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41. 发明申请

US20120053474A1 WIRELESS ECG IN IMPLANTABLE DEVICES 有权
标题翻译：无线心电图在可植入的设备
公开(公告)号：US20120053474A1
公开(公告)日：2012-03-01
申请号：US13288105
申请日：2011-11-03
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗器械表面上的电极的各种组合。

42. 发明授权

US07873413B2 Closed loop neural stimulation synchronized to cardiac cycles 有权
标题翻译：闭环神经刺激与心脏周期同步
公开(公告)号：US07873413B2
公开(公告)日：2011-01-18
申请号：US11459481
申请日：2006-07-24
申请人： Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人： Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及一种方法。根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。基于对神经刺激的检测反应来滴定神经刺激。本文提供了其它方面和实施例。

43. 发明授权

US07774061B2 Implantable cardiac device with ischemia response capability 有权
标题翻译：具有缺血反应能力的植入式心脏装置
公开(公告)号：US07774061B2
公开(公告)日：2010-08-10
申请号：US11318257
申请日：2005-12-23
申请人： Yi Zhang , Aaron McCabe , Kevin J. Stalsberg , Kent Lee , Marina V. Brockway , Joseph M. Pastore , Allan C. Shuros
发明人： Yi Zhang , Aaron McCabe , Kevin J. Stalsberg , Kent Lee , Marina V. Brockway , Joseph M. Pastore , Allan C. Shuros
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61B5/1102 , A61B2562/0219 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3925 , A61N1/3962
摘要： A cardiac device is described with the capability of detecting cardiac ischemia using multiple sensing modalities. The device may be configured to modify its behavior in delivering therapies to treat bradycardia or tachyarrhythmias in response to detection of cardiac ischemia.
摘要翻译：描述了具有使用多种感测方式检测心脏缺血的能力的心脏装置。该装置可以被配置为在递送疗法时修改其行为以响应于心脏缺血的检测来治疗心动过缓或快速性心律失常。

44. 发明申请

US20080021504A1 CLOSED LOOP NEURAL STIMULATION SYNCHRONIZED TO CARDIAC CYCLES 有权
标题翻译：闭环循环神经刺激同步心脏循环
公开(公告)号：US20080021504A1
公开(公告)日：2008-01-24
申请号：US11459481
申请日：2006-07-24
申请人： Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人： Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及一种方法。根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。基于对神经刺激的检测反应来滴定神经刺激。本文提供了其它方面和实施例。

45. 发明授权

US07212849B2 Methods and apparatuses for arrhythmia detection and classification using wireless ECG 有权
标题翻译：使用无线心电图进行心律失常检测和分类的方法和装置
公开(公告)号：US07212849B2
公开(公告)日：2007-05-01
申请号：US10975166
申请日：2004-10-28
申请人： Yi Zhang , Aaron McCabe , David J. Yonce , Julie Thompson
发明人： Yi Zhang , Aaron McCabe , David J. Yonce , Julie Thompson
IPC分类号： A61B5/0402
CPC分类号： A61N1/3956 , A61B5/0422 , A61B5/0452 , A61B5/686 , A61N1/3622 , A61N1/3706 , A61N1/3712 , A61N1/3756 , A61N1/3925 , A61N2001/083
摘要： A CRM system enhances intracardiac electrogram-based arrhythmia detection using a wireless electrocardiogram (ECG), which is a signal sensed with implantable electrodes and approximating a surface ECG. In one embodiment, an intracardiac electrogram allows for detection of an arrhythmia, and the wireless ECG allows for classification of the detected arrhythmia by locating its origin. In another embodiment, the wireless ECG is sensed as a substitute signal for the intracardiac electrogram when the sensing of the intracardiac electrogram becomes unreliable. In another embodiment, a cardiac signal needed for a particular purpose is selected from one or more intracardiac electrograms and one or more wireless ECGs based on a desirable signal quality. In another embodiment, intracardiac electrogram-based arrhythmia detection and wireless ECG-based arrhythmia detection confirm with each other before indicating a detection of arrhythmia of a certain type.
摘要翻译： CRM系统使用无线心电图（ECG）来增强基于心脏电图的心律失常检测，无线心电图（ECG）是用可植入电极感测并近似表面ECG的信号。在一个实施例中，心内电描记图允许检测心律失常，并且无线ECG允许通过定位其起点来分类检测到的心律失常。在另一个实施例中，当心脏电图的感测变得不可靠时，无线ECG被感测为心内电描记图的替代信号。在另一个实施例中，基于期望的信号质量，从一个或多个心内电描记图和一个或多个无线ECG选择特定目的所需的心脏信号。在另一个实施例中，基于心脏电图的心律失常检测和基于无线ECG的心律失常检测在指示某种类型的心律失常的检测之前相互确认。

46. 发明申请

US20060095083A1 Methods and apparatuses for arrhythmia detection and classification using wireless ECG 有权
标题翻译：使用无线心电图进行心律失常检测和分类的方法和装置
公开(公告)号：US20060095083A1
公开(公告)日：2006-05-04
申请号：US10975166
申请日：2004-10-28
申请人： Yi Zhang , Aaron McCabe , David Yonce , Julie Thompson
发明人： Yi Zhang , Aaron McCabe , David Yonce , Julie Thompson
IPC分类号： A61N1/362
CPC分类号： A61N1/3956 , A61B5/0422 , A61B5/0452 , A61B5/686 , A61N1/3622 , A61N1/3706 , A61N1/3712 , A61N1/3756 , A61N1/3925 , A61N2001/083
摘要： A CRM system enhances intracardiac electrogram-based arrhythmia detection using a wireless electrocardiogram (ECG), which is a signal sensed with implantable electrodes and approximating a surface ECG. In one embodiment, an intracardiac electrogram allows for detection of an arrhythmia, and the wireless ECG allows for classification of the detected arrhythmia by locating its origin. In another embodiment, the wireless ECG is sensed as a substitute signal for the intracardiac electrogram when the sensing of the intracardiac electrogram becomes unreliable. In another embodiment, a cardiac signal needed for a particular purpose is selected from one or more intracardiac electrograms and one or more wireless ECGs based on a desirable signal quality. In another embodiment, intracardiac electrogram-based arrhythmia detection and wireless ECG-based arrhythmia detection confirm with each other before indicating a detection of arrhythmia of a certain type.
摘要翻译： CRM系统使用无线心电图（ECG）来增强基于心脏电图的心律失常检测，无线心电图（ECG）是用可植入电极感测并近似表面ECG的信号。在一个实施例中，心内电描记图允许检测心律失常，并且无线ECG允许通过定位其起点来分类检测到的心律失常。在另一个实施例中，当心脏电图的感测变得不可靠时，无线ECG被感测为心内电描记图的替代信号。在另一个实施例中，基于期望的信号质量，从一个或多个心内电描记图和一个或多个无线ECG选择特定目的所需的心脏信号。在另一个实施例中，基于心脏电图的心律失常检测和基于无线ECG的心律失常检测在指示某种类型的心律失常的检测之前相互确认。

47. 发明授权

US07818051B2 Wireless ECG in implantable devices 有权
标题翻译：无线心电图在植入式设备
公开(公告)号：US07818051B2
公开(公告)日：2010-10-19
申请号：US11925657
申请日：2007-10-26
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
IPC分类号： A61B5/04
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

48. 发明授权

US07542800B2 Method and apparatus for synchronizing neural stimulation to cardiac cycles 有权
标题翻译：用于将神经刺激与心脏周期同步的方法和装置
公开(公告)号：US07542800B2
公开(公告)日：2009-06-02
申请号：US11099141
申请日：2005-04-05
申请人： Imad Libbus , Paul A. Haefner , Aaron McCabe , Yi Zhang
发明人： Imad Libbus , Paul A. Haefner , Aaron McCabe , Yi Zhang
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36114 , A61N1/365 , A61N1/36542 , A61N1/36564 , A61N1/36571
摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.
摘要翻译：神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。神经刺激脉冲的输送与该定时参考事件同步。定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与血流或压力。

49. 发明授权

US07299086B2 Wireless ECG in implantable devices 有权
标题翻译：无线心电图在植入式设备
公开(公告)号：US07299086B2
公开(公告)日：2007-11-20
申请号：US10795126
申请日：2004-03-05
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas R. Daum , Yi Zhang
IPC分类号： A61B5/0428 , A61N1/368
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

50. 发明申请

US20050288600A1 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US20050288600A1
公开(公告)日：2005-12-29
申请号：US10876008
申请日：2004-06-24
申请人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/042 , A61N1/365 , A61N1/375 , G06K9/62
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

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