专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20140356415A1 COMPOSITIONS AND VACCINES COMPRISING VESICLES AND METHODS OF USING THE SAME 有权
标题翻译：包含VESICLES的组合物和疫苗及其使用方法
公开(公告)号：US20140356415A1
公开(公告)日：2014-12-04
申请号：US14295306
申请日：2014-06-03
申请人： University of Maryland, College Park , University of Maryland, Baltimore
发明人： Philip R. DeShong , Lenea Stocker , Daniel C. Stein , Stefanie N. Vogel , Katharina Richard
IPC分类号： A61K9/127 , C07K14/195 , C07K14/22 , A61K39/095 , A61K39/02
CPC分类号： C07K14/195 , A61K39/0208 , A61K39/095 , A61K39/39 , A61K2039/55555 , C07K14/22
摘要： The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are useful to stimulate an antigen-specific immune response and, in some embodiments, a protective immune response in an animal after challenge to pathogens. The compositions of the disclosure are also useful for treatment and prevention of disease in a subject such as cancer.
摘要翻译：本公开涉及组合物，药物组合物，疫苗及其制备和使用方法。本公开的组合物可用于刺激抗原特异性免疫应答，并且在一些实施方案中，在攻击病原体后在动物中具有保护性免疫应答。本公开的组合物还可用于治疗和预防患者如癌症中的疾病。

42. 发明授权

US08180126B2 Detecting meniscal tears in non-invasive scans 有权
标题翻译：在非侵入性扫描中检测半月板撕裂
公开(公告)号：US08180126B2
公开(公告)日：2012-05-15
申请号：US12190584
申请日：2008-08-12
申请人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
发明人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
IPC分类号： G06K9/00
CPC分类号： A61B5/103 , A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/03 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/20132 , G06T2207/30004
摘要： Techniques for automatically detecting meniscus include receiving pixels from a scanning device directed to a knee of a subject. Also received is a region of interest that includes pixels that correspond to at least a portion of a meniscus of the knee. Without human intervention, a meniscus extraction threshold is determined based on pixel intensities in the region of interest. A meniscus object portion of the scan data is further determined without human intervention based on the meniscus extraction threshold and a geometrical constraint. Other techniques for automatically detecting meniscal tears includes receiving a meniscus object portion of scan data from a scanning device and receiving threshold data that indicates a meniscus extraction threshold. Without human intervention, a propensity for meniscal tears is determined based on the threshold data and the meniscus object portion of the scan data.
摘要翻译：用于自动检测弯液面的技术包括从指向对象的膝盖的扫描装置接收像素。还接收的是包括对应于膝盖的弯液面的至少一部分的像素的感兴趣区域。在没有人为干预的情况下，基于感兴趣区域中的像素强度来确定弯液面提取阈值。基于弯月面提取阈值和几何约束，进一步确定扫描数据的弯液面物体部分，而无需人为干预。用于自动检测半月板眼泪的其它技术包括从扫描装置接收扫描数据的弯月面物体部分，以及接收指示弯月面提取阈值的阈值数据。在没有人为干预的情况下，根据扫描数据的阈值数据和弯月面对象部分来确定半月板撕裂的倾向。

43. 发明授权

US07288532B1 Modified chitosan polymers and enzymatic methods for the production thereof 失效
标题翻译：改性壳聚糖聚合物及其制备方法
公开(公告)号：US07288532B1
公开(公告)日：2007-10-30
申请号：US09763324
申请日：1999-08-20
申请人： Gregory F. Payne , Guneet Kumar
发明人： Gregory F. Payne , Guneet Kumar
IPC分类号： C08G8/00 , C12P19/04
CPC分类号： C12P19/26 , C08B37/003
摘要： The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the presence of a chitosan polymer or oligomer to produce a modified chitosan polymer or oligomer. The invention also includes modified chitosan polymers or oligomers produced by the novel processes, in particular modified chitosan polymers or oligomers having useful functional properties, such as base solubility and/or high viscosity.
摘要翻译：本发明涉及用于制备改性壳聚糖聚合物或低聚物的均相酶催化方法。在壳聚糖聚合物或低聚物的存在下，使酶与酚底物反应以制备改性的壳聚糖聚合物或低聚物。本发明还包括通过新方法生产的改性壳聚糖聚合物或低聚物，特别是具有有用功能性质的改性壳聚糖聚合物或低聚物，例如碱溶解度和/或高粘度。

44. 发明公开

US20230152320A1 APPARATUS AND METHOD FOR AIRBORNE PATHOGEN DETECTION USING AN ELECTROCHEMICAL PLATFORM 审中-公开
公开(公告)号：US20230152320A1
公开(公告)日：2023-05-18
申请号：US18055333
申请日：2022-11-14
申请人： University Of Maryland, Baltimore , University of Maryland, Baltimore County
发明人： Dipanjan PAN , Maha Mohammad Shehadeh ALAFEEF
IPC分类号： G01N33/569 , G01N29/12 , G01N29/24 , G01N33/543
CPC分类号： G01N33/56983 , G01N29/12 , G01N29/2443 , G01N33/54373 , G01N2291/014 , G01N2291/023 , G01N2333/165
摘要： An apparatus is provided for airborne pathogen detection, which includes a crystal microbalance. The apparatus includes specific capture probes that are affixed to the crystal microbalance and are designed to bind to and capture a specific pathogen, such as a virus particle. This capture causes a change in mass of the crystal microbalance that can be detected. A method is provided for airborne pathogen detection, which includes calibrating a resonant frequency of the crystal microbalance to a mass on the crystal microbalance. The method also includes a step of conjugating the antibody to the crystal microbalance. The method also includes, for each measurement time, measuring a resonant frequency of the crystal microbalance and determining a mass change due to binding of the pathogen to the detector. This mass change is then related to pathogen load in the medium. A notification is output if the viral load exceeds a predetermined threshold.

45. 发明授权

US11523808B2 Device and method for transseptal puncture 有权
公开(公告)号：US11523808B2
公开(公告)日：2022-12-13
申请号：US16577345
申请日：2019-09-20
申请人： University of Maryland, Baltimore , University of Maryland Medical Center, LLC
发明人： James S. Gammie , Rachael Quinn , Chetan Pasrija
IPC分类号： A61B17/00 , A61B17/34 , A61B17/3207 , A61M25/01 , A61B18/00
摘要： The present invention provides transseptal puncture devices configured to access structures on the left side of the heart from the right side of the heart without requiring open-heart surgery. The devices have adjustable stiffness to enter the vasculature in a flexible, atraumatic fashion, then become rigid once in place to provide a stable platform for penetration of the fossa ovalis. The devices are further configured to controllably and stably extend a needle to puncture the FO. The devices include an indwelling blunt stylus that can extend perpendicularly from the device to increase the accuracy of placement near the fossa ovalis.

46. 发明申请

US20220249126A1 APPARATUS AND METHOD FOR SEPTAL PUNCH 有权
公开(公告)号：US20220249126A1
公开(公告)日：2022-08-11
申请号：US17526616
申请日：2021-11-15
申请人： University of Maryland, Baltimore , University of Maryland Medical System LLC , Protaryx Medical Inc.
发明人： James S. GAMMIE , Philip J. HAARSTAD , David BLAESER , Ryan BAUER , Stephen ROLLER , Rachael QUINN , Chetan PASRIJA , Edwin HLAVKA
IPC分类号： A61B17/34
摘要： In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

47. 发明授权

US11154325B2 Apparatus and method for septal punch 有权
公开(公告)号：US11154325B2
公开(公告)日：2021-10-26
申请号：US17315729
申请日：2021-05-10
申请人： University of Maryland, Baltimore , University of Maryland Medical System LLC , Protaryx Medical Inc.
发明人： James S. Gammie , Philip J. Haarstad , David Blaeser , Ryan Bauer , Stephen Roller , Rachael Quinn , Chetan Pasrija , Edwin Hlavka
IPC分类号： A61B17/34 , A61B17/00
摘要： In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

48. 发明授权

US10518098B2 Methods and systems for controlling magnetic fields and magnetic field induced current 有权
公开(公告)号：US10518098B2
公开(公告)日：2019-12-31
申请号：US15300979
申请日：2015-04-02
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： Liyi Elliott Hong , Fow-Sen Choa
IPC分类号： A61N2/00 , A61N1/40 , A61N2/02
摘要： The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain. The system is configured such that the DC magnetic fields may be used to manipulate the transient magnetic fields, in turn allowing significantly improved control and focus of the induced current within a specifically desired volume of interest within a patient's body.

49. 发明授权

US10179145B2 Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells 有权
公开(公告)号：US10179145B2
公开(公告)日：2019-01-15
申请号：US15001215
申请日：2016-01-19
申请人： University of Maryland, Baltimore , University of Maryland, College Park
发明人： Matthew Dowling , John Hess , Grant Bochicchio , Srinivasa Raghavan
IPC分类号： A61K31/722 , A61K47/56 , A61K47/61 , A61L27/20 , A61L26/00 , A61K9/127 , A61K9/70 , A61K47/69
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

50. 发明授权

US09413571B2 System and method for time reversal data communications on pipes using guided elastic waves 有权
标题翻译：使用引导弹性波在管道上进行时间反转数据通信的系统和方法
公开(公告)号：US09413571B2
公开(公告)日：2016-08-09
申请号：US13787079
申请日：2013-03-06
申请人： University of Maryland Eastern Shore , Carnegie Mellon University
发明人： Yuanwei Jin , Deshuang Zhao , Yujie Ying
IPC分类号： H04L25/49
CPC分类号： H04L25/4902
摘要： Embedded piezoelectric sensors in large civil structures for structural health monitoring applications require data communication capabilities to effectively transmit information regarding the structure's integrity between sensor nodes and to the central processing unit. Conventional communication modalities include electromagnetic waves or acoustical waves. While guided elastic waves can propagate over long distances on solid structures, their multi-modal and dispersive characteristics make it difficult to interpret the channel responses and to transfer useful information along pipes. Time reversal is an adaptive transmission method that can improve the spatiotemporal wave focusing. The present disclosure presents the basic principles of a time reversal based pulse position modulation (TR-PPM) method and demonstrates TR-PPM data communication by simulation. The present disclosure also experimentally demonstrates data communication with TR-PPM on pipes. Simulated and experimental results demonstrate that TR-PPM for data communications can be achieved successfully using guided elastic waves.
摘要翻译：用于结构健康监测应用的大型民用结构中的嵌入式压电传感器需要数据通信能力来有效地传输关于传感器节点之间的结构的完整性和中央处理单元的信息。常规的通信方式包括电磁波或声波。虽然引导弹性波可以在固体结构上长距离传播，但它们的多模态和分散特性使得难以解释通道响应并沿着管道传送有用信息。时间反演是一种可以改善时空波聚焦的自适应传输方法。本公开内容提出了基于时间反演的脉冲位置调制（TR-PPM）方法的基本原理，并通过仿真演示了TR-PPM数据通信。本公开还实验地演示了与管道上的TR-PPM的数据通信。模拟实验结果表明，使用引导弹性波可以成功实现用于数据通信的TR-PPM。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式