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41. 发明申请

US20140206760A1 MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIA 有权
标题翻译：作为TAFIA的抑制剂的大环尿素和磺酰胺衍生物
公开(公告)号：US20140206760A1
公开(公告)日：2014-07-24
申请号：US14226132
申请日：2014-03-26
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D413/12 , C07D267/00 , C07D273/02 , C07D273/01
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoaguability or fibrotic changes.
摘要翻译：本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高渗透性或纤维变性相关的一种或多种病症的药物。

42. 发明授权

US08741992B2 Polycarbonate compositions with phenolically substituted triazine derivative 有权
标题翻译：具有酚取代三嗪衍生物的聚碳酸酯组合物
公开(公告)号：US08741992B2
公开(公告)日：2014-06-03
申请号：US13513787
申请日：2010-12-01
申请人： Alexander Meyer , Claus Rüdiger , Ulrich Blaschke , Michael Wagner
发明人： Alexander Meyer , Claus Rüdiger , Ulrich Blaschke , Michael Wagner
IPC分类号： C08G63/02 , C08G64/00
CPC分类号： C08K5/3467 , B32B27/18 , B32B27/365 , C08K5/3492 , C08L69/00
摘要： Disclosed is a composition comprising polycarbonate and from 0.0001 weight % to 0.1000 weight % of 2-(2,4-dihydroxy)phenyl-4,6-di(4-phenyl)phenyl-1,3,5-triazine.
摘要翻译：公开了包含聚碳酸酯和0.0001重量％至0.1000重量％的2-（2,4-二羟基）苯基-4,6-二（4-苯基）苯基-1,3,5-三嗪的组合物。

43. 发明授权

US08609681B2 Spirocyclic nitriles as protease inhibitors 有权
公开(公告)号：US08609681B2
公开(公告)日：2013-12-17
申请号：US13248366
申请日：2011-09-29
申请人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
发明人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC分类号： A61K31/44 , C07D221/02
CPC分类号： C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
摘要： The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.

44. 发明授权

US08580777B2 Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa 有权
标题翻译：大环尿素和磺酰胺衍生物作为TAFIa的抑制剂
公开(公告)号：US08580777B2
公开(公告)日：2013-11-12
申请号：US12996460
申请日：2009-05-22
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D413/14 , C07D273/01 , A61K31/553 , A61P7/00
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译：本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。

45. 发明申请

US20130280452A1 SEAMLESS TAILGATE 有权
标题翻译：无缝TAILGATE
公开(公告)号：US20130280452A1
公开(公告)日：2013-10-24
申请号：US13878545
申请日：2011-10-25
申请人： Manfred Nawroth , Ulrich Grosser , Volkhard Krause , Michael Wagner
发明人： Manfred Nawroth , Ulrich Grosser , Volkhard Krause , Michael Wagner
IPC分类号： B60J5/10 , B32B27/36 , B60J1/18 , B32B3/30
CPC分类号： B60J5/10 , B32B3/30 , B32B27/365 , B60J1/18 , B60J5/107 , Y10T428/1352 , Y10T428/24479 , Y10T428/24521 , Y10T428/24612 , Y10T428/31507
摘要： The invention relates to a method for producing seamlessly manufactured vehicle components, in particular vehicle flaps, having a continuous support of a thermoplastic plastics material, which vehicle components have at least one transparent region that is an integral part of the support.
摘要翻译：本发明涉及用于生产无缝制造的车辆部件，特别是具有热塑性塑料材料的连续支撑的车辆翼片的方法，该车辆部件具有作为支撑件的组成部分的至少一个透明区域。

46. 发明申请

US20130126022A1 COMPONENT OF A BIOSENSOR AND PROCESS FOR PRODUCTION 有权
标题翻译：生物传感器的组成部分和生产过程
公开(公告)号：US20130126022A1
公开(公告)日：2013-05-23
申请号：US13635972
申请日：2011-03-10
申请人： Christian Schoen , Michael Wagner
发明人： Christian Schoen , Michael Wagner
IPC分类号： B01J4/00
CPC分类号： B01J4/001 , B01L3/502707 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0822 , B01L2300/0864 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B01L2400/0688 , B01L2400/088 , B81C1/00047 , B81C1/00063 , B81C2201/0105 , B81C2201/0143 , B81C2201/0156 , Y10T137/85938
摘要： The invention relates to a component (4) of a biosensor, comprising at least one first device (6) for receiving a sample liquid, wherein the device (6) is connected via a distributor channel (7) to further receiving devices (8 to 11), into each of which a feed channel (71, 72, 73, 74) branching off from the distributor channel (7) opens, and the feed channels (71, 72, 73, 74) are arranged in succession in flow direction (S) of the sample liquid passed on through the distributor channel (7). In accordance with the invention, it is envisaged that, in the distributor channel (7), in each case between two immediately successive feed channels (71, 72; 72, 73; 73, 74) in flow direction (S), at least one region (K) for at least temporary slowing or stoppage of the capillary flow of the sample liquid has been inserted. It is thus possible to control the capillary flow of the sample liquid such that always only one receiving device (8, 9, 10, 11) is filled with the volume flow of sample liquid available before the next is filled, and effectively simultaneous filling of the receiving devices (8, 9, 10, 11) is prevented. This leads to rapid and complete filling of the respective receiving device (8, 9, 10, 11). Additionally presented is a process with which the regions (K) can be inserted into the distributor channel (7) in a simple manner.
摘要翻译：本发明涉及生物传感器的组件（4），其包括用于接收样品液体的至少一个第一装置（6），其中所述装置（6）经由分配器通道（7）连接到另外的接收装置（8至其中，从分配器通道（7）分支出的进料通道（71,72,73,74）打开，并且进料通道（71,72,73,74）在流动方向上连续地排列（S）通过分配器通道（7）通过的样品液体。根据本发明，设想在分配器通道（7）中，在每种情况下，在流动方向（S）处的两个紧邻的供给通道（71,72; 72,73; 73,74）之间至少已经插入了用于至少暂时放慢或停止样品液体的毛细管流动的区域（K）。因此，可以控制样品液体的毛细管流动，使得总是只有一个接收装置（8,9,10,11）填充下一个填充之前可用的样品液体的体积流量，并且有效地同时填充接收装置（8,9,10,11）被防止。这导致相应的接收装置（8,9,10,11）的快速和完全的填充。另外提出了一种可以简单地将区域（K）插入到分配器通道（7）中的过程。

47. 发明授权

US08088925B2 Heteroaryl-carboxylic acid (sulfamoyl alkyl) amide-derivatives as factor Xa inhibitors 有权
标题翻译：杂芳基羧酸（氨磺酰基烷基）酰胺衍生物作为因子Xa抑制剂
公开(公告)号：US08088925B2
公开(公告)日：2012-01-03
申请号：US11940654
申请日：2007-11-15
申请人： Michael Wagner , Matthias Urmann , Volkmar Wehner , Martin Lorenz , Armin Bauer , Marc Nazare , Hans Matter
发明人： Michael Wagner , Matthias Urmann , Volkmar Wehner , Martin Lorenz , Armin Bauer , Marc Nazare , Hans Matter
IPC分类号： C07D401/02 , C07D403/02 , C07D333/10 , C07D333/28 , A61K31/4535 , A61K31/381 , A61K31/497
CPC分类号： C07D211/58 , C07D333/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14
摘要： The present invention relates to compounds of the formula I, which exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses.
摘要翻译：本发明涉及式I化合物，其具有强的抗血栓形成作用，并且适用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。

48. 发明申请

US20110304191A1 Head Support 有权
标题翻译：头部支持
公开(公告)号：US20110304191A1
公开(公告)日：2011-12-15
申请号：US13155913
申请日：2011-06-08
申请人： Christian MARKEL , Michael Wagner
发明人： Christian MARKEL , Michael Wagner
IPC分类号： B60N2/48
CPC分类号： B60N2/36 , B60N2/809 , B60N2/859
摘要： A head support for a backrest of a motor vehicle seat, which can be folded out of an upright use position into a cargo position directed in driving direction. The head support is mounted to be foldable toward the front side of the backrest between an upright operative position is in the use position, and a folded down inoperative position when the backrest is in the cargo position, around a horizontal head support spindle of a holder arranged at the backrest and carries the head support the head support spindle extends transverse to the driving direction. The holder is lowered completely or partially into a lowered position in the backrest in the inoperative position of the head support and can be raised from the lowered position into the raised position of the operative position.
摘要翻译：一种用于机动车辆座椅靠背的头部支撑件，其可以从直立使用位置折叠成朝向行进方向的货物位置。头部支撑件被安装成在靠背处于使用位置的直立操作位置和靠背处于货物位置的折叠不工作位置之间朝向靠背的前侧可折叠，围绕支架的水平头部支撑主轴位于靠背处并承载头部支撑件，头部支撑主体横向于驱动方向延伸。保持器在头部支撑件的不工作位置中完全或部分地降低到靠背中的降低位置，并且可以从下降位置升高到操作位置的升高位置。

49. 发明授权

US07825264B2 Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them 有权
标题翻译：取代的杂环，它们作为药物的用途，以及包含它们的药物制剂
公开(公告)号：US07825264B2
公开(公告)日：2010-11-02
申请号：US11954400
申请日：2007-12-12
申请人： Joachim Brendel , Heinrich Christian Englert , Stefan Peukert , Klaus Wirth , Michael Wagner , Jean-Marie Ruxer , Fabienne Pilorge
发明人： Joachim Brendel , Heinrich Christian Englert , Stefan Peukert , Klaus Wirth , Michael Wagner , Jean-Marie Ruxer , Fabienne Pilorge
IPC分类号： C07D215/14 , C07D403/06 , C07D295/03 , C07D275/02 , C07D211/40 , A61K31/55 , A61K31/47 , A61K31/4406 , A61K31/4015 , A61K31/425 , A61K31/45
CPC分类号： C07D401/06 , C07D207/27 , C07D211/76 , C07D275/02 , C07D401/14 , C07D409/06
摘要： The invention relates to compounds of formula I in which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译：本发明涉及其中A，R1，R2，R3，R4，R5，R6，R7和n具有权利要求中所述含义的式I化合物。该化合物特别适合作为抗心律失常活性成分，特别是用于治疗和预防房性心律失常，例如房颤（AF）或心房扑动。

50. 发明授权

US07775585B2 Fender configuration 有权
标题翻译：挡泥板配置
公开(公告)号：US07775585B2
公开(公告)日：2010-08-17
申请号：US12388526
申请日：2009-02-19
申请人： Klaus Feeser , Michael Soellner , Michael Wagner
发明人： Klaus Feeser , Michael Soellner , Michael Wagner
IPC分类号： B60R21/34
CPC分类号： B62D25/16 , B60R2021/343 , B62D25/163
摘要： A fender configuration for a motor vehicle has a fender and a deformation element which is C-shaped in cross section. For the substantially vertically oriented supporting of an upper edge of the fender, an upper limb of the deformation element is connected to the fender and a lower limb is connected to the vehicle body. It is important that the C-shaped deformation element is arranged such that it is open toward the associated fender.
摘要翻译：用于机动车辆的挡泥板配置具有翼子板和横截面为C形的变形元件。对于挡泥板的上边缘的基本垂直定向的支撑，变形元件的上肢连接到翼子板，并且下肢连接到车体。重要的是，C形变形元件被布置成使其朝向相关的挡泥板敞开。

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