专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US5670336A Method for recombinant production of osteogenic protein 失效
标题翻译：重组生产成骨蛋白OP-1的方法
公开(公告)号：US5670336A
公开(公告)日：1997-09-23
申请号：US376731
申请日：1995-01-20
申请人： Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
发明人： Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
IPC分类号： A61C8/00 , A61F2/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C07K14/51 , C12N15/18 , C12N15/12 , C12N15/00
CPC分类号： A61K9/0024 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/56 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L2430/02
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译：公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。

42. 发明授权

US5650276A Morphogenic protein screening method 失效
标题翻译：形态蛋白筛选方法
公开(公告)号：US5650276A
公开(公告)日：1997-07-22
申请号：US278729
申请日：1994-07-20
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H.L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H.L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , C12Q1/02
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
摘要翻译：公开了一种筛选候选化合物以调节哺乳动物系统中形态发生蛋白水平的能力的方法。所述方法包括确定指示已知产生形态发生的细胞培养物中形态发生水平的参数的参数，将候选化合物与培养物孵育足以允许化合物影响形态发生蛋白质的产生的时间，以及然后再次测定培养物以检测形态发生蛋白质生产水平的变化。

43. 发明授权

US5468845A Antibodies to osteogenic proteins 失效
标题翻译：成骨蛋白抗体
公开(公告)号：US5468845A
公开(公告)日：1995-11-21
申请号：US147023
申请日：1993-11-01
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger
IPC分类号： A61C8/00 , A61F2/00 , A61K6/00 , A61K9/00 , A61K38/00 , A61K38/18 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C04B14/12 , C04B20/06 , C07K14/51 , C07K16/18 , C07K14/435
CPC分类号： A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/54 , A61L27/56 , C04B14/12 , C04B20/068 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61L2300/412 , A61L2430/02 , Y10S530/84
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
摘要翻译：公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。

44. 发明授权

US5250302A Osteogenic devices 失效
标题翻译：成骨装置
公开(公告)号：US5250302A
公开(公告)日：1993-10-05
申请号：US827052
申请日：1992-01-28
申请人： Hermann Oppermann , Engin Ozkaynak , David C. Rueger , Thangavel Kuberasampath
发明人： Hermann Oppermann , Engin Ozkaynak , David C. Rueger , Thangavel Kuberasampath
IPC分类号： A61C8/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/36 , A61L27/56 , C07K14/51 , A01J25/12 , A21C3/00 , A21C11/00
CPC分类号： A61K9/0024 , A61L27/227 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/56 , C07K14/51 , A61C8/0006 , A61K38/00 , A61L2430/02
摘要： Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.
摘要翻译：公开了包含含有基本上纯的哺乳动物成骨蛋白质的基质和在哺乳动物中诱导软骨内骨生长的方法的成骨装置。还公开了表征成骨蛋白的部分氨基酸序列，氨基酸组成，溶解性和各种其他数据，以及编码共有成骨蛋白的核酸序列。

45. 发明申请

US20070166353A1 Osteogenic proteins 审中-公开
标题翻译：成骨蛋白
公开(公告)号：US20070166353A1
公开(公告)日：2007-07-19
申请号：US11643552
申请日：2006-12-20
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David Rueger , Roy Pang
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David Rueger , Roy Pang
IPC分类号： A61F2/02
CPC分类号： C07K14/47 , C07K5/0806 , C07K5/101
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
摘要翻译：公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。

46. 发明申请

US20050096339A1 Morphogen-induced modulation of inflammatory response 审中-公开
标题翻译：形态诱导的炎症反应调节
公开(公告)号：US20050096339A1
公开(公告)日：2005-05-05
申请号：US10865514
申请日：2004-06-09
申请人： Thangavel Kuberasampath , Roy Pang , Hermann Oppermann , David Rueger , Charles Cohen , Engin Ozkaynak , John Smart
发明人： Thangavel Kuberasampath , Roy Pang , Hermann Oppermann , David Rueger , Charles Cohen , Engin Ozkaynak , John Smart
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , A61K31/485
CPC分类号： A61K38/17 , A01N1/0226 , A61F2310/00365 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
摘要： The present invention is directed to methods and compositions for alleviating tissue destructive effects associated with the inflammatory response to tissue injury in a mammal. The methods and compositions include administering a therapeutically effective concentration of a morphogen or morphogen-stimulating agent sufficient to alleviate immune cell-mediated tissue destruction.
摘要翻译：本发明涉及减轻与哺乳动物对组织损伤的炎症反应相关的组织破坏作用的方法和组合物。所述方法和组合物包括施用足以减轻免疫细胞介导的组织破坏的治疗有效浓度的形态发生剂或形态发生剂。

47. 发明申请

US20060025571A1 Morphogen-induced dendritic growth 审中-公开
标题翻译：形态诱导树突生长
公开(公告)号：US20060025571A1
公开(公告)日：2006-02-02
申请号：US11226555
申请日：2005-09-13
申请人： David Rueger , Kuber Sampath , John Smart , Hermann Oppermann , Engin Ozkaynak , Charles Cohen , Dennis Higgins
发明人： David Rueger , Kuber Sampath , John Smart , Hermann Oppermann , Engin Ozkaynak , Charles Cohen , Dennis Higgins
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/51 , A01N1/021 , A61K38/00 , A61K38/1841 , A61K38/185
摘要： Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.
摘要翻译：公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。形态发生剂和神经营养因子可以组合使用。

48. 发明申请

US20060198835A1 Nucleic acid molecules encoding osteogenic proteins 失效
公开(公告)号：US20060198835A1
公开(公告)日：2006-09-07
申请号：US11331855
申请日：2006-01-13
申请人： Hermann Oppermann , Thangavel Kuberasampath , David Rueger , Engin Ozkaynak
发明人： Hermann Oppermann , Thangavel Kuberasampath , David Rueger , Engin Ozkaynak
IPC分类号： A61K38/48 , C12N9/64
CPC分类号： C07K14/51 , A61K38/00
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.

49. 发明授权

US5652118A Nucleic acid encoding a novel morphogenic protein, OP-3 失效
标题翻译：编码新型形态发生蛋白的核酸，OP-3
公开(公告)号：US5652118A
公开(公告)日：1997-07-29
申请号：US480528
申请日：1995-06-07
申请人： Engin Ozkaynak , Hermann Oppermann
发明人： Engin Ozkaynak , Hermann Oppermann
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61K48/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , C12N5/10 , C07H21/04 , C12N15/12 , C12N15/63
CPC分类号： A61K6/0032 , A01N1/0226 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , A61F2310/00365 , A61K48/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译：公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法体内的组织特异性生长和体内替换患病或受损组织的方法。

50. 发明申请

US20050255141A1 Osteogenic devices 审中-公开
公开(公告)号：US20050255141A1
公开(公告)日：2005-11-17
申请号：US11051568
申请日：2005-02-04
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David Rueger , Roy H. L. Pang
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David Rueger , Roy H. L. Pang
IPC分类号： A61C8/00 , A61F2/00 , A61K38/00 , A61K38/05 , A61K38/08 , A61K38/10 , A61L27/22 , A61L27/34 , A61L27/36 , A61L27/44 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , C07K14/51
CPC分类号： A61L27/3608 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L27/227 , A61L27/34 , A61L27/365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02 , C07K14/51 , C08L89/06
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式