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41. 发明授权

US07660449B2 Automated method for image analysis of residual protein 失效
标题翻译：残留蛋白图像分析自动化方法
公开(公告)号：US07660449B2
公开(公告)日：2010-02-09
申请号：US12102665
申请日：2008-04-14
申请人： Presley Hays , Michal L. Peri , Douglas Harrington
发明人： Presley Hays , Michal L. Peri , Douglas Harrington
IPC分类号： G06K9/00
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method for measuring residual protein in a cellular specimen including obtaining a low magnification image of a candidate object of interest, filtering the candidate object of interest pixels with a low pass filter, morphologically processing the candidate object of interest pixels to identify artifact pixels, identifying the candidate object of interest by eliminating artifact pixels, acquiring a higher magnification image of the subsample for the candidate object of interest, transforming pixels of the higher magnification image in a first color space to a second color space to differentiate higher magnification candidate object of interest pixels from background pixels, identifying an object of interest from the candidate object of interest pixels in the second color space, and determining the optical density of the protein in a cell contained in a subsample, wherein the optical density is indicative of the residual component of a cellular protein.
摘要翻译：一种用于测量细胞样本中残留蛋白质的方法，包括获得感兴趣的候选对象的低倍率图像，利用低通滤波器过滤候选对象像素，在形态上处理候选对象像素以识别伪像，识别通过消除伪影像素来获取所述候选对象，获取用于所述候选对象的子样本的较高放大图像，将第一颜色空间中的较高倍率图像的像素变换为第二颜色空间，以区分感兴趣的较高倍率候选对象从背景像素的像素，从第二颜色空间中的候选对象像素识别感兴趣的对象，以及确定子样本中包含的细胞中的蛋白质的光密度，其中光密度指示残留分量细胞蛋白。

42. 发明申请

US20090287421A1 Enhancing Flow Cytometry Discrimination with Geometric Transformation 有权
标题翻译：用几何变换增强流式细胞术鉴别
公开(公告)号：US20090287421A1
公开(公告)日：2009-11-19
申请号：US11632870
申请日：2005-07-27
申请人： George C Malachowski , Paul Barclay Purcell , Edward Allan Stanton
发明人： George C Malachowski , Paul Barclay Purcell , Edward Allan Stanton
IPC分类号： G01N15/00 , G06F19/00
CPC分类号： G01N15/1429 , G01N15/1436 , G01N15/1468 , G01N15/1475 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149
摘要： In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.
摘要翻译：在流式细胞术中，可以通过组合可以从颗粒的信号数据导出的n维参数数据，以数学方式获得代表变化的数值结果（48）来区分粒子（2）（8）。改变可能包括旋转改变，缩放变化，或甚至翻译改变。改变可以增强数据点的分离，其可以将对应于各个粒子的信号数据实时分类（49）到至少两个群体之一中。

43. 发明申请

US20090060303A1 METHOD AND APPARATUS FOR AUTOMATED IMAGE ANALYSIS OF BIOLOGICAL SPECIMENS 有权
标题翻译：用于生物样本自动图像分析的方法和装置
公开(公告)号：US20090060303A1
公开(公告)日：2009-03-05
申请号：US12201800
申请日：2008-08-29
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
摘要翻译：一种方法，包括在多个不同焦点位置获取医疗幻灯片的图像，确定相对于像素值平均值产生像素值的最大值的位置，其中所述确定包括使用像素值均值作为粗略焦点的粗略估计位置，随后精炼所述粗焦点位置以找到精细对焦位置，并且其中所述精炼包括拟合到多项式，并且使用多项式的指定部分作为焦点位置的精细估计，并且产生聚焦控制信号与所述最大值有关以控制焦点位置。

44. 发明授权

US07468796B2 Multiple-color monochromatic light absorption and quantification of light absorption in a stained sample 有权
标题翻译：多色单色光吸收和定量染色样品中的光吸收
公开(公告)号：US07468796B2
公开(公告)日：2008-12-23
申请号：US11200524
申请日：2005-08-08
申请人： Edgar A. Luther , Bruce Miller
发明人： Edgar A. Luther , Bruce Miller
IPC分类号： G01J3/51
CPC分类号： G01N21/31 , G01N15/0625 , G01N15/1434 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N2015/0065
摘要： An absorption detection system is provided. The system includes a plurality of monochromatic light sources and a separator for separating the light from the plurality of monochromatic light sources into a plurality of wavelengths. A plurality of detectors, receives light of a single wavelength to measure absorption of light in a biological sample.
摘要翻译：提供吸收检测系统。该系统包括多个单色光源和用于将来自多个单色光源的光分离成多个波长的分离器。多个检测器接收单个波长的光以测量生物样品中的光的吸收。

45. 发明申请

US20080258061A1 METHOD AND APPARATUS FOR AUTOMATED IMAGE ANALYSIS OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：用于生物样本自动图像分析的方法和装置
公开(公告)号：US20080258061A1
公开(公告)日：2008-10-23
申请号：US12102667
申请日：2008-04-14
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G01N23/04
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： An electronic microscope system including a processor, a movable stage movable in two orthogonal directions under control of the processor, the movable stage including at least one part that determines a current position of the movable stage, a microscope part, which magnifies a sample on the movable stage, an electronic camera part, which obtains an image of a magnified sample at a specified position controlled by the movable stage, and at least one vibration isolation mount, coupled to the stage and isolating vibration between the movable stage and the microscope part.
摘要翻译：一种电子显微镜系统，包括处理器，可在所述处理器的控制下在两个正交方向上移动的可移动台，所述可移动台包括确定所述可移动台的当前位置的至少一个部分，所述可移动台将所述可移动台上的样本放大可移动台，电子照相机部件，其获得由可移动台控制的指定位置处的放大样本的图像;以及至少一个隔离支架，耦合到该台并隔离可移动台与显微镜部件之间的振动。

46. 发明授权

US07361472B2 Methods for providing extended dynamic range in analyte assays 失效
标题翻译：在分析物测定中提供扩展动态范围的方法
公开(公告)号：US07361472B2
公开(公告)日：2008-04-22
申请号：US10084844
申请日：2002-02-25
申请人： Juan Yguerabide , Evangelina Yguerabide , Laurence Warden , Todd Peterson
发明人： Juan Yguerabide , Evangelina Yguerabide , Laurence Warden , Todd Peterson
IPC分类号： G01N33/53
CPC分类号： G01N15/1468 , C12Q1/6816 , G01N21/47 , G01N2021/6439 , C12Q2565/501 , C12Q2563/137
摘要： Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in detection technique and/or signal processing to extend the dynamic range to either or both of lower and higher concentrations.
摘要翻译：在使用散射光可检测的颗粒标签的测定中增强特异性检测一种或多种分析物的动态范围的方法。所述方法涉及利用检测技术和/或信号处理中的变化来将动态范围扩展到较低和较高浓度中的一个或两者。

47. 发明授权

US07359548B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US07359548B2
公开(公告)日：2008-04-15
申请号：US11594374
申请日：2006-11-07
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K9/00 , G09G5/02 , H04N9/73
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后将色彩空间转换的图像进行低通滤波，并将其与阈值进行比较，以从彩色转换图像的候选对象像素中去除伪影和背景对象。候选对象像素被形态地处理以将候选对象对象像素组合成为与斑点参数进行比较的组，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。以与低倍率图像相同的方式分析高倍率图像，以确认作为感兴趣对象的感兴趣的候选对象。存储每个确认的感兴趣对象的高放大图像以供病理学家进行后续检查和评估。

48. 发明授权

US07359536B2 Automated method for image analysis of residual protein 有权
标题翻译：残留蛋白图像分析自动化方法
公开(公告)号：US07359536B2
公开(公告)日：2008-04-15
申请号：US10728698
申请日：2003-12-05
申请人： Presley Hays , Michal L. Peri , Douglas Harrington
发明人： Presley Hays , Michal L. Peri , Douglas Harrington
IPC分类号： G06K9/00
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： An automated method for evaluating the amount of residual protein levels following treatment of cellular specimens. Particular methods include the measurement of maternal neutrophil alkaline phosphatase after treatment with or without urea or heat, measurement of leukocyte acid phosphatase after treatment with or without tartrate, and measurement of leukocyte esterase after treatment with α-naphthol butyrate with or without fluoride.
摘要翻译：一种用于评估细胞标本治疗后残留蛋白质水平的自动化方法。具体方法包括用或不用尿素或加热处理后测量母体嗜中性粒细胞碱性磷酸酶，用或不用酒石酸盐处理后测量白细胞酸性磷酸酶，以及在用或不含氟化物的α-萘酚丁酸酯处理后测定白细胞酯酶。

49. 发明申请

US20080013168A1 CYTOLOGICAL IMAGING SYSTEMS AND METHODS 有权
公开(公告)号：US20080013168A1
公开(公告)日：2008-01-17
申请号：US11861230
申请日：2007-09-25
申请人： Garrick Maenle , William Knox , David Zahniser
发明人： Garrick Maenle , William Knox , David Zahniser
IPC分类号： G02B21/00
CPC分类号： G01N1/30 , G01N15/1012 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/3151 , G01N2015/1006 , G01N2015/1472 , G01N2015/1488 , G02B21/0016 , G02B21/32 , G02B21/34 , G06K9/00134 , G06T7/0012 , G06T7/73 , G06T2207/30024
摘要： The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imaging system and methods for accommodating vibration in the imaging system. In particular, the methods and apparatus may be applied to the automated analysis of cytological specimen slides.

50. 发明申请

US20070166770A1 Novel immunocytostaining methods for enhanced dye ratio discrimination in rare event detection 有权
标题翻译：用于在罕见事件检测中增强染料比率鉴别的新型免疫细胞染色方法
公开(公告)号：US20070166770A1
公开(公告)日：2007-07-19
申请号：US11333731
申请日：2006-01-17
申请人： Huangpin Hsieh , Nicole Lazarus , Robert Krivacic , Douglas Curry , Richard Bruce
发明人： Huangpin Hsieh , Nicole Lazarus , Robert Krivacic , Douglas Curry , Richard Bruce
IPC分类号： G01N33/567
CPC分类号： G01N1/30 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/56966 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 μm or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.
摘要翻译：提供了一种制备包含潜在感兴趣的细胞的样品并使用基于激光的系统的激光进行新颖的激发和发射采集以及数据使用的方法，包括使用获得的数据进行直接和基于比率的测量。所制备的样品被配置为发射具有足够的光谱特性的信号，以在使用具有1至20μm或更大直径范围的激光光斑的成像系统中进行滤光以区分并消除所获得的成像事件之间的真阳性的大多数假阳性并以常规或新颖的方式激发荧光。这些过滤的事件可以随后在较短的时间内用另一种较高分辨率的装置例如荧光显微镜进行成像和证实。

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