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41. 发明授权

US06063376A Human deoxycytidine kinase 2 失效
标题翻译：人脱氧胞苷激酶2
公开(公告)号：US06063376A
公开(公告)日：2000-05-16
申请号：US860995
申请日：1997-10-16
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
IPC分类号： A61K38/00 , A61P31/18 , A61P37/02 , C12N9/12 , A61K38/45
CPC分类号： C12N9/1205 , A61K38/00
摘要： A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.
摘要翻译： PCT No.PCT / US95 / 00532 Sec。 371日期：1997年10月16日 102（e）日期1997年10月16日PCT提交1995年1月13日PCT公布。出版物WO96 / 21724 日期1996年7月18日公开了一种编码这种多肽的人脱氧胞苷激酶2多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽治疗恶性肿瘤和病毒感染的方法。还公开了抗这些多肽的拮抗剂及其作为治疗性免疫缺陷病症治疗剂的用途。还公开了用于检测与hdCK2核酸序列中的突变有关的疾病的诊断测定和由该核酸序列编码的多肽的浓度。

42. 发明授权

US6013473A Human mutY 失效
标题翻译：人类变态
公开(公告)号：US6013473A
公开(公告)日：2000-01-11
申请号：US813574
申请日：1997-03-07
申请人： Ying-Fei Wei
发明人： Ying-Fei Wei
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/30 , C12N9/22 , C12N9/24 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12P21/06 , C12N1/20
CPC分类号： C07K14/47 , C12N9/22 , C12N9/2471 , C12Y302/01023 , A61K38/00
摘要： A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了编码这种多肽的人类mutY多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽来预防和/或治疗与该基因突变有关的疾病的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

43. 发明授权

US5858705A Polynucleotides encoding human DNA ligase III and methods of using these polynucleotides 失效
标题翻译：编码人DNA连接酶III的多核苷酸和使用这些多核苷酸的方法
公开(公告)号：US5858705A
公开(公告)日：1999-01-12
申请号：US464402
申请日：1995-06-05
申请人： Ying-Fei Wei , Guo-Liang Yu , William A. Haseltine
发明人： Ying-Fei Wei , Guo-Liang Yu , William A. Haseltine
IPC分类号： A61K48/00 , C12N9/00 , C12N15/52 , C12N15/63
CPC分类号： C12N9/93 , A61K48/00 , C12N2799/026
摘要： A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
摘要翻译：公开了人DNA连接酶III多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了通过基因治疗将这种多肽应用于治疗与DNA连接酶III缺陷相关的病症的方法。还公开了抗这些多肽的拮抗剂及其作为破坏不想要的细胞的治疗剂的用途。还公开了用于检测突变DNA连接酶III基因的诊断测定。

44. 发明授权

US5747312A Human AlkB polypeptide 失效
标题翻译：人类AlkB多肽
公开(公告)号：US5747312A
公开(公告)日：1998-05-05
申请号：US783266
申请日：1997-01-15
申请人： Ying-Fei Wei , Granger G. Sutton, III
发明人： Ying-Fei Wei , Granger G. Sutton, III
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/22 , C12N15/12 , C12N9/00 , C12P21/06 , C12P19/56 , C07H17/00
CPC分类号： C07K14/4702 , C07K14/47 , C12N9/22 , A61K38/00 , A61K48/00
摘要： A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.
摘要翻译：公开了编码这种多肽的人hABH多肽和DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽来治疗由受损的DNA例如癌症引起的疾病的突变和治疗的方法。还公开了抗这些多肽的拮抗剂及其作为增强癌细胞化疗的治疗剂的用途。

45. 发明授权

US07927803B2 Human MutY 失效
标题翻译：人类MutY
公开(公告)号：US07927803B2
公开(公告)日：2011-04-19
申请号：US12204655
申请日：2008-09-04
申请人： Ying-Fei Wei
发明人： Ying-Fei Wei
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C12N9/22 , C12N9/2471 , C12Y302/01023
摘要： A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了编码这种多肽的人类mutY多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽来预防和/或治疗与该基因突变有关的疾病的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

46. 发明授权

US07829293B2 Antibodies to chemokine β-15 失效
标题翻译：趋化因子抗体; -15
公开(公告)号：US07829293B2
公开(公告)日：2010-11-09
申请号：US11537681
申请日：2006-10-02
申请人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
发明人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
IPC分类号： G01N33/48 , G01N33/50 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： C07K14/523
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
摘要翻译：本发明涉及人趋化因子CC蛋白家族的成员。特别地，提供编码趋化因子和bgr-15蛋白的分离的核酸分子。还提供了趋化因子和bgr-15多肽。本发明还涉及用于检测胸腺疾病的诊断方法和用于调节骨髓细胞增殖和分化的治疗方法。

47. 发明申请

US20100130417A1 TRANSFORMING GROWTH FACTOR ALPHA HII 审中-公开
标题翻译：转化生长因子ALPHA HII
公开(公告)号：US20100130417A1
公开(公告)日：2010-05-27
申请号：US12495569
申请日：2009-06-30
申请人： Ying-Fei Wei , Paul S. Meissner , Jian Ni
发明人： Ying-Fei Wei , Paul S. Meissner , Jian Ni
IPC分类号： A61K38/16 , C07H21/02 , C12N15/74 , C12N1/21 , C12P21/02 , C07K14/00 , C07K16/00 , A61K31/7088 , G01N33/53 , A61P31/04
CPC分类号： A61K38/1841 , A61K48/00 , C07K14/495 , Y10T436/143333
摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译：本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病，以及刺激胚胎发生和血管发生。还公开了抗这些多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

48. 发明申请

US20090311256A1 12 Human Secreted Proteins 有权
标题翻译： 12人类分泌蛋白
公开(公告)号：US20090311256A1
公开(公告)日：2009-12-17
申请号：US12264040
申请日：2008-11-03
申请人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , C07K16/00 , C12P21/02 , A61K31/7088 , A61K38/16 , C12Q1/68 , G01N33/53 , A61P9/00 , A61P3/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及12种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

49. 发明申请

US20080317756A1 Antibodies to Chemokine Alpha-5 审中-公开
公开(公告)号：US20080317756A1
公开(公告)日：2008-12-25
申请号：US12010210
申请日：2008-01-22
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , G01N33/566 , C12Q1/68 , A61K31/7105 , G01N33/53 , A61K38/17
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

50. 发明授权

US07320869B2 Antibodies to Chemokine Alpha-5 失效
标题翻译：趋化因子α-5抗体
公开(公告)号：US07320869B2
公开(公告)日：2008-01-22
申请号：US11224076
申请日：2005-09-13
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
IPC分类号： G01N33/53 , C12N5/12 , C07K16/24
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备此类抗体的组合物和方法。本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

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