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    • 41. 发明申请
    • Cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, and their shaping as support materials
    • 基于双硅烷,双硫醚,双亚砜,双糖和双糖的双砜和丁烷二基衍生物的交联聚合物及其成型作为载体材料
    • US20040068106A1
    • 2004-04-08
    • US10694844
    • 2003-10-29
    • Raphael Duval
    • C07H021/04C08B037/00
    • C08B15/10C07B57/00C08B15/005
    • There are described novel cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, their shaping as support materials useful for the separation or preparation of enantiomers; a process for preparing the said cross-linked polymer compounds, a process for preparing balls of support materials containing the said cross-linked polymer compounds; a method of obtaining balls of support materials useful in chromatography or in organic synthesis; and the use of the said support materials containing the cross-linked polymer compounds in separation or in preparation of enantiomers, through employment in chromatography or organic synthesis processes in a heterogeneous medium; and the use of the said cross-linked polymer compounds in the form of membranes in processes using percolation through membranes for the separation or the preparation of enantiomers.
    • 描述了基于双硅烷,双硫醚,双亚砜,双糖和双糖的双砜和丁烷二基衍生物的多糖和寡糖的新型交联聚合物,它们的成型作为用于分离或制备对映异构体的载体材料 ; 制备所述交联聚合物化合物的方法,制备包含所述交联聚合物化合物的载体材料球的方法; 获得可用于色谱法或有机合成的载体材料球的方法; 以及通过在异质介质中的色谱法或有机合成过程中使用分离或制备对映异构体的含有交联聚合物化合物的所述载体材料; 以及在使用膜渗透以分离或制备对映异构体的方法中使用所述膜形式的交联聚合物化合物。
    • 45. 发明申请
    • Cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides an oligosaccharides, and their shaping as support materials
    • 基于双硅烷,双硫醚,双亚砜,双砜的双砜和丁烷二基衍生物的交联聚合物是寡糖,并且它们的成型作为载体材料
    • US20010029282A1
    • 2001-10-11
    • US09838284
    • 2001-04-20
    • Institut Francais du Petrole
    • Raphael Duval
    • C08G077/42C08G075/20
    • C08B15/10C07B57/00C08B15/005
    • There are described novel cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, their shaping as support materials useful for the separation or preparation of enantiomers; a process for preparing the said cross-linked polymer compounds, a process for preparing balls of support materials containing the said cross-linked polymer compounds; a method of obtaining balls of support materials useful in chromatography or in organic synthesis; and the use of the said support materials containing the cross-linked polymer compounds in separation or in preparation of enantiomers, through employment in chromatography or organic synthesis processes in a heterogeneous medium; and the use of the said cross-linked polymer compounds in the form of membranes in processes using percolation through membranes for the separation or the preparation of enantiomers.
    • 描述了基于双硅烷,双硫醚,双亚砜,双糖和双糖的双砜和丁烷二基衍生物的多糖和寡糖的新型交联聚合物,它们的成型作为用于分离或制备对映异构体的载体材料 ; 制备所述交联聚合物化合物的方法,制备包含所述交联聚合物化合物的载体材料球的方法; 获得可用于色谱法或有机合成的载体材料球的方法; 以及通过在异质介质中的色谱法或有机合成过程中使用分离或制备对映异构体的含有交联聚合物化合物的所述载体材料; 以及在使用膜渗透以分离或制备对映异构体的方法中使用所述膜形式的交联聚合物化合物。
    • 47. 发明授权
    • Chemo-mechanical expansion delivery system
    • 化学机械膨胀输送系统
    • US5876741A
    • 1999-03-02
    • US892920
    • 1997-07-15
    • Eyal S. Ron
    • Eyal S. Ron
    • A61K8/02A61K8/04A61K9/00A61K9/52A61L27/52A61L27/54A61L31/14A61L31/16A61Q13/00A61Q19/00C08B15/00C08B31/00A61F2/02A61K9/22
    • C08B31/006A61K9/0004C08B15/005A61K2800/88C12N2533/30C12N2533/70
    • System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.
    • 将生物活性物质输送到环境中的系统。 容器由单个构件或两个配合构件组成,并且限定第一和第二隔室。 容器包括限定第一隔室的容器的至少一部分中的孔。 第一隔室包含聚合物凝胶网络,其响应于在生物环境中变化的环境条件而经历体积膨胀。 第二隔室包含有效量的生物活性化合物,并且可以包括与生物环境连通的至少一个通道。 仅当适当的环境条件或触发条件被满足时才启动并继续给药,因此聚合物凝胶网络的体积膨胀导致生物活性化合物被排放到生物环境中。