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41. 发明授权

US4754620A Dyeing apparatus 失效
标题翻译：染色设备
公开(公告)号：US4754620A
公开(公告)日：1988-07-05
申请号：US947648
申请日：1986-12-30
申请人： Kiyoshi Nakayama
发明人： Kiyoshi Nakayama
IPC分类号： D06B5/12 , D06B5/18 , D06B5/22
CPC分类号： D06B5/22
摘要： A low-liquor-ratio dyeing apparatus comprising a perforated cylindrical beam rotatably supported within a horizontal vessel for supporting on its periphery materials to be dyed, a liquid flow circulation system for forcing dying liquid through the materials radially outwardly of the beam, a sprinkler chamber mounted on the ceiling of the vessel for spraying the liquid over the upper portion of the beam, the ceiling of the vessel, and inner side walls of the vessel, and a liquid supply bypass pipe branched from the supply side of the circulation system and connected to the sprinkler chamber.
摘要翻译：一种低液比染色设备，包括可旋转地支撑在水平容器内的穿孔圆柱形梁，用于在其周边上支撑待染色的材料，用于迫使垂直的液体穿过材料径向向外的梁的液体流动循环系统，喷洒室安装在容器的天花板上，用于将液体喷射在梁的上部，容器的天花板和容器的内侧壁上，以及从循环系统的供给侧分支并连接的液体供应旁通管到喷淋室。

42. 发明授权

US4718642A Wire latticework and fence of wire latticework 失效
标题翻译：电线网格线材和栅栏
公开(公告)号：US4718642A
公开(公告)日：1988-01-12
申请号：US881129
申请日：1986-07-02
申请人： Kiyoshi Nakayama
发明人： Kiyoshi Nakayama
IPC分类号： E04H17/16
CPC分类号： E04H17/161
摘要： Wire latticework for a fence composed of vertical wire members and horizontal wire members. The latticework is formed at least at its upper with a cylindrical part which are provided by forming the end portions of the vertical wire members and the horizontal wire members thereon.
摘要翻译：用于由垂直线构件和水平线构件构成的栅栏的线网格。至少在其上部形成网格，其中形成有通过在其上形成垂直线构件的端部和水平线构件而提供的圆柱形部分。

43. 发明授权

US4626083A Electrically foldable door mirror 失效
标题翻译：电动折叠门镜
公开(公告)号：US4626083A
公开(公告)日：1986-12-02
申请号：US745663
申请日：1985-06-17
申请人： Kiyoshi Nakayama , Yasutoshi Ito , Toshiyuki Kumai
发明人： Kiyoshi Nakayama , Yasutoshi Ito , Toshiyuki Kumai
IPC分类号： G02B5/08 , B60R1/06 , B60R1/074 , G02B7/18
CPC分类号： B60R1/074
摘要： An electrically foldable door mirror comprising a base, a shaft erected on said base, a mirror body rotatably attached to said shaft, electric driving means for turning said mirror body, a pinion secured to the output shaft of said electric driving means, said pinion being engaged with a clutch gear attached to the upper portion of said shaft, means for automatically stopping said electric driving means, said stopping means being disposed between one surface of a fixed clutch fixed to the upper end of said shaft and a surface of said mirror body opposing said one surface of the fixed clutch, said stopping means comprising a printed circuit and contact pieces slidable thereon. The mirror body in the erected neutral position can be turned backward by actuating the electric driving means. When the mirror body has come to the position of the rear turning limit, the electric driving means is automatically stopped by the stopping means. The mirror body in the position of the rear turning limit can be returned to the erected neutral position by reversing the electric driving means. When the mirror body has come to the erected neutral position, the electric driving means is automatically stopped by the stopping means.
摘要翻译：一种电动可折叠的门镜，包括基座，竖立在所述基座上的轴，可旋转地连接到所述轴的镜体，用于转动所述镜体的电驱动装置，固定到所述电驱动装置的输出轴的小齿轮，所述小齿轮与固定在所述轴的上部的离合器齿轮接合，用于自动停止所述电动驱动装置的装置，所述止动装置设置在固定在所述轴的上端的固定离合器的一个表面与所述镜体之间与固定离合器的一个表面相对，所述止动装置包括印刷电路和可在其上滑动的接触件。竖起的中立位置的镜体可以通过驱动电驱动装置而向后转动。当镜体已经到达后转极限位置时，电动驱动装置被停止装置自动停止。通过反转电动驱动装置，后转向极限位置的镜体能够返回到竖立的中立位置。当镜体进入竖立中立位置时，电动驱动装置被停止装置自动停止。

44. 发明授权

US4086137A Process for the production of L-arginine by fermentation 失效
标题翻译：通过发酵生产L-精氨酸的方法
公开(公告)号：US4086137A
公开(公告)日：1978-04-25
申请号：US766630
申请日：1977-02-08
申请人： Kiyoshi Nakayama , Kazumi Araki , Hajime Yoshida
发明人： Kiyoshi Nakayama , Kazumi Araki , Hajime Yoshida
IPC分类号： C12P13/10 , C12R1/07 , C12D13/06
CPC分类号： C12P13/10 , Y10S435/839
摘要： L-arginine is produced by fermentation of a microorganism belonging to the genus Bacillus capable of producing L-arginine and having a nutritional requirement for at least one compound of the group consisting of methionine, histidine, threonine, proline, isoleucine, lysine, adenine, guanine and uracil or its precursor. L-arginine is accumulated in the culture liquor and may be recovered therefrom.
摘要翻译： L-精氨酸通过发酵能产生L-精氨酸的芽孢杆菌属的微生物产生，并且对至少一种由甲硫氨酸，组氨酸，苏氨酸，脯氨酸，异亮氨酸，赖氨酸，腺嘌呤，鸟嘌呤和尿嘧啶或其前体。 L-精氨酸在培养液中积聚并可从其中回收。

45. 发明授权

US08618094B2 Fused substituted aminopyrrolidine derivative 有权
标题翻译：熔融取代氨基吡咯烷衍生物
公开(公告)号：US08618094B2
公开(公告)日：2013-12-31
申请号：US12459612
申请日：2009-07-02
申请人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
发明人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
IPC分类号： C07D401/10 , C07D498/06 , A61K31/4709 , A61K31/5383
CPC分类号： C07D498/06 , C07D209/02 , C07D209/56 , C07D401/04 , C07D401/14 , C07D491/048 , C07D491/052 , Y02P20/55
摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
摘要翻译：提供了作为药物具有优异性能的喹诺酮合成抗菌剂，其不仅对革兰氏阴性菌具有很强的抗菌活性，而且对喹诺酮类抗菌剂具有低敏感性的革兰氏阳性球菌具有很强的抗菌活性，并且其表现出高安全性和优异的药代动力学。由式（I）表示的化合物或其盐或其水合物。具体地，其中取代基R6和R7与它们所键合的碳原子一起形成式（I）的喹诺酮衍生物形成可以含有氧原子作为环组成原子的环状结构，所述环状结构形成5- 4,5,5-或5-6稠合双环吡咯烷基取代基，该取代基与含有吡啶并苯并恶嗪结构的喹诺酮母体骨架Q结合。

46. 发明申请

US20130029977A9 Fused substituted aminopyrrolidine derivative 有权
公开(公告)号：US20130029977A9
公开(公告)日：2013-01-31
申请号：US12459612
申请日：2009-07-02
申请人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
发明人： Hisashi Takahashi , Satoshi Komoriya , Takahiro Kitamura , Takashi Odagiri , Hiroaki Inagaki , Toshifumi Tsuda , Kiyoshi Nakayama , Makoto Takemura , Kenichi Yoshida , Rie Miyauchi , Masatoshi Nagamochi
IPC分类号： A61K31/4709 , C07D498/06 , A61K31/5383 , A61P1/12 , A61P29/00 , A61P31/04 , A61P31/00 , A61P33/00 , A61P17/00 , A61P15/00 , A61P17/10 , A61P11/08 , A61P11/00 , A61P13/08 , A61P13/02 , A61P27/02 , A61P1/02 , A61P37/00 , A61P31/06 , A61P31/08 , C07D401/10
CPC分类号： C07D498/06 , C07D209/02 , C07D209/56 , C07D401/04 , C07D401/14 , C07D491/048 , C07D491/052 , Y02P20/55
摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

47. 发明授权

US08097622B2 Morpholinopurine derivatives 有权
公开(公告)号：US08097622B2
公开(公告)日：2012-01-17
申请号：US12579175
申请日：2009-10-14
申请人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
发明人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D473/34
摘要： There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.

48. 发明申请

US20110306709A1 COLOR-FADING PRIMER COMPOSITION 审中-公开
标题翻译：颜色渐变成分组成
公开(公告)号：US20110306709A1
公开(公告)日：2011-12-15
申请号：US13202652
申请日：2010-02-22
申请人： Tomoyuki Torii , Kiyoshi Nakayama , Yoshimitsu Nakayama , Takehiko Nakamura , Masaaki Murase
发明人： Tomoyuki Torii , Kiyoshi Nakayama , Yoshimitsu Nakayama , Takehiko Nakamura , Masaaki Murase
IPC分类号： C08K5/3417 , C09D133/00 , C09D175/00
CPC分类号： C09D5/002 , C08G18/289 , C08G18/6216 , C08G18/755 , C08K5/0041 , C09D7/41 , C09D133/08 , C09D167/00 , C09D175/04
摘要： The present invention provides a primer composition for sealant in which the coating quality can be visually inspected and which can sufficiently fade on exposure to the light. The primer composition for sealant use comprises (A) a binder resin and (B) one type or two or more types of pigment selected from the group composed of curcumin pigment, monascus pigment, chlorophyll, paprika pigment, marigold pigment and caramel pigment.
摘要翻译：本发明提供了一种用于密封剂的底漆组合物，其中可以目视检查涂层质量，并且可以在暴露于光时充分褪色。用于密封剂用途的底漆组合物包括（A）粘合剂树脂和（B）选自由姜黄色素，红曲霉，叶绿素，辣椒红色素，万寿菊颜料和焦糖色素组成的组中的一种或两种或更多种颜料。

49. 发明授权

US07056917B2 Drug efflux pump inhibitor 失效
标题翻译：药物外排泵抑制剂
公开(公告)号：US07056917B2
公开(公告)日：2006-06-06
申请号：US09842234
申请日：2001-04-26
申请人： Kiyoshi Nakayama , Masami Ohtsuka , Haruko Kawato , William Watkins , Jason Zhang , Monica Palme , Aesop Cho
发明人： Kiyoshi Nakayama , Masami Ohtsuka , Haruko Kawato , William Watkins , Jason Zhang , Monica Palme , Aesop Cho
IPC分类号： C07D417/06 , C07D417/12 , A61K31/427
CPC分类号： C07D417/06 , A61K31/427 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K45/06 , C07D417/12 , C07D471/04 , C12Q1/18
摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)— (R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.
摘要翻译：一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2， SUP>表示氢原子，卤素原子，羟基等，W 1表示-CH-CH - ， - CH 2 O - ， - CH- 2 CH 2 - 或类似物; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZ 0-4R 5（Z 0-4）的基团表示亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基，芳基等）。 -C（R 9） - （R 9） - （R 9） - （R 8） >和R 9表示氢原子，卤素原子，低级烷基等，Q表示酸性基团，但W 2和Q可以一起形成亚乙烯基乙二胺二酮或等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。

50. 发明申请

US20060106034A1 Drug efflux pump inhibitor 审中-公开
标题翻译：药物外排泵抑制剂
公开(公告)号：US20060106034A1
公开(公告)日：2006-05-18
申请号：US11320229
申请日：2005-12-29
申请人： Kiyoshi Nakayama , Masami Ohtsuka , Haruko Kawato , William Watkins , Jason Zhang , Monica Palme , Aesop Cho
发明人： Kiyoshi Nakayama , Masami Ohtsuka , Haruko Kawato , William Watkins , Jason Zhang , Monica Palme , Aesop Cho
IPC分类号： A61K31/519
CPC分类号： C07D417/06 , A61K31/427 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K45/06 , C07D417/12 , C07D471/04 , C12Q1/18
摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)−(R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.
摘要翻译：一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2， SUP>表示氢原子，卤素原子，羟基等，W 1表示-CH-CH-，-CH 2 O - ， - CH- 2 CH 2 - 或类似物; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZ 0-4R 5（Z 0-4）的基团表示亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基，芳基等）。 -C（R 9） - （R 9） - （R 9） - （R 8） >和R 9表示氢原子，卤素原子，低级烷基等，Q表示酸性基团，但W 2和Q可以一起形成亚乙烯基乙二胺二酮或等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。

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