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41. 发明申请

US20090029929A1 Decoy Nucleic Acid to Synoviolin Gene Promoter 审中-公开
标题翻译：诱饵核酸对滑膜蛋白基因启动子
公开(公告)号：US20090029929A1
公开(公告)日：2009-01-29
申请号：US10594146
申请日：2005-03-28
申请人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
发明人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
IPC分类号： A61K31/711 , A61K48/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C12N15/12 , C12N5/10
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/13
摘要： The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.
摘要翻译：本发明提供了用于滑膜炎基因启动子的诱饵核酸。还提供了诱饵核酸可以通过与滑膜素基因启动子的转录因子结合来抑制启动子活性。它还提供如（a）由如SEQ ID NO：11或12所示的核苷酸序列组成的诱饵核酸所表达的诱饵核酸; 并且还提供（b）由SEQ ID NO：11或12所示的具有缺失，取代或添加一个或几个核苷酸的核苷酸序列组成的具有抑制滑膜素基因启动子活性的功能的诱饵核酸。

42. 发明申请

US20080305102A1 Therapeutic Agent for Cancer Comprising Substance Capable of Inhibiting Expression or Function of Synoviolin as Active Ingredient and Screening Method for the Therapeutic Agent for Cancer 审中-公开
标题翻译：包含抑制作为活性成分的滑膜蛋白的表达或功能的物质的癌症治疗剂和癌症治疗剂的筛选方法
公开(公告)号：US20080305102A1
公开(公告)日：2008-12-11
申请号：US11993774
申请日：2006-06-23
申请人： Toshihiro Nakajima , Yukihiro Kato , Tadayuki Yamadera , Tetsuya Amano
发明人： Toshihiro Nakajima , Yukihiro Kato , Tadayuki Yamadera , Tetsuya Amano
IPC分类号： A61K39/395 , C07H21/00 , C07K16/18 , C07K2/00 , C12Q1/68 , G01N33/50 , A61K31/53 , C07D403/04 , C07D251/54 , A61P35/00 , A61K38/00 , A61K48/00
CPC分类号： G01N33/5011 , A01K2267/0325 , A61K31/53 , A61K31/7088 , A61K38/1709 , A61K38/53 , C12N9/93 , C12N15/1135 , C12N2310/11 , C12N2310/14 , G01N2500/00 , G01N2800/102
摘要： Inhibition of synoviolin function was found to activate the cancer-suppressing protein p53. Substances inhibiting the function of synoviolin are useful as cancer therapeutic agents. The inhibition of synoviolin function was also found to lead to the inhibition of p53 ubiquitination, increased activity of p53 phosphorylation proteins, and the like. Based on these findings, the present invention provides methods capable of efficiently screening for cancer therapeutic agents. Further, it was also found that regulation of the autoubiquitination of synoviolin protein suppresses the proliferation of rheumatoid arthritis synovial cells. Substances regulating the autoubiquitination of synoviolin protein are useful as anti-rheumatic agents. Moreover, the present invention provides methods of efficiently screening for anti-rheumatic agents.
摘要翻译：发现滑膜蛋白功能的抑制活化了癌症抑制蛋白p53。抑制滑膜素功能的物质可用作癌症治疗剂。还发现滑膜蛋白功能的抑制导致p53泛素化的抑制，p53磷酸化蛋白的活性增加等。基于这些发现，本发明提供能够有效筛选癌症治疗剂的方法。此外，还发现调节滑膜蛋白自身泛素化抑制类风湿性关节炎滑膜细胞的增殖。调节滑膜蛋白自身泛素化的物质可用作抗风湿药。此外，本发明提供了有效筛选抗风湿剂的方法。

43. 发明授权

US07307417B2 Rotation detecting device 有权
公开(公告)号：US07307417B2
公开(公告)日：2007-12-11
申请号：US11819766
申请日：2007-06-29
申请人： Minoru Tokuhara , Yukihiro Kato
发明人： Minoru Tokuhara , Yukihiro Kato
IPC分类号： G01B7/30 , G01R33/07 , G01R33/09
CPC分类号： G01D5/147 , G01D3/022 , G01D5/24452 , G01D5/2448 , G01P3/487
摘要： A rotation detecting device for detecting a rotating object includes a housing having a bearing and an mounting surface, a rotor member having magnetic peripheral portion and a rotary shaft that is supported by the bearing, a biasing permanent magnet for providing magnetic field around the mounting surface and the magnetic peripheral portion, an IC sensor chip including plural magnetic sensor elements disposed on the mounting surface to provide a sensing signal related to change in magnetic field around the sensor elements, and an IC signal processing chip that provides a rotation signal according to the sensing signal. In this device, the bearing and the mounting surface are integrally formed into the housing at a prescribed distance to secure an unchanged air gap distance.

44. 发明授权

US07304473B2 Rotational angle detecting device 有权
标题翻译：旋转角度检测装置
公开(公告)号：US07304473B2
公开(公告)日：2007-12-04
申请号：US11208761
申请日：2005-08-23
申请人： Susumu Kuroyanagi , Yukihiro Kato
发明人： Susumu Kuroyanagi , Yukihiro Kato
IPC分类号： G01B7/30 , G01R33/07
CPC分类号： G01D5/24438 , G01D5/145
摘要： A rotational angle detecting device includes a sensor portion disposed on a shaft. The sensor portion includes longitudinal hall elements disposed perpendicular to each other for outputting a hall voltage proportional to a magnetic flux induced by a magnet disposed on the shaft. The device also includes an engagement mechanism for maintaining a positional relationship with the magnet in which a center portion of the sensor is aligned with a center portion of the magnet.
摘要翻译：旋转角检测装置包括设置在轴上的传感器部。传感器部分包括彼此垂直设置的纵向霍尔元件，用于输出与由设置在轴上的磁体引起的磁通成比例的霍尔电压。该装置还包括用于保持与磁体的位置关系的接合机构，其中传感器的中心部分与磁铁的中心部分对准。

45. 发明申请

US20070247144A1 ROTATION DETECTING DEVICE 有权
标题翻译：旋转检测装置
公开(公告)号：US20070247144A1
公开(公告)日：2007-10-25
申请号：US11819766
申请日：2007-06-29
申请人： Minoru Tokuhara , Yukihiro Kato
发明人： Minoru Tokuhara , Yukihiro Kato
IPC分类号： G01B7/30
CPC分类号： G01D5/147 , G01D3/022 , G01D5/24452 , G01D5/2448 , G01P3/487
摘要： A rotation detecting device for detecting a rotating object includes a housing having a bearing and an mounting surface, a rotor member having magnetic peripheral portion and a rotary shaft that is supported by the bearing, a biasing permanent magnet for providing magnetic field around the mounting surface and the magnetic peripheral portion, an IC sensor chip including plural magnetic sensor elements disposed on the mounting surface to provide a sensing signal related to change in magnetic field around the sensor elements, and an IC signal processing chip that provides a rotation signal according to the sensing signal. In this device, the bearing and the mounting surface are integrally formed into the housing at a prescribed distance to secure an unchanged air gap distance.
摘要翻译：用于检测旋转物体的旋转检测装置包括具有轴承和安装表面的壳体，具有磁性周边部分的转子部件和由轴承支撑的旋转轴，用于在安装表面周围提供磁场的偏置永磁体和磁性周边部分，IC传感器芯片，其包括设置在安装表面上的多个磁性传感器元件，以提供与传感器元件周围的磁场变化相关的感测信号;以及IC信号处理芯片，其根据感应信号。在该装置中，轴承和安装表面以规定的距离一体地形成在壳体中，以确保空隙间距离的不变。

46. 发明申请

US20070238677A1 Pharmaceutical Composition Containing Hshrd3 审中-公开
标题翻译：含Hshrd3的药物组合物
公开(公告)号：US20070238677A1
公开(公告)日：2007-10-11
申请号：US10592918
申请日：2005-03-16
申请人： Toshihiro Nakajima , Tetsuya Amano , Satoshi Yamasaki , Naoko Yagishita , Takeshi Sasaki , Yukihiro Kato , Lei Zhang
发明人： Toshihiro Nakajima , Tetsuya Amano , Satoshi Yamasaki , Naoko Yagishita , Takeshi Sasaki , Yukihiro Kato , Lei Zhang
IPC分类号： A61K31/7088 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , A61P35/00 , C12N15/09 , C12N5/00
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/14
摘要： The present invention provides a pharmaceutical composition containing a substance which inhibits the proliferation of synovial tissue or synovial cells and the interleukin-6 production. It also provides a pharmaceutical composition for inhibiting the proliferation of synovial tissue or synovial cells and the interleukin-6 production, which is useful for diagnosing and treating at least one selected from the group consisting of rheumatoid arthritis, fibrosis, arthritis, cancers, and cerebral neural diseases. In addition, it provides a method for inhibiting the proliferation of synovial cells and the interleukin-6 production by inhibiting the expression of hsHRD3 in synovial cells.
摘要翻译：本发明提供含有抑制滑膜组织或滑膜细胞增殖的物质和白细胞介素-6产生的药物组合物。它还提供用于抑制滑膜组织或滑膜细胞增殖的药物组合物和白细胞介素-6产生，其可用于诊断和治疗选自以下的至少一种：类风湿性关节炎，纤维化，关节炎，癌症和脑神经疾病另外，通过抑制滑膜细胞中hsHRD3的表达，提供了抑制滑膜细胞增殖和白细胞介素-6产生的方法。

47. 发明申请

US20060097717A1 Rotation detecting device 有权
标题翻译：旋转检测装置
公开(公告)号：US20060097717A1
公开(公告)日：2006-05-11
申请号：US11263556
申请日：2005-11-01
申请人： Minoru Tokuhara , Yukihiro Kato
发明人： Minoru Tokuhara , Yukihiro Kato
IPC分类号： G01B7/30
CPC分类号： G01D5/147 , G01D3/022 , G01D5/24452 , G01D5/2448 , G01P3/487
摘要： A rotation detecting device for detecting a rotating object includes a housing having a bearing and an mounting surface, a rotor member having magnetic peripheral portion and a rotary shaft that is supported by the bearing, a biasing permanent magnet for providing magnetic field around the mounting surface and the magnetic peripheral portion, an IC sensor chip including plural magnetic sensor elements disposed on the mounting surface to provide a sensing signal related to change in magnetic field around the sensor elements, and an IC signal processing chip that provides a rotation signal according to the sensing signal. In this device, the bearing and the mounting surface are integrally formed into the housing at a prescribed distance to secure an unchanged air gap distance.
摘要翻译：用于检测旋转物体的旋转检测装置包括具有轴承和安装表面的壳体，具有磁性周边部分的转子部件和由轴承支撑的旋转轴，用于在安装表面周围提供磁场的偏置永磁体和磁性周边部分，IC传感器芯片，其包括设置在安装表面上的多个磁性传感器元件，以提供与传感器元件周围的磁场变化相关的感测信号;以及IC信号处理芯片，其根据感应信号。在该装置中，轴承和安装表面以规定的距离一体地形成在壳体中，以确保空隙间距离的不变。

48. 发明授权

US06980315B2 Data processing device for camera-integrated VTR, printer thereof, and method for operating the printer 失效
标题翻译：用于照相机集成VTR的数据处理装置，其打印机以及用于操作打印机的方法
公开(公告)号：US06980315B2
公开(公告)日：2005-12-27
申请号：US09765005
申请日：2001-01-18
申请人： Kouji Komatsu , Seiichi Morikawa , Yukihiro Kato , Keikichi Chiba , Junya Ishihara , Yoshinari Higuchi , Hajime Ishimitsu , Toshimitsu Kubodera , Masato Yamaguchi , Yoichi Miyajima , Hiroyuki Ohyama
发明人： Kouji Komatsu , Seiichi Morikawa , Yukihiro Kato , Keikichi Chiba , Junya Ishihara , Yoshinari Higuchi , Hajime Ishimitsu , Toshimitsu Kubodera , Masato Yamaguchi , Yoichi Miyajima , Hiroyuki Ohyama
IPC分类号： B41J29/00 , H04N5/225 , H04N5/765 , H04N5/77 , G06F15/00
CPC分类号： H04N5/772 , H04N5/225 , H04N5/765
摘要： A camera-integrated VTR system including a printer embodying a data processing device of the invention is provided, wherein various external data supplied from an external device and internal data generated or recorded internally are enabled to be exchanged selectively, easily and directly between respective components of the system without use of any additional component therebetween so as to be printed instantaneously. The printer of the camera-integrated VTR system comprises a picture display device; a memory device for storing a still picture displayed on the picture display device; and a print operation button for operating the printer, wherein the print operation button is a pushbutton switch which has two modes of states of a half-depressed mode and a full-depressed mode; and wherein the half-depressed mode of the print operation button allows for a portion of pictures displayed on the display device to be selected as a print picture and stored in the memory device; and the full-depressed mode of the print operation button allows to start printing of the print picture.
摘要翻译：提供了一种包括本发明的数据处理装置的打印机的照相机集成VTR系统，其中从外部设备提供的各种外部数据和内部产生或记录的内部数据能够被选择性地，容易地并直接地交换在该系统不使用它们之间的任何附加部件，以便瞬间打印。相机集成VTR系统的打印机包括图像显示装置; 用于存储显示在图像显示装置上的静止图像的存储装置; 以及用于操作打印机的打印操作按钮，其中打印操作按钮是具有半按压模式和全按压模式的两种状态模式的按钮开关; 并且其中打印操作按钮的半按压模式允许将显示在显示装置上的图像的一部分选择为打印图像并存储在存储装置中; 并且打印操作按钮的全按下模式允许开始打印打印图像。

49. 发明授权

US06927337B2 Electronic control unit for use in automotive vehicle 失效
标题翻译：用于汽车的电子控制单元
公开(公告)号：US06927337B2
公开(公告)日：2005-08-09
申请号：US10686645
申请日：2003-10-17
申请人： Toshiki Kobayashi , Hajime Katsuro , Yukihiro Kato , Toshio Fujimura , Toru Murowaki , Yutaka Obikane
发明人： Toshiki Kobayashi , Hajime Katsuro , Yukihiro Kato , Toshio Fujimura , Toru Murowaki , Yutaka Obikane
IPC分类号： B60R16/02 , B60R16/023 , H02G3/08 , H05K5/00
CPC分类号： B60R16/0239 , H02G3/08 , H05K5/0073
摘要： A box-shaped electronic control unit for use in an automotive vehicle includes a pair of side stays for mounting the electronic control unit on a vehicle. The side stay integrally formed with a bottom cover is bent upward to form a bent portion. When electronic control units are carried by a conveyer, they are placed on a conveyer belt so that the bent portions face one another, thereby to avoid overlapping of the electronic control units on the conveyer belt. To form the side stay having a sufficient mechanical strength endurable against a high vibrating force of the vehicle, a pair of ribs extending from both sides of the bottom cover are formed on the side stays.
摘要翻译：用于机动车辆的箱形电子控制单元包括用于将电子控制单元安装在车辆上的一对侧支架。与底盖一体形成的侧面保持架向上弯曲以形成弯曲部分。当电子控制单元由传送带承载时，它们被放置在传送带上，使得弯曲部分彼此面对，从而避免电子控制单元在传送带上重叠。为了形成具有抵抗车辆的高振动力耐受的足够的机械强度的侧撑，在侧撑上形成从底盖的两侧延伸的一对肋。

50. 发明授权

US06787989B2 Substrate with transparent conductive film and organic electroluminescence device using the same 失效
标题翻译：具有透明导电膜的衬底和使用其的有机电致发光器件
公开(公告)号：US06787989B2
公开(公告)日：2004-09-07
申请号：US09820385
申请日：2001-03-29
申请人： Shunji Wada , Yukihiro Kato
发明人： Shunji Wada , Yukihiro Kato
IPC分类号： H05B3300
CPC分类号： H01L51/0021 , Y10T428/163
摘要： A substrate with a transparent condcutive film is provided, which has a high work function and an excellent surface smoothness as well as a reduced specific resistance to thereby ensure a reduced power consumption and enhanced display quality. An ITO film 2 is formed on a glass substrate 1 by an ion plating method by using an ITO sintered compact with an SnO2 content of 4 to 6 wt %. The ITO film 2 obtained as above has a surface having a work function of 4.9 to 5.5 eV, a surface roughness of 1 to 10 nm, and a specific resistance of 1.6×10−4 &OHgr;·cm or less. An organic EL device using the substrate is provided, in which an organic multilayer film (hole transport layer 5, light-emitting layer 7, and electron transport layer 6) is laminated on the surface of the ITO film 2, and further a metal thin film layer 4 is laminated on the surface of the organic multilayer film.
摘要翻译：提供具有透明的保护膜的基板，其具有高功函数和优异的表面平滑度以及降低的电阻率，从而确保降低的功耗和增强的显示质量。通过使用SnO 2含量为4〜6重量％的ITO烧结体，通过离子镀法在玻璃基板1上形成ITO膜2。如上获得的ITO膜2具有功函数为4.9〜5.5eV，表面粗糙度为1〜10nm，电阻率为1.6×10 -4Ω·cm以下的表面。提供了一种使用该基板的有机EL器件，其中在ITO膜2的表面上层叠有机多层膜（空穴传输层5，发光层7和电子传输层6），并且还具有金属薄膜膜层4层叠在有机多层膜的表面上。

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