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41. 发明申请

US20110245512A1 HYDROXYLATED CONTRAST ENHANCEMENT AGENTS 有权
标题翻译：羟基对比增强剂
公开(公告)号：US20110245512A1
公开(公告)日：2011-10-06
申请号：US12956629
申请日：2010-11-30
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
IPC分类号： C07F7/18 , C07F9/40 , C07F9/6596 , C07F9/6561 , C07F9/38
CPC分类号： A61K49/103 , C07F9/3808 , C07F9/4075 , C07F9/6552 , C07F9/65522 , C07F9/6596
摘要： In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.
摘要翻译：一方面，本发明提供一种对比度增强剂，其包含具有结构I的铁螯合物及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1-C3烷基，b 是0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子。还提供了具有结构IX的金属螯合配体和包含对比度增强剂I的医药制剂。

42. 发明申请

US20110160430A1 FLUORINE-LABELED COMPOUNDS 失效
标题翻译：氟标签化合物
公开(公告)号：US20110160430A1
公开(公告)日：2011-06-30
申请号：US13032099
申请日：2011-02-22
申请人： Omayra Padilla de Jesus , Faisal Ahmed Syud , Rong Zhang , Ernest William Kovacs
发明人： Omayra Padilla de Jesus , Faisal Ahmed Syud , Rong Zhang , Ernest William Kovacs
IPC分类号： C07K2/00
CPC分类号： C07K1/13 , A61K51/08 , C07B59/008 , C07K5/0817 , C07K5/1019
摘要： Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.
摘要翻译：提供了将氟原子引入到多肽上的方法。还提供了使用方法，接头和生物缀合物制备的接头，生物缀合物和双功能化合物试剂。所述方法包括：（i）提供包含硫醇反应性末端和醛反应性末端的连接体; （ii）使接头的硫醇反应性末端与包含至少一个硫醇基团或其反应性衍生物的多肽反应; 和（iii）随后使接头的醛反应性末端与氟取代的醛反应。

43. 发明授权

US07763731B2 Anti-viral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US07763731B2
公开(公告)日：2010-07-27
申请号：US11613836
申请日：2006-12-20
申请人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
发明人： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie VL. Masse , Robert J. Carrick , Wenping He , Liangjun Lu
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

44. 发明申请

US20100035361A1 TWO HELIX BINDERS 有权
标题翻译：两个HELIX BINDERS
公开(公告)号：US20100035361A1
公开(公告)日：2010-02-11
申请号：US12337941
申请日：2008-12-18
申请人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
发明人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
IPC分类号： G01N33/566 , C07K14/00 , C07K5/10
CPC分类号： C07K14/00 , C07K14/31
摘要： An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
摘要翻译：衍生自葡萄球菌蛋白A的B结构域的分离的多肽Z结构域，其包含能够结合靶的一对反平行α螺旋。在这里提供了多肽中两个天然或非天然氨基酸之间的工程化二硫桥的引入。还提供了使用双螺旋粘合剂的方法。

45. 发明申请

US20090325313A1 TWO HELIX BINDERS 有权
标题翻译：两个HELIX BINDERS
公开(公告)号：US20090325313A1
公开(公告)日：2009-12-31
申请号：US12337945
申请日：2008-12-18
申请人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
发明人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
IPC分类号： G01N33/566 , C07K14/00
CPC分类号： C07K14/31
摘要： An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
摘要翻译：衍生自葡萄球菌蛋白A的B结构域的分离的多肽Z结构域，其包含能够结合靶的一对反平行α螺旋。在此提供了多肽中非天然氨基酸的引入。还提供了使用双螺旋粘合剂的方法。

46. 发明申请

US20090304231A1 Method of automatically detecting and tracking successive frames in a region of interesting by an electronic imaging device 有权
标题翻译：通过电子成像装置自动检测和跟踪感兴趣区域中的连续帧的方法
公开(公告)号：US20090304231A1
公开(公告)日：2009-12-10
申请号：US12155690
申请日：2008-06-09
申请人： Sheng-Min Lu , Rong Zhang , Jin Wang
发明人： Sheng-Min Lu , Rong Zhang , Jin Wang
IPC分类号： G06K9/00
CPC分类号： G06K9/4628 , G06K9/3233
摘要： A method of automatically detecting and tracking successive frames in a region of interesting by an electronic imaging device includes: decomposing a frame into intensity, color and direction features according to human perceptions; filtering an input image by a Gaussian pyramid to obtain levels of pyramid representations by down sampling; calculating the features of pyramid representations; using a linear center-surround operator similar to a biological perception to expedite the calculation of a mean value of the peripheral region; using the difference of each feature between a small central region and the peripheral region as a measured value; overlaying the pyramid feature maps to obtain a conspicuity map and unify the conspicuity maps of the three features; obtaining a saliency map of the frames by linear combination; and using the saliency map for a segmentation to mark an interesting region of a frame in the large region of the conspicuity maps.
摘要翻译：一种通过电子成像装置自动检测和跟踪感兴趣区域中的连续帧的方法包括：根据人的感知将帧分解为强度，颜色和方向特征; 通过高斯金字塔过滤输入图像，通过下采样获得金字塔表示的水平; 计算金字塔表示的特征; 使用类似于生物学感知的线性中心环绕算子来加速计算周边区域的平均值; 使用小中心区域和周边区域之间的每个特征的差作为测量值; 叠加金字塔特征图获得显眼图，统一三个特征的显眼图; 通过线性组合获得帧的显着图; 并使用显着性图进行分割，以标识显眼图中较大区域中的一个有趣区域。

47. 发明申请

US20080021764A1 Method and system for customer value calculation 审中-公开
标题翻译：客户价值计算方法和系统
公开(公告)号：US20080021764A1
公开(公告)日：2008-01-24
申请号：US11492510
申请日：2006-07-24
申请人： Kevin Walsh , Pascal Sero , Xiruo Wang , Yong Zhou , Qiugen Hu , Long Zhang , Rong Zhang
发明人： Kevin Walsh , Pascal Sero , Xiruo Wang , Yong Zhou , Qiugen Hu , Long Zhang , Rong Zhang
IPC分类号： G06Q90/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0201
摘要： A method and system for calculating a customer value is provided. At least one relationship type for at least one pair of customers which are selected from a plurality of customers is determined. A first customer from the plurality of customers is selected. At least one second customer having a direct relationship or an indirect relationship with the first customer based on the at least one relationship type which is selected from the relationship types is determined. The first customer value based on the first predetermined calculation rule by using first values and base values is calculated.
摘要翻译：提供了一种用于计算客户价值的方法和系统。确定从多个客户中选择的至少一对客户的至少一个关系类型。选择来自多个客户的第一客户。基于从关系类型中选择的至少一种关系类型，确定与第一顾客有直接关系或间接关系的至少一个第二顾客。计算基于通过使用第一值和基值的第一预定计算规则的第一顾客价值。

48. 发明授权

US07274713B2 Cell sequence number synchronization system and method 有权
标题翻译：单元序列号同步系统及方法
公开(公告)号：US07274713B2
公开(公告)日：2007-09-25
申请号：US10231217
申请日：2002-08-30
申请人： James E. Tatem, Jr. , Randy A. Drago , Chi-Yu Lu , Son Truong Ngo , Rong Zhang , Vahid Tabatabaee , Kirby Lee Nell
发明人： James E. Tatem, Jr. , Randy A. Drago , Chi-Yu Lu , Son Truong Ngo , Rong Zhang , Vahid Tabatabaee , Kirby Lee Nell
IPC分类号： H04J3/06
CPC分类号： H04L49/3081 , H04J3/0685 , H04L12/5601 , H04L49/15 , H04L49/30 , H04L2012/565 , H04L2012/5674
摘要： The present invention provides a system and method for enabling the synchronization of a switch and an interface device. Based on a comparison of cell sequence numbers included in cells received from the interface device to a current cell time within the switch, cell time adjustment information can be transmitted to the interface device. The cell time adjustment information is used by the interface device to determine the cell sequence number that is included in cells transmitted to the switch.
摘要翻译：本发明提供一种能够实现交换机和接口设备的同步的系统和方法。基于从接口装置接收到的小区中包含的小区序列号与交换机内的当前小区时间的比较，可以将小区时间调整信息发送到接口装置。接口装置使用小区时间调整信息来确定发送到交换机的小区中包括的小区序列号。

49. 发明申请

US20050075331A1 Anti-infective agents 审中-公开
标题翻译：抗感染剂
公开(公告)号：US20050075331A1
公开(公告)日：2005-04-07
申请号：US10679881
申请日：2003-10-06
申请人： John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
发明人： John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
IPC分类号： C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07D519/00 , C07D285/26 , A61K31/549 , C07D285/22
CPC分类号： C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
摘要翻译：本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。本发明还提供了抑制丙型肝炎病毒（HCV）聚合酶，抑制HCV病毒复制的方法以及治疗或预防HCV感染的方法。还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。

50. 外观设计

USD952560S1 Waterproof battery box 有权
公开(公告)号：USD952560S1
公开(公告)日：2022-05-24
申请号：US29759923
申请日：2020-11-25
申请人： Rong Zhang
设计人： Rong Zhang

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