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1. 发明授权

US09603899B2 PDGF induced cell homing 有权
公开(公告)号：US09603899B2
公开(公告)日：2017-03-28
申请号：US13877272
申请日：2011-10-03
申请人： Jeremy J. Mao , Wenli Zhao
发明人： Jeremy J. Mao , Wenli Zhao
IPC分类号： A61K38/18 , A61F13/00 , A61F2/00 , C12N5/00 , C12N5/0775 , A61L27/54 , A61K9/00
CPC分类号： A61K38/1858 , A61K9/00 , A61L27/54 , A61L2300/414 , C12N5/0068 , C12N5/0663 , C12N2501/105 , C12N2501/135 , C12N2501/15 , C12N2501/21 , C12N2533/40 , C12N2533/54 , C12N2533/74
摘要： Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a tissue defect. Further provided is a tissue scaffold comprising platelet-derived growth factor (PDGF). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.

2. 发明授权

US09199002B2 Hybrid soft tissue implants from progenitor cells and biomaterials 有权
标题翻译：来自祖细胞和生物材料的混合软组织植入物
公开(公告)号：US09199002B2
公开(公告)日：2015-12-01
申请号：US12601793
申请日：2008-05-23
申请人： Jeremy J. Mao , Eduardo K. Moioli
发明人： Jeremy J. Mao , Eduardo K. Moioli
IPC分类号： A61F2/12 , A61L27/38 , A61L27/52 , A61L27/56 , A61L27/22 , A61L27/18 , C12N5/077
CPC分类号： A61L27/38 , A61F2/12 , A61F2210/0061 , A61F2210/0076 , A61F2230/0095 , A61F2310/00383 , A61F2310/00994 , A61L27/18 , A61L27/222 , A61L27/3886 , A61L27/52 , A61L27/56 , C12N5/0653 , C12N2533/30 , C08L71/02
摘要： Provided are hybrid soft tissue constructs comprising a core material, a biomaterial matrix and mammalian cells. Also provided are methods of augmenting or reconstructing a soft tissue of a mammal. Additionally, methods of forming a hybrid soft tissue construct are provided. The use of the above constructs for augmenting or reconstructing a soft tissue of a mammal are further provided. Additionally provided is the use of the above constructs for the manufacture of a medicament for augmenting or reconstructing a soft tissue of a mammal.
摘要翻译：提供了包含核心材料，生物材料基质和哺乳动物细胞的混合软组织构建体。还提供了增强或重建哺乳动物的软组织的方法。此外，提供了形成混合软组织构建体的方法。进一步提供使用上述构建体来增强或重建哺乳动物的软组织。另外提供了上述构建体用于制造用于增强或重建哺乳动物的软组织的药物的用途。

3. 发明申请

US20100034892A1 TREATMENT FOR BONE FORMATION DISORDERS BY GROWTH FACTOR DELIVERY 审中-公开
标题翻译：通过生长因子递送治疗骨形成疾病
公开(公告)号：US20100034892A1
公开(公告)日：2010-02-11
申请号：US12439669
申请日：2007-08-22
申请人： Jeremy J. Mao
发明人： Jeremy J. Mao
IPC分类号： A61K9/16 , A61K35/12 , A61K38/16
CPC分类号： A61K38/18 , A61K9/50 , A61K31/7088 , A61K35/00 , A61K35/33 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K45/06
摘要： It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (CTGF), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof.
摘要翻译：已经发现，某些生长因子可以通过促进成纤维细胞分化和/或成骨细胞分化的抑制来延缓诸如颅缝合的组织部位的骨化。本文提供了通过将包含结缔组织生长因子（CTGF）和任选的其它生长因子或成纤维细胞或祖细胞的组合物施用于组织部位来治疗骨形成条件或病症例如解剖条件或异位矿化条件的方法有需要的受试者。

4. 发明申请

US20150335400A1 TOOTH SCAFFOLDS 审中-公开
标题翻译：牙齿痉挛
公开(公告)号：US20150335400A1
公开(公告)日：2015-11-26
申请号：US14660745
申请日：2015-03-17
申请人： Jeremy J. Mao
发明人： Jeremy J. Mao
IPC分类号： A61C8/00 , A61C13/00 , A61D5/00 , A61C8/02
CPC分类号： A61C8/0036 , A61C8/00 , A61C8/0006 , A61C8/0012 , A61C13/00 , A61C13/0019 , A61C13/08 , A61D5/00
摘要： Provided is a mammalian tooth-shaped scaffold including a composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting a scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing a scaffold in the shape of a mammalian tooth and adding at least one composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.
摘要翻译：提供了一种哺乳动物的牙齿支架，其包括具有趋化性，成骨，牙质发生，成骨或成骨的组合物。还提供了一种替代牙齿不存在的口腔中的牙齿，并且在缺牙处的位置处存在牙槽的方法。该方法包括将具有缺牙的形状的支架植入牙槽内。另外，提供了制造牙齿支架的方法。该方法包括合成具有哺乳动物牙齿形状的支架，并添加至少一种趋化性，成骨，牙质生成，萌生或成骨的组合物。

5. 发明授权

US08979534B2 Tooth scaffolds 有权
标题翻译：牙脚架
公开(公告)号：US08979534B2
公开(公告)日：2015-03-17
申请号：US13378789
申请日：2010-06-17
申请人： Jeremy J. Mao
发明人： Jeremy J. Mao
IPC分类号： A61C13/08 , A61L27/48 , A61L27/46 , A61L27/54 , A61L27/56 , C12N5/077 , A61C8/00 , A61K35/12
CPC分类号： A61L27/48 , A61C8/0036 , A61K35/12 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/622 , A61L2430/12 , C12N5/0654 , C12N2501/155 , C12N2501/21 , C12N2533/18 , C12N2533/40 , C12N2533/54 , C08L67/04
摘要： Provided is an acellular mammalian tooth-shaped scaffold including a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method includes implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method includes synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.
摘要翻译：提供了一种无细胞哺乳动物的牙齿支架，其包括具有趋化性，成骨性，牙质发生，萌生或成骨的化合物。还提供了一种替代牙齿不存在的口腔中的牙齿，并且在缺牙处的位置处存在牙槽的方法。该方法包括将具有缺牙的形状的无细胞支架植入牙槽。另外，提供了制造牙齿支架的方法。该方法包括合成哺乳动物牙齿形状的无细胞支架，并添加至少一种化学趋化，成骨，牙质，萌发或成骨的化合物。

6. 发明申请

US20150037382A1 MICROSPHERE SKIN TREATMENT 审中-公开
标题翻译：微胶囊治疗
公开(公告)号：US20150037382A1
公开(公告)日：2015-02-05
申请号：US14462298
申请日：2014-08-18
申请人： Jeremy J. Mao , Eduardo K. Moioli
发明人： Jeremy J. Mao , Eduardo K. Moioli
IPC分类号： A61K8/64 , A61K8/02 , A61K38/18 , A61K9/16
CPC分类号： A61K8/64 , A61K8/025 , A61K9/1647 , A61K38/00 , A61K38/1825 , A61K2800/412 , A61K2800/56 , A61Q19/08
摘要： This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (CTGF). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (CTGF) and basic fibroblast growth factor (bFGF). Additionally, methods of treating skin of a human are provided. The methods comprise administering to the skin microspheres comprising a growth factor that increases fibroblast proliferation or collagen, elastin, or glycosaminoglycan synthesis. Further provided are the use of the above microspheres for the treatment of the skin of a human. Additionally, this application proves the use of the above microsphere for the manufacture of a medicament for the treatment of the skin of a human.
摘要翻译：该应用提供了适用于组织工程的微球，其包含结缔组织生长因子（CTGF）。还提供了适用于组织工程的基质，材料或支架，其包括结缔组织生长因子（CTGF）和碱性成纤维细胞生长因子（bFGF）。此外，提供了治疗人的皮肤的方法。所述方法包括向包含增加成纤维细胞增殖或胶原蛋白，弹性蛋白或糖胺聚糖合成的生长因子的皮肤微球施用。还提供了上述微球体用于治疗人的皮肤的用途。此外，该申请证明使用上述微球体来制造用于治疗人的皮肤的药物。

7. 发明申请

US20110300203A1 CARTILAGE REGENERATION WITHOUT CELL TRANSPLANTATION 审中-公开
标题翻译：没有细胞迁移的细胞再生
公开(公告)号：US20110300203A1
公开(公告)日：2011-12-08
申请号：US13125580
申请日：2009-10-22
申请人： Jeremy J. Mao
发明人： Jeremy J. Mao
IPC分类号： A61K9/00 , A61P19/02 , C12N5/0775 , A61P19/04 , C12N5/071 , A61K38/18
CPC分类号： C07K14/475 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/622 , A61L2430/06
摘要： Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a cartilage defect. Further provided is a tissue scaffold comprising stromal cell-derived factor-1 (SDF-1) and transforming growth factor-β (TGF-β). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.
摘要翻译：提供使细胞迁移到支架的方法。还提供了治疗具有软骨缺损的哺乳动物的方法。还提供了包含基质细胞衍生因子-1（SDF-1）和转化生长因子-bgr的组织支架; （TGF-β）。另外，提供了能够招募细胞的组织支架的制造方法。

8. 发明申请

US20170112972A1 DERIVATION OF FIBROCHONDROCYTES FROM PROGENITOR CELLS 审中-公开
公开(公告)号：US20170112972A1
公开(公告)日：2017-04-27
申请号：US15345121
申请日：2016-11-07
申请人： Jeremy J. Mao , Chang Hun Lee
发明人： Jeremy J. Mao , Chang Hun Lee
IPC分类号： A61L27/54 , A61K38/18 , A61L27/18 , C12N5/077 , C12N5/00
CPC分类号： A61L27/54 , A61K38/18 , A61K38/1841 , A61L27/18 , A61L2300/414 , A61L2430/06 , C12N5/0062 , C12N5/0655 , C12N2501/10 , C12N2501/15 , C12N2506/03 , C12N2513/00 , C12N2531/00 , C12N2533/40
摘要： Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGFβ3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGFβ3.

9. 发明授权

US09487754B2 Derivation of fibrochondrocytes from progenitor cells 有权
标题翻译：衍生自祖细胞的纤维软骨细胞
公开(公告)号：US09487754B2
公开(公告)日：2016-11-08
申请号：US13877260
申请日：2011-10-03
申请人： Jeremy J. Mao , Chang Hun Lee
发明人： Jeremy J. Mao , Chang Hun Lee
IPC分类号： C12N5/00 , A61K38/18 , C12N5/077
CPC分类号： A61L27/54 , A61K38/18 , A61K38/1841 , A61L27/18 , A61L2300/414 , A61L2430/06 , C12N5/0062 , C12N5/0655 , C12N2501/10 , C12N2501/15 , C12N2506/03 , C12N2513/00 , C12N2531/00 , C12N2533/40
摘要： Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGFβ3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGFβ3.
摘要翻译：本文提供了用于从祖细胞如间充质干细胞形成纤维软骨细胞或纤维软骨细胞样细胞的组合物和方法。一方面提供包括CTGF和TGFβ3的纤维软骨细胞培养基，任选地通过具有不同释放曲线的微球包封。另一方面提供了用CTGF和TGFβ3培养从祖细胞形成纤维软骨细胞或纤维软骨细胞样细胞的方法。

10. 发明申请

US20140093481A1 PRODUCTION OF DENTIN, CEMENTUM AND ENAMEL BY CELLS 有权
标题翻译：细胞产生丹宁，水泥和ENAMEL
公开(公告)号：US20140093481A1
公开(公告)日：2014-04-03
申请号：US13877262
申请日：2011-10-03
申请人： Jeremy J. Mao , Mo Chen
发明人： Jeremy J. Mao , Mo Chen
IPC分类号： A61K35/32 , C12N5/077
CPC分类号： A61K35/32 , A23L33/10 , A23V2002/00 , A61K35/28 , A61K35/36 , A61K35/51 , A61K35/545 , C12N5/0654 , C12N5/0664 , C12N5/0697 , C12N2500/38 , C12N2501/39 , C12N2501/415 , C12N2501/998 , C12N2502/13 , C12N2502/1311 , C12N2502/1364 , C12N2533/18 , A23V2200/312
摘要： One aspect provides a method of forming a mineralized material by co-culturing a epithelial cell, such as ameloblasts, and mesenchymal cells, such as osteoblasts or odontoblasts, in a mineral-stimulating medium. Another aspect provides matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix. Methods of manufacturing such compositions and methods of treating mineralization-related conditions are also provided.
摘要翻译：一方面提供了通过在矿物质刺激性介质中共培养上皮细胞如成釉细胞和间充质细胞如成骨细胞或成牙质细胞来形成矿化材料的方法。另一方面提供了用上皮细胞和间充质细胞接种的基质，并注入能够在基质中形成矿化物质的矿物刺激介质。还提供了制造这种组合物的方法和处理矿化相关条件的方法。

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