专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US08143242B2 Malonamide derivatives with antithrombotic activity 有权
标题翻译：具有抗血栓活性的丙二酰胺衍生物
公开(公告)号：US08143242B2
公开(公告)日：2012-03-27
申请号：US12683736
申请日：2010-01-07
申请人： Henning Steinhagen , Hauke Szillat , Markus Follmann , Reinhard Kirsch , Volkmar Wehner , Hans Matter , Martin Lorenz , Kent W. Neuenschwander , Anthony C. Scotese
发明人： Henning Steinhagen , Hauke Szillat , Markus Follmann , Reinhard Kirsch , Volkmar Wehner , Hans Matter , Martin Lorenz , Kent W. Neuenschwander , Anthony C. Scotese
IPC分类号： A61K31/553 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/381 , A61K31/167 , C07D281/06 , C07D241/04 , C07D213/65 , C07D277/24 , C07D409/02 , C07C237/20
CPC分类号： C07D213/80 , C07C257/18 , C07C311/08 , C07C311/46 , C07C317/22 , C07C317/32 , C07C2601/14 , C07D211/42 , C07D213/30 , C07D213/34 , C07D309/08 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of formula I, The compounds of formula I are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I化合物。式I化合物是有价值的药理学活性化合物。它们表现出强烈的抗血栓形成作用，并且适用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶，特别是因子VIIa的抑制剂，并且通常可用于其中存在不需要的因子VIIa的活性或用于治疗或预防因子VIIa的抑制的条件。本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

42. 发明授权

US08044208B2 Imidazole derivatives as inhibitors of TAFIa 有权
标题翻译：咪唑衍生物作为TAFIa的抑制剂
公开(公告)号：US08044208B2
公开(公告)日：2011-10-25
申请号：US12102105
申请日：2008-04-14
申请人： Christopher Kallus , Holger Heitsch , Volkmar Wehner
发明人： Christopher Kallus , Holger Heitsch , Volkmar Wehner
IPC分类号： C07D413/00
CPC分类号： C07D413/14 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound of formula I: or any stereoisomeric form of the compound of the formula I or a mixture of these forms in any ratio or a physiologically acceptable salt of the compound of the formula I which inhibit the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor), and to a process for their preparation and to their use to treat described diseases where the substituents are as described in the specification.
摘要翻译：本发明涉及式I化合物或式I化合物的任何立体异构形式或其抑制酶TAFIa的式I化合物的任何比例或生理学上可接受的盐的这些形式的混合物活化的凝血酶可激活的纤维蛋白溶解抑制剂），以及它们的制备方法及其用于治疗所述疾病的用途，其中取代基如说明书中所述。

43. 发明授权

US07741341B2 Benzimidazole-derivatives as factor Xa inhibitors 有权
标题翻译：苯并咪唑衍生物作为因子Xa抑制剂
公开(公告)号：US07741341B2
公开(公告)日：2010-06-22
申请号：US10849436
申请日：2004-05-19
申请人： Marc Nazare , Michael Wagner , Volkmar Wehner , Hans Matter , Matthias Urmann , Kurt Ritter
发明人： Marc Nazare , Michael Wagner , Volkmar Wehner , Hans Matter , Matthias Urmann , Kurt Ritter
IPC分类号： A61K31/4523 , C07D401/14 , C07D409/14
CPC分类号： C07D235/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/08 , C07D495/04
摘要： The present invention relates to compounds of the formula I, wherein R0, R1, R2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I化合物，其中R 0，R 1，R 2，Q，V，G和M如本文所定义。式I的化合物是有价值的药理活性化合物。它们具有强烈的抗血栓形成作用，并且适用于例如治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及式I化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

44. 发明授权

US07358268B2 Imidazole derivatives as factor Xa inhibitors 有权
标题翻译：咪唑衍生物作为因子Xa抑制剂
公开(公告)号：US07358268B2
公开(公告)日：2008-04-15
申请号：US10728339
申请日：2003-12-04
申请人： Marc Nazare , Armin Bauer , Volkmar Wehner , David W. Will , Hans Matter , Michael Wagner , Herman Schreuder
发明人： Marc Nazare , Armin Bauer , Volkmar Wehner , David W. Will , Hans Matter , Michael Wagner , Herman Schreuder
IPC分类号： A61K31/42 , C07D261/04 , C07D413/04
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting the formation of thrombin or for therapeutically or prophylactically treating a patient suffering from, or subject to, or associated with a disease state associated with a cardiovascular disorder.
摘要翻译：本发明涉及可用于抑制因子Xa的活性的式（I）化合物。本发明还涉及包含所述化合物的组合物，其制备方法，其用途，例如抑制凝血酶的形成或用于治疗或预防性地治疗患有或与疾病状态有关的患者或与之相关的患者伴有心血管疾病。

45. 发明申请

US20070179122A1 Beta-Aminoacid-Derivatives As Factor Xa Inhibitors 审中-公开
标题翻译： β-氨基酸衍生物作为因子Xa抑制剂
公开(公告)号：US20070179122A1
公开(公告)日：2007-08-02
申请号：US11469513
申请日：2006-09-01
申请人： Matthias Urmann , Marc Nazare , Volkmar Wehner , Hans Matter , Armin Bauer , Michael Wagner
发明人： Matthias Urmann , Marc Nazare , Volkmar Wehner , Hans Matter , Armin Bauer , Michael Wagner
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , A61K31/541 , A61K31/496 , A61K31/5377 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07K5/0202 , C07D265/32 , C07D265/33 , C07D291/06 , C07D295/112 , C07D409/12 , C07D409/14 , C07D413/12 , C07D419/12
摘要： The present invention relates to compounds of the formula I, in which R0; R1; R2; R3; R4; R5, R, Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboemboic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I化合物，其中R 0， R＆lt; 1＆gt;; R 2; 3＆lt; 3＆gt; R 4; R 5，R，Q; V，G和M具有权利要求中所示的含义。式I的化合物是有价值的药理活性化合物。它们表现出强烈的抗血栓形成作用，并且适用于例如治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及式I化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

46. 发明申请

US20050009829A1 Benzimidazole-derivatives as factor Xa inhibitors 有权
标题翻译：苯并咪唑衍生物作为因子Xa抑制剂
公开(公告)号：US20050009829A1
公开(公告)日：2005-01-13
申请号：US10849436
申请日：2004-05-19
申请人： Marc Nazare , Michael Wagner , Volkmar Wehner , Hans Matter , Matthias Urmann , Kurt Ritter
发明人： Marc Nazare , Michael Wagner , Volkmar Wehner , Hans Matter , Matthias Urmann , Kurt Ritter
IPC分类号： C07D235/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/08 , C07D495/04 , A61K31/52 , A61K31/4709 , A61K31/513 , A61K31/517 , C07D473/02 , C07
CPC分类号： C07D235/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/08 , C07D495/04
摘要： The present invention relates to compounds of the formula I, wherein R0, R1, R2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I化合物，其中R 0，R 1，R 2，Q，V，G和M如本文所定义。式I的化合物是有价值的药理活性化合物。它们具有强烈的抗血栓形成作用，并且适用于例如治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及式I化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

47. 发明授权

US5877322A Substituted pyridines, their preparation, and their use as pesticides and fungicides 失效
标题翻译：取代的吡啶，它们的制备及其作为农药和杀真菌剂的用途
公开(公告)号：US5877322A
公开(公告)日：1999-03-02
申请号：US305040
申请日：1994-09-12
申请人： Dieter Bernd Reuschling , Adolf Heinz Linkies , Volkmar Wehner , Rainer Preuss , Wolfgang Schaper , Harald Jakobi , Peter Braun , Werner Knauf , Burkhard Sachse , Anna Waltersdorfer , Manfred Kern , Peter Lummen , Werner Bonin
发明人： Dieter Bernd Reuschling , Adolf Heinz Linkies , Volkmar Wehner , Rainer Preuss , Wolfgang Schaper , Harald Jakobi , Peter Braun , Werner Knauf , Burkhard Sachse , Anna Waltersdorfer , Manfred Kern , Peter Lummen , Werner Bonin
IPC分类号： A01C1/00 , A01M1/20 , A01N43/40 , B27K3/34 , C07D213/68 , C07D213/74 , C07D213/76 , C07D213/89
CPC分类号： C07D213/74 , A01N43/40 , C07D213/68 , C07D213/76 , C07D213/89
摘要： The invention relates to compounds of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, halogen, an aliphatic radical or an aromatic radical, X is O, S or optionally substituted imino, Y is a bond or a bivalent optionally substituted hydrocarbon radical and Z is optionally substituted cycloalkyl or cycloalkenyl. The invention furthermore relates to processes for their preparation and their use as pesticides, in particular as insecticides, acaricides and fungicides.
摘要翻译：本发明涉及下式化合物：其中R 1，R 2，R 3和R 4为H，卤素，脂族基团或芳族基团，X为O，S或任选取代的亚氨基，Y为一个或多个二价任选取代的烃基，Z是任选取代的环烷基或环烯基。本发明还涉及其制备方法及其作为农药的用途，特别是作为杀虫剂，杀螨剂和杀真菌剂。

48. 发明授权

US08598177B2 Imidazopyridazines as PAR1 inhibitors, production thereof, and use as medicaments 有权
标题翻译：咪唑并哒嗪作为PAR1抑制剂，其制备及用作药物
公开(公告)号：US08598177B2
公开(公告)日：2013-12-03
申请号：US12851198
申请日：2010-08-05
申请人： Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
发明人： Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
IPC分类号： A61K31/501 , A61K31/50 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, R9, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
摘要翻译：本发明涉及新的式I化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，Q1，Q2和Q3各自如下所定义。式I的化合物具有抗血栓形成活性并特别抑制蛋白酶活化的受体1（PAR1）。本发明还涉及制备式I化合物及其作为药物的用途的方法。

49. 发明授权

US07772270B2 Imino acid derivatives as inhibitors of matrix metalloproteinases 有权
标题翻译：亚氨基酸衍生物作为基质金属蛋白酶的抑制剂
公开(公告)号：US07772270B2
公开(公告)日：2010-08-10
申请号：US11405834
申请日：2006-04-18
申请人： Manfred Schudok , Sven Ruf , Hans Matter , Volkmar Wehner , Reinhard Kirsch , Petra Lennig
发明人： Manfred Schudok , Sven Ruf , Hans Matter , Volkmar Wehner , Reinhard Kirsch , Petra Lennig
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D403/12 , C07D209/42 , C07D209/52 , C07D405/12 , C07D409/12 , C07D417/14 , C07D495/04
摘要： The invention relates to a bicycloazaheterocyclyl carboxylic acid sulfonamide derivative of formula I herein, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use.
摘要翻译：本发明涉及本文所述的式I的双环氮杂杂环羧酸磺酰胺衍生物，包含其的药物制剂，其制备方法及其药物用途的方法。

50. 发明申请

US20080280946A1 Azaindole-Derivatives As Factor Xa Inhibitors 审中-公开
标题翻译：阿魏酸衍生物作为因子Xa抑制剂
公开(公告)号：US20080280946A1
公开(公告)日：2008-11-13
申请号：US11934177
申请日：2007-11-02
申请人： Marc NAZARE , Volkmar Wehner , David William Will , Kurt Ritter , Matthias Urmann , Hans Matter
发明人： Marc NAZARE , Volkmar Wehner , David William Will , Kurt Ritter , Matthias Urmann , Hans Matter
IPC分类号： A61K31/437 , C07D471/02 , A61P7/00 , A61P9/00
CPC分类号： C07D471/04
摘要： Indazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I wherein R0, R1, R2, R3, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：作为因子Xa抑制剂的吲唑衍生物本发明涉及式I化合物，其中R 0，R 1，R 2，R 2， SEQ ID NO 3，Q，V，G和M如本文所定义。式I的化合物是有价值的药理活性化合物。它们具有强烈的抗血栓形成作用，并且适用于例如治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及式I化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式