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41. 发明授权

US07935538B2 Indicator immobilization on assay devices 有权
标题翻译：指示剂固定在测定装置上
公开(公告)号：US07935538B2
公开(公告)日：2011-05-03
申请号：US11640100
申请日：2006-12-15
申请人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
发明人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N21/78 , G01N33/558 , Y10S435/97 , Y10S436/81
摘要： A lateral flow assay device for detecting the presence or quantity of an analyte in a test sample is provided. The device comprises a chromatographic medium that defines a detection zone, wherein a crosslinked network is non-diffusively immobilized within the detection zone. The crosslinked network contains a small molecule indicator that is configured to undergo a detectable color change in the presence of the analyte.
摘要翻译：提供了用于检测测试样品中分析物的存在或数量的侧流测定装置。该装置包括限定检测区的色谱介质，其中交联网络非扩散地固定在检测区内。交联网络包含小分子指示剂，其被配置为在分析物存在下经历可检测的颜色变化。

42. 发明申请

US20110015063A1 Multiple Component Materials Having A Color-Changing Composition 审中-公开
标题翻译：具有变色组合物的多组分材料
公开(公告)号：US20110015063A1
公开(公告)日：2011-01-20
申请号：US12503380
申请日：2009-07-15
申请人： JunMo Gil , Xuedong Song
发明人： JunMo Gil , Xuedong Song
IPC分类号： B01J20/26 , G01N31/22 , B05D3/02
CPC分类号： A61L15/22 , A61F13/00051 , A61F13/00991 , A61F13/15577 , A61F13/42 , A61F2013/422 , A61F2013/427 , A61F2013/428 , A61L15/48 , A61L15/56 , C08J7/047
摘要： The present invention relates to a multiple-component material including a substrate and a film layer on the substrate. The film layer includes a color-changing composition to indicate a change in condition, such as a change in pH. The color-changing composition includes a water-insoluble, film-forming polymer, a charged surfactant, a charged colorant and a pH adjuster.
摘要翻译：本发明涉及在基板上包括基板和薄膜层的多组分材料。膜层包括变色组合物，以指示条件的变化，例如pH的变化。变色组合物包括水不溶性，成膜聚合物，带电荷的表面活性剂，带电荷的着色剂和pH调节剂。

43. 发明申请

US20100062543A1 Polyelectrolytic Internal Calibration System of a Flow-Through Assay 有权
标题翻译：流通测定的聚电解内部校准系统
公开(公告)号：US20100062543A1
公开(公告)日：2010-03-11
申请号：US12616821
申请日：2009-11-12
申请人： Xuedong Song , Ning Wei , Curtis N. Sayre
发明人： Xuedong Song , Ning Wei , Curtis N. Sayre
IPC分类号： G01N33/558
CPC分类号： A47B13/086 , A47B3/0912
摘要： A flow-through assay for detecting the quantity of an analyte residing in a test sample is provided. The flow-through assay contains a porous membrane that is in fluid communication with probe conjugates that contain a specific binding member and a detectable probe. The porous membrane also defines a detection zone and a calibration zone. The calibration zone contains a polyelectrolyte substantially non-diffusively immobilized on the porous membrane. The polyelectrolyte is capable of generating a detectable calibration signal that can be readily compared (visually, quantitatively, and the like) to a detection signal to determine the amount of analyte in the test sample.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的量的流通测定。流通测定包含多孔膜，其与含有特异性结合成员和可检测探针的探针缀合物流体连通。多孔膜还限定了检测区域和校准区域。校准区域包含基本上非扩散地固定在多孔膜上的聚电解质。聚电解质能够产生可检测的校准信号，其可以容易地与检测信号进行比较（视觉上，定量等）以确定测试样品中分析物的量。

44. 发明授权

US07575887B2 Detection of proteases secreted from pathogenic microorganisms 有权
标题翻译：检测病原微生物分泌的蛋白酶
公开(公告)号：US07575887B2
公开(公告)日：2009-08-18
申请号：US11364810
申请日：2006-02-28
申请人： Xuedong Song
发明人： Xuedong Song
IPC分类号： C12Q1/37
CPC分类号： C12Q1/44 , G01N33/52 , G01N33/558 , G01N33/573
摘要： A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the protease to release a compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium.
摘要翻译：提供了用于检测测试样品中蛋白酶（例如氨基肽酶）的存在或不存在的诊断测试试剂盒。测试试剂盒包括能够在蛋白酶存在下被切割以释放化合物的底物。试剂盒还包括含有色谱介质的侧流装置。色谱介质限定了检测区域，其中含有能够与化合物反应形成第二试剂（例如芳族偶氮化合物）的第一试剂（例如重氮离子）。第二试剂显示与第一试剂的颜色不同的颜色。侧流装置还包括位于邻近色谱介质的吸收材料，吸收材料在流过色谱介质后接收测试样品。

45. 发明申请

US20090127509A1 CROSS-LINKED ENCAPSULATED PHOSPHORSCENT MOLECULES 有权
标题翻译：交联粘附的磷光体分子
公开(公告)号：US20090127509A1
公开(公告)日：2009-05-21
申请号：US11772499
申请日：2007-07-02
申请人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
发明人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
IPC分类号： C09K11/02
CPC分类号： C08K5/0041 , C08F214/06 , C08K9/08 , C08L53/00 , C09K11/02 , C09K11/06 , C09K2211/185 , Y10T428/2998 , C08L2666/02
摘要： There is provided herein cross-linked, phosphorescent micro- and nanoparticles and applications of those particles. The invention uses halogen-containing polymers and co-polymers (HCPs) as an encapsulation matrix for organic and organometallic phosphorescent compounds to form micro- or nanoparticles. The phosphorescence of these encapsulated phosphorescent particles is substantially unaffected by phosphorescence quenchers such as oxygen and water molecules at ambient conditions. The invention provides methods of making cross-linked phosphorescent particles. HCPs may be directly cross-linked through linking moieties that are a part of the polymer, or cross-linked through other separate bridging or cross-linking materials Cross-linked particles are more stable than the non-cross-linked counterparts and more resistant to temperature, surfactants, and organic solvents.
摘要翻译：本文提供了交联的磷光微粒和纳米颗粒以及这些颗粒的应用。本发明使用含卤聚合物和共聚物（HCP）作为有机和有机金属磷光化合物的包封基质以形成微米或纳米颗粒。这些包封的磷光颗粒的磷光在环境条件下基本上不受磷光猝灭剂如氧和水分子的影响。本发明提供制备交联磷光颗粒的方法。 HCP可以通过作为聚合物的一部分的连接部分直接交联，或者通过其它单独的桥连或交联材料交联。交联颗粒比非交联对应物更稳定，并且更耐抗温度，表面活性剂和有机溶剂。

46. 发明申请

US20080147019A1 Antimicrobial component system containing metallic nanoparticles and chitosan and/or its derivatives 审中-公开
标题翻译：含有金属纳米粒子和壳聚糖和/或其衍生物的抗微生物组分体系
公开(公告)号：US20080147019A1
公开(公告)日：2008-06-19
申请号：US11641637
申请日：2006-12-19
申请人： Xuedong Song , Bao T. Do , Robert B. Johnson
发明人： Xuedong Song , Bao T. Do , Robert B. Johnson
IPC分类号： A01N25/08 , A01N59/16 , A01N59/20 , A01P1/00 , A61J15/00 , A61M16/04 , A61M25/00
CPC分类号： C09D5/14 , C08B37/003 , C08L5/08 , C09D105/08
摘要： A material composition, including metallic nanoparticles of silver, silver alloys, or copper, having antimicrobial properties is disclosed. The metallic nanoparticles are embedded or encapsulated in a matrix formed of chitosan or chitosan derivative-based compounds.
摘要翻译：公开了一种材料组合物，包括具有抗微生物性质的银，银合金或铜的金属纳米颗粒。将金属纳米颗粒嵌入或包封在由壳聚糖或壳聚糖衍生物基化合物形成的基质中。

47. 发明申请

US20080090253A1 Membrane-Based Lateral Flow Assay Devices that Utilize Phosphorescent Detection 有权
标题翻译：使用磷光检测的膜基侧流测定装置
公开(公告)号：US20080090253A1
公开(公告)日：2008-04-17
申请号：US11956397
申请日：2007-12-14
申请人： Xuedong Song
发明人： Xuedong Song
IPC分类号： C12M1/34 , G01N33/53
CPC分类号： G01N33/558 , G01N21/6428 , G01N33/5302 , G01N33/54313 , G01N33/54393 , G01N33/582 , G01N33/587 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的存在或量的侧向流动的基于膜的测定装置。该器件利用磷光来检测激发的磷光标记产生的信号。标签可能具有长的发光寿命，从而在检测期间实际上消除了许多来源的背景干扰，例如散射光和自发荧光。此外，磷光标记物可以被包封在颗粒内以将标记物遮蔽猝灭剂，例如氧气或水，这可能会破坏磷光信号。

48. 发明授权

US07285424B2 Membrane-based assay devices 有权
标题翻译：基于膜的测定装置
公开(公告)号：US07285424B2
公开(公告)日：2007-10-23
申请号：US10228836
申请日：2002-08-27
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

49. 发明授权

US07247375B2 Polymeric matrices for the encapsulation of phosphorescent molecules for analytical applications 有权
标题翻译：用于分析应用的磷光分子封装的聚合物基质
公开(公告)号：US07247375B2
公开(公告)日：2007-07-24
申请号：US10837093
申请日：2004-04-30
申请人： Xuedong Song , Bin Wu
发明人： Xuedong Song , Bin Wu
IPC分类号： B32B5/16
CPC分类号： C09K11/06 , C09K2211/18 , Y10T428/256 , Y10T428/2991 , Y10T428/2998
摘要： The invention involves encapsulation of phosphorescent molecules in polymeric matrices to prevent phosphorescence quenching. Specifically, polymers containing a significant portion of halogens have been found to be good matrices for encapsulation of phosphorescent molecules to provide strong phosphorescence at ambient conditions. Those encapsulated phosphorescent molecules can find a wide variety of applications for detection of many species, including biological and chemical molecules as well as micro-organisms.
摘要翻译：本发明涉及将磷光分子封装在聚合物基质中以防止磷光猝灭。具体地，已经发现含有相当大部分卤素的聚合物是用于封装磷光分子的良好基质，以在环境条件下提供强磷光。这些包封的磷光分子可以发现多种用于检测许多物种的应用，包括生物和化学分子以及微生物。

50. 发明授权

US07091049B2 Enhanced diffraction-based biosensor devices 有权
$Enhanced diffraction-based biosensor devices$
标题翻译：增强的基于衍射的生物传感器装置
公开(公告)号：US07091049B2
公开(公告)日：2006-08-15
申请号：US10180219
申请日：2002-06-26
申请人： Rameshbabu Boga , Chibueze Obinna Chidebelu-Eze , Rosann M. Kaylor , Xuedong Song
发明人： Rameshbabu Boga , Chibueze Obinna Chidebelu-Eze , Rosann M. Kaylor , Xuedong Song
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , C12Q1/6825 , Y10S435/808 , Y10S436/805 , Y10S436/815 , Y10S436/816 , Y10S436/817 , C12Q2563/107
摘要： An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance with the analyte of interest, the tag emitting a measurable parameter that is different from optical diffraction characteristics of the analyte. The biosensor may be a “fluoroptical” system wherein the detection tag is a fluorescence emitting substance, including fluorescent-labeled diffraction enhancing elements. The enhanced diffraction biosensor system may determine the presence of analytes in biological fluids both qualitatively and quantitatively.
摘要翻译：提供了一种增强衍射的生物传感器系统和方法，用于检测测试介质中感兴趣的分析物。该系统将至少一种额外的检测标签物质与感兴趣的分析物结合，该标签发射不同于分析物的光学衍射特性的可测量参数。生物传感器可以是“荧光光谱”系统，其中检测标签是荧光发射物质，包括荧光标记的衍射增强元件。增强的衍射生物传感器系统可以定性和定量地确定生物流体中分析物的存在。

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