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41. 发明申请

US20150192542A1 METHOD OF MANUFACTURING AN ELECTROPHORESIS CASSETTE 审中-公开
标题翻译：制造电解质CASSETTE的方法
公开(公告)号：US20150192542A1
公开(公告)日：2015-07-09
申请号：US14403638
申请日：2013-05-31
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Camilla Larsson , Henrik Ostlin , Stefan Sjolander , Anders Jahge , Kajas Stridsberg-Friden
IPC分类号： G01N27/447 , B29C45/16
CPC分类号： G01N27/44704 , B29C45/1676 , B29K2021/003 , B29K2101/12 , G01N27/44743 , G01N27/44756
摘要： Method of manufacturing an electrophoresis gel cassette with a cassette housing defining a gel compartment for molding a gel member,comprising the steps of: molding in a rigid material a cassette housing member with an external face, an internal face defining at least a section of the gel compartment, and at least one opening for providing access to the gel compartment from the external face, and molding a closing member formed to close the at least one opening of the cassette housing member at the external face, wherein the closing member is molded with the cassette housing member acting partly as mold, and is comprised of an elastic material with non-permanent adhesion to the rigid material to make the closing member selectively removable.
摘要翻译：制造具有限定用于模制凝胶构件的凝胶室的盒壳体的电泳凝胶盒的方法，包括以下步骤：在刚性材料中模制具有外表面的盒壳体构件，限定至少一部分凝胶室，以及至少一个用于从外表面进入凝胶隔室的开口，以及模制封闭件，其形成为在外表面封闭盒壳件的至少一个开口，其中封闭件用所述盒壳体部件部分地作为模具起作用，并且由弹性材料构成，所述弹性材料具有与所述刚性材料的非永久性粘合以使所述封闭构件可选择性地移除。

42. 发明申请

US20150153272A1 METHODS AND APPARATUS FOR MEASURING THE LIGHT ABSORBANCE OF A SUBSTANCE IN A SOLUTION 有权
标题翻译：用于测量溶液中物质的光吸收的方法和装置
公开(公告)号：US20150153272A1
公开(公告)日：2015-06-04
申请号：US14404860
申请日：2013-05-30
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Hanno Ehring , Fredrik Lars Jarhede , Erik Ostlund
IPC分类号： G01N21/33
CPC分类号： G01N21/33 , G01N21/3151 , G01N30/74 , G01N2021/3181 , G01N2030/8827 , G01N2201/062
摘要： Disclosed is an apparatus for measuring the absorbance of a substance in a solution, comprising: i) a sample cell (30) of known path length (b) for containing said solution (S), said cell being transparent to light of a predefined wavelength spectrum; ii) plural LED's each being independently operable by means of a controller (25) each for emitting light, within said predefined wavelength spectrum, along a light path; iii) a band pass filter (22) in the light path; iv) a beam splitter (24) for dividing light from said source propagating along the path into a first portion and a second portion, said first portion being directable by the beam splitter toward a reference detector (42) and said second portion being directable into the cell (30); v) a reference detector (42) for detecting the intensity of said first portion of light directed by said beam splitter; and vi) a sample detector (40) for detecting the intensity of the second portion propagating from the cell; the apparatus allowing a sample in the cell to be inexpensively subjected to more than one wavelength of light for quicker or more accurate analysis.
摘要翻译：公开了一种用于测量溶液中物质的吸光度的装置，包括：i）用于容纳所述溶液（S）的已知路径长度（b）的样品池（30），所述池对于预定波长的光是透明的光谱; ii）多个LED各自可以通过控制器（25）独立操作，每个控制器用于沿所述光路在所述预定波长光谱内发射光; iii）光路中的带通滤波器（22）; iv）用于将沿着路径传播的光源的光分离成第一部分和第二部分的分束器（24），所述第一部分可被分束器引向参考检测器（42），并且所述第二部分可被引导到细胞（30）; v）用于检测由所述分束器引导的所述第一部分光的强度的参考检测器（42）和vi）用于检测从单元传播的第二部分的强度的样本检测器（40）允许细胞中的样品经济地经受多于一个波长的光的装置，用于更快或更准确的分析。

43. 发明申请

US20150080554A1 AFFINITY CHROMATOGRAPHY MATRIX 审中-公开
标题翻译：亲属色谱矩阵
公开(公告)号：US20150080554A1
公开(公告)日：2015-03-19
申请号：US14385336
申请日：2013-03-26
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Mats Ander , Goran Bauren , Tomas Bjorkman , Per-Mikael Aberg , Gustav Rodrigo
IPC分类号： C07K16/00 , C07K14/31 , G01N33/68 , B01J20/291
CPC分类号： C07K16/00 , B01D15/3809 , B01J20/286 , B01J20/291 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J2220/80 , C07K1/22 , C07K14/31 , G01N33/6854
摘要： The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to H18 of the B domain of Protein A or of Protein Z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to H18 of the B domain of protein A or of protein Z is not serine, threonine or lysine.
摘要翻译：本发明公开了一种免疫球蛋白结合蛋白，其包含葡萄球菌蛋白A（E，D，A，B，C）或蛋白Z或其功能变体的一个或多个突变的免疫球蛋白结合结构域（单体），其中至少一个一个或多个突变单体，在对应于蛋白A或蛋白Z的B结构域的H18的位置处的天冬酰胺或组氨酸已被缺失或被不是脯氨酸或天冬酰胺的第一氨基酸残基取代，并且其中，如果第57位的氨基酸残基是脯氨酸，28位的氨基酸残基是天冬酰胺，则相应于蛋白A的B结构域或蛋白Z的H18位置的氨基酸残基不是丝氨酸，苏氨酸或赖氨酸。

44. 发明申请

US20150041009A1 DEVICE FOR DELIVERY OF SAMPLE FLUID 审中-公开
标题翻译：用于输送样品流体的装置
公开(公告)号：US20150041009A1
公开(公告)日：2015-02-12
申请号：US14385516
申请日：2013-03-28
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Klaus Gebauer , Ekta Mahajan , Eric Faldt
IPC分类号： F16K11/10
CPC分类号： F16K11/10 , A61M5/1408 , A61M2039/242 , B01D15/14 , F16K15/144 , F16K15/145 , F16K15/148 , F16K27/0209 , Y10T137/7838 , Y10T137/789 , Y10T137/87684 , G01N2030/328 , G01N2030/6056
摘要： The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
摘要翻译：本发明涉及一种用于输送流体的装置（1），所述装置包括至少两个柔性材料的流体管道（12-17），每个流体管道的一端可以连接到流体源并且在相对端连接到具有入口端和出口端的歧管（18），每个所述流体管道（12-17）包括用于关闭和打开管道的夹紧阀（19）。根据本发明，止回阀（20）设置在连接到歧管（18）的端部中的至少一个所述流体管道（12-17）中。

45. 发明授权

US08921120B2 Method for determination of macromolecular multimers 有权
标题翻译：高分子多聚体测定方法
公开(公告)号：US08921120B2
公开(公告)日：2014-12-30
申请号：US13503391
申请日：2010-10-22
申请人： Ewa Pol
发明人： Ewa Pol
IPC分类号： G01N33/566 , C07K1/14 , G01N33/543
CPC分类号： C07K1/14 , G01N33/54373
摘要： A method of determining multimers of a macromolecule monomer in a sample containing the macromolecule comprises the steps of (i) determining the total concentration of macromolecule in the sample, (ii) determining by a biosensor-based detection method, especially mass-sensing, the active concentration of macromolecule in the sample, wherein physical characteristics of the macromolecule monomer are used, (iii) comparing the relationship of determined active macromolecule concentration to total macromolecule concentration for the sample with a corresponding relationship for an at least substantially multimer-free macromolecule-containing sample, and (iv) from a resulting difference determining the presence of multimers in the sample. The method may be used in the purification of macromolecules, such as proteins.
摘要翻译：在含有大分子的样品中测定高分子单体的多聚体的方法包括以下步骤：（i）测定样品中大分子的总浓度，（ii）通过基于生物传感器的检测方法，特别是质量感测，样品中的高分子的活性浓度，其中使用大分子单体的物理特性，（iii）比较所测定的活性大分子浓度与样品的总大分子浓度的关系，其对应于至少基本上不含多聚体的大分子 - （iv）从得到的差异确定样品中多聚体的存在。该方法可用于纯化大分子如蛋白质。

46. 发明授权

US08857779B2 Holder for a holographic grating 有权
标题翻译：用于全息光栅的支架
公开(公告)号：US08857779B2
公开(公告)日：2014-10-14
申请号：US13262251
申请日：2010-03-29
申请人： Mikael Hornqvist , Patrik Akerstrom , Stig Tormod
发明人： Mikael Hornqvist , Patrik Akerstrom , Stig Tormod
IPC分类号： F16M13/00 , G01J3/18 , G02B7/00 , G01J3/02 , G01J3/42 , G01J3/28
CPC分类号： G01J3/02 , G01J3/0202 , G01J3/1838 , G01J3/42 , G01J2003/2866 , G02B7/004
摘要： An adjustable holder (1) for a concave holographic grating (2) for enabling the correct positioning of the grating vis-à-vis a light entrance port (15) and a light exit port (20), characterized in, that it comprises a grating hinge (10) fixed to said grating, said grating hinge (10) enabling rotational adjustment of the grating position with respect to said holder (1), the center point of the rotational adjustment being located at the vertex of said grating (2).
摘要翻译：一种用于凹面全息光栅（2）的可调节保持器（1），用于相对于光入口（15）和光出口（20）能够正确定位光栅，其特征在于，其包括固定到所述光栅的光栅铰链（10），所述光栅铰链（10）能够相对于所述保持器（1）旋转调节所述光栅位置，所述旋转调节的中心点位于所述光栅（2）的顶点处，。

47. 发明申请

US20140272999A1 PURIFICATION OF NUCLEIC ACID 有权
标题翻译：纯化核酸
公开(公告)号：US20140272999A1
公开(公告)日：2014-09-18
申请号：US14352122
申请日：2012-10-25
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Camilla Estmer Nilsson , Johan Ohman
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/1006 , C12N15/1013 , C12N15/1017
摘要： The present invention relates to a simple and efficient method to isolate and purify nucleic acids, preferably genomic DNA, from complex samples compared with available methods, by using a ligand which relies on hydrogen bonding to purify the nucleic acids. Preferably the ligand is bound to magnetic beads/particles. More closely the method comprises adding a sample comprising nucleic acid to a polymer having neutral charge; reversibly binding said nucleic acid to said polymer by hydrogen bonding under pH conditions 5. The method is very suitable for sample preparation of nucleic acids, for example for PCR applications.
摘要翻译：本发明涉及通过使用依赖于氢键来提纯核酸的配体，与可用的方法相比，从复杂样品中分离和纯化核酸，优选基因组DNA的简单而有效的方法。优选地，配体结合磁珠/颗粒。更紧密地，该方法包括将含有核酸的样品添加到具有中性电荷的聚合物中; 在PH条件<5下通过氢键可逆地将所述核酸结合到所述聚合物上; 洗涤所述聚合物; 并在pH> 5的条件下从所述聚合物中洗脱所述核酸。该方法非常适用于核酸的样品制备，例如用于PCR应用。

48. 发明申请

US20140263012A1 PARALLEL ASSEMBLY OF CHROMATOGRAPY COLUMN MODULES 有权
标题翻译：色谱柱模块的平行组装
公开(公告)号：US20140263012A1
公开(公告)日：2014-09-18
申请号：US14290357
申请日：2014-05-29
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： KLAUS GEBAUER
IPC分类号： B01D15/14
CPC分类号： B01D15/14 , B01D15/1864 , B01D15/1885 , B01D15/22 , G01N30/466 , G01N30/6039 , G01N30/6043 , G01N30/6091 , G01N2030/8881 , Y10T29/49826
摘要： A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
摘要翻译：色谱柱模块（3a，b，c; 13a，b，c; 53a，b，c，90a，b）的平行组件（2; 11; 51），该组件具有一个共同的组装入口（15; 55）和一个共同组装出口（17; 57），每个柱模块包括填充有色谱介质的床空间（29），并且每个柱模块包括集成流体导管，当列模块与其他柱模块连接时，适于连接床柱模块的空间（29）与组件入口（15; 55）和组件出口（17; 57）相连，其中流体导管从组装入口到一个床空间的总长度和/或体积与从同一床空间到组装出口的流体导管的长度和/或体积对于安装在平行组件中的所有床空间和模块基本相同。

49. 发明授权

US08821718B2 Automated fluid handling system 有权
标题翻译：自动流体处理系统
公开(公告)号：US08821718B2
公开(公告)日：2014-09-02
申请号：US13376929
申请日：2010-06-04
申请人： Johan Blomberg , Mats Lundkvist
发明人： Johan Blomberg , Mats Lundkvist
IPC分类号： B01D35/00 , B01D35/22 , B01J10/00 , A47B47/00 , G01N30/88 , G01N35/00
CPC分类号： G01N35/1097 , B01D15/08 , B01D15/10 , B01D17/12 , B01D29/60 , B01D2201/54 , G01N30/24 , G01N30/38 , G01N30/88 , G01N2030/027 , G01N2030/8804 , G01N2030/8881 , G01N2035/00326 , Y10T137/6416 , Y10T137/6525 , Y10T137/6851 , Y10T137/85986 , Y10T137/87885
摘要： Automated fluid handling system comprising a housing (20) and two or more fluid handling units (26) arranged as interchangeable modular components with an external fluidics section (30) and an internal non fluidics section (32), and wherein the housing (20) comprises a liquid handling panel (22) with two or more of component positions for receiving said interchangeable modular components (26) such that the external fluidics section (30) is separated from the non fluidics section (32) by the liquid handling panel (22).
摘要翻译：自动流体处理系统包括壳体（20）和布置为具有外部流体部分（30）和内部非流体部分（32）的可互换模块化部件的两个或更多个流体处理单元（26），并且其中壳体（20）包括具有用于接收所述可互换模块化部件（26）的两个或更多个部件位置的液体处理板（22），使得外部流体部分（30）通过液体处理板（22）与非流体部分（32）分离）。

50. 发明申请

US20140224739A1 CHROMATOGRAPHY COLUMNS, SYSTEMS AND METHODS 有权
标题翻译：色谱柱，系统和方法
公开(公告)号：US20140224739A1
公开(公告)日：2014-08-14
申请号：US14252874
申请日：2014-04-15
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： KLAUS GEBAUER
IPC分类号： B01D15/18
CPC分类号： G01N30/6004 , B01D15/18 , B01D15/22 , G01N30/6017 , G01N30/6021 , G01N30/6052 , G01N30/606
摘要： The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
摘要翻译：本发明涉及轴流色谱柱，通过使用这种色谱柱分离液体中的一种或多种分析物的方法，以及采用这种色谱柱的系统。该柱包括第一端口和第二端口，第一端口和第二端口在色谱柱上的床空间的水平以上基本相同的水平或高度。

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