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41. 发明授权

US09260375B2 Metallo-β-lactamase inhibitors 有权
标题翻译：金属和β-内酰胺酶抑制剂
公开(公告)号：US09260375B2
公开(公告)日：2016-02-16
申请号：US13306372
申请日：2011-11-29
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： C07C57/02 , A61K31/43 , A61K31/397 , A61K31/00 , C07C69/593 , A61K31/194 , C07C57/145 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/618 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C237/22 , C07C279/08 , C07C323/54 , C07D211/46 , C07D211/60 , C07D213/80 , C07D295/192 , C07D309/06 , A61K31/407 , A61K31/546
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

42. 发明授权

US09169190B2 Methods for making retinoids and uses thereof 有权
标题翻译：维生素A的制备方法及用途
公开(公告)号：US09169190B2
公开(公告)日：2015-10-27
申请号：US13856631
申请日：2013-04-04
申请人： The UAB Research Foundation
发明人： Wayne J. Brouillette , Donald D. Muccio , Venkatram Reddy Atigadda , John M. Ruppert , Susan M. Lobo Ruppert
IPC分类号： C07C205/00 , C07C229/00 , C07C59/40 , C07C63/333 , C07C61/00 , A61K31/20 , A61K31/195 , C07C57/50 , C07C29/14 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/61 , C07C45/67 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07D311/96 , C12C11/02 , C07C57/26
CPC分类号： A61K31/202 , A61K9/0014 , A61K45/06 , C07B2200/09 , C07C29/14 , C07C45/29 , C07C45/292 , C07C45/30 , C07C45/513 , C07C45/61 , C07C45/673 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C57/26 , C07C57/50 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/28 , C07D311/96 , C12C11/02 , C07C33/16 , C07C69/618
摘要： Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.
摘要翻译：本文描述了制备类视黄醇的方法。本文还描述了类视黄醇及其使用方法。

43. 发明授权

US09146427B2 Norbornene monomer, polynorbornene derivative, liquid crystal photoalignment film containing the same and liquid crystal display containing the same 有权
标题翻译：降冰片烯单体，聚降冰片烯衍生物，含有该降冰片烯衍生物的液晶光取代膜和含有该衍生物的液晶显示器
公开(公告)号：US09146427B2
公开(公告)日：2015-09-29
申请号：US14227878
申请日：2014-03-27
申请人： LG CHEM, LTD.
发明人： Dai-Seung Choi , Heon Kim , Sung-Ho Chun , Sung-Joon Oh , Dong-Woo Yoo , Yu-Chan Kang
IPC分类号： C07C69/76 , G02F1/1337 , C07C51/567 , C07C69/618 , C07C69/734 , C08F132/08 , C07C57/50
CPC分类号： G02F1/13378 , C07C51/567 , C07C57/50 , C07C69/618 , C07C69/734 , C07C2602/42 , C08F132/08 , G02F1/133711 , G02F1/133788 , Y10T428/10 , Y10T428/1005 , C07C61/29
摘要： The present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same. More particularly, the present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same, which have an alignment property by photoreaction, excellent thermal stability and photoreactivity, the increased photo-reaction rate and reliability of the alignment film, thereby showing high manufacturing process efficiency.
摘要翻译：本发明涉及降冰片烯单体，聚降冰片烯衍生物，含有该降冰片烯衍生物的液晶取向膜，以及包含该降冰片烯单体的液晶显示装置。更具体地，本发明涉及降冰片烯单体，聚降冰片烯衍生物，包含该降冰片烯单体的液晶取向膜和包含该降冰片烯衍生物的液晶取向膜，以及具有该降冰片烯单体的液晶显示装置，其具有通过光反应的取向性，优异的热稳定性和光反应性提高了取向膜的光反应速度和可靠性，从而显示出高的制造工艺效率。

44. 发明申请

US20140295097A1 NORBORNENE MONOMER, POLYNORBORNENE DERIVATIVE, LIQUID CRYSTAL PHOTOALIGNMENT FILM CONTAINING THE SAME AND LIQUID CRYSTAL DISPLAY CONTAINING THE SAME 有权
公开(公告)号：US20140295097A1
公开(公告)日：2014-10-02
申请号：US14227904
申请日：2014-03-27
申请人： LG CHEM, LTD.
发明人： Dai-Seung CHOI , Heon KIM , Sung-Ho CHUN , Sung-Joon OH , Dong-Woo YOO , Yu-Chan KANG
IPC分类号： G02F1/1337
CPC分类号： G02F1/13378 , C07C51/567 , C07C57/50 , C07C69/618 , C07C69/734 , C07C2602/42 , C08F132/08 , G02F1/133711 , G02F1/133788 , Y10T428/10 , Y10T428/1005 , C07C61/29
摘要： The present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same. More particularly, the present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same, which have an alignment property by photoreaction, excellent thermal stability and photoreactivity, the increased photo-reaction rate and reliability of the alignment film, thereby showing high manufacturing process efficiency.

45. 发明申请

US20130317106A1 METHODS FOR MAKING RETINOIDS AND USES THEREOF 有权
标题翻译：制备反应物的方法及其用途
公开(公告)号：US20130317106A1
公开(公告)日：2013-11-28
申请号：US13856631
申请日：2013-04-04
申请人： The UAB Research Foundation
发明人： Wayne J. Brouillette , Donald D. Muccio , Venkatram Reddy Atigadda , John M. Ruppert , Susan M. Lobo Ruppert
IPC分类号： C07C57/50 , C07C57/26
CPC分类号： A61K31/202 , A61K9/0014 , A61K45/06 , C07B2200/09 , C07C29/14 , C07C45/29 , C07C45/292 , C07C45/30 , C07C45/513 , C07C45/61 , C07C45/673 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C57/26 , C07C57/50 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/28 , C07D311/96 , C12C11/02 , C07C33/16 , C07C69/618
摘要： Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.
摘要翻译：本文描述了制备类视黄醇的方法。本文还描述了类视黄醇及其使用方法。

46. 发明授权

US08093294B2 Metallo-β-lactamase inhibitors 有权
标题翻译：金属和β-内酰胺酶抑制剂
公开(公告)号：US08093294B2
公开(公告)日：2012-01-10
申请号：US11889296
申请日：2007-08-10
申请人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
发明人： Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
IPC分类号： A61K31/19 , A61K31/43 , A61K31/545
CPC分类号： A61K31/225 , A61K31/166 , A61K31/194 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/546 , A61K45/06 , C07C51/00 , C07C57/13 , C07C57/145 , C07C57/26 , C07C57/42 , C07C57/50 , C07C59/52 , C07C59/64 , C07C59/70 , C07C69/593 , C07C69/60 , C07C69/608 , C07C69/618 , C07C69/732 , C07C69/734 , C07C217/22 , C07C233/65 , C07C235/20 , C07C235/84 , C07C237/22 , C07C279/08 , C07C279/14 , C07C323/54 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/12 , C07D211/46 , C07D211/60 , C07D213/55 , C07D213/80 , C07D233/60 , C07D295/15 , C07D295/16 , C07D295/192 , C07D309/06 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
摘要翻译：公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

47. 发明授权

US07045540B2 Selective estrogen receptor modulators 有权
标题翻译：选择性雌激素受体调节剂
公开(公告)号：US07045540B2
公开(公告)日：2006-05-16
申请号：US11152888
申请日：2005-06-15
申请人： Robert F. Kaltenbach , Simon P. Robinson , George L. Trainor
发明人： Robert F. Kaltenbach , Simon P. Robinson , George L. Trainor
IPC分类号： A61K31/31 , C07D257/04
CPC分类号： C07D257/04 , C07C51/487 , C07C57/50 , C07C59/54 , C07C59/72 , C07C69/618 , C07C69/734 , C07C255/34 , C07C311/51 , C07C2601/10 , C07C2602/10 , C07C2602/12 , C07D277/80 , C07D311/58 , C07D333/34
摘要： The present invention provides, inter alia, triphenylethylene derivatives, such as, 5-{2-[4-(1,2-Diphenyl-but-1-enyl)-phenyl]-vinyl}-1H-tetrazole, as selective estrogen receptor modulators. Also provided are methods for treating estrogen stimulated diseases in mammals including, but not limited to, for example, breast, uterine, ovarian, prostate and colon cancer; osteoporosis; endometriosis; uterine fibroid; Alzheimer's disease; macular degeneration; urinary incontinence; and type II diabetes, as well as, pharmaceutical compositions comprising at least one compound of the present invention.
摘要翻译：本发明特别提供三苯基乙烯衍生物，例如5- {2- [4-（1,2-二苯基 - 丁-1-烯基） - 苯基] - 乙烯基} -1H-四唑，作为选择性雌激素受体调制器还提供了用于治疗哺乳动物中雌激素刺激的疾病的方法，包括但不限于例如乳腺癌，子宫癌，卵巢癌，前列腺癌和结肠癌; 骨质疏松症子宫内膜异位症子宫肌瘤阿尔茨海默氏病; 黄斑变性; 尿失禁和II型糖尿病，以及包含至少一种本发明化合物的药物组合物。

48. 发明授权

US06927224B2 Selective estrogen receptor modulators 有权
标题翻译：选择性雌激素受体调节剂
公开(公告)号：US06927224B2
公开(公告)日：2005-08-09
申请号：US10216253
申请日：2002-08-09
申请人： Robert F. Kaltenbach , Simon P. Robinson , George L. Trainor
发明人： Robert F. Kaltenbach , Simon P. Robinson , George L. Trainor
IPC分类号： C07D295/08 , A61K31/085 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/24 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/381 , A61K31/429 , A61K31/4453 , A61P1/00 , A61P3/10 , A61P9/00 , A61P13/00 , A61P13/08 , A61P15/00 , A61P19/10 , A61P25/28 , A61P35/00 , A61P43/00 , C07C51/487 , C07C57/50 , C07C59/54 , C07C59/72 , C07C69/618 , C07C69/734 , C07C255/34 , C07C311/51 , C07D257/04 , C07D277/80 , C07D311/58 , C07D333/34 , C07C311/00
CPC分类号： C07D257/04 , C07C51/487 , C07C57/50 , C07C59/54 , C07C59/72 , C07C69/618 , C07C69/734 , C07C255/34 , C07C311/51 , C07C2601/10 , C07C2602/10 , C07C2602/12 , C07D277/80 , C07D311/58 , C07D333/34
摘要： The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for the treatment and/or prevention of estrogen stimulated diseases in mammals including breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular disease, and benign proliferative disorders, as well as pharmaceutical compositions of the compounds of the present invention.
摘要翻译：本发明特别提供三苯基乙烯衍生物，例如3- {4- [6-（3-甲氧基 - 苯基）-8,9-二氢-7H-苯并环庚烯-5-基] - 苯基} - 丙烯酸，作为选择性雌激素受体调节剂。还提供了用于治疗和/或预防哺乳动物包括乳腺，子宫，卵巢，前列腺和结肠癌，骨质疏松症，心血管疾病和良性增殖性疾病的哺乳动物中雌激素刺激性疾病的方法，以及本发明化合物的药物组合物发明。

49. 发明授权

US06642273B2 Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics 失效
标题翻译： 6-叔丁基-1,1-二甲基茚满的4-位不饱和衍生物及其在人兽药和化妆品中的应用
公开(公告)号：US06642273B2
公开(公告)日：2003-11-04
申请号：US10214665
申请日：2002-08-09
申请人： Angel De Lera , Beatriz Dominguez
发明人： Angel De Lera , Beatriz Dominguez
IPC分类号： A61K3119
CPC分类号： C07D333/38 , A61K8/31 , A61K8/362 , A61K8/37 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61Q7/00 , A61Q19/00 , A61Q19/004 , C07C57/50 , C07C63/66 , C07C69/618 , C07C69/76 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/915
摘要： An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: in which: X represents: a divalent radical of formula: and Y represents a divalent radical of following formula: R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, r′ and r″, which are identical or different, represent H, lower alkyl, —COR7, aryl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, or r′ and r″, taken together form a heterocycle selected from the group consisting of piperidino, morpholino, pyrrolidino and piperazino radical, the latter optionally being substituted in the 4-position by a C1-C6 alkyl radical or a mono- or polyhydroxyalkyl, and the salts of the compounds of formula (I), when R1 represents a carboxylic acid functional group, and the geometrical and optical isomers of the compounds of formula (I).
摘要翻译：对应于下式的6-叔丁基-1,1-二甲基茚的4-位的不饱和衍生物：其中：X表示：式的二价基团，Y表示下式的二价基团：R 1表示 -CH 3， - （CH 2）p -OR 4， - （CH 2）p-COR 5或-S（O）t -R 6，p为0,1,2或3，t为0,1或2，R 4表示H，低级烷基，-COR 7，芳基，芳烷基，单 - 或多羟基烷基或聚醚基，R 5表示H，低级烷基，-OR 8或R 6表示H或低级烷基，R 7表示低级烷基，R 8表示H，烷基，烯基，炔基芳基，芳烷基，单或多羟基烷基，选自葡萄糖，半乳糖，甘露糖和葡糖醛酸的残基或衍生自赖氨酸，甘氨酸和天冬氨酸的氨基酸残基的糖残基，r'和r“ ，其相同或不同，表示H，低级烷基，-COR 7，芳基，选自葡萄糖，半乳糖，甘露糖和葡萄糖的残基的糖残基衍生自赖氨酸，甘氨酸和天冬氨酸或r'和r“的氨基酸残基一起形成选自哌啶子基，吗啉代，吡咯烷子基和哌嗪基的杂环，后者任选被取代在当R1表示羧酸官能团时，通过C 1 -C 6烷基或单 - 或多羟基烷基的4-位和式（I）化合物的盐，以及式（I）化合物的几何和旋光异构体（一世）。

50. 发明授权

US06610883B1 Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors 失效
标题翻译：对类视黄醇X受体具有选择性活性的化合物，以及调节由类视黄醇X受体介导的过程的方法
公开(公告)号：US06610883B1
公开(公告)日：2003-08-26
申请号：US09115615
申请日：1998-07-13
申请人： Marcus F. Boehm , Richard A. Heyman , Lin Zhi , Chan Kou (Jack) Hwang , Steve White , Alex Nadzan
发明人： Marcus F. Boehm , Richard A. Heyman , Lin Zhi , Chan Kou (Jack) Hwang , Steve White , Alex Nadzan
IPC分类号： C07C6336
CPC分类号： C07D213/79 , C07B2200/09 , C07C57/26 , C07C57/48 , C07C57/50 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/17 , C07C65/19 , C07C65/36 , C07C65/40 , C07C69/76 , C07C233/66 , C07C233/75 , C07C233/81 , C07C235/84 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/20 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D213/80 , C07D257/04 , C07D303/38 , C07D307/68 , C07D311/58 , C07D333/38 , C07D405/04
摘要： Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, pyrrole, and polyenoic acid derivatives including carbocyclic polyenoic acids. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.
摘要翻译：调节视网膜X受体介导的方法的化合物，组合物和方法，使用对类维生素A受体（RXR）亚类的成员具有选择性的类视黄醇样化合物，优于视黄酸受体（RAR）亚类的成员，。这些化合物的实例是二环苄基，吡啶基，噻吩，呋喃基，吡咯和多烯酸衍生物，包括碳环多烯酸。所公开的方法使用化合物调节由视黄醇X受体选择性介导的过程。

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