit 13 located on the upper face of the element substrate 10 to perform detection of an analyte; and a second cover member 2 joined to the first cover member 1 and covering the detection element 3, and including an inflow port 14 from which the analyte flows in and a groove 15 extending from the inflow port 14 to at least above the detection unit.
摘要翻译：在提供包括吸声机构的生物传感器的同时，使用诸如表面声波装置的检测元件包括：第一盖构件1，其包括在其上表面上的元件容纳凹部5; 包括元件基板10的检测元件3和位于元件基板10的上表面上的至少一个检测单元13，以执行分析物的检测; 以及与第一盖构件1接合并覆盖检测元件3的第二盖构件2，并且包括被分析物流入的流入口14和从流入口14延伸到至少在检测单元上方的槽15。

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