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41. 发明申请

US20130217802A1 METHOD FOR MANUFACTURING RUBBER COMPOSITION 审中-公开
标题翻译：制造橡胶组合物的方法
公开(公告)号：US20130217802A1
公开(公告)日：2013-08-22
申请号：US13876978
申请日：2011-10-03
申请人： Seiichi Katou , Satoshi Horie
发明人： Seiichi Katou , Satoshi Horie
IPC分类号： C08L9/06 , C08J3/20
CPC分类号： C08L9/06 , B60C1/0016 , C08J3/203 , C08J3/2056 , C08J2321/00 , C08K3/013 , C08K5/09 , C08K5/18 , C08K5/548 , C08L21/00
摘要： A method for producing a rubber composition containing a rubber component (A) of at least one selected from natural rubbers and synthetic dienic rubbers, a filler containing an inorganic filler (B), and a silane coupling agent (C) of a compound having a mercapto group, wherein the rubber composition is kneaded in multiple stages, in the first stage of kneading, the rubber component (A), all or a part of the inorganic filler (B), and all or a part of the silane coupling agent (C) are kneaded, then in the first stage or in the subsequent kneading stage, at least one compound selected from an acidic compound (D) and a basic compound (E) is added, and the highest temperature of the rubber composition in the final stage of kneading is from 60 to 120° C.
摘要翻译：一种含有选自天然橡胶和合成二烯橡胶中的至少一种的橡胶组分（A）的橡胶组合物的制备方法，含有无机填料（B）的填料和含有无机填料（B）的化合物的硅烷偶联剂（C）巯基，其中橡胶组合物在多个阶段被捏合，在第一阶段的捏合中，橡胶组分（A），全部或部分无机填料（B）和全部或部分硅烷偶联剂（ C），然后在第一阶段或随后的捏合阶段中，加入至少一种选自酸性化合物（D）和碱性化合物（E）的化合物，最终的橡胶组合物的最高温度搅拌阶段为60〜120℃

42. 发明申请

US20120149929A1 PROCESS FOR PRODUCING SILANE COUPLING AGENT 有权
标题翻译：生产硅烷偶联剂的方法
公开(公告)号：US20120149929A1
公开(公告)日：2012-06-14
申请号：US13392411
申请日：2010-08-26
申请人： Yasuo Fukushima , Satoshi Horie
发明人： Yasuo Fukushima , Satoshi Horie
IPC分类号： C07F7/10
CPC分类号： C07F7/1804 , B01J31/0212 , B01J31/143 , B01J2231/42
摘要： Provided is a process for producing a silane coupling agent, which can shorten the time required for the production process. A process for producing a silane coupling agent, characterized by comprising a step of reacting a silane compound (A) with a compound (B) which has a hydroxyl group and further contains an atom having an unshared electron pair other than an oxygen atom derived from the hydroxyl group, in the presence of a metal-containing catalyst (m) to obtain a silane compound (C) which has an alkoxyl group containing the atom having the unshared electron pair other than the oxygen atom derived from the hydroxyl group.
摘要翻译：提供一种可以缩短生产过程所需时间的硅烷偶联剂的制造方法。一种硅烷偶联剂的制备方法，其特征在于包括使硅烷化合物（A）与具有羟基的化合物（B）反应的步骤，并且还含有除衍生自氧原子的氧原子以外的未共享电子对的原子羟基，在含金属的催化剂（m）的存在下，得到含有除了由羟基衍生的氧原子以外的非共有电子对的原子的烷氧基的硅烷化合物（C）。

43. 发明授权

US07954823B2 Sealing ring for reciprocating motion 有权
标题翻译：用于往复运动的密封圈
公开(公告)号：US07954823B2
公开(公告)日：2011-06-07
申请号：US12223667
申请日：2007-02-02
申请人： Satoshi Horie , Masashi Nakao
发明人： Satoshi Horie , Masashi Nakao
IPC分类号： F16J9/20 , F16J15/18 , F16J15/32
CPC分类号： F16J15/3204 , F16J15/164
摘要： A sealing ring used for reciprocating motion and having low friction characteristics. The sealing ring is held at one of two members that move relative to each other and slidably in intimate contact with the other. The sealing ring has an end sliding part having an arcuate cross section and slidably in intimate contact with the other and also has a recessed surface formed in at least either a rear face or both side faces in an axial direction. The sealing ring satisfies the relationships of A/2
摘要翻译：用于往复运动并具有低摩擦特性的密封环。密封环保持在相对于彼此移动并且可滑动地彼此紧密接触的两个构件中的一个构件中。密封环具有端部滑动部分，其具有弓形横截面并且可滑动地彼此紧密接触，并且还具有形成在轴向方向上的至少任一个后表面或两个侧面中的凹陷表面。密封圈满足A / 2

44. 发明申请

US20100297662A1 ANTIBODY AND USE THEREOF 有权
标题翻译：抗体及其用途
公开(公告)号：US20100297662A1
公开(公告)日：2010-11-25
申请号：US12734359
申请日：2008-10-29
申请人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
发明人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
IPC分类号： G01N33/566 , C07K16/18 , C12M1/34 , C12N5/12 , C07H21/00 , C12N15/63
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821
摘要： An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid β fibrils or monomeric amyloid β-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid β fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid β-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
摘要翻译：本发明提供的抗体与淀粉样蛋白前体蛋白的反应性低，与淀粉样蛋白和淀粉样蛋白相比具有比淀粉样蛋白球体更高的反应性。原纤维或单体淀粉样蛋白和蛋白质。根据本发明，提供了与淀粉样蛋白前体蛋白具有比淀粉样前体蛋白更高反应性的抗体，并且具有以下特性中的任何一种或多种：（i）与淀粉样蛋白相比具有更高的淀粉样蛋白球体活性; 原纤维（ii）与淀粉样蛋白和单糖淀粉样蛋白相比，与淀粉样蛋白球体的反应性更高; 和（iii）抑制淀粉样蛋白球体诱导的神经元细胞死亡的活性。

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