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    • 42. 发明申请
    • METHOD FOR THE PREPARATION OF 1,3-PROPANEDIOL FROM SUCROSE
    • 从苏木糖制备1,3-丙二醇的方法
    • US20130309737A1
    • 2013-11-21
    • US13808251
    • 2011-07-05
    • Philippe SoucailleCedric Boisart
    • Philippe SoucailleCedric Boisart
    • C12P7/18
    • C12P7/18C12N1/20C12N9/1096C12N15/52C12Y101/01021C12Y206/01052C12Y401/01001Y02E50/17
    • The present invention concerns a microorganism genetically modified for the bioproduction of 1,3-propanediol from sucrose, wherein the microorganism comprises: a two-step metabolic pathway for the production of 1,3-propanediol, comprising a first step of decarboxylation of 4-hydroxy-2-ketobutyrate with an enzyme having a 2-keto acid decarboxylase activity, and a second step of reduction of the obtained 3 -hydroxypropionaldehyde with an enzyme having hydroxy aldehyde reductase activity, and genes enabling the microorganism to utilize sucrose as sole carbon source. The invention also concerns a new method for the biological preparation of 1,3-propanediol by fermentation, comprising cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium comprising a source of sucrose, and recovering the 1,3 -propanediol being produced. In a preferred aspect of the invention, the source of sucrose is obtained from plant biomass.
    • 本发明涉及一种遗传修饰用于从蔗糖生物制造1,3-丙二醇的微生物,其中微生物包括:用于生产1,3-丙二醇的两步代谢途径,其包括第一步脱羧化4- 具有2-酮酸脱羧酶活性的酶的2-羟基-2-酮丁酸酯,以及使用具有羟基醛还原酶活性的酶还原所得3-羟基丙醛的第二步骤,以及使微生物能够利用蔗糖作为唯一碳源的基因 。 本发明还涉及通过发酵生物制备1,3-丙二醇的新方法,包括培养所述经遗传修饰的微生物,其中培养在包含蔗糖源的合适培养基中进行,并回收1,3-丙二醇 正在生产。 在本发明的优选方面,蔗糖源由植物生物量获得。