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41. 发明授权

US5210730A Tracking error detecting apparatus for use in multibeam optical disk device 失效
标题翻译：跟踪错误检测装置在多光盘光盘设备中的使用
公开(公告)号：US5210730A
公开(公告)日：1993-05-11
申请号：US640353
申请日：1991-01-17
申请人： Akio Hayashi , Koichi Okabe , Shozo Nakagawa
发明人： Akio Hayashi , Koichi Okabe , Shozo Nakagawa
IPC分类号： G11B7/09 , G11B7/135 , G11B7/14 , G11B7/24
CPC分类号： G11B7/14 , G11B7/0901
摘要： In a multi-beam optical disk device in which a signal is recorded on or reproduced from an optical disk by means of a plurality of light beams, a tracking error detecting apparatus is constructed such that the plurality of light beams projected from an optical head are made incident upon the optical disk and one of these light beams is made incident upon a groove formed in the optical disk and a first tracking error signal is derived from the one light beam reflected by or transmitted through the groove, and all the light beams are made incident upon a groove formed in the optical disk and a second tracking error signal is derived from all the beams reflected by or transmitted through the groove.
摘要翻译： PCT No.PCT / JP90 / 00624 Sec。 371日期1991年1月17日 102（e）日期1991年1月17日PCT提交1990年5月17日PCT公布。 WO90 / 14665 PCT公开日期：1990年11月29日。在通过多个光束将信号记录在光盘上或从光盘再现的多光束光盘装置中，构造跟踪误差检测装置，使得多个光从光头投影的光束入射到光盘上，并且这些光束中的一个入射到形成在光盘中的凹槽上，并且从由凹槽反射或透过的一个光束导出第一跟踪误差信号并且所有光束入射到形成在光盘中的凹槽上，并且从由凹槽反射或透过凹槽的所有光束导出第二跟踪误差信号。

42. 发明授权

US5045239A Non-linear optical material 失效
标题翻译：非线性光学材料
公开(公告)号：US5045239A
公开(公告)日：1991-09-03
申请号：US362464
申请日：1989-03-17
申请人： Seizo Miyata , Toshiyuki Watanabe , Yoshitaka Goto , Akio Hayashi , Masaharu Nakayama
发明人： Seizo Miyata , Toshiyuki Watanabe , Yoshitaka Goto , Akio Hayashi , Masaharu Nakayama
IPC分类号： G02F1/361
CPC分类号： G02F1/3613
摘要： A non-linear optical material comprises a derivative of chalcone represented by the following general formulae (I) or (II) of: ##STR1## wherein R.sub.1 and R.sub.2 each represent a halogen atom, a hydroxyl group, an amino group, a dimethylamino group, a nitro group, a cyano group, a phenyl group, an acetyl group, an alkyl group having 1 to 18 carbon atoms or an alkyloxy group having 1 to 22 carbon atoms; n.sub.1 and n.sub.2 each represent an interger of from 0 to 21; and m.sub.1 and m.sub.2 each represent an integer of from 0 to 5.
摘要翻译： PCT No.PCT / JP88 / 00740 Sec。 371日期：1989年3月17日 102（e）日期1989年3月17日PCT提交1988年7月22日PCT公布。出版物WO89 / 01181 日期：1989年2月9日。非线性光学材料包含由以下通式（I）或（II）表示的查耳酮衍生物：其中R 1和R 2各自表示卤素原子，羟基，氨基，二甲基氨基，硝基，氰基，苯基，乙酰基，碳原子数1〜18的烷基或具有1〜22个的烷氧基的烷基碳原子 n1和n2分别表示从0到21的整数; m1和m2各自表示0〜5的整数。

43. 发明申请

US20140215771A1 Fastener Stringer and Fastener Chain, and Manufacturing Method of Fastener Chain 有权
标题翻译：紧固件链条和紧固件链，以及紧固件链的制造方法
公开(公告)号：US20140215771A1
公开(公告)日：2014-08-07
申请号：US13994858
申请日：2010-12-17
申请人： Akio Hayashi , Kanae Maruoka , Takeshige Kurata , Aya Takamoto
发明人： Akio Hayashi , Kanae Maruoka , Takeshige Kurata , Aya Takamoto
IPC分类号： A44B19/34 , A44B19/46
CPC分类号： A44B19/34 , A44B19/46 , Y10T24/25 , Y10T29/49984
摘要： The fastener stringer is arranged with at least one printable resin layer to which ink can be fixed on the entire surface of fastener elements. Printing by an inkjet method is carried out at least on the exposed surfaces exposed on the first tape surface side in the tape front- and back direction of the fastener elements, the inner surfaces of the first tape surface side facing the tape inward side, along with the first tape surface of the fastener tape. A desired pattern can thereby be stably formed not only on the fastener tape and the exposed surfaces of the fastener elements, but can also be formed on the inner surfaces of the fastener elements. Therefore, a pattern can be formed in a continuous manner on the fastener tape and the fastener elements, and decorativeness and design unattainable in the past can be obtained.
摘要翻译：紧固件纵梁布置有至少一个可印刷树脂层，油墨可以在其上固定在紧固件元件的整个表面上。至少在暴露在紧固件的带前后方向上的第一带表面侧的暴露表面上，通过喷墨方法进行印刷，第一带表面侧的内表面面向带内侧与拉链带的第一带表面。因此，可以不仅在拉链带和拉链件的露出表面上稳定地形成所需的图案，而且还可以形成在拉链件的内表面上。因此，可以在拉链带和紧固件上连续地形成图案，并且可以获得过去不可能实现的装饰性和设计。

44. 发明授权

US08563771B2 Process for production of precursor compound for radioactive halogen-labeled organic compound 有权
标题翻译：用于放射性卤素标记的有机化合物的前体化合物的制备方法
公开(公告)号：US08563771B2
公开(公告)日：2013-10-22
申请号：US12448311
申请日：2007-12-17
申请人： Masahito Toyama , Akio Hayashi
发明人： Masahito Toyama , Akio Hayashi
IPC分类号： C07C61/04
CPC分类号： G21H5/02 , A61K51/0406 , C07B59/001 , C07B2200/09 , C07C303/28 , C07C303/44 , C07C2601/04 , Y02P20/55 , C07C309/73 , C07C309/65 , C07C309/66
摘要： A process is provided for producing a labeled precursor which is useful for production of a radioactive fluorine-labeled amino acid compound. In the reaction step for introducing a leaving group to a mixture of syn-form and anti-form of FACBC, a base is allowed to present in the reaction system to produce a syn-leaving group adduct, which is unreactive with the base and is highly stable, and an anti-leaving group adduct which can react with the base to form a water-soluble compound. By employing a purification method utilizing such a difference in solubility, the syn-leaving group adduct can be separated selectively. The base may be a linear- or branched-chain primary to tertiary alkylamine having 1 to 10 carbon atoms, a nitrogen-containing heterocyclic compound with 2 to 20 carbon atoms, and a nitrogen-containing hetero aromatic compound with 2 to 20 carbon atoms.
摘要翻译：提供了一种制备可用于制备放射性氟标记的氨基酸化合物的标记前体的方法。在用于将离去基团引入到FACBC的正构形式和抗体形式的混合物的反应步骤中，允许碱在反应体系中存在以产生与碱不反应的合成离去基团加合物，并且是高度稳定的抗脱离基加合物，其可与碱反应形成水溶性化合物。通过使用利用这种溶解度差异的纯化方法，可以选择性地分离出合成离去基加成物。碱可以是具有1-10个碳原子的直链或支链伯 - 叔烷基胺，具有2-20个碳原子的含氮杂环化合物和具有2-20个碳原子的含氮杂芳族化合物。

45. 发明授权

US08343459B2 Method for production of radiation diagnostic imaging agent 有权
标题翻译：辐射诊断成像剂生产方法
公开(公告)号：US08343459B2
公开(公告)日：2013-01-01
申请号：US12526667
申请日：2008-02-12
申请人： Daisaku Nakamura , Soichi Nakamura , Masahito Toyama , Akio Hayashi
发明人： Daisaku Nakamura , Soichi Nakamura , Masahito Toyama , Akio Hayashi
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07C229/48 , A61K9/0019 , A61K47/26 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07B63/04 , C07B2200/05 , C07C2601/04
摘要： A method for producing a radioactive diagnostic imaging agent which contains a radioactive halogen-labeled amino acid compound as an effective ingredient and has a composition that can inhibit radiolysis of the effective ingredient, thereby further improving stability, is provided. Disclosed is a method for producing a radioactive diagnostic imaging agent, comprising a solution preparation step of preparing a solution containing a radioactive halogen-labeled amino acid compound, and a dilution step of diluting the solution containing the radioactive fluorine-labeled organic compound in order to adjust radioactive concentration thereof, which further comprises an acid addition step of adding an acid to the solution containing the radioactive fluorine-labeled organic compound, after the solution preparation step and before the dilution step, wherein the acid is added in the acid addition step in an amount sufficient to adjust the pH of the solution resulting from the dilution step to 2.0-5.9, for example, in an amount corresponding to 0.40-2.8 mmol per 1 L of the solution resulting from the dilution step.
摘要翻译：提供了含有放射性卤素标记的氨基酸化合物作为有效成分并具有能够抑制有效成分的放射线析出，从而进一步提高稳定性的组成的放射性诊断显像剂的制造方法。本发明公开了一种放射性诊断显像剂的制造方法，其特征在于，包括：制备含有放射性卤素标记的氨基酸化合物的溶液的溶液制备工序，以及稀释含有放射性氟标记的有机化合物的溶液的稀释步骤，调整其放射性浓度，其还包括在溶液制备步骤之后和稀释步骤之前在含有放射性氟标记的有机化合物的溶液中加入酸的酸添加步骤，其中在酸添加步骤中加入酸足以将由稀释步骤得到的溶液的pH调节至2.0-5.9的量，例如，相对于每1L由稀释步骤得到的溶液为0.40-2.8mmol的量。

46. 发明申请

US20100332524A1 Name Searching Apparatus 审中-公开
标题翻译：名称检索装置
公开(公告)号：US20100332524A1
公开(公告)日：2010-12-30
申请号：US12826318
申请日：2010-06-29
申请人： Takayuki UCHIDA , Yukihiro Kawamata , Hiroto Sasaki , Osamu Tomobe , Akio Hayashi
发明人： Takayuki UCHIDA , Yukihiro Kawamata , Hiroto Sasaki , Osamu Tomobe , Akio Hayashi
IPC分类号： G06F17/30
CPC分类号： G06F16/9537
摘要： In a destination search function, a narrow search function for displaying the number of hits and next candidates, when an index having data on the number of hits and the next candidate characters is held and a narrow search is speeded up referring to the index during a search. Only about a narrow search result in which the hit numbers is large such that a search time is elongated when referring to numbers, indexes in which the number of hits and next candidate characters as the narrow search result are computed are previously stored. At the time of performing the narrow search, when the number of hits is small and the numbers and the next candidates are not registered, the numbers is counted. When the number of hits and the next candidate characters are registered in the index, the narrow search results are computed by using its registration result.
摘要翻译：在目的地搜索功能中，用于显示命中次数和下一个候选的窄搜索功能，当具有关于命中次数和下一个候选字符的数据的索引被保持并且在一个搜索。只有在命中数大的狭义搜索结果中，预先存储了当参考数字时搜索时间变长，计算命中次数和下一候选字符的索引作为窄搜索结果的索引。在执行窄搜索时，当命中次数少且没有登记号码和下一个候选者时，对该号码进行计数。当在索引中登记命中次数和下一候选字符时，通过使用其注册结果来计算窄搜索结果。

47. 发明授权

US07796857B2 Video playback apparatus 有权
标题翻译：视频播放设备
公开(公告)号：US07796857B2
公开(公告)日：2010-09-14
申请号：US11154818
申请日：2005-06-17
申请人： Kazushige Hiroi , Yoshifumi Fujikawa , Norikazu Sasaki , Riri Ueda , Akio Hayashi , Yukio Fujii , Atsuo Kawaguchi
发明人： Kazushige Hiroi , Yoshifumi Fujikawa , Norikazu Sasaki , Riri Ueda , Akio Hayashi , Yukio Fujii , Atsuo Kawaguchi
IPC分类号： H04N5/93 , G11B27/00 , H04N5/91 , H04N7/00 , G11B21/08 , G11B7/085 , G11B27/02
CPC分类号： G11B27/105 , G11B2220/2545 , G11B2220/2562 , H04N5/76 , H04N5/93
摘要： A video playback apparatus includes: video data inputting unit; a ranking data inputting/generating unit that inputs or generates ranking data where scenes in video data are ranked according to importance; a playback scene determination parameter inputting unit that inputs parameters when determining scenes to be played back according to importance; a playback scene determining unit that determines playback scenes based on ranking data and playback scene determination parameters; and a display unit that displays playback scenes. A viewing time of video data that the user desires and a maximum time width of each playback scene are inputted to the playback scene determination parameter inputting unit, and the playback scene determining unit cuts scenes so that the playback time of the playback scenes fits the maximum time width, and determines the playback scenes so that the sum of the playback time of the playback scenes fits within the viewing time.
摘要翻译：视频播放装置包括：视频数据输入单元; 排序数据输入/生成单元，其输入或生成视频数据中的场景根据重要性进行排名的排序数据; 播放场景确定参数输入单元，其根据重要性来确定要重放的场景时输入参数; 回放场景确定单元，其基于排序数据和重放场景确定参数来确定回放场景; 以及显示重放场景的显示单元。用户期望的视频数据的观看时间和每个重放场景的最大时间宽度被输入到回放场景确定参数输入单元，并且回放场景确定单元切断场景，使得回放场面的回放时间适合最大时间宽度，并且确定回放场景，使得回放场景的回放时间之和适合观看时间。

48. 发明申请

US20100092387A1 Novel Compound Having Affinity For Amyloid 有权
标题翻译：具有淀粉样蛋白亲和力的新型化合物
公开(公告)号：US20100092387A1
公开(公告)日：2010-04-15
申请号：US12308715
申请日：2007-06-21
申请人： Shigeyuki Tanifuji , Akio Hayashi , Daisaku Nakamura , Shinya Takasaki , Storey Anthony Eamon , Denis Raymond Christophe Bouvet
发明人： Shigeyuki Tanifuji , Akio Hayashi , Daisaku Nakamura , Shinya Takasaki , Storey Anthony Eamon , Denis Raymond Christophe Bouvet
IPC分类号： A61K51/04 , C07D471/04
CPC分类号： C07D471/04 , A61K51/0455
摘要： A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): or a salt thereof, wherein R1 is a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms; R2 is a radioactive halogen substituent; and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimer's disease comprising a compound represented by the above formula or a salt thereof is also provided.
摘要翻译：具有与淀粉样蛋白亲和性的化合物，显示出与正常组织的足够快速的清除，并且由下式（1）表示的毒性如诱变性被抑制：或其盐，其中R1是选自氢，羟基，羧基，硫酸根基，氨基，硝基，氰基，具有1-4个碳原子的烷基取代基或具有1-4个碳原子的烷氧基取代基; R2是放射性卤素取代基; 并且m为0〜2的整数，还提供了含有上述式所示化合物或其盐的阿尔茨海默病的低毒性诊断剂。

49. 发明申请

US20100028258A1 Radioactive Diagnostic Imaging Agent 有权
标题翻译：放射诊断成像剂
公开(公告)号：US20100028258A1
公开(公告)日：2010-02-04
申请号：US12518307
申请日：2007-11-20
申请人： Akio Hayashi , Toshiyuki Shinmura , Daisaku Nakamura , Soichi Takasaki , Shinji Tokunaga , Emi Kaneko , Masahito Toyama
发明人： Akio Hayashi , Toshiyuki Shinmura , Daisaku Nakamura , Soichi Takasaki , Shinji Tokunaga , Emi Kaneko , Masahito Toyama
IPC分类号： A61K51/04 , A61K101/02
CPC分类号： A61K49/0433 , A61K47/26 , A61K51/04 , A61K51/0406 , C07B59/001
摘要： A composition including a radioactive fluorine-labeled amino acid compound is provided, which can be prevented from radiolysis. Disclosed is a composition which includes a solution containing a radioactive fluorine-labeled amino acid compound as an effective ingredient, in which the pH value of the solution is kept at 2.0-5.9, more preferably 2.0-4.9 in order to inhibit radiolysis. Also, it is possible to further inhibit radiolysis by adding thereto a pharmaceutical additive capable of inhibiting radiolysis, such as a sugar, a sugar alcohol and a sugar lactone, whilst the pH is kept at 2.0-5.9.
摘要翻译：提供了包含放射性氟标记的氨基酸化合物的组合物，其可以防止放射分解。公开了含有放射性氟标记的氨基酸化合物作为有效成分的溶液的组合物，其中溶液的pH值保持在2.0-5.9，更优选为2.0-4.9，以抑制放射分解。此外，通过在pH保持在2.0〜5.9的同时向其中添加能够抑制放射分解的药物添加剂，例如糖，糖醇和糖内酯，可以进一步抑制放射分解。

50. 发明申请

US20070161604A1 Highly active lysophosphatidic acid and method of screening therewith 失效
标题翻译：高活性溶血磷脂酸及其筛选方法
公开(公告)号：US20070161604A1
公开(公告)日：2007-07-12
申请号：US10584283
申请日：2004-12-22
申请人： Akio Hayashi , Shinji Nakade , Hidehiro Suzuki
发明人： Akio Hayashi , Shinji Nakade , Hidehiro Suzuki
IPC分类号： A61K31/665 , G01N33/53 , C07F9/02 , C07F9/28 , C07K16/18
CPC分类号： A61K31/665 , A61K45/06 , C07F9/10 , C07F9/65742 , C07K16/18 , G01N33/92 , G01N2500/00 , A61K2300/00
摘要： There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.
摘要翻译：提供了一种筛选LPA参与的疾病的预防和/或治疗物质的方法，其特征在于由式（I），（II）和（III）中任何一种表示的化合物：[其中字符的含义在描述中被描述]被使用。通过本发明的筛选方法或筛选试剂盒获得的化合物，它们的盐，它们的溶剂合物和前体药物将调节人和其它哺乳动物中高活性LPA与LPA受体的结合，从而可以将其用作预防和/或其中LPA参与的疾病的治疗剂，例如尿病，中枢神经疾病，炎性疾病，循环系统疾病，癌症，糖尿病，免疫系统疾病和消化性疾病。

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