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41. 发明申请

US20130210049A1 Polymeric Support With Nanofeatures for Cell Culture 审中-公开
标题翻译：用于细胞培养的纳米聚合物支持
公开(公告)号：US20130210049A1
公开(公告)日：2013-08-15
申请号：US13838882
申请日：2013-03-15
申请人： Melinda LARSEN , Riffard JEAN-GILLES , Sharon SEQUEIRA , David SOSCIA , James CASTRACANE
发明人： Melinda LARSEN , Riffard JEAN-GILLES , Sharon SEQUEIRA , David SOSCIA , James CASTRACANE
IPC分类号： C12N5/071
CPC分类号： C12N5/0633 , C12N5/0068 , C12N2533/40 , C12N2535/00
摘要： The invention provides a cell support device comprising a nanofiber structure disposed on a concave surface of a substrate. and the curvature of the substrate in combination with the nanotopography provided by the nanofiber support provides the necessary environmental cues that promote organization, growth, differentiation and morphogenesis of secretory epithelial cells, such as salivary gland epithelial cells. The nanotopography of the device is influenced by features of the nanofiber structure including nanofiber diameter, pore size, biochemical modification and curvature.
摘要翻译：本发明提供了一种细胞支持装置，其包括设置在基底的凹表面上的纳米纤维结构。并且与由纳米纤维支撑体提供的纳米形态相结合的底物的曲率提供了促进分泌上皮细胞如唾液腺上皮细胞的组织，生长，分化和形态发生的必要环境线索。器件的纳米形貌受到纳米纤维直径，孔径，生物化学改性和曲率等纳米纤维结构特征的影响。

42. 发明申请

US20130156820A1 PRODUCTION METHOD OF TISSUE REGENERATION MATERIAL AND TISSUE REGENERATION MATERIAL 审中-公开
标题翻译：组织再生材料和组织再生材料的生产方法
公开(公告)号：US20130156820A1
公开(公告)日：2013-06-20
申请号：US13710622
申请日：2012-12-11
申请人： GC Corporation
发明人： Katsuyuki YAMANAKA , Katsushi YAMAMOTO , Yuuhiro SAKAI , Yusuke SHIGEMITSU
IPC分类号： A61L27/56
CPC分类号： A61L27/56 , C12M23/04 , C12M25/14 , C12N5/0068 , C12N2533/40
摘要： Provided is a production method of a tissue regeneration material whereby a cell suspension can be seeded and cultured on a porous support having relatively large pores. The method comprises: contacting a porous body to a holding plate having a contact angle to water of 15 to 90°, the porous body being formed of a bioabsorbable polymer material, having a thickness of 2 to 100 mm, an interconnected porous structure with a pore diameter of 180 to 3500 μm and an average pore diameter of 350 to 2000 μm, a porosity of 60 to 95%, and a compressive strength of 0.05 to 1 MPa, and being filled with a cell suspension having a cell density of 5×106 to 1×108 cell/ml; and arranging the holding plate to be on the porous body, and keeping the porous body still, to thereby seed cells on the porous body.
摘要翻译：提供了一种组织再生材料的制造方法，其中可以将细胞悬浮液接种并培养在具有较大孔的多孔载体上。该方法包括：使多孔体与水的接触角为15〜90°的保持板接触，所述多孔体由厚度为2〜100mm的生物可吸收聚合物材料形成，所述多孔体具有与孔径为180〜3500μm，平均孔径为350〜2000μm，孔隙率为60〜95％，抗压强度为0.05〜1MPa，填充有细胞密度为5× 106〜1×108个细胞/ ml; 并且将保持板设置在多孔体上，并且保持多孔体静止，从而将细胞接种在多孔体上。

43. 发明授权

US08357528B2 Microfabricated compositions and processes for engineering tissues containing multiple cell types 有权
标题翻译：包含多种细胞类型的工程组织的微型组合物和方法
公开(公告)号：US08357528B2
公开(公告)日：2013-01-22
申请号：US13156675
申请日：2011-06-09
申请人： Joseph P. Vacanti , Jeffrey T. Borenstein , Eli Weinberg
发明人： Joseph P. Vacanti , Jeffrey T. Borenstein , Eli Weinberg
IPC分类号： C12M1/14
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
摘要翻译：本发明涉及一种三维体系及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔室的通道，并且其中每个隔室可包括不同的细胞类型。

44. 发明申请

US20120329157A1 CELL CONSTRUCT COMPRISING POLYMER BLOCKS HAVING BIOCOMPATIBILITY AND CELLS 有权
标题翻译：包含生物相容性和细胞的聚合物块的细胞构建
公开(公告)号：US20120329157A1
公开(公告)日：2012-12-27
申请号：US13582362
申请日：2011-03-01
申请人： Kentaro Nakamura
发明人： Kentaro Nakamura
IPC分类号： C12N5/071
CPC分类号： A61L27/58 , A61L27/222 , A61L27/38 , C12N5/0068 , C12N2533/40 , C12N2533/76
摘要： It is an object of the present invention to provide a cell three-dimensional construct that has a thickness sufficient for tissue regeneration and comprises cells uniformly distributed therein. The present invention provides a cell construct comprising polymer blocks having biocompatibility and cells, wherein the plural polymer blocks are arranged in spaces between the plural cells.
摘要翻译：本发明的一个目的是提供一种细胞三维结构，其具有足以用于组织再生的厚度并且包括均匀分布于其中的细胞。本发明提供了包含具有生物相容性和细胞的聚合物嵌段的细胞构建体，其中多个聚合物嵌段被布置在多个细胞之间的空间中。

45. 发明申请

US20120329156A1 THREE-DIMENSIONAL SCAFFOLD AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：三维SCAFFOLD及其制造方法
公开(公告)号：US20120329156A1
公开(公告)日：2012-12-27
申请号：US13511188
申请日：2011-03-04
申请人： Dong-Woo Cho , Jong Young Kim , Jin-Hyung Shim
发明人： Dong-Woo Cho , Jong Young Kim , Jin-Hyung Shim
IPC分类号： C12N5/071
CPC分类号： A61L27/40 , A61L27/14 , A61L27/52 , A61L27/56 , C12M25/14 , C12N5/0068 , C12N2533/40 , C12N2533/54 , C12N2533/80
摘要： A scaffold having a reinforced tissue regeneration ability and a method of manufacturing the same are provided. The scaffold is formed in a lattice form by alternately stacking biodegradable synthetic polymer-hydrogel layers. In this case, the biodegradable synthetic polymer-hydrogel layer is formed by disposing a plurality of biodegradable synthetic polymer-hydrogel units including a biodegradable synthetic polymer and a hydrogel at a predetermined gap.
摘要翻译：提供了具有增强组织再生能力的支架及其制造方法。通过交替堆叠可生物降解的合成聚合物 - 水凝胶层，以格子形式形成支架。在这种情况下，可生物降解的合成聚合物 - 水凝胶层通过以预定间隙设置包括可生物降解的合成聚合物和水凝胶的多个可生物降解的合成聚合物 - 水凝胶单元而形成。

46. 发明授权

US08338402B2 Scaffold 有权
标题翻译：脚手架
公开(公告)号：US08338402B2
公开(公告)日：2012-12-25
申请号：US12300636
申请日：2007-05-10
申请人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhern , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
发明人： Nicholas Fry , Anthony Dagger , David Morsley , Helene Lecomte , Roy Trayhern , Mark Howard , Sarah Freestone , Brian Thomson , Mark Smith , Rebecca Crallan
IPC分类号： A61K31/585 , A61K31/19 , A61L15/00 , C08G63/08
CPC分类号： C12N5/0068 , A61F13/00068 , C12N2533/40
摘要： The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibers having a mean fiber diameter of between from about 1.2 to 4.0 microns, wherein the fibers comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material.
摘要翻译：本发明涉及可用作导向组织再生和修复的医疗装置的支架，特别是本发明涉及包含平均纤维直径在约1.2至4.0微米之间的纤维的支架，其中纤维包含乙交酯。本发明还涉及支架用于选择性捕获细胞源材料的细胞群体的用途。

47. 发明申请

US20120313284A1 METHODS OF MANUFACTURING BIOMATERIALS WITH MICROSPHERE GRADIENTS 有权
标题翻译：用微生物梯度制备生物材料的方法
公开(公告)号：US20120313284A1
公开(公告)日：2012-12-13
申请号：US13591087
申请日：2012-08-21
申请人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
发明人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
IPC分类号： B29C67/20
CPC分类号： C12N5/0075 , C12N2533/10 , C12N2533/40
摘要： Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
摘要翻译：方法可以制备组织工程支架，其包括连接在一起的多个生物相容性微球体以形成三维基质。基质可以包括用于生长细胞的多个孔。生物相容性微球可以包括第一组和第二组微球。第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。第二组微球可以具有不同于第一特性的第二特性，以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性，刚度，颜色，辐射透明度，无线电等等。

48. 发明申请

US20120282573A1 TOOTH SCAFFOLDS 有权
标题翻译：牙齿痉挛
公开(公告)号：US20120282573A1
公开(公告)日：2012-11-08
申请号：US13378789
申请日：2010-06-17
申请人： Jeremy J. Mao
发明人： Jeremy J. Mao
IPC分类号： A61C13/08
CPC分类号： A61L27/48 , A61C8/0036 , A61K35/12 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/622 , A61L2430/12 , C12N5/0654 , C12N2501/155 , C12N2501/21 , C12N2533/18 , C12N2533/40 , C12N2533/54 , C08L67/04
摘要： Provided is an acellular mammalian tooth-shaped scaffold comprising a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.
摘要翻译：提供了一种无细胞哺乳动物的牙齿支架，其包含具有趋化性，成骨，牙质发生，萌生或成骨的化合物。还提供了一种替代牙齿不存在的口腔中的牙齿，并且在缺牙处的位置处存在牙槽的方法。该方法包括将具有缺牙的形状的无细胞支架植入牙槽内。另外，提供了制造牙齿支架的方法。该方法包括合成哺乳动物牙齿形状的无细胞支架，并加入至少一种化学趋化性，成骨性，牙质发生，萌生或成骨的化合物。

49. 发明授权

US08277832B2 Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals 有权
标题翻译：具有预定义3D空间和时间控制生物材料，孔隙度和/或生物活性信号的基于微球的材料
公开(公告)号：US08277832B2
公开(公告)日：2012-10-02
申请号：US12248530
申请日：2008-10-09
申请人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
发明人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
IPC分类号： A61F2/00 , C12N11/08 , C12N5/07
CPC分类号： C12N5/0075 , C12N2533/10 , C12N2533/40
摘要： A tissue engineering scaffold for growing cells can include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
摘要翻译：用于生长细胞的组织工程支架可以包括连接在一起以形成三维基质的多个生物相容性微球。基质可以包括用于生长细胞的多个孔。生物相容性微球可以包括第一组和第二组微球。第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。第二组微球可以具有不同于第一特性的第二特性，以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性，刚度，颜色，辐射透明度，无线电等等。

50. 发明申请

US20120195850A1 USE OF POLYMER D-LACTIC ACID (PDLA) OR EQUIVALENTS THEREOF TO INHIBIT GROWTH OF CANCER CELLS AND DIAGNOSE CANCERS 有权
标题翻译：使用聚合物D-乳酸（PDLA）或其抑制癌细胞生长和诊断癌症的方法
公开(公告)号：US20120195850A1
公开(公告)日：2012-08-02
申请号：US13360567
申请日：2012-01-27
申请人： Joel S. Goldberg , Joe Brice Weinberg
发明人： Joel S. Goldberg , Joe Brice Weinberg
IPC分类号： A61K31/765 , A61K31/225 , C08G63/06 , G01N33/566 , A61P35/00 , C12N5/09 , C07C69/68
CPC分类号： C08G63/06 , A61K31/765 , C07C59/08 , C12N5/0693 , C12N2533/40 , G01N33/5011 , G01N33/57407
摘要： The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.
摘要翻译：本发明提供了在肿瘤细胞内或附近螯合或捕获L-乳酸的方法，其包括将分离的D-乳酸聚合物（PDLA）或其等同的衍生物或类似物与肿瘤细胞接触，使得PDLA结合L-乳酸在细胞内或细胞附近，从而在肿瘤细胞中或附近螯合或捕获L-乳酸盐。

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