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41. 发明申请

US20060294608A1 Novel haemopoietin receptor and genetic sequences encoding same 审中-公开
标题翻译：新型造血素受体和编码相同的遗传序列
公开(公告)号：US20060294608A1
公开(公告)日：2006-12-28
申请号：US11509410
申请日：2006-08-24
申请人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
发明人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , C07K14/71 , C07K16/28
CPC分类号： C07K14/715 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0381 , C07K16/2866 , C12N15/8509
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

42. 外观设计

USD521415S1 Motor scooter 有权
公开(公告)号：USD521415S1
公开(公告)日：2006-05-23
申请号：US29234715
申请日：2005-07-22
申请人： Tetsuo Kojima , Fujio Nakamura , Kenji Tako
设计人： Tetsuo Kojima , Fujio Nakamura , Kenji Tako

43. 外观设计

USD520154S1 Rear combination lamp for two-wheeled motor vehicles 失效
标题翻译：后轮组合灯用于两轮汽车
公开(公告)号：USD520154S1
公开(公告)日：2006-05-02
申请号：US29203277
申请日：2004-04-13
申请人： Tetsuo Kojima , Fujio Nakamura
设计人： Tetsuo Kojima , Fujio Nakamura

44. 发明授权

US06866998B1 Cellular assays for identifying signaling peptides 失效
标题翻译：用于鉴定信号肽的细胞测定
公开(公告)号：US06866998B1
公开(公告)日：2005-03-15
申请号：US09555165
申请日：1998-11-26
申请人： Toshio Kitamura , Tetsuo Kojima
发明人： Toshio Kitamura , Tetsuo Kojima
IPC分类号： C07K14/715 , C12N15/12 , C12N15/62 , C12N15/867 , C12Q1/68 , C12P21/04 , C12P21/06
CPC分类号： C12N15/625 , C07K2319/02 , C07K2319/75 , C12N2799/027 , C12Q1/6897
摘要： The invention includes a DNA encoding a known translocatable protein, for example, human mpl, lacking secretory ability due to deletion of its secretory signal and the major part of the extracellular region thereof. This DNA is present in an expression vector into which a test cDNA from a cDNA library is ligated. The expression vector containing the known DNA and the test cDNA expresses a chimeric protein encoded by these two nucleic acid molecules. Cells expressing the newly constructed vector are capable of proliferating if the test cDNA is a secretory protein. Thus, cDNAs encoding secretory proteins including type I membrane proteins and type II membrane proteins can be detected and isolated by constructing a cDNA library and screening it for ability to promote cell proliferation.
摘要翻译：本发明包括编码已知可转运蛋白的DNA，例如人mpl，由于其分泌信号的缺失及其主要部分缺乏分泌能力。该DNA存在于其中连接来自cDNA文库的测试cDNA的表达载体中。含有已知DNA和测试cDNA的表达载体表达由这两种核酸分子编码的嵌合蛋白质。如果测试cDNA是分泌蛋白，则表达新构建的载体的细胞能够增殖。因此，可以通过构建cDNA文库并筛选其来促进细胞增殖的能力来检测和分离包括I型膜蛋白和II型膜蛋白的分泌蛋白的cDNA。

45. 发明授权

US06633495B2 DC apparatus and vehicle using the same 有权
标题翻译：直流设备和使用其的车辆
公开(公告)号：US06633495B2
公开(公告)日：2003-10-14
申请号：US10101529
申请日：2002-03-20
申请人： Seiji Ishda , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
发明人： Seiji Ishda , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
IPC分类号： H02M324
CPC分类号： H02M1/143
摘要： The voltage applied to a power converter is detected by a voltage detector, a function generator produces a voltage proportional to this detected voltage, and a high-pass filter detects an AC component superimposed on the voltage. An adder adds a bias voltage to this AC component, and an adder adds the output from the adder and the output from the function generator. The output from the adder is compared with a triangular wave produced from a rectangular wave generator, and a switching element is controlled to make switching operation according to the compared result. When a DC current is decreased by the AC component, a resistance current Ib is increased so that the AC components superimposed on the current and resistance current can be cancelled out.
摘要翻译：施加到功率转换器的电压由电压检测器检测，功能发生器产生与该检测电压成比例的电压，高通滤波器检测叠加在电压上的AC分量。加法器向该AC分量加上偏置电压，加法器将来自加法器的输出和来自函数发生器的输出相加。将来自加法器的输出与由矩形波发生器产生的三角波进行比较，并且根据比较结果控制开关元件进行开关操作。当直流电流被交流分量降低时，电阻电流Ib增加，从而可以消除叠加在电流和电阻电流上的交流分量。

46. 发明授权

US06456909B1 Control apparatus of electric vehicle 失效
标题翻译：电动车控制装置
公开(公告)号：US06456909B1
公开(公告)日：2002-09-24
申请号：US09651721
申请日：2000-08-30
申请人： Motomi Shimada , Tetsuo Kojima , Kiyoshi Nakata , Eiichi Toyota , Toshihiko Sekizawa
发明人： Motomi Shimada , Tetsuo Kojima , Kiyoshi Nakata , Eiichi Toyota , Toshihiko Sekizawa
IPC分类号： B60L700
CPC分类号： B60L7/26 , B60L2200/26 , Y02T10/7258
摘要： To determine the timing of the electrical brake for completely stopping in electrical braking control, and also to achieve both sure stopping and good riding comfort in an electric vehicle powered by the motor by decreasing the braking force at a prescribed rate of change, the torque of the electric motor is controlled by controlling the power converter which powers the motor using a power converter controller. The deceleration of the motor is computed based on the detected speed of the electric motor which is as an output of the speed detection means, the subsequent speed of the electric motor is estimated based on the detected speed and the deceleration rate of the electric motor at the time the detected rotational speed of the electric motor falls below a prescribed speed, and torque control is carried out using an electric power converter controller, based on the estimated speed.
摘要翻译：为了确定在电制动控制中完全停止的电动制动器的时机，并且通过以规定的变化率减小制动力，也能够实现由电动机驱动的电动车辆的确定停止和良好的乘坐舒适性，通过控制使用功率转换器控制器为电机供电的功率转换器来控制电动机。基于作为速度检测装置的输出的电动机的检测速度来计算电动机的减速度，基于电动机的检测速度和减速度来估计电动机的后续速度电动机的检测转速下降到低于规定速度的时间，并且使用电力转换控制器基于估计速度进行转矩控制。

47. 发明授权

US06393034B1 Laser apparatus and laser processing apparatus 有权
标题翻译：激光设备和激光加工设备
公开(公告)号：US06393034B1
公开(公告)日：2002-05-21
申请号：US09477706
申请日：2000-01-05
申请人： Susumu Konno , Shuichi Fujikawa , Tetsuo Kojima
发明人： Susumu Konno , Shuichi Fujikawa , Tetsuo Kojima
IPC分类号： H01S311
CPC分类号： H01S3/109 , H01S3/08 , H01S3/08059 , H01S3/08072 , H01S3/0815 , H01S3/11
摘要： An intracavity wavelength conversion laser apparatus has a stable resonator in which a solid-state laser active medium, a resonator Q-value modulating element, and a wavelength conversion crystal, a nonlinear element, are arranged along a laser optical axis for generating a Q pulse wavelength conversion laser beam. A mirror constituting the stable resonator, which is positioned close to the wavelength conversion crystal, is a convex mirror, whereby the Q pulse wavelength conversion laser beam has a short pulse width. The laser apparatus is easily operated with high efficiency and has a small size. The Q pulse wavelength conversion laser beam is generated with excellent reproducibility and stability, and the wavelength conversion crystal is less susceptible to optical damage.
摘要翻译：腔内波长转换激光装置具有稳定的谐振器，其中固体激光器活性介质，谐振器Q值调制元件和波长转换晶体，非线性元件沿激光光轴布置以产生Q脉冲波长转换激光束。构成靠近波长转换晶体的稳定谐振器的反射镜是凸面镜，由此Q脉冲波长转换激光束具有短的脉冲宽度。激光装置容易操作，效率高，体积小。产生Q脉冲波长转换激光束具有优异的再现性和稳定性，并且波长转换晶体不易受光损伤。

48. 发明授权

US5892789A Solid-state laser apparatus 失效
标题翻译：固态激光装置
公开(公告)号：US5892789A
公开(公告)日：1999-04-06
申请号：US899889
申请日：1997-07-24
申请人： Koji Yasui , Takafumi Kawai , Tetsuo Kojima , Susumu Konno
发明人： Koji Yasui , Takafumi Kawai , Tetsuo Kojima , Susumu Konno
IPC分类号： H01S3/07 , H01S3/08 , H01S3/091 , H01S3/0941 , H01S3/10 , H01S3/109 , H01S3/136 , H01S3/16 , H01S3/23 , H01S3/14
CPC分类号： H01S3/025 , H01S3/07 , H01S3/10 , H01S3/0407 , H01S3/042 , H01S3/08072 , H01S3/093 , H01S3/094057 , H01S3/0941 , H01S3/109
摘要： A solid-state laser apparatus comprises a plurality of solid-state materials each having an active solid-state medium and arranged in a row with a predetermined space on an optical axis of light incident thereon. An optical rotation material and an angle adjusting instrument for adjusting an angle between the optical rotation material and the optical axis of incident light are disposed in at least a space selected from among the plural spaces. The laser apparatus further comprises a laser optical system for extracting a laser beam emitted by the plural solid-state materials.
摘要翻译：固体激光装置包括多个固态材料，每个固态材料具有活性固态介质，并且在入射到其上的光的光轴上以预定的空间排成一行。用于调整光旋转材料与入射光的光轴之间的角度的光学旋转材料和角度调节装置设置在从多个空间中选择的至少一个空间中。激光装置还包括用于提取由多个固态材料发射的激光束的激光光学系统。

49. 发明授权

US08337841B2 Methods of screening for antibody light chains 有权
标题翻译：筛选抗体轻链的方法
公开(公告)号：US08337841B2
公开(公告)日：2012-12-25
申请号：US10542839
申请日：2004-01-21
申请人： Tetsuo Kojima
发明人： Tetsuo Kojima
IPC分类号： A61K39/395 , C12N1/21 , C12N15/74 , C40B40/10
CPC分类号： C07K16/005 , C07K2317/31 , C07K2317/55
摘要： The present invention relates to methods of screening for commonly shared light chains, in which the method comprises the steps of (a) generating a host secreting the heavy chain of an antibody that binds to a desired antigen; (b) introducing an antibody light chain library into the host of step (a) to generate libraries presenting antibodies composed of the heavy chain and the light chains; (c) selecting a library presenting antibodies that bind specifically to the desired antigen of step (a); (d) introducing the library selected in step (c) into a host secreting the heavy chain of an antibody that binds to a desired antigen different from the antigen of step (a) to generate libraries that display antibodies composed of the heavy chains and light chains; and (e) selecting a library that displays antibodies that bind specifically to the desired antigen of step (d).
摘要翻译：本发明涉及筛选普遍共享的轻链的方法，其中该方法包括以下步骤：（a）产生分泌结合所需抗原的抗体重链的宿主; （b）将抗体轻链文库导入步骤（a）的宿主，以产生呈现由重链和轻链组成的抗体的文库; （c）选择呈递与步骤（a）的所需抗原特异性结合的抗体的文库; （d）将步骤（c）中选择的文库导入分泌与不同于步骤（a）的抗原的期望抗原结合的抗体的重链的宿主，以产生显示由重链和光组成的抗体的文库链条和（e）选择显示与步骤（d）的所需抗原特异性结合的抗体的文库。

50. 发明申请

US20120253016A1 ANTIBODY MOLECULES THAT BIND TO IL-6 RECEPTOR 审中-公开
标题翻译：与IL-6受体结合的抗体分子
公开(公告)号：US20120253016A1
公开(公告)日：2012-10-04
申请号：US13524528
申请日：2012-06-15
申请人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
发明人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
IPC分类号： C07K16/00 , C12N15/63 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
摘要： The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
摘要翻译：本发明通过改变作为人源化抗IL-6受体IgG1抗体的TOCILIZUMAB的可变区和恒定区的氨基酸序列来提供优于TOCILIZUMAB的第二代分子的药物组合物，以增强抗原 - 中和能力增强，药代动力学改善，治疗效果较差，免疫原性，安全性和物理化学性质（稳定性和均一性）均有改善。本发明还提供了制备这些药物组合物的方法。通过适当地组合CDR结构域，可变区和恒定区中的氨基酸序列改变，本发明人成功地生产出优于TOCILIZUMAB的第二代分子。

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