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41. 发明申请

US20120277574A1 SYSTEMS AND METHODS FOR GUIDING CATHETERS USING REGISTERED IMAGES 审中-公开
标题翻译：使用注册图像引导导管的系统和方法
公开(公告)号：US20120277574A1
公开(公告)日：2012-11-01
申请号：US13461589
申请日：2012-05-01
申请人： Dorin Panescu
发明人： Dorin Panescu
IPC分类号： A61B6/03 , A61B8/12 , A61B5/055 , A61B6/12
CPC分类号： A61B5/0422 , A61B5/06 , A61B5/062 , A61B5/6858 , A61B8/543 , A61B18/1492 , A61B34/20 , A61B90/36 , A61B2017/00053 , A61B2017/00703 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00839 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/2063 , A61B2034/2072 , A61B2090/365 , A61B2090/378 , A61B2090/3782 , A61B2090/3929 , A61B2090/3958 , A61B2562/0219 , G06T7/30 , G06T19/003 , G06T19/006 , G06T2207/30048 , G06T2210/41
摘要： Systems and methods for imaging a body cavity and for guiding a treatment element within a body cavity are provided. A system may include an imaging subsystem having an imaging device and an image processor that gather image data for the body cavity. A mapping subsystem may be provided, including a mapping device and a map processor, to identify target sites within the body cavity, and provide location data for the sites. The system may also include a location processor coupled to a location element on a treatment device to track the location of the location element. The location of a treatment element is determined by reference to the location element. A treatment subsystem including a treatment device having a treatment element and a treatment delivery source may also be provided. A registration subsystem receives and registers data from the other subsystems, and displays the data.
摘要翻译：提供了用于使体腔成像和用于引导体腔内的治疗元件的系统和方法。系统可以包括成像子系统，其具有成像装置和收集体腔的图像数据的图像处理器。可以提供映射子系统，包括映射设备和地图处理器，以识别体腔内的目标位置，并提供站点的位置数据。系统还可以包括耦合到处理设备上的位置元件的位置处理器，以跟踪位置元件的位置。治疗元件的位置通过参考位置元件来确定。还可以提供包括具有治疗元件和治疗递送源的治疗装置的治疗子系统。注册子系统从其他子系统接收和注册数据，并显示数据。

42. 发明授权

US08032218B2 Implantable cardiac device with satellite refresh 有权
标题翻译：可植入式心脏设备，具有卫星刷新功能
公开(公告)号：US08032218B2
公开(公告)日：2011-10-04
申请号：US12183438
申请日：2008-07-31
申请人： Louis Wong , Dorin Panescu
发明人： Louis Wong , Dorin Panescu
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/37288 , A61N1/378
摘要： In one embodiment an implantable cardiac device is provided that includes an implantable cardiac stimulation device with an implantable satellite device coupled to it. The implantable satellite device has a charge storage device. The implantable stimulation device having a refresh generator configured to generate a charge and voltage balanced multi-phasic refresh signal with a duration less than a capacitive time constant of an electrode-electrolyte interface of the implantable cardiac device and transmit the charge and voltage balanced multi-phasic refresh signal to the implantable satellite device for charging the charge storage device. In various embodiments, the charge and voltage balanced multi-phasic refresh signal having alternating phase signs and null durations between the alternating phases. In some embodiments, the refresh generator is configured to modulate the multi-phasic waveform refresh signal. The multi-phasic waveform refresh signal may be modulated to contain configuration information, status information, or other information.
摘要翻译：在一个实施例中，提供了可植入的心脏装置，其包括可植入的心脏刺激装置，其中可植入的卫星装置与其联接。可植入式卫星装置具有电荷存储装置。所述可植入刺激装置具有刷新发生器，其被配置为产生具有小于所述可植入心脏装置的电极 - 电解质界面的电容时间常数的持续时间的充电和电压平衡多相刷新信号，并且传送所述充电和电压平衡多相刷新信号，相位刷新信号到可植入式卫星装置，用于对电荷存储装置充电。在各种实施例中，充电和电压平衡的多相刷新信号在交替相位之间具有交替的相位符号和空持续时间。在一些实施例中，刷新发生器配置成调制多相波形刷新信号。可以调制多相波形刷新信号以包含配置信息，状态信息或其他信息。

43. 发明申请

US20110112415A1 SYSTEM AND METHOD FOR AUTOMATED EKG ANALYSIS 审中-公开
标题翻译：用于自动EKG分析的系统和方法
公开(公告)号：US20110112415A1
公开(公告)日：2011-05-12
申请号：US12614361
申请日：2009-11-06
申请人： Bosko Bojovic , Uros Mitrovic , Ljupco Hadzievski , Dorin Panescu , Ihor Gussak
发明人： Bosko Bojovic , Uros Mitrovic , Ljupco Hadzievski , Dorin Panescu , Ihor Gussak
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011
摘要： Systems and methods for analyzing electronic cardiac signals for use in clinical diagnostics are described. Parameters pertinent to a first cardiac condition of a patient, such as determining an orientation of a vector related to the cardiac activity of said patient, and comparing the vector orientation relative to a centerpoint of a population distribution representative of a second cardiac condition, may be utilized. The second cardiac condition may be selected from the group consisting of benign early repolarization, left ventricular hypertrophy, and right bundle branch block. System and method embodiments are configured to assist in the analysis of details of EKG signals and vector cardiograms to determine how patients should be categorized into specific cardiac risk categories, such as an acute coronary syndrome category.
摘要翻译：描述用于分析用于临床诊断的电子心脏信号的系统和方法。与患者的第一心脏病状相关的参数，例如确定与所述患者的心脏活动相关的载体的方向，以及比较相对于代表第二心脏病的群体分布的中心点的载体方向，可以是利用。第二心脏病状可以选自良性早期复极化，左心室肥大和右束支传导阻滞。系统和方法实施例被配置为协助分析EKG信号和载体心电图的细节，以确定如何将患者分类为特定的心脏危险类别，例如急性冠状动脉综合征类别。

44. 发明授权

US07699829B2 Catheter with sensor tip and method of use of same 有权
标题翻译：带传感器端头的导管及其使用方法
公开(公告)号：US07699829B2
公开(公告)日：2010-04-20
申请号：US11037154
申请日：2005-01-19
申请人： Chad G. Harris , Matthew L. Hawk , Timothy J. Mickley , Dorin Panescu , Maria Palasis , Jacob Rooney , Toby Freyman
发明人： Chad G. Harris , Matthew L. Hawk , Timothy J. Mickley , Dorin Panescu , Maria Palasis , Jacob Rooney , Toby Freyman
IPC分类号： A61M31/00
CPC分类号： A61B5/0422 , A61B5/6852 , A61B2018/00875 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M25/0136 , A61M2025/0096 , A61N1/0568
摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.
摘要翻译：一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

45. 发明授权

US07676264B1 Systems and methods for use by an implantable medical device for evaluating ventricular dyssynchrony based on T-wave morphology 有权
标题翻译：基于T波形态的可植入医疗装置用于评估心室不同步的系统和方法
公开(公告)号：US07676264B1
公开(公告)日：2010-03-09
申请号：US11734850
申请日：2007-04-13
申请人： Ajit Pillai , Mihir Naware , Dorin Panescu
发明人： Ajit Pillai , Mihir Naware , Dorin Panescu
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/0452 , A61B5/7239 , A61N1/365
摘要： Techniques are provided for detecting and evaluating ventricular dyssynchrony based on morphological features of the T-wave and for controlling therapy in response thereto. For example, the number of peaks in the T-wave, the area under the peaks, the number of points of inflection, and the slope of the T-wave can be used to detect ventricular dyssynchrony and evaluate its severity. As ventricular dyssynchrony often arises due to heart failure, the degree of dyssynchrony may also be used as a proxy for tracking the progression of heart failure. Pacing therapy is automatically and adaptively adjusted based on the degree of ventricular dyssynchrony so as to reduce the dyssynchrony and thereby improve cardiac function.
摘要翻译：提供了基于T波的形态学特征和用于控制对其的治疗来检测和评价心室不同步的技术。例如，可以使用T波中的峰数，峰下的面积，拐点的数量和T波的斜率来检测心室不同步并评估其严重程度。由于心脏衰竭经常出现心室不同步，不同步程度也可用作跟踪心力衰竭进展的代理。基于心室不同步程度自动调整起搏治疗，减少不同步，从而改善心脏功能。

46. 发明申请

US20100023085A1 ADAPTABLE COMMUNICATION SENSITIVITY FOR AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：适用于可植入医疗器械的通信灵敏度
公开(公告)号：US20100023085A1
公开(公告)日：2010-01-28
申请号：US12179336
申请日：2008-07-24
申请人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
发明人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
IPC分类号： A61N1/375
CPC分类号： A61N1/37276 , H04W52/0245 , Y02D70/26
摘要： A wireless communication threshold for an implantable medical device is automatically adapted in an attempt to maintain optimum signal detection sensitivity. In some aspects, a threshold level may be adapted to account for current environmental conditions, implant conditions, device conditions, or other conditions that may affect the reception of wireless signals at the device. In some aspects, the determination of an optimum level for the threshold involves a tradeoff relating to effectively detecting target signals while avoiding detection of noise and/or interference. In some aspects, adaptation of a threshold may be based on maximum energy levels associated with one or more sets of RF energy sample data. In some aspects, adaptation of a threshold may be based on the number of false wakeups that occur during a period of time.
摘要翻译：可植入医疗装置的无线通信阈值自动适应于试图维持最佳信号检测灵敏度。在一些方面，阈值水平可以适应于考虑当前环境条件，植入条件，设备条件或可能影响在设备处的无线信号的接收的其他条件。在一些方面，确定阈值的最佳电平涉及与有效地检测目标信号有关的折中，同时避免噪声和/或干扰的检测。在一些方面，阈值的适应可以基于与一个或多个RF能量样本数据集相关联的最大能级。在一些方面，阈值的适应可以基于在一段时间内发生的假唤醒的数量。

47. 发明申请

US20070055227A1 Probe used for an ocular procedure 审中-公开
标题翻译：探针用于眼部手术
公开(公告)号：US20070055227A1
公开(公告)日：2007-03-08
申请号：US11222890
申请日：2005-09-08
申请人： Steve Khalaj , Dorin Panescu , Larry Hood
发明人： Steve Khalaj , Dorin Panescu , Larry Hood
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B2018/143 , A61F9/0079
摘要： A medical device used to denature corneal tissue. The device includes a probe and an applanator that can flatten the cornea. The probe has a plurality of electrodes that extend through apertures of the applanator and into the cornea. The electrodes deliver energy into the cornea to denature corneal tissue. The corneal tissue is denatured in a pattern that can correct for refractive conditions of the eye.
摘要翻译：用于使角膜组织变性的医疗器械。该装置包括可以使角膜变平的探针和压平器。探针具有多个电极，其延伸穿过压扁器的孔并进入角膜。电极将能量传递到角膜以使角膜组织变性。角膜组织变形，可以校正眼睛的折射状况。

48. 发明授权

US06788969B2 Interactive systems and methods for controlling the use of diagnostic or therapeutic instruments in interior body regions 有权
标题翻译：用于控制在内部身体区域使用诊断或治疗仪器的交互式系统和方法
公开(公告)号：US06788969B2
公开(公告)日：2004-09-07
申请号：US10267715
申请日：2002-10-10
申请人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne , David McGee , David K. Swanson
发明人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne , David McGee , David K. Swanson
IPC分类号： A61B50402
CPC分类号： A61B5/0422 , A61B5/0464 , A61B5/06 , A61B5/063 , A61B5/6858 , A61B5/7435 , A61B5/7445 , A61B5/7475 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , G06F19/00 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： An interface is associated with a structure which, in use, is deployed in an interior body region of a patient. The structure includes an operative element coupled to a controller, which establishes an operating condition for the operative element to perform a diagnostic or therapeutic procedure in the interior body region. The interface generates a first display comprising an image of the structure at least partially while the operative element performs the procedure. The interface also generates a second display comprising one or more data fields reflecting the operating condition of the controller. The interface enables selection of the first display or the second display for viewing on a display screen.
摘要翻译：界面与在使用中部署在患者的内部身体区域中的结构相关联。该结构包括耦合到控制器的操作元件，其建立操作元件在内部身体区域中执行诊断或治疗过程的操作条件。该接口在操作元件执行该过程时至少部分地生成包括该结构的图像的第一显示器。接口还产生包括反映控制器的操作条件的一个或多个数据字段的第二显示器。该接口使得能够选择第一显示器或第二显示器以在显示屏幕上观看。

49. 发明授权

US06565511B2 Systems for recording use of structures deployed in association with heart tissue 有权
公开(公告)号：US06565511B2
公开(公告)日：2003-05-20
申请号：US10114779
申请日：2002-04-02
申请人： Dorin Panescu , David K. Swanson , David F. Dueiri , David McGee , Daniel A. Dupree , James G. Whayne , Robert R. Burnside , Tuan Nguyen
发明人： Dorin Panescu , David K. Swanson , David F. Dueiri , David McGee , Daniel A. Dupree , James G. Whayne , Robert R. Burnside , Tuan Nguyen
IPC分类号： A61B800
CPC分类号： A61B5/6858 , A61B5/0422 , A61B5/06 , A61B5/065 , A61B5/7435 , A61B2562/0209 , A61B2562/043 , A61B2562/08 , G06F19/00
摘要： A system records use of a structure deployed in operative association with heart tissue in a patient. An image controller generates an image of the structure while in use in the patient. An input receives data including information identifying the patient. An output processes the image in association with the data as a patient-specific, data base record for storage, retrieval, or manipulation.

50. 发明授权

US06490468B2 Systems for recording use of structures deployed in association with heart tissue 有权
公开(公告)号：US06490468B2
公开(公告)日：2002-12-03
申请号：US09804880
申请日：2001-03-12
申请人： Dorin Panescu , David K. Swanson , David F. Dueiri , David McGee , Daniel A. Dupree , James G. Whayne , Robert R. Burnside , Tuan Nguyen
发明人： Dorin Panescu , David K. Swanson , David F. Dueiri , David McGee , Daniel A. Dupree , James G. Whayne , Robert R. Burnside , Tuan Nguyen
IPC分类号： A61B505
CPC分类号： A61B5/6858 , A61B5/0422 , A61B5/06 , A61B5/065 , A61B5/7435 , A61B2562/0209 , A61B2562/043 , A61B2562/08 , G06F19/00
摘要： A system records use of a structure deployed in operative association with heart tissue in a patient. An image controller generates an image of the structure while in use in the patient. An input receives data including information identifying the patient. An output processes the image in association with the data as a patient-specific, data base record for storage, retrieval, or manipulation.

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