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41. 发明授权

US06625493B2 Orientation of patient's position sensor using external field 有权
标题翻译：患者位置传感器使用外部场的方向
公开(公告)号：US06625493B2
公开(公告)日：2003-09-23
申请号：US09939197
申请日：2001-08-24
申请人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
发明人： Mark W. Kroll , Chris Sorensen , Gene A. Bornzin
IPC分类号： A61N1362
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36542
摘要： An implantable cardiac stimulation device is equipped with an accelerometer-based sensor to sense a patient's movement and produce a vertical acceleration component indicative of a patient's acceleration in a vertical direction. A vertical velocity component is computed from the vertical acceleration component. The device may be further equipped with a magnetic field sensor to sense the earth's magnetic field as a way to obtain a true vertical orientation, against which the accelerometer-based sensor can be calibrated.
摘要翻译：可植入心脏刺激装置配备有基于加速度计的传感器，以感测患者的运动并产生指示患者在垂直方向上的加速度的垂直加速度分量。从垂直加速度分量计算垂直速度分量。该装置可以进一步配备有磁场传感器，以感测地球的磁场，作为获得真正的垂直取向的方式，基于加速度计的传感器可被校准。

42. 发明授权

US07653440B1 Stimulation lead and methods of stimulating 有权
标题翻译：刺激引导和刺激方法
公开(公告)号：US07653440B1
公开(公告)日：2010-01-26
申请号：US11172755
申请日：2005-06-30
申请人： Gene A. Bornzin , Mark W. Kroll
发明人： Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0587 , A61N1/3621 , A61N1/3684 , A61N2001/0585
摘要： An exemplary method includes passing a lead through a wall of an epicardial vein, an epicardial venous structure and/or a cardiac chamber wherein the lead includes an electrode portion; positioning the electrode portion proximate to an autonomic nerve and/or other tissue region; and delivering an electrical signal to the electrode portion to stimulate the autonomic nerve and/or other tissue region and thereby change cardiac function.
摘要翻译：一种示例性方法包括使引线通过心外膜静脉壁，心外膜静脉结构和/或心室，其中引线包括电极部分; 将电极部分定位成靠近自主神经和/或其他组织区域; 并向电极部分输送电信号以刺激自主神经和/或其他组织区域，从而改变心脏功能。

43. 发明授权

US07467012B1 Respiration parameters controlled by heart rate 有权
标题翻译：呼吸参数由心率控制
公开(公告)号：US07467012B1
公开(公告)日：2008-12-16
申请号：US11166617
申请日：2005-06-24
申请人： Euljoon Park , Gene A. Bornzin , Mark W. Kroll
发明人： Euljoon Park , Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/05 , A61B5/08
CPC分类号： A61B5/0809 , A61B5/0205 , A61N1/056 , A61N1/3601 , A61N1/3611 , A61N1/36514 , A61N2001/0585
摘要： Heart rate information is used at least in part to obtain one or more parameters for inducing respiration. In various implementations, respiratory parameters, such as a target breathing rate or a target tidal volume may be delivered by an implantable device to a patient during periods of altered respiration, such as sleep apnea or exercise. A respiratory parameter may also be obtained from a physiological variable, a patient's physical activity level, or metabolic demands.
摘要翻译：心率信息至少部分地用于获得用于诱导呼吸的一个或多个参数。在各种实施方案中，诸如目标呼吸频率或目标潮气量之类的呼吸参数可以在改变呼吸的时段（例如睡眠呼吸暂停或运动）期间由可植入装置递送给患者。也可以从生理变量，患者的身体活动水平或代谢需求获得呼吸参数。

44. 发明授权

US07386342B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US07386342B1
公开(公告)日：2008-06-10
申请号：US10937756
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

45. 发明授权

US07359752B1 Configurable test load for an implantable medical device 有权
标题翻译：可植入医疗设备的可配置测试负载
公开(公告)号：US07359752B1
公开(公告)日：2008-04-15
申请号：US11181708
申请日：2005-07-13
申请人： Gene A. Bornzin , Mark W. Kroll
发明人： Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/00
CPC分类号： A61N1/372 , A61B50/30 , A61N1/37235 , A61N2001/37294 , G06F19/3481 , G16H40/63
摘要： A test assembly for an implantable medical device, which includes a patient simulator capable of providing signals to the implantable medical device that are representative of the patient's organ function to thereby test whether the implantable medical device is capable of detecting circumstances requiring the deliver of therapy. The patient simulator further includes a plurality of loads that can be selected to correspond to the loads actually seen by the implantable medical device when delivering therapy to the patient.
摘要翻译：一种用于可植入医疗装置的测试组件，其包括能够向可植入医疗装置提供代表患者器官功能的信号的患者模拟器，从而测试可植入医疗装置是否能够检测需要递送治疗的情况。患者模拟器还包括多个负载，其可以选择以对应于当向患者递送治疗时由可植入医疗装置实际看到的负载。

46. 发明授权

US07149584B1 System and method for determining patient posture based on 3-D trajectory using an implantable medical device 失效
公开(公告)号：US07149584B1
公开(公告)日：2006-12-12
申请号：US10328642
申请日：2002-12-23
申请人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
发明人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/36535 , A61N1/36542 , A61N1/37235
摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

47. 发明授权

US07024243B1 System and methods for preventing, detecting, and terminating pacemaker mediated tachycardia in biventricular implantable cardiac stimulation device 失效
标题翻译：起搏器介入性心动过速在双心室可植入心脏刺激装置中的预防，检测和终止的系统和方法
公开(公告)号：US07024243B1
公开(公告)日：2006-04-04
申请号：US10367504
申请日：2003-02-13
申请人： Gene A. Bornzin , Mark W. Kroll
发明人： Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/362 , A61B5/0464
CPC分类号： A61B5/0464 , A61B5/04525 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3702
摘要： Various techniques are described for preventing pacemaker mediated tachycardia (PMT) within biventricular pacing systems and for detecting and terminating PMT should it nevertheless arise. In a first prevention technique, refractory periods applied to the atrial channel are synchronized to begin with a second of a pair of ventricular pacing pulses to more effectively prevent T-wave oversensing on the atrial channel. In a second prevention technique, the sensitivity of the atrial channel is reduced during T-waves also to prevent T-wave oversensing. In a third prevention technique, template matching is performed on the ventricular channels to prevent T-wave oversensing. In a fourth prevention technique, T-wave detection windows are applied to both the ventricular and atrial channels subsequent to any paced or sensed events. In a first detection technique, PMT is detected based upon a degree of variation within V-pulse to P-wave pacing intervals. In a second detection technique, PMT is detected based upon a degree variation within ventricular pacing intervals. In either case, if the degree of variation is too low, indicative of PMT, ventricular refractory periods are expanded to terminate the PMT.
摘要翻译：描述了用于在双心室起搏系统中预防起搏器介导的心动过速（PMT）的各种技术，并且如果仍然出现则检测和终止PMT。在第一预防技术中，应用于心房通道的不应期同步于开始于一对心室起搏脉冲的第二个，以更有效地防止心房通道上的T波过度感觉。在第二种预防技术中，在T波期间心房通道的灵敏度降低，以防止T波过度感染。在第三种预防技术中，对心室通道进行模板匹配以防止T波过度感染。在第四种预防技术中，T波检测窗口被应用于任何节奏或感测事件之后的心室和心房通道。在第一检测技术中，基于V脉冲到P波起搏间隔内的变化程度来检测PMT。在第二检测技术中，基于心室起搏间隔内的程度变化检测PMT。在任一情况下，如果变异程度太低，则指示PMT，扩大心室不应期以终止PMT。

48. 发明授权

US06662047B2 Pacing mode to reduce effects of orthostatic hypotension and syncope 有权
标题翻译：起搏模式可降低直立性低血压和晕厥的作用
公开(公告)号：US06662047B2
公开(公告)日：2003-12-09
申请号：US09947203
申请日：2001-09-05
申请人： Chris Sorensen , Mark W. Kroll , Gene A. Bornzin
发明人： Chris Sorensen , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1365
CPC分类号： A61N1/36585 , A61N1/36535 , A61N1/36542 , A61N1/36564
摘要： An implantable cardiac stimulation device is programmed to administer pacing therapy in response to a change in a patient's position and a drop in blood pressure. The stimulation device is equipped with a position sensor to sense a position parameter indicative of when a patient changes from a supine position to an upright position and a pressure sensor to sense a pressure parameter indicative of a patient's blood pressure. The device administers cardiac pacing therapy to the patient based on both the position parameter and the pressure parameter.
摘要翻译：可植入心脏刺激装置被编程为响应于患者位置的变化和血压下降而施加起搏治疗。刺激装置配备有位置传感器，用于感测指示患者什么时候从仰卧位变为直立位置的位置参数，以及压力传感器来感测指示患者血压的压力参数。该装置基于位置参数和压力参数对患者进行心脏起搏治疗。

49. 发明授权

US06748261B1 Implantable cardiac stimulation device for and method of monitoring progression or regression of heart disease by monitoring interchamber conduction delays 有权
标题翻译：通过监测车间传导延迟，可植入心脏刺激装置和监测心脏病进展或消退的方法
公开(公告)号：US06748261B1
公开(公告)日：2004-06-08
申请号：US09675462
申请日：2000-09-28
申请人： Mark W. Kroll , Joseph J. Florio , Gene A. Bornzin , Euljoon Park , Kerry A. Bradley
发明人： Mark W. Kroll , Joseph J. Florio , Gene A. Bornzin , Euljoon Park , Kerry A. Bradley
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61N1/3684
摘要： A system and method, for use in an implantable cardiac stimulation device, monitors progression or regression in heart disease such as congestive heart failure. The system includes a sensing circuit that derives an electrogram signal indicative of the electrical activity of the patient's heart. A processor processes the electrogram signal to determine interchamber conduction delays which are then stored in memory. The stored interchamber conduction delays may be later retrieved by way of a telemetry circuit. Relative changes in the interchamber conduction delays, over time, are indicative of progression or regression in the heart disease. The relative changes in the interchamber conduction delays may be further used to automatically adjust pacing parameters of the implantable cardiac stimulation device.
摘要翻译：用于可植入心脏刺激装置的系统和方法监测心脏疾病如充血性心力衰竭的进展或消退。该系统包括感测电路，其导出指示患者心脏的电活动的电描绘信号。处理器处理电描记图信号以确定然后存储在存储器中的车间传导延迟。存储的车间传导延迟可以稍后通过遥测电路检索。随着时间的推移，间歇传导延迟的相对变化表明心脏病发展或消退。室间传导延迟的相对变化可以进一步用于自动调整可植入心脏刺激装置的起搏参数。

50. 发明授权

US07813798B2 Systems and methods for preventing, detecting, and terminating pacemaker mediated tachycardia in biventricular implantable cardiac stimulation systems 有权
标题翻译：起搏器介入性心动过速在双心室可植入心脏刺激系统中的预防，检测和终止的系统和方法
公开(公告)号：US07813798B2
公开(公告)日：2010-10-12
申请号：US11734130
申请日：2007-04-11
申请人： Gene A. Bornzin , Mark W. Kroll
发明人： Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684 , A61N1/3956
摘要： Various techniques are described for preventing pacemaker mediated tachycardia (PMT) within biventricular pacing systems and for detecting and terminating PMT should it nevertheless arise. In a first prevention technique, refractory periods applied to the atrial channel are synchronized to begin with a second of a pair of ventricular pacing pulses to more effectively prevent T-wave oversensing on the atrial channel. In a second prevention technique, the sensitivity of the atrial channel is reduced during T-waves also to prevent T-wave oversensing. In a third prevention technique, template matching is performed on the ventricular channels to prevent T-wave oversensing. In a fourth prevention technique, T-wave detection windows are applied to both the ventricular and atrial channels subsequent to any paced or sensed events.
摘要翻译：描述了用于在双心室起搏系统中预防起搏器介导的心动过速（PMT）的各种技术，并且如果仍然出现则检测和终止PMT。在第一预防技术中，应用于心房通道的不应期同步于开始于一对心室起搏脉冲的第二个，以更有效地防止心房通道上的T波过度感觉。在第二种预防技术中，在T波期间心房通道的灵敏度降低，以防止T波过度感染。在第三种预防技术中，对心室通道进行模板匹配以防止T波过度感染。在第四种预防技术中，T波检测窗口被应用于任何节奏或感测事件之后的心室和心房通道。

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