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41. 发明申请

US20090005745A1 Transdermal drug delivery systems for delivering anti-inflammatory drugs 审中-公开
标题翻译：用于递送抗炎药物的透皮药物递送系统
公开(公告)号：US20090005745A1
公开(公告)日：2009-01-01
申请号：US12156473
申请日：2008-05-30
申请人： Jie Zhang , Kevin S. Warner
发明人： Jie Zhang , Kevin S. Warner
IPC分类号： A61K9/70 , A61F7/08
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36° C. to 42° C., and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置用于将人皮肤部位加热至特定的温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5 小时。

42. 发明授权

US07447030B2 Thermal module having a housing integrally formed with a roll cage of an electronic product 失效
标题翻译：散热模块具有与电子产品的卷笼一体形成的壳体
公开(公告)号：US07447030B2
公开(公告)日：2008-11-04
申请号：US11309613
申请日：2006-08-31
申请人： Ching-Bai Hwang , Jie Zhang
发明人： Ching-Bai Hwang , Jie Zhang
IPC分类号： H05K7/20 , F28F7/00
CPC分类号： F28D15/0275 , F28D15/0233 , F28D15/0266 , F28F9/00 , F28F2250/08
摘要： A thermal module includes a roll cage mounted to an enclosure of an electronic product, a centrifugal blower, and a fin assembly. The centrifugal blower is disposed in the roll cage and includes a housing integrally formed with the roll cage and defining an air outlet therein, a cover attached to the housing to cooperatively define a receiving chamber therebewteen, and a rotor rotatably disposed in the receiving chamber for producing an airflow. The fin assembly is disposed at the air outlet of the blower to perform heat convection with the airflow flowing therethrough.
摘要翻译：热模块包括安装到电子产品的外壳上的卷笼，离心式鼓风机和散热片组件。离心鼓风机设置在滚子保持器中，并且包括与滚子保持架一体形成并且在其中限定出气口的壳体，附接到壳体的盖，以协同地限定其中的接收室，以及可旋转地设置在接收室中的转子，产生气流。翅片组件设置在鼓风机的出风口处，以随着流过其中的气流进行热对流。

43. 发明申请

US20080225475A1 Computer case with locking side panel and bezel 失效
标题翻译：带锁定侧面板和表圈的电脑机箱
公开(公告)号：US20080225475A1
公开(公告)日：2008-09-18
申请号：US11953860
申请日：2007-12-11
申请人： Jie Zhang , Xiao-Yong Qin , Hung-Chun Lu , Wen-Kang Lo , Guang-Yao Lee , Chun-Chi Liang
发明人： Jie Zhang , Xiao-Yong Qin , Hung-Chun Lu , Wen-Kang Lo , Guang-Yao Lee , Chun-Chi Liang
IPC分类号： G06F1/16 , A47B81/00
CPC分类号： G06F1/181
摘要： A computer case includes a chassis comprising a first wall and a second wall detachably attached to the first wall, a cover detachably attached to the first wall, and means for coupling the cover to the first wall. The coupling means is driven by the second wall to fix the cover to the first wall and prevent the cover from being detached from the first wall before the second wall disengaged from the first wall.
摘要翻译：计算机外壳包括底架，其包括可拆卸地附接到第一壁的第一壁和第二壁，可拆卸地附接到第一壁的盖以及用于将盖连接到第一壁的装置。联接装置由第二壁驱动以将盖固定到第一壁上，并且在第二壁与第一壁分离之前防止盖与第一壁分离。

44. 发明申请

US20080151498A1 Heat-Radiating Device with a Guide Structure 审中-公开
标题翻译：具有导向结构的散热装置
公开(公告)号：US20080151498A1
公开(公告)日：2008-06-26
申请号：US11661242
申请日：2005-09-06
申请人： Jie Zhang
发明人： Jie Zhang
IPC分类号： H01L23/467
CPC分类号： G06F1/20 , F28F3/02 , F28F13/06 , H01L23/3672 , H01L2924/0002 , H01L2924/00
摘要： A heat-radiating device with a guide includes a radiator and a fan. The radiator includes a base and a plurality of radiating fins protruding upward from the top surface of the base. The fan is mounted to one side of the radiator, the air flow from the fan passes through the air gap between two adjacent radiating fins so as to flow out from the side opposite the fan. These radiating fins is protruded bently toward its one side to form a guide structure which inclines from the further side of the base to the closer side of the base in the air flow direction so that the air flow flows downward to the heated electronic elements to radiate heat for them. The guide structure of the present invention is formed integrally with the radiating fins, thus advantages of low cost and easy manufacture are obtained.
摘要翻译：具有引导件的散热装置包括散热器和风扇。散热器包括从基座的顶表面向上突出的基部和多个散热片。风扇安装在散热器的一侧，来自风扇的空气流通过两个相邻散热片之间的空气间隙，从风扇相对侧流出。这些散热片朝向其一侧倾斜地突出，以形成从空气流动方向从底座的另一侧向底部的更靠侧倾斜的引导结构，使得空气流向下流动到被加热的电子元件以辐射为他们热。本发明的导向结构与散热片一体形成，因此获得了低成本和容易制造的优点。

45. 发明授权

US07378509B2 NF-kappaB oligonucleotide decoy molecules 失效
标题翻译： NF-κB寡核苷酸诱饵分子
公开(公告)号：US07378509B2
公开(公告)日：2008-05-27
申请号：US11004512
申请日：2004-12-02
申请人： Leslie M. McEvoy , Christi Parham , Jie Zhang , Rolf Ehrhardt
发明人： Leslie M. McEvoy , Christi Parham , Jie Zhang , Rolf Ehrhardt
IPC分类号： C07H21/04
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

46. 发明申请

US20080105410A1 HEAT DISSIPATION APPARATUS 审中-公开
标题翻译：散热装置
公开(公告)号：US20080105410A1
公开(公告)日：2008-05-08
申请号：US11556594
申请日：2006-11-03
申请人： Ching-Bai Hwang , Jie Zhang
发明人： Ching-Bai Hwang , Jie Zhang
IPC分类号： H05K7/20
CPC分类号： G06F1/20 , G06F2200/201 , H05K7/20172
摘要： A heat dissipation apparatus (10) includes a heat-dissipating fan (14) and a fin assembly (12). The heat-dissipating fan includes a casing (141) and a plurality of blades (142) rotatably received in the casing. The casing defines an air outlet (148) through which an airflow generated by the blades flows. The air outlet has a front side (148b) and a rear side (148a). The airflow first reaches the front side and then flows towards the rear side. The fin assembly is arrangepd at the air outlet of the fan, and includes a plurality of first fins (121) adjacent to the rear side of the air outlet and a plurality of second fins (122) adjacent to the front side of the air outlet. The first fins are integrally formed with the casing of the fan, whilst the second fins consist of a stack of individually formed fins.
摘要翻译：散热装置（10）包括散热风扇（14）和散热片组件（12）。散热风扇包括壳体（141）和可旋转地容纳在壳体中的多个叶片（142）。壳体限定出风口（148），由叶片产生的气流通过该出口流动。出风口具有前侧（148b）和后侧（148a）。气流首先到达前侧，然后朝向后方流动。翅片组件布置在风扇的出风口处，并且包括邻近空气出口的后侧的多个第一翅片（121）和与排气口的前侧相邻的多个第二翅片（122）。第一散热片与风扇的壳体一体形成，而第二散热片由单独形成的散热片组成。

47. 发明申请

US20080058325A1 COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 有权
标题翻译：化合物，方法和用于抑制PARP的药物组合物
公开(公告)号：US20080058325A1
公开(公告)日：2008-03-06
申请号：US11834334
申请日：2007-08-06
申请人： Vincent Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Xing , Qun Liu
发明人： Vincent Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Xing , Qun Liu
IPC分类号： A61K31/5377 , A61K31/5025 , A61P19/02 , A61P25/24 , A61P25/28 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/06 , A61P9/10 , C07D237/26 , C07D413/14
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”) compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供抑制含有这些化合物的聚（ADP-核糖）聚合酶（“PARP”）组合物的化合物和使用这些PARP抑制剂来治疗，预防和/或改善本文所述病症的作用的方法。

48. 发明申请

US20080019927A1 Compositions and methods for dermally treating neuropathy with minoxidil 审中-公开
标题翻译：用米诺地尔皮肤治疗神经病变的组合物和方法
公开(公告)号：US20080019927A1
公开(公告)日：2008-01-24
申请号：US11888905
申请日：2007-08-01
申请人： Jie Zhang , Kevin Warner , Sanjay Sharma
发明人： Jie Zhang , Kevin Warner , Sanjay Sharma
IPC分类号： A61K9/12 , A61K31/165 , A61K31/415 , A61K31/445 , A61P17/00 , A61K31/505 , A61K31/56
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含有可用于治疗包括糖尿病性神经病变神经病变的米诺地尔的粘合剂固化制剂。制剂可以包括一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种能够在持续的时间内以治疗有效速率递送米诺地尔的至少一种非挥发性溶剂的非挥发性溶剂体系。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

49. 发明申请

US20070196293A1 Compositions and methods for treating photo damaged skin 审中-公开
标题翻译：治疗照片损伤皮肤的组合物和方法
公开(公告)号：US20070196293A1
公开(公告)日：2007-08-23
申请号：US11640102
申请日：2006-12-14
申请人： Jie Zhang , Kevin Warner , Sanjay Sharma
发明人： Jie Zhang , Kevin Warner , Sanjay Sharma
IPC分类号： A61K31/4745 , A61K35/64
CPC分类号： A61K9/7015 , A61K31/473 , A61K31/513 , A61K31/573 , A61K47/10 , A61K47/42
摘要： The present invention is drawn to formulations, methods, and solidified layers for topical delivery of an immune modulating agent for treatment of photo damaged skin. The formulation can include an immune modulating agent, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein non-volatile solvent system is capable of facilitating the delivery of immune modulating agent at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于局部递送用于治疗光损伤皮肤的免疫调节剂的制剂，方法和固化层。制剂可以包括免疫调节剂，溶剂载体和固化剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中非挥发性溶剂体系能够促进免疫调节剂在治疗上的递送有效率在一段持续的时间内。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

50. 发明申请

US20070190124A1 Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs 审中-公开
标题翻译：两种或多种含固化剂的组合物和用于药物真皮递送的方法
公开(公告)号：US20070190124A1
公开(公告)日：2007-08-16
申请号：US11640444
申请日：2006-12-14
申请人： Jie Zhang , Kevin Warner , Sanjay Sharma
发明人： Jie Zhang , Kevin Warner , Sanjay Sharma
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/7015 , A61F13/0253 , A61K31/473 , A61K31/513 , A61K31/573 , A61K47/10 , A61K47/42 , A61L15/44 , A61L15/58 , A61L2300/402
摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least two solidifying agents. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和至少两种固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包括至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂的非挥发性溶剂），其能够在持续的时间段内以治疗有效率促进药物的递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

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