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41. 发明申请

US20070208048A1 New Aryl Imidazoles and Related Compounds as C5a Receptor Modulators 失效
标题翻译：新的芳基咪唑和相关化合物作为C5a受体调节剂
公开(公告)号：US20070208048A1
公开(公告)日：2007-09-06
申请号：US11680865
申请日：2007-03-01
申请人： George Luke , George Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand Chenard , Yang Gao , Bingsong Han , Xiao He
发明人： George Luke , George Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand Chenard , Yang Gao , Bingsong Han , Xiao He
IPC分类号： A61K31/505 , A61K31/415 , A61K31/44 , A61K31/50
CPC分类号： C07D233/64 , A61K31/4164 , C07D233/68 , C07D235/02 , C07D235/30 , C07D237/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the ring system represented by is a 5 membered heteroaryl ring system, in which x is 0, A is chosen from carbon and heteroatoms nitrogen, oxygen, and sulfur, and E and G are independently carbon or nitrogen provided that the 5 membered heteroaryl ring system does not contain more than 3 heteroatoms or more than 1 oxygen or sulfur atom, or a 6 membered heteroaryl ring system, in which x is 1, A, B, E, and G are independently chosen from carbon and nitrogen, provided that the 6 membered heteroaryl ring system does not contain more than 3 nitrogen atoms. The remaining variables, Ar1, Ar2, R, R1, R2, R3, R4, R5, R6, y and z are defined herein Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
摘要翻译：本发明提供芳基取代的咪唑，吡唑，吡啶并且其中由其表示的环系是5元杂芳基环系的相关化合物，其中x为0，A选自碳和杂原子氮，氧和硫，并且E和G独立地为碳或氮，条件是5元杂芳基环系不包含多于3个杂原子或多于1个氧或硫原子，或6元杂芳基环系，其中x为1，A，B E和G独立地选自碳和氮，条件是6元杂芳基环系不含3个以上的氮原子。其余的变量Ar 1，R 2，R 1，R 1，R 2，R 2， 3，R 4，R 5，R 6，y和z在本文中定义。这些化合物是C5a受体的配体。本发明优选的化合物作用以高亲和力结合C5a受体，在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物。它还涉及这些化合物在治疗各种炎性和免疫系统疾病中的应用。

42. 发明申请

US20060264006A1 Method and apparatus for RFID device assembly 审中-公开
标题翻译：用于RFID设备组装的方法和设备
公开(公告)号：US20060264006A1
公开(公告)日：2006-11-23
申请号：US11437033
申请日：2006-05-19
申请人： Kouroche Kian , Xiao He
发明人： Kouroche Kian , Xiao He
IPC分类号： H01L21/00 , H01L21/30
CPC分类号： H01L21/3043 , H01L21/67132 , H01L21/6835 , H01L21/6836 , H01L24/83 , H01L24/90 , H01L2221/68322 , H01L2221/68327 , H01L2221/68336 , H01L2221/6834 , H01L2221/68354 , H01L2221/68359 , H01L2221/68368 , H01L2224/16225 , H01L2224/2919 , H01L2224/32225 , H01L2224/73204 , H01L2224/83192 , H01L2224/83851 , H01L2224/90 , H01L2924/00011 , H01L2924/00014 , H01L2924/01029 , H01L2924/01077 , H01L2924/07811 , H01L2924/14 , H01L2924/00 , H01L2924/0665 , H01L2224/0401
摘要： A process is disclosed for creating semiconductor devices such as RFID assemblies wherein an array of dies is spaced apart at a pitch matching the pitch of straps on a web of straps before they are mounted to a chip carrier substrate. The substrate is then cut into strips to form one or more linear aggregations of dies. The linear aggregation of dies is then transferred by an assembly mechanism onto the web of straps and electrically attached to a plurality of straps or interposers arranged in a corresponding array. The spacing, or pitch, between the dies in the die array may be changed to match the pitch of the straps or interposers in the corresponding array before or after a wafer substrate is removed from the die array. An RFID device created using the process inventive is also disclosed.
摘要翻译：公开了一种用于制造诸如RFID组件的半导体器件的工艺，其中，在将芯片阵列安装到芯片载体衬底之前，其中阵列阵列以匹配条带上的带的间距的间距分隔开。然后将基材切成条带以形成一个或多个模具的线性聚集体。然后，模具的线性聚集通过组装机构转移到带的网状物上，并电连接到以相应阵列布置的多个带或插入物。在芯片阵列中的晶片衬底被移除之前或之后，可以改变管芯阵列中的管芯之间的间距或间距以匹配相应阵列中的带或插入件的间距。还公开了使用本发明创造的RFID设备。

43. 发明授权

US08586739B2 Heterocyclic compounds and their uses 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08586739B2
公开(公告)日：2013-11-19
申请号：US13468212
申请日：2012-05-10
申请人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian S. Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer L. Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian S. Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer L. Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： C07D487/04 , C07D473/34 , C07D241/40 , C07D241/44 , C07D215/14 , C07D215/26 , C07D215/22 , C07D417/14 , C07D417/04 , A61K31/52 , A61P35/00 , A61P19/02 , A61P37/06 , A61P19/08
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要： Substituted bicyclic heteroaryls having the general structure: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid Leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：具有一般结构的取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分投诉，慢性包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性疾病。本发明还使得能够治疗依赖于p110delta活性或与p110delta活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

44. 发明授权

US08575183B2 Heterocyclic compounds and their uses 有权
公开(公告)号：US08575183B2
公开(公告)日：2013-11-05
申请号：US13078192
申请日：2011-04-01
申请人： Timothy David Cushing , Jason A. Duquette , Xiao He , Julia Lohman , Youngsook Shin
发明人： Timothy David Cushing , Jason A. Duquette , Xiao He , Julia Lohman , Youngsook Shin
IPC分类号： A01N43/90 , A61K31/519 , C07D239/02
CPC分类号： C07D403/12 , C07D401/14 , C07D409/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

45. 发明授权

US08329910B2 Quinolines for the treatment of PI3K-δ mediated diseases 有权
标题翻译：喹诺酮用于治疗PI3K-δ介导的疾病
公开(公告)号：US08329910B2
公开(公告)日：2012-12-11
申请号：US13187188
申请日：2011-07-20
申请人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： C07D215/12
CPC分类号： C07D401/12 , C07D401/14
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including nut not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括不限于白血病的坚果，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

46. 发明申请

US20120094972A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 失效
公开(公告)号：US20120094972A1
公开(公告)日：2012-04-19
申请号：US13377210
申请日：2010-06-25
申请人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号： A61K31/5415 , C07D491/107 , C07D471/04 , C07D401/14 , C07D491/20 , C07D473/00 , C07D417/14 , C07D513/04 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/52 , A61K31/538 , A61P19/08 , A61P19/02 , A61P27/02 , A61P29/00 , A61P17/06 , A61P1/00 , A61P13/10 , A61P17/00 , A61P35/00 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

47. 发明授权

US08076376B2 Aniline sulfonamide derivatives and their uses 失效
标题翻译：苯胺磺酰胺衍生物及其用途
公开(公告)号：US08076376B2
公开(公告)日：2011-12-13
申请号：US11490143
申请日：2006-07-21
申请人： Jay P. Powers , Xiao He , Dustin McMinn , Yosup Rew , Daqing Sun
发明人： Jay P. Powers , Xiao He , Dustin McMinn , Yosup Rew , Daqing Sun
IPC分类号： A61K31/18 , C07C311/37
CPC分类号： C07C311/21 , C07C311/44 , C07C2601/02 , C07C2601/04
摘要： Aniline sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R1, R2, R3, R4, R5, R6, and L are set forth in the description.
摘要翻译：根据式I的苯胺磺酰胺衍生物具有治疗效用，特别是治疗糖尿病，肥胖症和相关病症和疾病：其中R1，R2，R3，R4，R5，R6和L在说明书中阐述。

48. 发明申请

US20110245257A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 有权
公开(公告)号：US20110245257A1
公开(公告)日：2011-10-06
申请号：US13078192
申请日：2011-04-01
申请人： Timothy D. Cushing , Jason A. Duquette , Xiao He , Julia Lohman , Youngsook Shin
发明人： Timothy D. Cushing , Jason A. Duquette , Xiao He , Julia Lohman , Youngsook Shin
IPC分类号： A61K31/506 , C07D403/12 , C07D471/04 , C07D473/34 , C07D401/14 , C07D409/12 , A61K31/52 , A61K31/519 , A61P19/02 , A61P17/06 , A61P29/00 , A61P37/00 , A61P1/00 , A61P25/00 , A61P35/00
CPC分类号： C07D403/12 , C07D401/14 , C07D409/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

49. 发明申请

US20110152277A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：US20110152277A1
公开(公告)日：2011-06-23
申请号：US13036236
申请日：2011-02-28
申请人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： A61K31/519 , C07D473/34 , A61K31/52 , A61P19/02 , A61P17/06 , A61P29/00 , A61P35/00 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

50. 发明申请

US20100311991A1 PROCESS FOR THE PREPARATION OF DOCETAXEL, ITS INTERMEDIATES, AND METHODS FOR PREPARATION THEREOF 有权
标题翻译：制备DOCETAXEL及其中间体的方法及其制备方法
公开(公告)号：US20100311991A1
公开(公告)日：2010-12-09
申请号：US12741714
申请日：2009-05-22
申请人： Xin Shen , Huaxing Zhan , Jidong Yang , Xiao He , Fuxing Lin , Shaohong Wu
发明人： Xin Shen , Huaxing Zhan , Jidong Yang , Xiao He , Fuxing Lin , Shaohong Wu
IPC分类号： C07D305/14 , C07C271/66 , C07C269/06
CPC分类号： C07D305/14 , C07C269/04 , C07C269/06 , C07C271/22 , Y02P20/55
摘要： The present invention disclosed an process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl group of compound 4 obtained from step a to prepare compound 5; c) removing one tert-butoxycarbonyl of compound 5 obtained from step b to prepare compound 6; d) removing one acetyl of compound 6 obtained from step c to prepare compound 1; wherein, R1 represents tert-butyl dimethyl silyl, triethylsilyl, ethoxyethyl, tetrahydropyranyl, trichloroethoxycarbonyl or methoxymethyl, Boc is tert-butoxycarbonyl, Ac is acetyl, and Ph is phenyl. The present invention also disclosed intermediates of docetaxel and methods for preparation thereof. In the methods for preparation of the present invention, the protective groups used are easy to be removed, the purification of the intermediates is easy, the cost is lower, the yield and the purity are higher, and the processes can be scaled to commercial implementation.
摘要翻译：本发明公开了一种制备多西紫杉醇1的方法，包括以下步骤：a）化合物2和3的羟基酰化反应得到化合物4; b）由步骤a获得的化合物4的羟基的脱保护基团R1，以制备化合物5; c）除去由步骤b获得的化合物5的一个叔丁氧基羰基，制备化合物6; d）除去由步骤c获得的化合物6的一个乙酰基，制备化合物1; 其中，R1表示叔丁基二甲基甲硅烷基，三乙基甲硅烷基，乙氧基乙基，四氢吡喃基，三氯乙氧基羰基或甲氧基甲基，Boc是叔丁氧基羰基，Ac是乙酰基，Ph是苯基。本发明还公开了多西紫杉醇的中间体及其制备方法。在本发明的制备方法中，所使用的保护基团易于除去，中间体的纯化容易，成本低，产率和纯度高，并且可以将其扩展到商业实施。

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