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41. 发明申请

US20110190624A1 OPTICAL SYSTEM AND METHOD FOR LOCALIZING THE FOSSA OVALIS DURING TRANS-SEPTAL PROCEDURES 有权
标题翻译：光学系统和方法，用于在分离过程中定位FOSSA OVALIS
公开(公告)号：US20110190624A1
公开(公告)日：2011-08-04
申请号：US12696488
申请日：2010-01-29
申请人： Can CINBIS , Xiaonan SHEN , Jonathan KUHN
发明人： Can CINBIS , Xiaonan SHEN , Jonathan KUHN
IPC分类号： A61B6/12
CPC分类号： A61B5/14552 , A61B5/0044 , A61B5/0075 , A61B5/0084 , A61B5/061 , A61B5/064 , A61B5/065 , A61B5/1459 , A61B5/4887 , A61B5/6852 , A61B5/72 , A61B90/39 , A61B2017/00061 , A61B2017/00243 , A61B2090/306 , A61B2562/0242
摘要： A system and method for identifying the location of a medical device within a patient's body may be used to localize the fossa ovalis for trans-septal procedures. The systems and methods measure light reflected by tissues encountered by an optical array. An optical array detects characteristic wavelengths of tissues that are different distances from the optical array. The reflectance of different wavelengths of light at different distances from an optical array may be used to identify the types of tissue encountered, including oxygenated blood in the left atrium as detected from the right atrium through the fossa ovalis.
摘要翻译：可以使用用于识别患者体内的医疗装置的位置的系统和方法来定位卵圆形卵巢用于反间隔手术。系统和方法测量由光学阵列遇到的组织反射的光。光学阵列检测与光学阵列不同距离的组织的特征波长。可以使用与光学阵列不同距离的不同波长的光的反射率来识别遇到的组织的类型，包括从右心房通过卵圆窝检测到的左心房中的氧合血液。

42. 发明申请

US20110178395A1 IMAGING METHOD AND SYSTEM 审中-公开
标题翻译：成像方法与系统
公开(公告)号：US20110178395A1
公开(公告)日：2011-07-21
申请号：US12756765
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
IPC分类号： A61B6/00
CPC分类号： A61B5/064 , A61B1/00041 , A61B1/0005 , A61B1/0008 , A61B1/00096 , A61B1/00149 , A61B1/00172 , A61B1/042 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/065 , A61B5/445 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B8/12 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B90/20 , A61B90/36 , A61B2090/364 , A61B2562/0242 , G02B21/0012 , G02B21/0024
摘要： Imaging systems and methods are provided herein. An imaging system for imaging a surgical site, may include a macroscopic visualization system; and an imaging apparatus with a probe, the imaging apparatus being adapted to image the observational field and generate second image data; wherein the system is operable to control the macroscopic visualization system and the imaging apparatus to image the site and the observational field respectively at substantially the same time, and to associate the first image data and the second image data. Imaging methods provided herein may include the steps of: imaging the site with a macroscopic visualization system and generating first image data; imaging at substantially the same time an observational field with an imaging apparatus and generating second image data; and associating the first image data and the second image data.
摘要翻译：本文提供成像系统和方法。用于成像外科手术部位的成像系统可以包括宏观可视化系统; 以及具有探针的成像装置，所述成像装置适于对所述观察场进行成像并生成第二图像数据; 其中所述系统可操作以控制所述宏观可视化系统和所述成像装置，以在基本相同的时间分别对所述场地和所述观测场进行成像，并且将所述第一图像数据和所述第二图像数据相关联。本文提供的成像方法可以包括以下步骤：用宏观可视化系统对站点进行成像并产生第一图像数据; 在大体上相同的时间成像具有成像装置的观察场并产生第二图像数据; 以及将所述第一图像数据和所述第二图像数据相关联。

43. 发明申请

US20110060200A1 IN VIVO BLOOD SPECTROMETRY 审中-公开
标题翻译：血液血液光谱仪
公开(公告)号：US20110060200A1
公开(公告)日：2011-03-10
申请号：US12946506
申请日：2010-11-15
申请人： Peter Bernreuter
发明人： Peter Bernreuter
IPC分类号： A61B5/1455
CPC分类号： A61B5/1464 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/6826 , A61B5/6838 , A61B2562/0242
摘要： A process and apparatus for determining the arterial and venous oxygenation of blood in vivo with improved precision. The optical properties of tissue are measured by determination of differential and total attenuations of light at a set of wavelengths. By choosing distinct wavelengths and using the measured attenuations, the influence of variables such as light scattering, absorption and other optical tissue properties is canceled out or minimized.
摘要翻译：用于以更高的精度确定体内血液的动脉和静脉氧合的方法和装置。通过确定一组波长的光的差分和总衰减来测量组织的光学性质。通过选择不同的波长并使用测量的衰减，消除或最小化光散射，吸收和其他光学组织性质等变量的影响。

44. 发明申请

US20100121200A1 DIAGNOSTIC AND PROGNOSTIC ASSISTANCE DEVICE FOR PHYSIOPATHOLOGICAL TISSUE CHANGES 审中-公开
标题翻译：用于生理性病理组织变化的诊断和预防辅助装置
公开(公告)号：US20100121200A1
公开(公告)日：2010-05-13
申请号：US12596025
申请日：2008-04-18
申请人： Odile Carvalho , Laurence Roy , Marc Benderitter
发明人： Odile Carvalho , Laurence Roy , Marc Benderitter
IPC分类号： A61B6/00
CPC分类号： A61B5/445 , A61B5/0059 , A61B5/444 , A61B2562/0242
摘要： Said device applies in particular to in vivo diagnostic and prognostic assistance for physiopathological changes to biological tissues. It comprises a coherent light source (13) for emitting coherent light along a first direction (X), for the purpose of illuminating a biological tissue (16) in first and second areas thereof, the first area being sound and the second area liable to include changes, the tissue thus illuminated generating a speckle phenomenon, means (14) for observing the speckle field in a second direction (Y) and for acquiring the speckle, and means (18) for varying the angle between the first and second directions, in order to observe the speckle field at different angles, so as to acquire information about the tissue at various depths in this tissue, support and absorption means (20, 28) to maintain a constant distance between the surface of the tissue and the observation and acquisition means and to absorb possible movements of the tissue, electronic means (22) for processing the speckle figures obtained by means of the observation and acquisition means, said processing being carried out in particular by a fractal method, in order to compare the first and second areas, and electronic means (24) for analysing the processing of the figures, by statistical methods, making it possible to validate the comparison made between the first and second areas.
摘要翻译：所述装置特别适用于生物组织的生理病理变化的体内诊断和预后辅助。它包括用于沿着第一方向（X）发射相干光的相干光源（13），用于照亮其第一和第二区域中的生物组织（16），第一区域是声音，第二区域易于包括变化，如此照射的组织产生斑点现象，用于在第二方向（Y）上观察斑点并获取散斑的装置（14）以及用于改变第一和第二方向之间的角度的装置（18）为了观察不同角度的斑点，以获取关于该组织，支撑和吸收装置（20,28）中不同深度的组织的信息，以保持组织表面与观察和获取装置并且吸收组织的可能运动，用于处理通过观察和获取装置获得的散斑图形的电子装置（22），所述处理特别地执行通过分形法，为了比较第一和第二区域，以及用于分析图形的处理的电子装置（24），通过统计方法，使得有可能验证第一和第二区域之间的比较。

45. 发明授权

US07623906B2 Diffuse reflectance spectroscopy 失效
标题翻译：漫反射光谱
公开(公告)号：US07623906B2
公开(公告)日：2009-11-24
申请号：US10292109
申请日：2002-11-12
申请人： M. Ries Robinson , Robert G. Messerschmidt
发明人： M. Ries Robinson , Robert G. Messerschmidt
IPC分类号： A61B6/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0242
摘要： An improved method and apparatus for diffuse reflectance spectroscopy. A specular control device is provided that can discriminate between diffusely reflected light that is reflected from selected depths or layers within the tissue. The specular control device permits a spectroscopic analyzer to receive the diffusely reflected light that is reflected from, for example, a first layer or depth within the tissue, while preventing the remaining diffusely reflected light from reaching the spectroscopic analyzer. Furthermore, the specular control device may prevent the specularly reflected light (e.g. surface reflected light) from reaching the spectroscopic analyzer.
摘要翻译：一种用于漫反射光谱的改进方法和装置。提供了一种镜面控制装置，其可以区分从组织内的选定深度或层反射的漫反射光。镜面控制装置允许光谱分析仪接收从例如组织内的第一层或深度反射的漫反射光，同时防止剩余的漫反射光到达光谱分析仪。此外，镜面控制装置可以防止镜面反射光（例如表面反射光）到达光谱分析仪。

46. 发明申请

US20090266999A1 Apparatus and method for fluorescent imaging 审中-公开
标题翻译：用于荧光成像的装置和方法
公开(公告)号：US20090266999A1
公开(公告)日：2009-10-29
申请号：US12421254
申请日：2009-04-09
申请人： Beat Krattiger
发明人： Beat Krattiger
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , A61B1/00096 , A61B1/043 , A61B1/0638 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B2562/0242 , G01N21/4795 , G01N21/6408 , G01N2021/1787 , G01N2021/6484 , G02B23/2446 , G02B23/2484 , H04N13/275
摘要： An apparatus and method for fluorescent imaging. The apparatus includes a light-generating means for generating at least one modulated fluorescence excitation beam, a light retransmitting means for retransmitting the fluorescence excitation beam onto an area that is to be examined, a light-imaging means for imaging a fluorescent beam from the area to be examined onto a first image sensor, a control and evaluation means for controlling the light-generating means to power the first image sensor and for evaluating the data supplied by the first image sensor to generate a fluorescent image, where the fluorescent excitation beam may be continuously modulated, the first image sensor is a solid state detector that may be powered phase-sensitively, and the data supplied by the first image sensor contain pixel by pixel phase information on the fluorescent beam.
摘要翻译：一种用于荧光成像的装置和方法。该装置包括用于产生至少一个调制荧光激发光束的光产生装置，用于将荧光激发光束重新发射到待检查的区域上的光重传装置，用于对来自该区域的荧光束进行成像的光成像装置检查第一图像传感器，控制和评估装置，用于控制发光装置为第一图像传感器供电并评估由第一图像传感器提供的数据以产生荧光图像，其中荧光激发光束可以被连续调制，第一图像传感器是可以相位敏感地供电的固态检测器，并且由第一图像传感器提供的数据在荧光束上包含逐个像素的相位信息。

47. 发明申请

US20090028461A1 IMAGING OF BURIED STRUCTURES 有权
标题翻译： BURIED结构的成像
公开(公告)号：US20090028461A1
公开(公告)日：2009-01-29
申请号：US10598077
申请日：2005-02-15
申请人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
发明人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
IPC分类号： G06K9/36 , G06K9/00 , A61B17/34
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/489 , A61B2562/0242 , G01N21/35 , G01N21/359 , G06T7/12 , G06T7/174 , G06T2207/10048 , G06T2207/20224 , G06T2207/30076 , G06T2207/30101
摘要： A method of obtaining an image of buried structures in an object, comprising partially irradiating said object by light of a wavelength that images said buried structure; and obtaining a complementary partial image of said buried structure by light diffused from a non-irradiated image area.According to the method, an image can be obtained while discarding specular reflections of the object. Thus, deeper structures will be better visible. In a further aspect, the invention offers a method of enhancing imaging of buried structures in an object, comprising: analysing said image as a first image in order to detect the edges of said buried structure; obtaining a second image by irradiating said object with a second light that visually images said object; and combining said first and second images for defining edges of said buried structure in said visual image.
摘要翻译：一种获得物体中埋藏结构的图像的方法，包括通过对所述掩埋结构进行成像的波长的光部分照射所述物体; 以及通过从非照射图像区域扩散的光获得所述掩埋结构的互补部分图像。根据该方法，可以在丢弃对象的镜面反射的同时获得图像。因此，更深层的结构将会更加明显。在另一方面，本发明提供了一种增强物体中掩埋结构的成像的方法，包括：分析所述图像作为第一图像，以便检测所述掩埋结构的边缘; 通过用视觉图像所述物体的第二光照射所述物体来获得第二图像; 以及将所述第一和第二图像组合用于在所述视觉图像中定义所述掩埋结构的边缘。

48. 发明授权

US07353055B2 Non-invasive analysis system 有权
标题翻译：非侵入性分析系统
公开(公告)号：US07353055B2
公开(公告)日：2008-04-01
申请号：US10870121
申请日：2004-06-17
申请人： Josh N. Hogan
发明人： Josh N. Hogan
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/0066 , A61B5/14532 , A61B5/1455 , A61B2562/0242
摘要： A non-invasive analysis system suitable for measuring blood glucose concentration includes a broadband set of coherent beams, with relatively low divergence angle, optical source. It further includes an optical processing system which provides a probe and a reference beam, applies the probe beam to the target to be analyzed, recombines the beams interferometrically and varies the relative phase relationships of the two beams. It further includes control and processing systems.
摘要翻译：适用于测量血糖浓度的非侵入性分析系统包括具有相对低发散角的相干光束的宽带组，光源。它还包括提供探针和参考光束的光学处理系统，将探测光束施加到待分析的目标，使光束干涉地重新组合并改变两个光束的相对相位关系。它还包括控制和处理系统。

49. 发明授权

US07242480B2 Low coherence interferometry for detecting and characterizing plaques 失效
标题翻译：用于检测和表征斑块的低相干干涉测量
公开(公告)号：US07242480B2
公开(公告)日：2007-07-10
申请号：US11039987
申请日：2005-01-21
申请人： Gerard A. Alphonse
发明人： Gerard A. Alphonse
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/45 , A61B5/0066 , A61B5/0086 , A61B5/02007 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/6852 , A61B2562/0242 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method for determining a characteristic of tissue in a biological sample comprising: directing light at the biological sample at a first depth and receiving that light reflected from the biological; directing the light at a reflecting device and receiving that light reflected from the reflecting device. The method also includes: interfering the light reflected from the biological sample and the light reflected from the reflecting device; detecting light resulting from the interfering; and determining a first phase associated with the light resulting from the interfering based on the first depth. The method further includes: varying an effective light path length to define a second depth; determining a second phase associated with the light resulting from the interfering based on the second depth; and determining the characteristic of the biological sample from the first phase and the second phase.
摘要翻译：一种用于确定生物样品中组织特征的方法，包括：在第一深度处引导光生物样品并接收从生物学反射的光; 将光引导到反射装置并接收从反射装置反射的光。该方法还包括：干扰从生物样品反射的光和从反射装置反射的光; 检测由干扰产生的光; 以及基于所述第一深度确定与由所述干扰产生的光相关联的第一阶段。该方法还包括：改变有效光路长度以限定第二深度; 确定与基于所述第二深度的所述干扰产生的光相关联的第二阶段; 以及从第一阶段和第二阶段确定生物样本的特性。

50. 发明申请

US20070027391A1 Optical diagnosis and treatment apparatus 审中-公开
标题翻译：光学诊断和治疗仪器
公开(公告)号：US20070027391A1
公开(公告)日：2007-02-01
申请号：US11493699
申请日：2006-07-27
申请人： Shinichi Kohno
发明人： Shinichi Kohno
IPC分类号： A61B5/05 , A61B18/18
CPC分类号： A61B18/24 , A61B5/0068 , A61B5/0073 , A61B2017/00057 , A61B2562/0242
摘要： An optical diagnosis and treatment apparatus includes a pulsed light source, an illumination optical system for illuminating a region of a living body through a guide tube, a light condensing means for condensing pulsed light, an optical scan means for two-dimensionally scanning the region, a light detection means for detecting the pulsed light reflected from the region, an operation means for reconstructing, based on an output from the light detection means, a tomographic image of the region, an image display means for displaying the tomographic image based on an output from the operation means and a light intensity switching means for switching the intensity of the pulsed light at least between two levels. The two levels are a level at which vaporization of living body tissue due to multi-photon absorption occurs at a convergence position of the pulsed light and a level at which vaporization does not occur.
摘要翻译：光学诊断和治疗设备包括脉冲光源，用于通过引导管照射生物体的区域的照明光学系统，用于聚集脉冲光的聚光装置，用于二维扫描该区域的光学扫描装置，用于检测从该区域反射的脉冲光的光检测装置，用于基于来自光检测装置的输出重建该区域的断层图像的操作装置，用于基于输出显示断层图像的图像显示装置来自操作装置和光强度切换装置，用于至少在两个水平之间切换脉冲光的强度。这两个水平是在脉冲光的会聚位置处发生的由多光子吸收引起的活体组织蒸发的水平和不发生蒸发的水平。

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