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41. 发明申请

US20180333395A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS 审中-公开
公开(公告)号：US20180333395A1
公开(公告)日：2018-11-22
申请号：US16038739
申请日：2018-07-18
申请人： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
发明人： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC分类号： A61K31/4192 , C07D249/06 , C07D401/14 , C07D401/04 , A61K31/27 , A61K31/454
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

42. 发明授权

US09534205B2 Combined chemical and genetic approaches for generation of induced pluripotent stem cells 有权
公开(公告)号：US09534205B2
公开(公告)日：2017-01-03
申请号：US12933391
申请日：2009-03-17
申请人： Yan Shi , Caroline Desponts , Sheng Ding , Hongyan Zhou , Tongxiang Lin , Wenlin Li , Saiyong Zhu
发明人： Yan Shi , Caroline Desponts , Sheng Ding , Hongyan Zhou , Tongxiang Lin , Wenlin Li , Saiyong Zhu
IPC分类号： C12N5/00 , C12N5/074 , C12N15/85
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.

43. 发明授权

US09018018B2 Method and apparatus for determining the cell activation of a target cell by an activator 有权
标题翻译：用于通过活化剂确定靶细胞的细胞活化的方法和装置
公开(公告)号：US09018018B2
公开(公告)日：2015-04-28
申请号：US12486674
申请日：2009-06-17
申请人： Matthias Amrein , Yan Shi
发明人： Matthias Amrein , Yan Shi
IPC分类号： G01N33/00 , G01Q60/42 , B82Y35/00 , G01N33/50 , G01Q20/00
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/5008 , G01Q20/00
摘要： The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe sample arrangement with a target cell and with an activator assigned to the target cell, the measuring probe being loaded with the activator, and the sample holder being loaded with the target cell, or vice versa; relative mutual displacement of the measuring probe and the sample holder until contact is made between the target cell and the activator by means of a displacement apparatus of the probe measuring device; recording of measurement values, indicating binding between the target cell and the activator, for the measuring probe with the probe measuring device during the relative displacement of the measuring probe and the sample holder; and determination of a dimension for the cell activation of the target cell from the measurement values recorded.
摘要翻译：本发明涉及一种用于通过活化剂确定靶细胞的细胞活化的方法和装置，所述方法具有以下步骤：提供具有测量探针和样品架的探针样品装置的探针测量装置; 将探针样品装置与目标细胞装载并分配给目标细胞的激活剂，测量探针装载有活化剂，并且样品保持器装载目标细胞，反之亦然; 通过探头测量装置的位移装置接触测量探针和样品架之间的相对相互位移，直到目标单元与激活器接触; 在测量探头和样品架的相对位移期间，使用探针测量装置记录测量值，指示目标单元和激活器之间的结合; 以及从记录的测量值确定靶细胞的细胞活化的维度。

44. 发明申请

US20140088418A1 FUNCTIONAL-IMAGING-BASED ABLATION MONITORING 有权
标题翻译：基于功能成像的ABIATION监测
公开(公告)号：US20140088418A1
公开(公告)日：2014-03-27
申请号：US14007029
申请日：2012-03-27
申请人： Emil Radulescu , Sheng-Wen Huang , Ramon Erkamp , Ladislav Jankovic , Yan Shi , Khalid Shahzad
发明人： Emil Radulescu , Sheng-Wen Huang , Ramon Erkamp , Ladislav Jankovic , Yan Shi , Khalid Shahzad
IPC分类号： A61B5/00 , A61B18/18 , A61B18/14 , A61K49/00
CPC分类号： A61B5/4836 , A61B5/0044 , A61B5/0059 , A61B5/0084 , A61B5/0095 , A61B5/6852 , A61B5/742 , A61B18/1492 , A61B18/18 , A61B2018/00577 , A61B2090/378 , A61B2576/00 , A61K49/0002
摘要： Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined (110, 122) by subtraction or division to effect the piece-wise cancellation/enhancement for display (218) of the resulting signal in real time.
摘要翻译：用于在生物组织中定位的功能成像需要测量组织（240）中的电磁辐射的响应。用于实时监测心脏消融的导管（200）用于区分出血区域（232）与夹心的坏死和健康组织，或区分外源光声造影剂与边界的天然组织。选择一对波长用于相应地出血区域或存在造影剂的辐射的差异吸收（244）以及其他地方相对相似的吸收。可以使用近红外激光器或LED光源来连续采集要比较的两个数据集（S310，S320），每个代表一个时间波形。或者，采集是用于微波诱导的热声数据的一对波段。在任一情况下，数据集对的成员通过减法或除法组合（110,122）以实现分段取消/增强以实时显示（218）所得到的信号。

45. 发明授权

US07795291B2 Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method 有权
标题翻译：可用作抗动脉粥样硬化，抗血脂异常，抗糖尿病和抗肥胖剂的取代的酸衍生物和方法
公开(公告)号：US07795291B2
公开(公告)日：2010-09-14
申请号：US11773545
申请日：2007-07-05
申请人： Joseph A. Tino , Peter T. W. Cheng , Yan Shi , Jun Li , Ranjan Mukherjee
发明人： Joseph A. Tino , Peter T. W. Cheng , Yan Shi , Jun Li , Ranjan Mukherjee
IPC分类号： A61K31/421 , C07D263/30
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R1 is halogen; and X is hydrogen or halogen, and salts thereof, which compounds are useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic, and anti-obesity agents.
摘要翻译：提供具有式（I）结构的化合物：其中R1是卤素; 并且X是氢或卤素，及其盐，该化合物可用作抗动脉粥样硬化，抗血脂异常，抗糖尿病和抗肥胖剂。

46. 发明授权

US07659281B2 HMG-CoA reductase inhibitors 有权
标题翻译： HMG-CoA还原酶抑制剂
公开(公告)号：US07659281B2
公开(公告)日：2010-02-09
申请号：US11789335
申请日：2007-04-24
申请人： Philip D. Stein , Steven P. Seitz , David J. Carini , Yan Shi , Jeffrey A. Robl , Jay A. Markwalder , Chunhong He
发明人： Philip D. Stein , Steven P. Seitz , David J. Carini , Yan Shi , Jeffrey A. Robl , Jay A. Markwalder , Chunhong He
IPC分类号： A01N43/42 , A61K31/44 , C07D221/18 , C07D221/22
CPC分类号： C07D221/16 , C07D471/04
摘要： Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis wherein variables A and B are defined herein.
摘要翻译：提供以下结构的化合物是HMG CoA还原酶抑制剂，因此有效抑制胆固醇生物合成，调节血清脂质，例如降低LDL胆固醇和/或增加HDL胆固醇，以及治疗高脂血症和血脂异常，高胆固醇血症，高甘油三酯血症和动脉粥样硬化其中变量A和B在本文中定义。

47. 发明申请

US20080286867A1 Method of Inducing Embryonic Stem Cells Into Pancreatic Cells 有权
标题翻译：诱导胚胎干细胞进入胰腺细胞的方法
公开(公告)号：US20080286867A1
公开(公告)日：2008-11-20
申请号：US11911378
申请日：2006-04-14
申请人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
发明人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
IPC分类号： C12N5/06
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.
摘要翻译：本发明提供了基于与激活素A，全反式视黄酸和任选地能够诱导胚胎干细胞分化成胰岛素生成细胞的其它成熟因子的组合诱导的简单的三步法。还提供了用于诱导胚胎干细胞分化成胰岛素生成细胞的试剂盒。

48. 发明申请

US20080120448A1 REMOTE MOUSE AND KEYBOARD USING BLUETOOTH 审中-公开
标题翻译：远程鼠标和键盘使用蓝牙
公开(公告)号：US20080120448A1
公开(公告)日：2008-05-22
申请号：US11562398
申请日：2006-11-21
申请人： Yan Shi , Kong-Kat Wong , Difei Tang , Wei Hun Liew , Sun Hsuen Shaw
发明人： Yan Shi , Kong-Kat Wong , Difei Tang , Wei Hun Liew , Sun Hsuen Shaw
IPC分类号： G06F13/12
CPC分类号： G06F3/0231 , G06F3/03543
摘要： A remote pointing device and keyboard system and method for remotely mimicking the pointing device and keyboard of a personal computing device (such as a laptop or desktop computer) using a handheld computing device (such as Pocket PC or smartphone). Remote control is achieved using Bluetooth wireless technology. A user inputs commands on a touch panel of the handheld device to remotely control the pointing device on the personal computing device. Similarly, the user input data on a keypad of the handheld device to remotely enter keystrokes to the personal computing device, thereby bypassing the keyboard. This allows the user to remotely access the pointing device and keyboard of the personal computing device through the touch panel and keypad of the handheld device.
摘要翻译：用于使用手持计算设备（例如Pocket PC或智能手机）远程模拟个人计算设备（例如膝上型或台式计算机）的指点设备和键盘的远程指点设备和键盘系统和方法。使用蓝牙无线技术实现遥控。用户在手持设备的触摸面板上输入命令以远程控制个人计算设备上的指点设备。类似地，用户在手持设备的键盘上输入数据以远程输入到个人计算设备的击键，从而绕过键盘。这允许用户通过手持设备的触摸面板和小键盘远程访问个人计算设备的指点设备和键盘。

49. 发明申请

US20070249583A1 HMG-CoA reductase inhibitors 有权
标题翻译： HMG-CoA还原酶抑制剂
公开(公告)号：US20070249583A1
公开(公告)日：2007-10-25
申请号：US11789335
申请日：2007-04-24
申请人： Philip D. Stein , Steven P. Seitz , David J. Carini , Yan Shi , Jeffrey A. Robl , Jay A. Markwalder , Chunhong He
发明人： Philip D. Stein , Steven P. Seitz , David J. Carini , Yan Shi , Jeffrey A. Robl , Jay A. Markwalder , Chunhong He
IPC分类号： A61K31/553 , A61K31/55 , A61K31/473
CPC分类号： C07D221/16 , C07D471/04
摘要： Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis wherein A is chosen from B is chosen from wherein the variables R1 to R7, m, n, are as defined herein.A method for treating the above diseases employing the above compounds is also provided.
摘要翻译：提供以下结构的化合物是HMG CoA还原酶抑制剂，因此有效抑制胆固醇生物合成，调节血清脂质，例如降低LDL胆固醇和/或增加HDL胆固醇，以及治疗高脂血症和血脂异常，高胆固醇血症，高甘油三酯血症和动脉粥样硬化其中A选自B，其中变量R 1至R 7，m，n，如本文所定义。还提供了使用上述化合物治疗上述疾病的方法。

50. 发明授权

US07166586B2 Sulfonamide lactam inhibitors of FXa and method 有权
标题翻译： FXa的磺酰胺内酰胺抑制剂及方法
公开(公告)号：US07166586B2
公开(公告)日：2007-01-23
申请号：US10374299
申请日：2003-02-26
申请人： Stephen P. O'Connor , Michael Lawrence , Yan Shi , Philip D. Stein
发明人： Stephen P. O'Connor , Michael Lawrence , Yan Shi , Philip D. Stein
IPC分类号： C07D41/02 , A61K31/454 , A61K31/445
CPC分类号： C07D211/56 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/08
摘要： Sulfonamide lactams of the following formula wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
摘要翻译：下式的磺酰胺内酰胺其中X，R 1，R 2，R 3，R 4，R 4， R 4a，R 5，R 5a，R 6，R 6a，R 6，R 5，提供了本文所述的哪些抑制因子Xa并且可用作治疗与血栓形成相关的心血管疾病的抗凝剂。

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