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    • 42. 发明申请
    • NOVEL CHONDROITIN SULFATE HAVING DECREASED MOLECULAR WEIGHT AND USE THEREOF
    • 具有降解分子量的新型磺酸钠及其用途
    • US20100286085A1
    • 2010-11-11
    • US12680995
    • 2008-10-01
    • Kazuhiro KojimaYukio GotoHiroshi Maeda
    • Kazuhiro KojimaYukio GotoHiroshi Maeda
    • A61K31/715C08B37/08A61P7/02
    • A61M1/287A61K31/726A61K31/737C08B37/0069C08J3/28C08J2305/08C08K3/02C08K3/08C08K5/09C08L5/08
    • An object of the present invention is to provide a chondroitin sulfate having a decreased molecular weight which has utilization as an inhibitor of peritoneal disorder caused by long-term use of a peritoneal dialysis fluid containing glucose or a polysaccharide thereof as an osmotic agent, utilization as an osmotic agent in a peritoneal dialysis fluid, and the like. The chondroitin sulfate having a decreased molecular weight of the present invention as a means for achieving the object is characterized by having a weight average molecular weight of from 1000 to 20000 and containing a constituent disaccharide unit represented by the following structural formula in an amount of from 65 o to 100% (molar ratio) of the total. -[4GlcAβ1-3GalNAc(6S)β1]- (wherein GlcA represents a D-glucuronic acid residue; GalNAc represents an N-acetyl-D-galactosamine residue; β1-3 represents a β1-3 glycosidic linkage; β1-4 represents a β1-4 glycosidic linkage; and (6S) indicates that position 6 of the monosaccharide residue is sulfated)
    • 本发明的目的是提供一种具有降低的分子量的硫酸软骨素,其具有作为腹膜病的抑制剂的作用,其可以长期使用含有葡萄糖或其多糖的腹膜透析液作为渗透剂,利用为 腹膜透析液中的渗透剂等。 本发明的分子量降低的硫酸软骨素作为实现目的的手段,其特征在于重均分子量为1000〜20000,含有下列结构式所示的构成的二糖单元,其量为 65〜100%(摩尔比)。 - [4GlcA&bgr; 1-3GalNAc(6S)&bgr; 1] - (其中GlcA表示D-葡萄糖醛酸残基; GalNAc表示N-乙酰基-D-半乳糖胺残基;< bgr; 1-3代表& 糖苷键; 1-4表示1-4糖苷键;(6S)表示单糖残基的6位被硫酸化)