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41. 发明授权

US5871731A Oral administration of immunoglobulin preparations for treatment of chronic pain syndrome 失效
标题翻译：口服免疫球蛋白G制剂用于治疗慢性疼痛综合征
公开(公告)号：US5871731A
公开(公告)日：1999-02-16
申请号：US763582
申请日：1996-12-10
申请人： Gunter Sprotte , Helge Karch , Reinhard Lissner , Wolfgang Moller
发明人： Gunter Sprotte , Helge Karch , Reinhard Lissner , Wolfgang Moller
IPC分类号： A61K38/00 , A61K39/40 , C07K16/02 , C07K16/04 , C07K16/12 , A61K39/395 , A61K39/38 , C07K16/00
CPC分类号： C07K16/1228 , A61K39/40 , C07K16/02 , C07K16/04 , C07K16/1207 , C07K16/121 , A61K38/00 , Y10S530/833
摘要： The invention concerns the oral administration of immunoglobulins from plasma, colostral milk, milk, eggs or cell cultures for the therapy and prophylaxis of heavy therapy-refractory pain conditions in patients without typical pathological anatomical correlates.
摘要翻译：本发明涉及来自血浆，初乳，乳，卵或细胞培养物的免疫球蛋白的口服施用，用于治疗和预防无典型病理解剖学相关性患者的重度治疗难治性疼痛病症。

42. 发明授权

US5531988A Bacteria and immunoglobulin-containing composition for human gastrointestinal health 失效
标题翻译：用于人类胃肠健康的细菌和含免疫球蛋白的组合物
公开(公告)号：US5531988A
公开(公告)日：1996-07-02
申请号：US331140
申请日：1994-10-28
申请人： Stephen M. Paul
发明人： Stephen M. Paul
IPC分类号： A23L1/305 , A23L1/308 , A61K9/00 , A61K39/395 , A61K39/40 , A61K39/42 , C07K16/04 , A01N63/04 , A61K35/00 , A61K47/00
CPC分类号： C07K16/04 , A23L33/19 , A23L33/21 , A61K39/395 , A61K39/39508 , A61K39/40 , A61K39/42 , A61K9/0095 , A23V2002/00 , A23V2250/54248 , A23V2250/5425 , A23V2250/5434 , Y10S424/809 , Y10S514/867
摘要： A composition for promoting gastrointestinal health comprises an effective amount of a beneficial human intestinal microorganism and an effective amount of an immunoglobulin composition comprising concentrated immunologically active immunoglobulins. Preferred beneficial human intestinal bacteria include lactobacilli and bifidobacteria. The immunologically active immunoglobulins are preferably purified from bovine milk, milk products, or whey. Methods of use are also described.
摘要翻译：用于促进胃肠健康的组合物包含有效量的有益的人肠微生物和有效量的包含浓缩的免疫活性免疫球蛋白的免疫球蛋白组合物。优选的有益人肠细菌包括乳酸杆菌和双歧杆菌。免疫活性的免疫球蛋白优选从牛奶，乳制品或乳清中纯化。还描述了使用方法。

43. 发明授权

US5179197A Secretory component-containing composition 失效
标题翻译：包含组分成分的组合物
公开(公告)号：US5179197A
公开(公告)日：1993-01-12
申请号：US669089
申请日：1991-03-15
申请人： Toshiaki Uchida , Kaoru Sato , Sunichi Dosako , Chouemon Kanno , Norihiro Azuma , Hitoshi Kuriki
发明人： Toshiaki Uchida , Kaoru Sato , Sunichi Dosako , Chouemon Kanno , Norihiro Azuma , Hitoshi Kuriki
IPC分类号： A23J1/20 , A23C9/146 , A23J3/08 , A61K38/00 , C07K1/18 , C07K14/00 , C07K14/47 , C07K14/76 , C07K16/00 , C07K16/04
CPC分类号： C07K16/04 , A23C9/1465 , C07K14/47 , A61K38/00 , Y10S530/833 , Y10S530/861
摘要： A secretory component-containing composition which is obtainable by contacting a milk or a whey with a cation exchange resin to allow the resin to absorb a secretory component contained in the milk or the whey and then eluting the secretory component and which has the following properties:(a) contains a secretory component with the purity of at least 20% by weight,(b) contains, besides the secretory component, at least an immunoglobulin and/or a serum albumin, and(c) has anti-infectious effects.

44. 发明授权

US4834974A Immunologically active whey fraction and recovery process 失效
$Immunologically active whey fraction and recovery process$
标题翻译：免疫活性乳清分数和恢复过程
公开(公告)号：US4834974A
公开(公告)日：1989-05-30
申请号：US946435
申请日：1986-12-24
申请人： Gerald H. Stott , David O. Lucas
发明人： Gerald H. Stott , David O. Lucas
IPC分类号： A61K39/00 , A23C9/142 , A23J1/20 , A23K1/18 , A61K39/395 , A61P37/04 , C07K14/435 , C07K16/00 , C07K16/04
CPC分类号： A23C9/1425 , A23J1/205 , A23K50/60 , C07K16/04 , A23V2002/00 , Y10S530/833
摘要： A dry, immunologically active filtered product is produced through the controlled one or two stage ultrafiltration of liquid whey containing immunologically active immunoglobulin (Ig). When a predetermined quantity of the filtered product with an active Ig concentration of at least about seven percent of total solids is fed to newborn calves, the product functions as a substitute for natural colostrum, providing both temporary passive immunity as well as initiation of the active immune system of the animal. Disease resistance and growth rate in animals including humans is enhanced by oral administration of the filtered product. The immunological properties of the filtered product result from the presence of substantially enhanced concentrations of active Ig as well as other immunologically active whey components in comparison to the immunologically ineffective concentrations of these materials in the liquid whey ultrafiltration feedstock.

45. 发明授权

US4816252A Product and process for transferring passive immunity to newborn domestic animals using ultrafiltered whey containing immunoglobulins 失效
标题翻译：使用含有免疫球蛋白的超滤乳清将被动免疫转移给新生儿家畜的产品和方法
公开(公告)号：US4816252A
公开(公告)日：1989-03-28
申请号：US818610
申请日：1986-01-13
申请人： Gerald H. Stott , Dave Lucas
发明人： Gerald H. Stott , Dave Lucas
IPC分类号： A23C9/142 , A23J1/20 , A23K1/18 , C07K16/04 , A61K39/395 , A61K35/20
CPC分类号： A23C9/1425 , A23J1/205 , A23K50/60 , C07K16/04 , A23V2002/00 , Y10S530/833
摘要： The present invention relates to a product and process for assuring the transfer of adequate passive immunity to newborn domestic animals. Immunologically active immunoglobulins are extracted from the whey byproduct of dairy manufacturing by using ultrafiltration techniques to separate the large immuoglobulin molecules from the whey. The ultrafiltration retentate is dried to produce a filtered product having a high concentration of immunoglobulins. The dry filtered product is assayed to verify the immunological activity of the product and to measure the distribution and concentration of pathogen specific antibodies. The dry filtered product is stored. Subsequently, a dose of the product containing at least a minimum weight ratio of immunologically active Ig is fed to the newborn animal to transfer passive immunity. Ion exchange techniques can be combined with ultrafiltration techniques to significantly increase the Ig concentration in the ultimate product while simultanously reducing the net cost of producing the product. They whey-derived product may also be used on a continuous basis as a food supplement for an animal to enable the immunologically active immunoglobulin molecules in the product to attack pathogens present in the digestive system of the animal.
摘要翻译：本发明涉及一种确保向新生儿家畜转移足够的被动免疫的产品和方法。通过使用超滤技术从乳制品的乳清副产物中提取免疫活性的免疫球蛋白以从乳清中分离出大的免疫球蛋白分子。将超滤保留物干燥以产生具有高浓度免疫球蛋白的过滤产物。测定干燥过滤的产物以验证产物的免疫活性并测量病原体特异性抗体的分布和浓度。储存干燥过滤的产品。随后，将含有至少最小重量比的免疫活性Ig的产品的剂量喂给新生动物以转移被动免疫。离子交换技术可以与超滤技术结合，以显着提高最终产品中的Ig浓度，同时降低生产产品的净成本。它们的乳清衍生产品也可以连续使用作为动物的食物补充物，以使产品中免疫活性的免疫球蛋白分子能够攻击存在于动物消化系统中的病原体。

46. 发明授权

US3646193A Iga antibody from lacteal fluids 失效
标题翻译：来自流体液体的IGA抗体
公开(公告)号：US3646193A
公开(公告)日：1972-02-29
申请号：US3646193D
申请日：1969-07-25
申请人： MICHAELSON JOSEPH B , SHORT JOHN W
发明人： MICHAELSON JOSEPH B , SHORT JOHN W
IPC分类号： A61K38/00 , C07K16/04 , A61K27/00
CPC分类号： C07K16/04 , A23V2002/00 , A61K38/00 , Y10S424/804 , A23V2250/54244 , A23V2250/5434 , A23V2300/30 , A23V2300/34
摘要： A NEW IGA ANTIBODY, A LACTIMMUNIN, HAS BEEN DISCOVERED. UNIQUELY, THE NEW PRODUCT, DERIVED FROM IMMUNE LACTEAL FLUIDS SUCH AS MILK WHEY OR COLOSTRUM, CONFERS PASSIVE IMMUNITY WITHOUT SENSITIZING EFFECTS EVEN WHEN ADMINISTERED PARENTERALLY. THE PRODUCT IS PREPARED BY SELECTIVELY CLEAVING THE RELATIVELY LARGE LACTEAL FLUID DERIVED ANTIBODY MOLECULES INTO RELATIVELY SMALLER CONSTITUENTS HAVING EITHER ALLERGENIC OR ANTIBODY PROPERTIES AND ISOLATING THE NONALLERGENIC, ANTIBODY CONSTITUENT. THE CLEAVING IS EASILY ACCOMPLISHED BY PROTEOLYTIC DIGESTION OF THE IMMUNE LACTEAL FLUID.

47. 发明申请

US20170056497A1 Method of Treating Protozoal Gastrointestinal Disorders in Immunocompromised Patients 审中-公开
标题翻译：治疗免疫受损患者原发性胃肠道疾病的方法
公开(公告)号：US20170056497A1
公开(公告)日：2017-03-02
申请号：US15253733
申请日：2016-08-31
申请人： Joseph Whelihan , Jada Eley
发明人： Joseph Whelihan , Jada Eley
IPC分类号： A61K39/395 , C07K16/12 , A61K39/085 , A61K39/09 , A61K39/02 , A61K39/108 , A61K39/104 , A61K39/112 , A61K39/102 , A61K31/51 , A61K31/525 , A61K31/4415 , A61K31/714 , A61K31/519 , A61K31/593 , A61K31/375 , A61K31/355 , A61K33/06 , A61K33/30 , A23C3/02 , C07K16/04
CPC分类号： A61K39/39508 , A23C9/1322 , A23C9/1422 , A23C9/20 , A23C2210/202 , A23C2230/15 , A23V2002/00 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/593 , A61K31/714 , A61K33/06 , A61K33/30 , A61K35/742 , A61K39/025 , A61K39/0258 , A61K39/0266 , A61K39/0275 , A61K39/0283 , A61K39/085 , A61K39/092 , A61K39/102 , A61K39/104 , A61K2039/505 , A61K2039/52 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/70 , C07K16/04 , C07K16/12 , A61K2300/00 , A23V2200/32 , A23V2200/3204 , A23V2250/5424 , A23V2250/70
摘要： The invention relates to a method for treating protozoal gastrointestinal disorders in immunocompromised patients. It includes a method for the isolation of a factor from the milk of hyperimmunized animals in a substantially pure form, and to the use of said factor in combination with vitamins and minerals.
摘要翻译：本发明涉及一种在免疫受损患者中治疗原生动物胃肠道疾病的方法。其包括以基本上纯的形式从超免疫动物的乳分离因子的方法，以及所述因子与维生素和矿物质的组合的使用。

48. 发明授权

US09475860B2 Process for obtaining immunoglobulins from colostral milk 有权
标题翻译：从初乳中获得免疫球蛋白的方法
公开(公告)号：US09475860B2
公开(公告)日：2016-10-25
申请号：US14168586
申请日：2014-01-30
申请人： DMK Deutsches Milchkontor GmbH
发明人： Sven-Rainer Döring
IPC分类号： C07K16/04 , A23C9/142 , A23J3/08 , A23C9/20
CPC分类号： C07K16/04 , A23C9/1422 , A23C9/206 , A23J3/08
摘要： Suggested is a process for obtaining immunoglobulins, wherein (a) colostral milk from days 0 to 7 is subjected to thermal treatment, skimming the cream, (b) the skimmed milk such obtained is subjected to sterile microfiltration thus producing a first retentate R1 which contains the casein, and a first permeate P1, (c) the first permeate P1 is subjected to ultrafiltration thus producing a second permeate P2 which contains lactose and minerals, and a second retentate R2, in which the immunoglobulins are concentrated.

49. 发明申请

US20150252106A1 ANTIBODY THERAPY FOR MODULATING FUNCTION OF INTESTINAL RECEPTORS AND METHODS OF TREATING DIABETES AND OBESITY 审中-公开
标题翻译：用于调节功能受体的抗体治疗方法和治疗糖尿病和肥胖的方法
公开(公告)号：US20150252106A1
公开(公告)日：2015-09-10
申请号：US14658569
申请日：2015-03-16
申请人： AVAXIA BIOLOGICS, INCORPORATED
发明人： Barbara S. Fox
IPC分类号： C07K16/28 , C07K16/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/04 , C07K16/2896 , C07K2317/12 , C07K2317/34 , C07K2317/76
摘要： The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.
摘要翻译：本发明提供了配制用于直接递送至包含靶向顶端肠道受体特异性抗体的患者胃肠道的药物组合物。本发明还提供了治疗患者疾病和病症的方法，包括直接给予患者胃肠道的方法，其中本发明的组合物，其中由抗体调节靶顶端肠道受体处理该病症。

50. 发明授权

US08834872B2 Uses of antibodies 有权
标题翻译：使用抗体
公开(公告)号：US08834872B2
公开(公告)日：2014-09-16
申请号：US13927491
申请日：2013-06-26
申请人： A.C.N. 135 493 391 Pty Ltd.
发明人： Antony William Scammell
IPC分类号： A61K39/395 , A61K35/20 , C07K16/02 , C07K16/04 , G01N33/574 , A61K35/56 , C07K16/28
CPC分类号： C07K16/28 , A61K35/20 , A61K35/57 , C07K16/02 , C07K16/04 , C07K16/2866 , G01N33/57407
摘要： The present invention provides a method of preparing an antibody containing milk or egg product for use in preventing and/or treating of a non infectious medical condition. The invention also provides non-systemic modes of administering pharmaceutical compositions including the antibody containing milk or egg products, including to the GI tract.
摘要翻译：本发明提供一种制备用于预防和/或治疗非传染性医学病症的含有乳或蛋制品的抗体的方法。本发明还提供了包括含有抗体的乳或蛋制品（包括胃肠道）的药物组合物的非系统性模式。

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