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41. 发明授权

US08617904B2 Sperm cell processing methods 有权
标题翻译：精子细胞加工方法
公开(公告)号：US08617904B2
公开(公告)日：2013-12-31
申请号：US13776294
申请日：2013-02-25
申请人： Inguran, LLC
发明人： Gary Durack , Muhammad Anzar , Cindy Ludwig , Jeffrey A. Graham , Kathleen S. Crowley , Bradley Didion
IPC分类号： G01N1/18 , C12N5/076 , G01N33/48
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A method of processing animal sperm cells that includes: collecting sperm cells from a male animal; sorting the sperm cells to obtain a quantity of sperm cells having a desired characteristic, the quantity of sorted sperm cells being contained in a first volume of fluid having a first concentration of sperm cells; and subjecting the sperm cells to concentration steps in which the concentration of the sperm cells is increased to a second concentration greater than the first concentration.
摘要翻译：一种处理动物精子细胞的方法，包括：从雄性动物收集精子细胞; 分选精子细胞以获得一定数量的具有所需特征的精细胞，分选精子细胞的数量被包含在具有第一精子细胞浓度的第一体积的流体中; 并使精子细胞进行浓缩步骤，其中精子细胞的浓度增加到大于第一浓度的第二浓度。

42. 发明申请

US20130330707A1 METHOD AND APPARATUS FOR DOSING AND SUPPLY OF NUTRIENTS DERIVED FROM DEWATERING PROCESSES 审中-公开
标题翻译：从排水过程中排出和供应营养物质的方法和装置
公开(公告)号：US20130330707A1
公开(公告)日：2013-12-12
申请号：US13651605
申请日：2012-10-15
申请人： AFS BIOOIL CO.
发明人： Oleg Krifuks , Vadim Krifuks
IPC分类号： C12Q3/00
CPC分类号： C12Q3/00 , C12M41/48 , C12M47/08 , C12N1/00
摘要： A method and apparatus to combine the dewatering filtrate, biomass, and nutrients into a single stream for ease of homogenization, and then separate the products and feeds to be reused. The system comprises of an automated control system which monitors the nutrient levels in the effluent in real time, as well as the current levels within the biomass, an ultrasonic wave generator for homogenization, and a centrifuge for separation of the useful products. The method and automated control are a result of thorough analysis and research in the area of microorganism cultivation in a variety of phototrophic, heterotrophic, and hybrid bioreactors. By combining waste effluent with process streams in a bio facility, the electrical and chemical demands of a treatment step are negated.
摘要翻译：将脱水滤液，生物质和营养物质组合成单一流以便于均化的方法和装置，然后分离待再利用的产物和饲料。该系统包括自动化控制系统，其实时监测流出物中的营养物质水平，以及生物质内的当前水平，用于均化的超声波发生器和用于分离有用产物的离心机。该方法和自动化控制是在各种光养，异养和混合生物反应器中微生物培养领域的全面分析和研究的结果。通过将废物流出物与生物设备中的工艺流相结合，处理步骤的电化学需求被否定。

43. 发明申请

US20130224786A1 FLOW CYTOMETER APPARATUS AND METHOD 有权
标题翻译：流量计仪器和方法
公开(公告)号：US20130224786A1
公开(公告)日：2013-08-29
申请号：US13782417
申请日：2013-03-01
申请人： INGURAN, LLC
发明人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
IPC分类号： C12N5/071
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles.
摘要翻译：一种用于根据一种或多种颗粒特性分级颗粒的多通道装置。该装置包括多个流式细胞术单元，每个流式细胞术单元可操作以通过用电磁辐射束询问含有颗粒的流体流来分类颗粒混合物中的颗粒。流式细胞术单元共享包括以下至少一个的综合平台：（1）通常的颗粒供应; （2）共同住房; （3）用于控制单元的操作的通用处理器; （4）用于从各单元接收和处理信息的通用处理器; 和（5）普通流体输送系统。集成平台可以包括电磁辐射的共同来源。本发明的方法包括使用共享整合平台的多个流式细胞仪单元来进行诸如分析或分选颗粒的流量计操作。

44. 发明申请

US20130224726A1 METHOD AND APPARATUS FOR CALIBRATING A FLOW CYTOMETER 有权
标题翻译：用于校准流量计的方法和装置
公开(公告)号：US20130224726A1
公开(公告)日：2013-08-29
申请号：US13762003
申请日：2013-02-07
申请人： INGURAN, LLC
发明人： Gary Durack , Jeffrey D. Wallace , Gary P. Vandre , Lon A. Westfall , Jeremy T. Hatcher , Niraj V. Nayak
IPC分类号： C12N5/071
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles.
摘要翻译：一种用于根据一种或多种颗粒特性分级颗粒的多通道装置。该装置包括多个流式细胞术单元，每个流式细胞术单元可操作以通过用电磁辐射束询问含有颗粒的流体流来分类颗粒混合物中的颗粒。流式细胞术单元共享包括以下至少一个的综合平台：（1）通常的颗粒供应; （2）共同住房; （3）用于控制单元的操作的通用处理器; （4）用于从各单元接收和处理信息的通用处理器; 和（5）普通流体输送系统。集成平台可以包括电磁辐射的共同来源。本发明的方法包括使用共享整合平台的多个流式细胞仪单元来进行诸如分析或分选颗粒的流量计操作。

45. 发明申请

US20130224725A1 METHODS FOR PROCESSING SPERM CELLS 有权
标题翻译：处理细胞的方法
公开(公告)号：US20130224725A1
公开(公告)日：2013-08-29
申请号：US13782469
申请日：2013-03-01
申请人： Inguran, LLC
发明人： Gary Durack , Anzar Muhammad , Cynthia L. Ludwig , Jeffrey A. Graham , Kathleen S. Crowley , Bradley Didion
IPC分类号： A01N1/02
CPC分类号： C12N5/0612 , A01N1/0284 , C12N5/06 , C12N5/061 , C12Q1/02 , C12Q3/00 , G01N15/1468 , G01N15/147 , G01N21/63 , G01N21/6428 , G01N33/48 , G01N33/5005 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , Y10T436/10 , Y10T436/115831 , Y10T436/12 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles.
摘要翻译：一种用于根据一种或多种颗粒特性分级颗粒的多通道装置。该装置包括多个流式细胞术单元，每个流式细胞术单元可操作以通过用电磁辐射束询问含有颗粒的流体流来分类颗粒混合物中的颗粒。流式细胞术单元共享包括以下至少一个的综合平台：（1）通常的颗粒供应; （2）共同住房; （3）用于控制单元的操作的通用处理器; （4）用于从各单元接收和处理信息的通用处理器; 和（5）普通流体输送系统。集成平台可以包括电磁辐射的共同来源。本发明的方法包括使用共享整合平台的多个流式细胞仪单元来进行诸如分析或分选颗粒的流量计操作。

46. 发明申请

US20130196422A1 SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS 有权
公开(公告)号：US20130196422A1
公开(公告)日：2013-08-01
申请号：US13747834
申请日：2013-01-23
申请人： Beckman Coulter, Inc.
发明人： Brian D. WILSON , Matthew S. DAVIS , Matthew D. ERICKSON , Alan N. JOHNSON , Garrick A. MAURER , Daniel R. SCHMIDT , Joshua D. WILTSIE
IPC分类号： C12Q1/68
CPC分类号： G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
摘要： Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

47. 发明申请

US20130143313A1 SEPARATIVE HARVESTING DEVICE 审中-公开
标题翻译：分离式收藏设备
公开(公告)号：US20130143313A1
公开(公告)日：2013-06-06
申请号：US13754167
申请日：2013-01-30
申请人： Sarfaraz K. Niazi
发明人： Sarfaraz K. Niazi
IPC分类号： C12M1/00
CPC分类号： F24F7/06 , C12M23/14 , C12M25/14 , C12M27/16 , C12M29/06 , C12M41/32 , C12M47/10 , C12Q3/00 , Y10T137/0318
摘要： A harvesting device for capturing a biological product directly by binding the secreted biological product with a resin, discarding the nutrient medium and eluting the biological product as a concentrated solution, eliminating the steps of sterile filtration and volume reduction, thus allowing one to combine the steps of recombinant expression and separation of a biological product. The method allows loading of resin for column-purification, eliminating all steps of perfusion process and maintaining a sink condition of a toxic product in nutrient medium to optimize productivity of host cells. The instant invention also allows harvesting of solubilized inclusion bodies after the cells have been lysed and refolding of proteins inside the bioreactor.
摘要翻译：一种用于通过将分泌的生物制品与树脂结合而直接捕获生物制品的收获装置，废弃营养培养基并以生物产物作为浓缩溶液洗脱，消除了无菌过滤和体积减少的步骤，从而允许将步骤重组表达和分离生物制品。该方法允许加载用于柱纯化的树脂，消除灌注过程的所有步骤并保持营养培养基中有毒产物的沉淀条件以优化宿主细胞的生产力。本发明还允许在细胞已经裂解并在生物反应器内重新折叠蛋白质之前收获溶解的包涵体。

48. 发明申请

US20130137110A1 SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS 有权
公开(公告)号：US20130137110A1
公开(公告)日：2013-05-30
申请号：US13747888
申请日：2013-01-23
申请人： Beckman Coulter, Inc.
发明人： Charles S. KRAIHANZEL
IPC分类号： C12Q1/68
CPC分类号： G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
摘要： Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

49. 发明授权

US08440452B2 Integrated bio-reactor monitor and control system 有权
公开(公告)号：US08440452B2
公开(公告)日：2013-05-14
申请号：US13235241
申请日：2011-09-16
申请人： Larry Eugene West
发明人： Larry Eugene West
IPC分类号： G05B21/00
CPC分类号： C12M41/48 , C12Q3/00 , G05B15/02 , G05D21/02
摘要： Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. A sensor system interacts with the bioreactor to receive information related to a condition of the bioreactor and/or receive a sample from the bioreactor, which it analyzes. The sensor system sends data signals related to the information and/or the sample to a controller, which determines a control signal based on the received information. The controller sends the control signal to the sensor system which, based on the control signal, performs an action that affects a condition of the bioreactor or affects the sensor system itself.

50. 发明申请

US20130078610A1 METHOD AND SYSTEM FOR THERMAL CYCLING OF MICROFLUIDIC SAMPLES 有权
标题翻译：微流体样品热循环的方法和系统
公开(公告)号：US20130078610A1
公开(公告)日：2013-03-28
申请号：US13429861
申请日：2012-03-26
申请人： Jake Kimball , Brandon Ripley , Gang Sun , Dominique Toppani , Myo Thu Maung
发明人： Jake Kimball , Brandon Ripley , Gang Sun , Dominique Toppani , Myo Thu Maung
IPC分类号： B01L7/00 , C12Q3/00
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/025 , B01L2200/147 , B01L2300/0819 , B01L2300/0893 , B01L2300/1805 , B01L2300/1822 , C12P19/34 , C12Q3/00 , G01N21/6408 , G01N21/6428 , G01N21/6456 , G01N21/76
摘要： A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25° C.
摘要翻译：用于微流体装置的热循环仪包括控制器，其可操作以提供与散热器热连通的一系列电信号，散热器和加热元件，并可操作以从控制器接收一系列电信号。热循环仪还包括与加热元件热连通的热卡盘。热卡盘包括可操作以与微流体装置进行热接触的加热表面。加热表面的特征在于每秒2.5摄氏度和5.5摄氏度/秒之间的温度升高速率，并且支撑微流体装置的第一部分的加热表面的第一部分与加热表面的第二部分之间的温度差支撑微流体装置的第二部分小于0.25℃

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