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41. 发明申请

US20060135986A1 Vaso-occlusive device having pivotable coupling 失效
标题翻译：具有可枢转耦合的血管闭塞装置
公开(公告)号：US20060135986A1
公开(公告)日：2006-06-22
申请号：US11022189
申请日：2004-12-22
申请人： Michael Wallace , Kamal Ramzipoor
发明人： Michael Wallace , Kamal Ramzipoor
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, comprises locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further comprises severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译：用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件推动器构件到闭塞构件。输送导管可用于将血管闭塞成员递送至血管部位。一种使用所述组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将所述导管定位在所述动脉瘤颈内，以及操纵所述推动器构件以将所述血管闭塞构件置于所述动脉瘤囊内。该方法还包括切断可分开的连接点以将血管闭塞构件与推动器构件分离。结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。

42. 发明授权

US06966892B2 Apparatus for deployment of micro-coil using a catheter 失效
标题翻译：使用导管展开微型线圈的装置
公开(公告)号：US06966892B2
公开(公告)日：2005-11-22
申请号：US10290777
申请日：2002-11-07
申请人： Deepak Gandhi , Kamal Ramzipoor
发明人： Deepak Gandhi , Kamal Ramzipoor
IPC分类号： A61B17/00 , A61B17/12 , A61F2/84 , A61F7/12 , A61F11/00 , A61M29/00
CPC分类号： A61B17/12113 , A61B17/12 , A61B17/12022 , A61B17/12136 , A61B17/1214 , A61B2017/00477 , A61B2017/00867 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209 , A61B2018/00005 , A61B2090/037 , A61F2002/9505 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a tubular collar that can be heated by a heater such as an electrical resistance coil to expand the collar and release and deploy the therapeutic device. The apparatus for deployment of a therapeutic device such as a micro-coil may also provide for a pusher member and a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a heater within the distal portion of the pusher member, for heating and breaking the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.
摘要翻译：用于展开诸如微型线圈的治疗装置的装置将治疗装置可拆卸地安装到推动器构件的远侧部分。在一个实施例中，治疗装置通过可被诸如电阻线圈的加热器加热的管状套环可拆卸地安装到推动器构件的远端部分，以扩大套环并释放和展开治疗装置。用于展开诸如微型线圈的治疗装置的装置还可以提供用于将治疗装置固定到推动器构件的推动器构件和连接器纤维。连接器纤维通过在推动器构件的远端部分内的加热器，用于加热和断开连接器纤维以在实现治疗装置在脉管系统期望的放置期间释放治疗装置。

43. 发明申请

US20050113864A1 Apparatus for deployment of micro-coil using a catheter 有权
公开(公告)号：US20050113864A1
公开(公告)日：2005-05-26
申请号：US11020936
申请日：2004-12-22
申请人： Deepak Gandhi , Kamal Ramzipoor
发明人： Deepak Gandhi , Kamal Ramzipoor
IPC分类号： A61B17/00 , A61B17/12 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12113 , A61B17/12 , A61B17/12022 , A61B17/12136 , A61B17/1214 , A61B2017/00477 , A61B2017/00867 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209 , A61B2018/00005 , A61B2090/037 , A61F2002/9505 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a tubular collar that can be heated by a heater such as an electrical resistance coil to expand the collar and release and deploy the therapeutic device. The apparatus for deployment of a therapeutic device such as a micro-coil may also provide for a pusher member and a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a heater within the distal portion of the pusher member, for heating and breaking the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.

44. 发明申请

US20050113863A1 Intravascular device deployment mechanism incorporating mechanical detachment 失效
标题翻译：血管内装置部署机构结合机械脱离
公开(公告)号：US20050113863A1
公开(公告)日：2005-05-26
申请号：US11020810
申请日：2004-12-22
申请人： Kamal Ramzipoor , Tom Holdych
发明人： Kamal Ramzipoor , Tom Holdych
IPC分类号： A61B17/00 , A61B17/12 , A61F2/06 , A61F2/84 , A61M29/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00477 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61B2017/12077 , A61B2018/00005 , A61F2/95 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a cutter member such as a cutting ring within the distal portion of the pusher member, for cutting the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.
摘要翻译：用于展开诸如微型线圈的治疗装置的装置将治疗装置可拆卸地安装到推动器构件的远侧部分。在一个实施例中，治疗装置通过用于将治疗装置固定到推动器构件的连接器纤维可拆卸地安装到推动器构件的远端部分。连接器纤维在推动器构件的远端部分内通过诸如切割环的切割器件，用于当实现治疗装置在脉管系统期望的放置期间切割连接器纤维以释放治疗装置。

45. 发明授权

US06835185B2 Intravascular device deployment mechanism incorporating mechanical detachment 失效
标题翻译：血管内装置部署机构结合机械脱离
公开(公告)号：US06835185B2
公开(公告)日：2004-12-28
申请号：US10113781
申请日：2002-04-01
申请人： Kamal Ramzipoor , Tom Holdych
发明人： Kamal Ramzipoor , Tom Holdych
IPC分类号： A61M3100
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00477 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61B2017/12077 , A61B2018/00005 , A61F2/95 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a cutter member such as a cutting ring within the distal portion of the pusher member, for cutting the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.
摘要翻译：用于展开诸如微型线圈的治疗装置的装置将治疗装置可拆卸地安装到推动器构件的远侧部分。在一个实施例中，治疗装置通过用于将治疗装置固定到推动器构件的连接器纤维可拆卸地安装到推动器构件的远端部分。连接器纤维在推动器构件的远端部分内通过诸如切割环的切割器件，用于当实现治疗装置在脉管系统期望的放置期间切割连接器纤维以释放治疗装置。

46. 发明授权

US06695863B1 Sheath for an adjustable length balloon 失效
标题翻译：护套为可调节长度的气球
公开(公告)号：US06695863B1
公开(公告)日：2004-02-24
申请号：US08767119
申请日：1997-01-08
申请人： Kamal Ramzipoor , James C. Peacock, III , Gary Schneiderman
发明人： Kamal Ramzipoor , James C. Peacock, III , Gary Schneiderman
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M2025/1068 , A61M2025/1081
摘要： A dilatation catheter assembly which has a dilatation catheter with a sheath mounted on the catheter shaft having an inner lumen extending in the distal portion of the sheath which is configured to slidably receive at least a portion of the dilatation balloon on the distal end of the catheter. The position of the sheath is fixed with respect to the catheter, e.g. a friction fit or bonded in some manner, before the assembly is inserted into the patient's vasculature with the distal portion of the sheath covering a portion of the balloon but leaving a portion of the balloon uncovered with a length equal to the stenotic region to be dilated so that the entire stenosis can be dilated at the same time. The distal portion of the sheath is preferably formed of a flexible polymeric tube with inelastic reinforcement to prevent substantial expansion thereof when the balloon is inflated.
摘要翻译：一种扩张导管组件，其具有安装在导管轴上的护套的扩张导管，其具有在护套的远端部分中延伸的内腔，其构造成可滑动地容纳导管远端上的至少一部分扩张球囊。护套的位置相对于导管固定，例如，摩擦配合或以某种方式结合，在将组件插入患者的脉管系统中之前，护套的远端部分覆盖气囊的一部分，但是使球囊的一部分未被覆盖，其长度等于要扩张的狭窄区域使整个狭窄可以同时扩张。护套的远端部优选地由具有非弹性加强件的柔性聚合物管形成，以防止当气囊膨胀时其大量膨胀。

47. 发明授权

US06254549B1 Guidewire replacement device with flexible intermediate section 有权
标题翻译：导丝更换装置具有柔性中间部分
公开(公告)号：US06254549B1
公开(公告)日：2001-07-03
申请号：US09285808
申请日：1999-04-01
申请人： Kamal Ramzipoor
发明人： Kamal Ramzipoor
IPC分类号： A61B500
CPC分类号： A61M25/09041 , A61M29/02
摘要： A guidewire replacement device having a proximal shaft section, a distal shaft section and a flexible intermediate shaft section which facilitate the articulation of the distal shaft section with respect to the proximal shaft section. The intermediate shaft section has as aperture for the egress or exit of an in-place guidewire during a guidewire exchange. The proximal end of an in-place guidewire is inserted through the distal guidewire port in the distal end of the distal shaft section, through the distal section and out the aperture in the intermediate shaft section. The exchange device is advanced through the inner lumen of a guiding catheter over the in-place guidewire until the distal end of the exchange device extends through the proximal guidewire port of a rapid exchange type intraluminal catheter. Once the guidewire exchange device is properly placed, the in-place guidewire can then be withdrawn from the patient. The replacement guidewire can then be advanced through the inner lumen of the proximal shaft section, the guidewire passageway of the intermediate section, the inner lumen of the distal section into the guidewire receiving inner lumen of the intraluminal catheter. The guidewire exchange device may then be removed from the patient.
摘要翻译：一种导线更换装置，其具有近轴部分，远端轴部分和柔性中间轴部分，其有助于远侧轴部分相对于近端轴部分的铰接。中间轴部分在导丝交换期间具有用于就地导丝的出口或出口的孔。原位导丝的近端穿过远端部分的远端中的远侧导丝端口插入，并穿过中间轴部分的孔。交换装置通过引导导管的内腔前进穿过原位导丝，直到交换装置的远端延伸穿过快速交换型管腔内导管的近端导丝端口。一旦导线更换装置被正确放置，就可以从患者中撤出就地引导线。然后，替换导丝可以推进通过近端轴部分的内腔，中间部分的导丝通道，远端部分的内腔进入导管中，从而接纳管腔内导管的内腔。然后可以从患者移除导丝交换装置。

48. 发明授权

US10646359B2 Stent fabrication via tubular casting processes 有权
公开(公告)号：US10646359B2
公开(公告)日：2020-05-12
申请号：US13476853
申请日：2012-05-21
申请人： Kamal Ramzipoor , Alfred N. K. Chia , Liwei Wang
发明人： Kamal Ramzipoor , Alfred N. K. Chia , Liwei Wang
IPC分类号： A61F2/82 , A61L31/04 , A61L31/14 , A61F2/07 , A61L31/06 , A61L31/16 , B29C41/00 , B29C41/14 , A61F2/24 , A61F2/30 , B29C49/00 , B29K105/00 , B29L31/00
摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

49. 发明授权

US09908143B2 Stent fabrication via tubular casting processes 有权
公开(公告)号：US09908143B2
公开(公告)日：2018-03-06
申请号：US13476858
申请日：2012-05-21
申请人： Kamal Ramzipoor , Alfred N. K. Chia , Liwei Wang , Chang Y. Lee
发明人： Kamal Ramzipoor , Alfred N. K. Chia , Liwei Wang , Chang Y. Lee
IPC分类号： A61F2/82 , B05D1/18 , A61F2/91 , A61F2/915
CPC分类号： B05D1/18 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2210/0076
摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

50. 发明授权

US09622754B2 Intravascular device deployment mechanism incorporating mechanical detachment 有权
公开(公告)号：US09622754B2
公开(公告)日：2017-04-18
申请号：US11433115
申请日：2006-05-12
申请人： Kamal Ramzipoor , Tom Holdych
发明人： Kamal Ramzipoor , Tom Holdych
IPC分类号： A61B17/12 , A61B17/00 , A61B18/00 , A61F2/95
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00477 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61B2017/12077 , A61B2018/00005 , A61F2/95 , A61F2002/9511
摘要： The apparatus for deployment of a therapeutic device such as a micro-coil detachably mounts the therapeutic device to a distal portion of a pusher member. In one embodiment, the therapeutic device is detachably mounted to the distal portion of the pusher member by a connector fiber for securing the therapeutic device to the pusher member. The connector fiber passes through a cutter member such as a cutting ring within the distal portion of the pusher member, for cutting the connector fiber to release the therapeutic device when a desired placement of the therapeutic device within the vasculature is achieved.

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